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Journal Articles

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

Silvia Buonamici, PhD, Akihide Yoshimi, MD PhD, Michael Thomas, Michael Seiler, PhD, Betty Chan, PhD, Benjamin Caleb, Rachel Darman, PhD, Peter Fekkes, PhD, Craig Karr, PhD, Gregg F. Keaney, PhD, Virginia M. Klimek, MD, Kaiko Kunii, Linda Lee, Stanley Chun-Wei Lee, PhD, Xiang Liu, PhD, Carol Meeske, Yoshiharu Mizui, PhD, Eric Padron, MD, Eunice Park, PhD, Ermira Pazolli, PhD, Sudeep Prajapati, PhD, Justin Taylor, MD, John Wang, PhD, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, MD, Omar Abdel-Wahab, MD, Peter G Smith, PhD
Journal: Blood
Blood (2016) 128 (22): 966.
https://doi.org/10.1182/blood.V128.22.966.966
Published: 2016
Journal Articles

Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells

Silvia Buonamici, PhD, Rachel Darman, PhD, Samantha Perino, BS, Anant Agrawal, PhD, Shouyong Peng, PhD, Michael Seiler, PhD, Kian Huat Lim, PhD, Erica B. Bhavsar, Jacob Feala, PhD, Esther A. Obeng, MDPhD, Suzanna Bailey, PhD, Betty Chan, PhD, Peter Fekkes, PhD, Gregg F. Keaney, PhD, Pavan Kumar, PhD, Kaiko Kunii, Linda Lee, MS, Crystal Mackenzie, Mark Matijevic, Yoshiharu Mizui, PhD, Khin Myint, Eunice Park, Ermira Pazolli, Michael Thomas, John Wang, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, Richard R. Furman, MD, Benjamin L Ebert, MD PhD, Peter G Smith, PhD
Journal: Blood
Blood (2015) 126 (23): 1643.
https://doi.org/10.1182/blood.V126.23.1643.1643
Published: 2015
Journal Articles

Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation

Silvia Buonamici, PhD, Samantha Perino, Kian Huat Lim, Jacob Feala, Esther A. Obeng, MDPhD, Michelle Aicher, Daniel Aird, Suzanna Bailey, Anna Berkenblit, Betty Chan, Corcoran Erik, Laura Corson, PhD, Rachel Darman, Peter Fekkes, Richard R. Furman, MD, Gregg F Keaney, PhD, Pavan Kumar, Kaiko Kunii, Linda Lee, Crystal Mackenzie, Eunice Park, Xiaoling Puyang, Anand Selvaraj, Michael Thomas, John Wang, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, Yoshiharu Mizui, PhD, Benjamin L. Ebert, MDPhD, Peter G Smith, PhD
Journal: Blood
Blood (2014) 124 (21): 4615.
https://doi.org/10.1182/blood.V124.21.4615.4615
Published: 2014