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Journal Articles

OTT-MAL Activates the Notch Signaling Transcription Factor RBPJ and Cooperates with Mutant MPL to Induce Acute Megakaryoblastic Leukemia

Thomas Mercher, Ph.D, Glen D. Raffel, MD, PhD, Sandra A Moore, Melanie G Cornejo, Dominique Baudry-Bluteau, Ph.D, Nicolas Cagnard, Jonathan Jesneck, Yana Pikman, Dana E. Cullen, Ifor Williams, Koichi Akashi, MD, PhD, Hirokazu Shigematsu, Jean-Pierre Bourquin, MD, PhD, Marco Giovannini, MD, PhD, William Vainchenker, Ross L Levine, MD, Benjamin H. Lee, MD, PhD, Olivier Bernard, D. Gary Gilliland

Blood (2008) 112 (11): 508.

https://doi.org/10.1182/blood.V112.11.508.508

Published: 2008

Journal Articles

Notch1 Expression Is Regulated at Post-Transcriptional Level by 3′UTR Region in Hematopoietic Stem Cell Development

Shin-ichi Mizuno, MD, PhD, Hidetoshi Ozawa, PhD, Tadafumi Iino, MD, Yojiro Arinobu, MD, PhD, Chong Yong, MD, PhD, Hirokazu Shigematsu, MD, PhD, Koichi Akashi, MD, PhD

Blood (2008) 112 (11): 2457.

https://doi.org/10.1182/blood.V112.11.2457.2457

Published: 2008

Journal Articles

Reciprocal Activation of GATA-1 and PU.1 Marks Initial Specification of Hematopoietic Stem Cells into Myelo-Erythroid and Myelo-Lymphoid Lineages.

Yojiro Arinobu, MD, PhD, Shin-ichi Mizuno, M.D., Ph.D., Yong Chong, M.D., Ph.D., Hirokazu Shigematsu, M.D., Ph.D., Tadafumi Iino, M.D., Hiromi Iwasaki, M.D., Ph.D., Thomas Graf, Ph.D., Robin Mayfield, Ph.D., Susan Chan, Ph.D., Philippe Kastner, Ph.D., Koichi Akashi, M.D., Ph.D.

Blood (2007) 110 (11): 1228.

https://doi.org/10.1182/blood.V110.11.1228.1228

Published: 2007

Journal Articles

In Vivo Permanent Marking of Cells with RAG1 Activation History Demonstrates That Lymphoid and Myeloid Derived Dendritic Cells Operate an Identical Developmental Program after Their Lineage Commitment.

Yong Chong, MD, PhD, Tadafumi Iino, MD., Ph.D, Shin-ichi Mizuno, MD., Ph.D, Hirokazu Shigematsu, MD., Ph.D, Yojiro Arinobu, MD., Ph.D, Hiromi Iwasaki, MD., Ph.D, Koichi Akashi, MD., Ph.D

Blood (2007) 110 (11): 1328.

https://doi.org/10.1182/blood.V110.11.1328.1328

Published: 2007

Journal Articles

Delineation of the Common Developmental Pathway for Granulocyte/Monocyte and Lymphoid Lineages by Using an Expression Reporter for PU.1.

Yojiro Arinobu, MD, PhD, Shin-ichi Mizuno, M.D. Ph.D., Hirokazu Shigematsu, M.D. Ph.D., Hidetoshi Ozawa, Yong Chong, M.D. Ph.D, Hiromi Iwasaki, M.D. Ph.D., Philippe Kastner, Ph.D., Susan Chan, Ph.D., Koichi Akashi, M.D. Ph.D.

Blood (2006) 108 (11): 1656.

https://doi.org/10.1182/blood.V108.11.1656.1656

Published: 2006

Journal Articles

In Vivo Permanent Marking of Cells with RAG1 Activation History Demonstrates Only a Minor Contribution of the Lymphoid Pathway to Dendritic Cell Development.

Yong Chong, MD, PhD, Shin-ichi Mizuno, MD., Ph.D., Hirokazu Shigematsu, MD., Ph.D., Yojiro Arinobu, MD., Ph.D., Tadafumi Iino, MD., Ph.D., Hiromi Iwasaki, MD., Ph.D., Koichi Akashi, MD., Ph.D.

Blood (2006) 108 (11): 1268.

https://doi.org/10.1182/blood.V108.11.1268.1268

Published: 2006

Journal Articles

LRF/Pokemon Plays a Pivotal Role in B Versus T Lymphoid Lineage Fate Decision at the Early Lymphoid Progenitor Stage by Opposing Notch1 Signaling.

Takahiro Maeda, MD, PhD, Taha Merghoub, PhD, Lin Dong, MD, Manami Maeda, MD.PhD., Robin Hobbs, PhD, Johannes Zakrzewski, MD, Marcel van den Brink, MD.PhD., Hirokazu Shigematsu, MD.PhD., Koichi Akashi, MD.PhD., Arthur Zelent, PhD, Julie Teruya-Feldstein, MD, Giorgio Cattoretti, MD, Pier Paolo Pandolfi, MD.PhD.

Blood (2006) 108 (11): 778.

https://doi.org/10.1182/blood.V108.11.778.778

Published: 2006

Journal Articles

Notch1 Expression Is Regulated at Translational Level by 3′UTR Region in Hematopoietic Stem Cell Development.

Shin-ichi Mizuno, MD, PhD, Hidetoshi Ozawa, Hirokazu Shigematsu, MD, PhD, Yojiro Arinobu, MD, PhD, Chong Yong, MD, PhD, Tadafumi Iino, MD, PhD, Koichi Akashi, MD, PhD

Blood (2006) 108 (11): 782.

https://doi.org/10.1182/blood.V108.11.782.782

Published: 2006

Journal Articles

Ott1(Rbm15) Is Essential for Pre-B Differentiation and Has an Inhibitory Role in Myeloid and Megakaryocytic Lineages.

Glen D. Raffel, MD, PhD, Thomas Mercher, Ph.D., Hirokazu Shigematsu, M.D., Ifor R. Williams, M.D., Ph.D., Dana E. Cullen, Koichi Akashi, M.D., Ph.D., Olivier A. Bernard, Ph.D., D. Gary Gilliland, M.D., Ph.D.

Blood (2006) 108 (11): 784.

https://doi.org/10.1182/blood.V108.11.784.784

Published: 2006

Journal Articles

Oncogenic K-ras cooperates with PML-RARα to induce an acute promyelocytic leukemia-like disease

Iris T. Chan, Jeffery L. Kutok, Ifor R. Williams, Sarah Cohen, Sandra Moore, Hirokazu Shigematsu, Timothy J. Ley, Koichi Akashi, Michelle M. Le Beau, D. Gary Gilliland

Blood (2006) 108 (5): 1708–1715.

https://doi.org/10.1182/blood-2006-04-015040

Published: 2006

Journal Articles

Identification of Bipotent Basophil/Mast Cell Progenitors in Adult Murine Hematopoiesis.

Yojiro Arinobu, MD, PhD, Hiromi Iwasaki, MD, Michael F. Gurish, PhD, Shinichi Mizuno, MD, PhD, Hirokazu Shigematsu, MD, PhD, Hidetoshi Ozawa, Daniel G. Tenen, MD, Frank K. Austen, MD, Koichi Akashi, MD, PhD

Blood (2005) 106 (11): 633.

https://doi.org/10.1182/blood.V106.11.633.633

Published: 2005

Journal Articles

Lineage Instruction by Oncogenic Tyrosine Kinase Fusions.

Hirokazu Shigematsu, MD, PhD, Shin-ichi Mizuno, MD, Ph.D, Hiromi Iwasaki, MD, Yojiro Arinobu, MD, Ph.D, Hidetoshi Ozawa, PhD, David W. Sternberg, MD, Ph.D, Brian Huntly, MD, Ph.D, D. Gary Gilliland, MD, Ph.D, Koichi Akashi, MD, Ph.D

Blood (2005) 106 (11): 643.

https://doi.org/10.1182/blood.V106.11.643.643

Published: 2005

Journal Articles

Human Conventional and Plasmacytoid Dendritic Cells Can Originate from Both Lymphoid and Myeloid Progenitors in a New Humanized Mouse System.

Fumihiko Ishikawa, MD, PhD, Tadafumi Iino, MD, Hiroaki Niiro, MD, PhD, Shuro Yoshida, MD, Toshihiro Miyamoto, MD, PhD, Hirokazu Shigematsu, MD, PhD, Leonard D. Shultz, PhD, Mine Harada, MD, Koichi Akashi, MD, PhD

Blood (2005) 106 (11): 2273.

https://doi.org/10.1182/blood.V106.11.2273.2273

Published: 2005

Journal Articles

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Hiromi Iwasaki, Chamorro Somoza, Hirokazu Shigematsu, Estelle A. Duprez, Junko Iwasaki-Arai, Shin-ichi Mizuno, Yojiro Arinobu, Kristin Geary, Pu Zhang, Tajhal Dayaram, Maris L. Fenyus, Shannon Elf, Susan Chan, Philippe Kastner, Claudia S. Huettner, Richard Murray, Daniel G. Tenen, Koichi Akashi

Blood (2005) 106 (5): 1590–1600.

https://doi.org/10.1182/blood-2005-03-0860

Published: 2005

Includes: Supplemental data

Journal Articles

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype

Joseph D. Growney, Hirokazu Shigematsu, Zhe Li, Benjamin H. Lee, Jennifer Adelsperger, Rebecca Rowan, David P. Curley, Jeffery L. Kutok, Koichi Akashi, Ifor R. Williams, Nancy A. Speck, D. Gary Gilliland

Blood (2005) 106 (2): 494–504.

https://doi.org/10.1182/blood-2004-08-3280

Published: 2005

Journal Articles

Loss of Runx1 Perturbs Adult Hematopoiesis and Is Associated with a Myeloproliferative Phenotype.

Joseph D. Growney, PhD, Hirokazu Shigematsu, PhD, Zhe Li, PhD, Benjamin H. Lee, MD, Jennifer Adelsperger, Rebecca Rowan, David P. Curley, Koichi Akashi, MD PhD, Ifor R. Williams, MD PhD, Nancy A. Speck, PhD, D. Gary Gilliland, MD PhD

Blood (2004) 104 (11): 227.

https://doi.org/10.1182/blood.V104.11.227.227

Published: 2004

Journal Articles

The Ordered Expression of Transcription Factors Directs Hierarchical Lineage Specification of Eosinophils, Basophils and Mast Cells.

Hiromi Iwasaki, M.D., Yojiro Arinobu, M.D., Ph.D., Shin-ichi Mizuno, M.D. Ph.D., Hirokazu Shigematsu, M.D. Ph.D., Kiyoshi Takatsu, M.D. Ph.D., Daniel G. Tenen, M.D., Koichi Akashi, M.D. Ph.D.

Blood (2004) 104 (11): 224.

https://doi.org/10.1182/blood.V104.11.224.224

Published: 2004

Journal Articles

TEL/PDGFβR Tyrosine Kinase Fusion Specifically Activates Myeloid Differentiation Programs, and Converts Lymphoid Progenitors into the Myeloid Lineage.

Hirokazu Shigematsu, M.D., Ph.D., Hiromi Iwasaki, M.D., Shin-ichi Mizuno, M.D., Ph.D., David W. Sternberg, M.D., Brian J.P. Huntly, M.D., Ph.D., D. Gary Gilliland, M.D., Ph.D., Koichi Akashi, M.D., Ph.D.

Blood (2004) 104 (11): 387.

https://doi.org/10.1182/blood.V104.11.387.387

Published: 2004

Journal Articles

Identification of Progenitors Committed to Basophil and/or Mast Cell Lineages.

Yojiro Arinobu, M.D.,Ph.D., Hiromi Iwasaki, M.D., Michael F. Gurish, Ph.D., Shi-ichi Mizuno, M.D. Ph.D., Hirokazu Shigematsu, M.D. Ph.D., Koichi Akashi, M.D. Ph.D.

Blood (2004) 104 (11): 779.

https://doi.org/10.1182/blood.V104.11.779.779

Published: 2004

NARROW

OTT-MAL Activates the Notch Signaling Transcription Factor RBPJ and Cooperates with Mutant MPL to Induce Acute Megakaryoblastic Leukemia

Notch1 Expression Is Regulated at Post-Transcriptional Level by 3′UTR Region in Hematopoietic Stem Cell Development

Reciprocal Activation of GATA-1 and PU.1 Marks Initial Specification of Hematopoietic Stem Cells into Myelo-Erythroid and Myelo-Lymphoid Lineages.

In Vivo Permanent Marking of Cells with RAG1 Activation History Demonstrates That Lymphoid and Myeloid Derived Dendritic Cells Operate an Identical Developmental Program after Their Lineage Commitment.

Delineation of the Common Developmental Pathway for Granulocyte/Monocyte and Lymphoid Lineages by Using an Expression Reporter for PU.1.

In Vivo Permanent Marking of Cells with RAG1 Activation History Demonstrates Only a Minor Contribution of the Lymphoid Pathway to Dendritic Cell Development.

LRF/Pokemon Plays a Pivotal Role in B Versus T Lymphoid Lineage Fate Decision at the Early Lymphoid Progenitor Stage by Opposing Notch1 Signaling.

Notch1 Expression Is Regulated at Translational Level by 3′UTR Region in Hematopoietic Stem Cell Development.

Ott1(Rbm15) Is Essential for Pre-B Differentiation and Has an Inhibitory Role in Myeloid and Megakaryocytic Lineages.

Oncogenic K-ras cooperates with PML-RARα to induce an acute promyelocytic leukemia-like disease

Identification of Bipotent Basophil/Mast Cell Progenitors in Adult Murine Hematopoiesis.

Lineage Instruction by Oncogenic Tyrosine Kinase Fusions.

Human Conventional and Plasmacytoid Dendritic Cells Can Originate from Both Lymphoid and Myeloid Progenitors in a New Humanized Mouse System.

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype

Loss of Runx1 Perturbs Adult Hematopoiesis and Is Associated with a Myeloproliferative Phenotype.

The Ordered Expression of Transcription Factors Directs Hierarchical Lineage Specification of Eosinophils, Basophils and Mast Cells.

TEL/PDGFβR Tyrosine Kinase Fusion Specifically Activates Myeloid Differentiation Programs, and Converts Lymphoid Progenitors into the Myeloid Lineage.

Identification of Progenitors Committed to Basophil and/or Mast Cell Lineages.

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American Society of Hematology

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American Society of Hematology

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