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Journal Articles

p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia

Shannon Elf, Dean Blevins, Lingtao Jin, Tae-Wook Chung, Ifor R. Williams, Benjamin H. Lee, Jian-Xin Lin, Warren J. Leonard, Jack Taunton, Hanna J. Khoury, Sumin Kang

Blood (2011) 117 (25): 6885–6894.

https://doi.org/10.1182/blood-2010-10-315721

Published: 2011

Includes: Supplemental data

Journal Articles

FoxO Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress.

Zuzana Tothova, Ramya Kollipara, Brian J. Huntly, Benjamin H. Lee, Diego H. Castrillon, Emmanuelle A. Passegue, Dana E. Cullen, Elizabeth P. McDowell, Suzan Lazo-Kallanian, Ifor R. Williams, Ronald A. DePinho, D. Gary Gilliland

Blood (2006) 108 (11): 439.

https://doi.org/10.1182/blood.V108.11.439.439

Published: 2006

Journal Articles

Ott1(Rbm15) Is Essential for Pre-B Differentiation and Has an Inhibitory Role in Myeloid and Megakaryocytic Lineages.

Glen D. Raffel, MD, PhD, Thomas Mercher, Ph.D., Hirokazu Shigematsu, M.D., Ifor R. Williams, M.D., Ph.D., Dana E. Cullen, Koichi Akashi, M.D., Ph.D., Olivier A. Bernard, Ph.D., D. Gary Gilliland, M.D., Ph.D.

Blood (2006) 108 (11): 784.

https://doi.org/10.1182/blood.V108.11.784.784

Published: 2006

Journal Articles

Oncogenic K-ras cooperates with PML-RARα to induce an acute promyelocytic leukemia-like disease

Iris T. Chan, Jeffery L. Kutok, Ifor R. Williams, Sarah Cohen, Sandra Moore, Hirokazu Shigematsu, Timothy J. Ley, Koichi Akashi, Michelle M. Le Beau, D. Gary Gilliland

Blood (2006) 108 (5): 1708–1715.

https://doi.org/10.1182/blood-2006-04-015040

Published: 2006

Journal Articles

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype

Joseph D. Growney, Hirokazu Shigematsu, Zhe Li, Benjamin H. Lee, Jennifer Adelsperger, Rebecca Rowan, David P. Curley, Jeffery L. Kutok, Koichi Akashi, Ifor R. Williams, Nancy A. Speck, D. Gary Gilliland

Blood (2005) 106 (2): 494–504.

https://doi.org/10.1182/blood-2004-08-3280

Published: 2005

Journal Articles

Constitutively activated FGFR3 mutants signal through PLCγ-dependent and -independent pathways for hematopoietic transformation

Jing Chen, Ifor R. Williams, Benjamin H. Lee, Nicole Duclos, Brian J. P. Huntly, Daniel J. Donoghue, D. Gary Gilliland

Blood (2005) 106 (1): 328–337.

https://doi.org/10.1182/blood-2004-09-3686

Published: 2005

Journal Articles

Loss of Runx1 Perturbs Adult Hematopoiesis and Is Associated with a Myeloproliferative Phenotype.

Joseph D. Growney, PhD, Hirokazu Shigematsu, PhD, Zhe Li, PhD, Benjamin H. Lee, MD, Jennifer Adelsperger, Rebecca Rowan, David P. Curley, Koichi Akashi, MD PhD, Ifor R. Williams, MD PhD, Nancy A. Speck, PhD, D. Gary Gilliland, MD PhD

Blood (2004) 104 (11): 227.

https://doi.org/10.1182/blood.V104.11.227.227

Published: 2004

Journal Articles

Constitutively Activated FGFR3 Mutants Signal through PLCγ- Dependent and -Independent Pathways for Hematopoietic Transformation.

Jing Chen, Ph.D, Ifor R. Williams, M.D., Ph.D., Benjamin H. Lee, M.D., Ph.D., Nicole Duclos, Brian J.P. Huntly, M.D., Ph.D., Daniel J. Donoghue, Ph.D., D. Gary Gilliland, M.D., Ph.D.

Blood (2004) 104 (11): 1423.

https://doi.org/10.1182/blood.V104.11.1423.1423

Published: 2004

Journal Articles

PKC412 Effectively Inhibits Constitutively Activated FGFR3 Mutants in Murine Leukemia Models and t(4;14) Myeloma Cell Lines.

Jing Chen, Ph.D., Benjamin H. Lee, M.D., Ph.D., Ifor R. Williams, M.D., Ph.D., Jeffery L. Kutok, M.D., Ph.D., Nicole Duclos, Sarah Cohen, Jennifer Adelsperger, Rachel Okabe, Allison Coburn, Sandra Moore, Brian J.P. Huntly, M.D., Ph.D., Constantine S. Mitsiades, M.D., Kenneth C. Anderson, M.D., James D. Griffin, M.D., Doriano Fabbro, Ph.D., D. Gary Gilliland, M.D., Ph.D.

Blood (2004) 104 (11): 2448.

https://doi.org/10.1182/blood.V104.11.2448.2448

Published: 2004

Journal Articles

PKC412 Inhibits the ZNF198-FGFR1 Fusion Tyrosine Kinase and Is Efficacious in Treatment of t(8;13)(p11;q12) Associated Stem Cell Myeloproliferative Disease.

Blood (2004) 104 (11): 2549.

https://doi.org/10.1182/blood.V104.11.2549.2549

Published: 2004

Journal Articles

MOZ-TIF2 , but Not BCR-ABL , Confers Properties of Leukemic Stem Cells to Committed Murine Hematopoietic Progenitors.

Brian J.P. Huntly, MD, PhD, Hirokazu Shigematzu, PhD, Kenji Deguchi, MD, PhD, Benjamin Lee, MD, PhD, Shinichi Mizuno, Nicky Duclos, BSc, Rebecca Rowan, BSc, Sonia Amaral, BSc, David Curley, BSc, Ifor R. Williams, MD, PhD, Koichi Akashi, MD, PhD, Gary Gilliland, MD, PhD

Blood (2004) 104 (11): 62.

https://doi.org/10.1182/blood.V104.11.62.62

Published: 2004

Journal Articles

Positive and negative regulatory roles of the WW-like domain in TEL-PDGFβR transformation

Jing Chen, Ifor R. Williams, Jeffery L. Kutok, Nicole Duclos, Ema Anastasiadou, Shane C. Masters, Haian Fu, D. Gary Gilliland

Blood (2004) 104 (2): 535–542.

https://doi.org/10.1182/blood-2004-01-0169

Published: 2004

Journal Articles

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

Louise M. Kelly, Qing Liu, Jeffrey L. Kutok, Ifor R. Williams, Christina L. Boulton, D. Gary Gilliland

Blood (2002) 99 (1): 310–318.

https://doi.org/10.1182/blood.V99.1.310

Published: 2002

Journal Articles

H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22)

Juerg Schwaller, Ema Anastasiadou, Danielle Cain, Jeff Kutok, Sarah Wojiski, Ifor R. Williams, Roberta LaStarza, Barbara Crescenzi, David W. Sternberg, Patrick Andreasson, Roberta Schiavo, Salvatore Siena, Cristina Mecucci, D. Gary Gilliland

Blood (2001) 97 (12): 3910–3918.

https://doi.org/10.1182/blood.V97.12.3910

Published: 2001

Journal Articles

Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3

Michael H. Tomasson, Ifor R. Williams, Shaoguang Li, Jeffrey Kutok, Danielle Cain, Silke Gillessen, Glenn Dranoff, Richard A. Van Etten, D. Gary Gilliland

Blood (2001) 97 (5): 1435–1441.

https://doi.org/10.1182/blood.V97.5.1435

Published: 2001

Journal Articles

TEL/PDGFβR Induces Hematologic Malignancies in Mice That Respond to a Specific Tyrosine Kinase Inhibitor

Michael H. Tomasson, Ifor R. Williams, Robert Hasserjian, Chirayu Udomsakdi, Shannon M. McGrath, Juerg Schwaller, Brian Druker, D. Gary Gilliland

Blood (1999) 93 (5): 1707–1714.

https://doi.org/10.1182/blood.V93.5.1707

Published: 1999

NARROW

p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia

FoxO Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress.

Ott1(Rbm15) Is Essential for Pre-B Differentiation and Has an Inhibitory Role in Myeloid and Megakaryocytic Lineages.

Oncogenic K-ras cooperates with PML-RARα to induce an acute promyelocytic leukemia-like disease

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype

Constitutively activated FGFR3 mutants signal through PLCγ-dependent and -independent pathways for hematopoietic transformation

Loss of Runx1 Perturbs Adult Hematopoiesis and Is Associated with a Myeloproliferative Phenotype.

Constitutively Activated FGFR3 Mutants Signal through PLCγ- Dependent and -Independent Pathways for Hematopoietic Transformation.

PKC412 Effectively Inhibits Constitutively Activated FGFR3 Mutants in Murine Leukemia Models and t(4;14) Myeloma Cell Lines.

PKC412 Inhibits the ZNF198-FGFR1 Fusion Tyrosine Kinase and Is Efficacious in Treatment of t(8;13)(p11;q12) Associated Stem Cell Myeloproliferative Disease.

MOZ-TIF2 , but Not BCR-ABL , Confers Properties of Leukemic Stem Cells to Committed Murine Hematopoietic Progenitors.

Positive and negative regulatory roles of the WW-like domain in TEL-PDGFβR transformation

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22)

Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3

TEL/PDGFβR Induces Hematologic Malignancies in Mice That Respond to a Specific Tyrosine Kinase Inhibitor

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American Society of Hematology

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American Society of Hematology

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