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Journal Articles

STAG2 Mutations Drive Development of Myelodysplastic Syndromes by Promoting R-Loop-Mediated Genomic Instability and Activation of cGAS-STING

Lin Han, Benjamin Braun, Caroline A. Conway, Amy Wang, Johann-Christoph Jann, Yihua Wang, Kate I. Drachman, Qingqing Yan, Elodie Hatchi, Phillip Wulfridge, William Doyle, Caroline N. Pitton, Kavitha Sarma, Zuzana Tothova

Blood (2024) 144 (Supplement 1): 4105.

https://doi.org/10.1182/blood-2024-210909

Published: 2024

Journal Articles

STAG2 loss Induces HSC Programs By Modulating Accessibility of AP-1 Bound Enhancers

Amy Wang, Lin Han, Benjamin Braun, Caroline Pitton, Johann-Christoph Jann, Zuzana Tothova

Blood (2023) 142 (Supplement 1): 1385.

https://doi.org/10.1182/blood-2023-190327

Published: 2023

Journal Articles

STAG2 Somatic Mutations Are Associated with Specific Dysplastic Megakaryocytic and Myeloid Cell Features in Myelodysplastic Syndrome

Waihay J Wong, Rebecca L. Zon, Caleb Ho, Olga Pozdnyakova, Donna S. Neuberg, Elisabeth M Battinelli, Marlise R. Luskin, Zuzana Tothova, Elizabeth A. Morgan, Christopher James Gibson, Benjamin L. Ebert

Blood (2023) 142 (Supplement 1): 3233.

https://doi.org/10.1182/blood-2023-187172

Published: 2023

Journal Articles

Subunit-Specific Analysis of Cohesin-Mutant Myeloid Malignancies Reveals Distinct Ontogeny and Outcomes

Blood (2023) 142 (Supplement 1): 999.

https://doi.org/10.1182/blood-2023-187519

Published: 2023

Journal Articles

Splicing Modulators Impair DNA Damage Response and Induce Killing of Cohesin-Mutant MDS/AML

Emily C Wheeler, Benjamin Martin, William Doyle, Rebecca Gorelov, Melanie Donahue, Johann-Christoph Jann, Omar Abdel-Wahab, Justin Taylor, Michael Seiler, Silvia Buonamici, Roger Belizaire, Karen Adelman, Zuzana Tothova

Blood (2022) 140 (Supplement 1): 6888–6889.

https://doi.org/10.1182/blood-2022-170996

Published: 2022

Journal Articles

Cohesin mutations in myeloid malignancies

Johann-Christoph Jann, Zuzana Tothova

Blood (2021) 138 (8): 649–661.

https://doi.org/10.1182/blood.2019004259

Published: 2021

Journal Articles

Talazoparib Treatment Preferentially Depletes Cohesin-Mutant Clones in New In Vivo M odels of Cohesin-Mutant Myeloid Diseases

Mounica Vallurupalli, MD, Rebecca Gorelov, BS, Jacqueline S Garcia, MD, Elizabeth A Morgan, MD, Benjamin Ebert, MD, Zuzana Tothova, MD PhD

Blood (2019) 134 (Supplement_1): 560.

https://doi.org/10.1182/blood-2019-130308

Published: 2019

Journal Articles

STAG2 Mutations Alter Cohesin Ring Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 940.

https://doi.org/10.1182/blood-2018-99-117480

Published: 2018

Journal Articles

Generation of Models of Human Hematologic Malignancies Using CRISPR Genome Engineering

Zuzana Tothova, MD PhD, John M Krill-Burger, MCS, Katerina D Popova, BA, Quinlan Sievers, BA, David Yudovich, BSc, Roger Belizaire, MD PhD, Jon C. Aster, MD PhD, Elizabeth A. Morgan, MD, Aviad Tsherniak, MSc, Benjamin L Ebert, MD PhD

Blood (2016) 128 (22): 741.

https://doi.org/10.1182/blood.V128.22.741.741

Published: 2016

Journal Articles

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification

Melanie G. Cornejo, Vinciane Mabialah, Stephen M. Sykes, Tulasi Khandan, Cristina Lo Celso, Cécile K. Lopez, Paola Rivera-Muñoz, Philippe Rameau, Zuzana Tothova, Jon C. Aster, Ronald A. DePinho, David T. Scadden, D. Gary Gilliland, Thomas Mercher

Blood (2011) 118 (5): 1264–1273.

https://doi.org/10.1182/blood-2011-01-328567

Published: 2011

Includes: Supplemental data

Journal Articles

A Regulatory Network Between Notch and AKT Signaling Pathways Differentially Controls Megakaryocyte Development From Hematopoietic Stem or Committed Progenitor Cells.

Melanie G Cornejo, Stephen M Sykes, Cristina Lo Celso, Zuzana Tothova, Jon Aster, MD, PhD, Ronald A DePinho, MD, David T Scadden, MD, D. Gary Gilliland, MD, PhD, Thomas Mercher, Ph.D

Blood (2009) 114 (22): 384.

https://doi.org/10.1182/blood.V114.22.384.384

Published: 2009

Journal Articles

p16 INK4a Is a Key Downstream Mediator of the Deleterious Effects of FoxO Deficiency on Maintenance of the Hematopoietic Stem Cell Compartment.

Zuzana Tothova, Stephen M Sykes, Dena S Leeman, James W Horner, Norman Sharpless, Ronald A DePinho, D. Gary Gilliland

Blood (2008) 112 (11): 1405.

https://doi.org/10.1182/blood.V112.11.1405.1405

Published: 2008

Journal Articles

Leukemogenic FLT3 Mutations Confer Enhanced Proliferation and Survival Properties to Multipotent Progenitor Cells in a Murine Model of Chronic Myelomonocytic Leukemia.

Benjamin H. Lee, Zuzana Tothova, Ross L. Levine, Kristina Anderson, Natalija Buza-Vidas, Dana E. Cullen, Elizabeth P. McDowell, Jennifer Adelsperger, Stefan Frohling, Brian J.P. Huntly, Miloslav Beran, Sten Eirik Jacobsen, D. Gary Gilliland

Blood (2007) 110 (11): 1613.

https://doi.org/10.1182/blood.V110.11.1613.1613

Published: 2007

Journal Articles

FoxO Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress.

Zuzana Tothova, Ramya Kollipara, Brian J. Huntly, Benjamin H. Lee, Diego H. Castrillon, Emmanuelle A. Passegue, Dana E. Cullen, Elizabeth P. McDowell, Suzan Lazo-Kallanian, Ifor R. Williams, Ronald A. DePinho, D. Gary Gilliland

Blood (2006) 108 (11): 439.

https://doi.org/10.1182/blood.V108.11.439.439

Published: 2006

Journal Articles

The Role of Forkhead Transcription Factors FoxO1, FoxO3 and FoxO4 in Hematopoiesis and Leukemogenesis.

Zuzana Tothova, Ramya Kollipara, Ronald A. DePinho, D. Gary Gilliland

Blood (2005) 106 (11): 1350.

https://doi.org/10.1182/blood.V106.11.1350.1350

Published: 2005

Journal Articles

NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a

Ting-Lei Gu, Zuzana Tothova, Blanca Scheijen, James D. Griffin, D. Gary Gilliland, David W. Sternberg

Blood (2004) 103 (12): 4622–4629.

https://doi.org/10.1182/blood-2003-03-0820

Published: 2004

NARROW

STAG2 Mutations Drive Development of Myelodysplastic Syndromes by Promoting R-Loop-Mediated Genomic Instability and Activation of cGAS-STING

STAG2 loss Induces HSC Programs By Modulating Accessibility of AP-1 Bound Enhancers

STAG2 Somatic Mutations Are Associated with Specific Dysplastic Megakaryocytic and Myeloid Cell Features in Myelodysplastic Syndrome

Subunit-Specific Analysis of Cohesin-Mutant Myeloid Malignancies Reveals Distinct Ontogeny and Outcomes

Splicing Modulators Impair DNA Damage Response and Induce Killing of Cohesin-Mutant MDS/AML

Cohesin mutations in myeloid malignancies

Talazoparib Treatment Preferentially Depletes Cohesin-Mutant Clones in New In Vivo M odels of Cohesin-Mutant Myeloid Diseases

STAG2 Mutations Alter Cohesin Ring Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia

Generation of Models of Human Hematologic Malignancies Using CRISPR Genome Engineering

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification

A Regulatory Network Between Notch and AKT Signaling Pathways Differentially Controls Megakaryocyte Development From Hematopoietic Stem or Committed Progenitor Cells.

p16 INK4a Is a Key Downstream Mediator of the Deleterious Effects of FoxO Deficiency on Maintenance of the Hematopoietic Stem Cell Compartment.

Leukemogenic FLT3 Mutations Confer Enhanced Proliferation and Survival Properties to Multipotent Progenitor Cells in a Murine Model of Chronic Myelomonocytic Leukemia.

FoxO Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress.

The Role of Forkhead Transcription Factors FoxO1, FoxO3 and FoxO4 in Hematopoiesis and Leukemogenesis.

NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a

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American Society of Hematology

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American Society of Hematology

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