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Philippe Rameau
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Journal Articles

Amplification of Von Willebrand Factor-Positive CALR mut Disease-Initiating Hematopoietic Stem Cells Is Associated to the Activation of the PERK/EiF2a Branch of Unfolded Protein Response

Camelia Benlabiod, Gurvan Hermange, Laetitia Borderon, Quentin Blampey, Maxime Evrard, Antonio Rodriguez Romera, Stéphanie G. Moreno, Nathalie Gault, Philippe Rameau, Cyril Catelain, Elodie Rosa, Bethan Psaila, Claus Nerlov, Sten Eirik Waelgaard Jacobsen, William Vainchenker, Hana Raslova, Paul-Henry Cournède, Isabelle Plo, Caroline Marty
Journal: Blood
Blood (2024) 144 (Supplement 1): 752.
https://doi.org/10.1182/blood-2024-205477
Published: 2024
Journal Articles

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

Matthieu Mosca, Gurvan Hermange, Amandine Tisserand, Robert Noble, Christophe Marzac, Caroline Marty, Cécile Le Sueur, Hugo Campario, Gaëlle Vertenoeil, Mira El-Khoury, Cyril Catelain, Philippe Rameau, Cyril Gella, Julien Lenglet, Nicole Casadevall, Rémi Favier, Eric Solary, Bruno Cassinat, Jean-Jacques Kiladjian, Stefan N. Constantinescu, Florence Pasquier, Michael E. Hochberg, Hana Raslova, Jean-Luc Villeval, François Girodon, William Vainchenker, Paul-Henry Cournède, Isabelle Plo
Journal: Blood
Blood (2021) 138 (22): 2231–2243.
https://doi.org/10.1182/blood.2021010986
Published: 2021
Includes: Supplemental data
Journal Articles

SRSF2-P95Hdelays Myelofibrosis Development through Altered JAK/STAT Signaling in JAK2-V617F Megakaryocytes

Christophe Willekens, Lucie Laplane, Tracy Dagher, Camélia Benlabiod, Catherine Lacout, Philippe Rameau, Cyril Catelain, Alexia Alfaro, Valérie Edmond, Nicolas Signolle, Aymeric Silvin, Florent Ginhoux, Valentine Marchand, Nathalie Droin, Remco Hoogenboezem, Rebekka K. Schneider, Alexander V Penson, Omar Abdel-Wahab, Patrick Gonin, Caroline Marty, Isabelle Plo, Jean-Luc Villeval, Francoise Porteu, William Vainchenker, Eric Solary
Journal: Blood
Blood (2021) 138 (Supplement 1): 2544.
https://doi.org/10.1182/blood-2021-149757
Published: 2021
Journal Articles

Dual role of EZH2 in megakaryocyte differentiation

Stefania Mazzi, Philippe Dessen, Mathieu Vieira, Virginie Dufour, Marie Cambot, Mira El Khoury, Iléana Antony-Debré, Brahim Arkoun, Francesca Basso-Valentina, Salwa BenAbdoulahab, Valerie Edmond, Philippe Rameau, Rachel Petermann, Monika Wittner, Bruno Cassinat, Isabelle Plo, Najet Debili, Hana Raslova, William Vainchenker
Journal: Blood
Blood (2021) 138 (17): 1603–1614.
https://doi.org/10.1182/blood.2019004638
Published: 2021
Includes: Supplemental data
Journal Articles

Modeling Acute Megakaryoblastic Leukemia of Down Syndrome Using Induced Pluripotent Stem Cells

Brahim Arkoun, Virginie Dufour, Aurélie Siret, Stefania Mazzi, Yasmine Mammasse, Mathieu Vieira, Fabien Boudia, Elie Robert, Zakia Aid, Marie Cambot, Rachel Petermann, Sylvie Souquere, Philippe Rameau, Cyril Catelain, Romain Diot, Gérard Tachdjian, Najet Debili, Isabelle Plo, Hana Raslova, Sebastien Malinge, Eric Soler, Thomas Mercher, William Vainchenker
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-140986
Published: 2020
Journal Articles

Predicting the Long-Term Efficacy of Ifnα in JAK2 V617F and Calr -Mutated MPN Patients

Amandine Tisserand, Robert Noble, PhD, Matthieu Mosca, PhD, Christophe Marzac, MD, Gaelle Vertenoeil, MD, Hugo Campario, PharmD, Mira El-Khoury, PhD, Caroline Marty, PhD, Philippe Rameau, Nicole Casadevall, MD, Eric Solary, MD PhD, Florence Pasquier, MD PhD, Hana Raslova, PhD, Bruno Cassinat, PharmD, PhD, Stefan N Constantinescu, MD PhD, Jean-Jacques Kiladjian, MD PhD, Francois Girodon, MD PhD, Michael Hochberg, PhD, Villeval Jean-Luc, PhD, William Vainchenker, MD PhD, Isabelle Plo
Journal: Blood
Blood (2019) 134 (Supplement_1): 4196.
https://doi.org/10.1182/blood-2019-127903
Published: 2019
Journal Articles

ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia

Cecile Thirant, PhD, Cecile K Lopez, Cathy Ignacimouttou, M'Boyba Diop, Lou Le Mouël, MD, Clarisse Thiollier, MD PhD, Aurelie Siret, Philippe Dessen, Zakia Aid, Julie Riviere, PhD, Philippe Rameau, Celine Lefebvre, Mehdi Khaled, PhD, Guy Leverger, MD, Paola Fabiola Ballerini, MDPhD, Arnaud Petit, MD PhD, Hana Raslova, PhD, Catherine Carmichael, Benjamin T. Kile, PhD, Eric Soler, PhD, John Crispino, PhD, Christian Wichmann, MD, Camille Lobry, PhD, Francoise Pfumio, PhD, Juerg Schwaller, MD, Nathalie M. Droin, PhD, William Vainchenker, MD PhD, Olivier A. Bernard, PhD, Sebastien Malinge, PhD, Thomas Mercher, PhD
Journal: Blood
Blood (2016) 128 (22): 572.
https://doi.org/10.1182/blood.V128.22.572.572
Published: 2016
Journal Articles

Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia

Dorothée Selimoglu-Buet, Orianne Wagner-Ballon, Véronique Saada, Valérie Bardet, Raphaël Itzykson, Laura Bencheikh, Margot Morabito, Elisabeth Met, Camille Debord, Emmanuel Benayoun, Anne-Marie Nloga, Pierre Fenaux, Thorsten Braun, Christophe Willekens, Bruno Quesnel, Lionel Adès, Michaela Fontenay, Philippe Rameau, Nathalie Droin, Serge Koscielny, Eric Solary
Journal: Blood
Blood (2015) 125 (23): 3618–3626.
https://doi.org/10.1182/blood-2015-01-620781
Published: 2015
Includes: Supplemental data
Journal Articles

The formin DIAPH1 (mDia1) regulates megakaryocyte proplatelet formation by remodeling the actin and microtubule cytoskeletons

Jiajia Pan, Larissa Lordier, Deborah Meyran, Philippe Rameau, Yann Lecluse, Susan Kitchen-Goosen, Idinath Badirou, Hayat Mokrani, Shuh Narumiya, Arthur S. Alberts, William Vainchenker, Yunhua Chang
Journal: Blood
Blood (2014) 124 (26): 3967–3977.
https://doi.org/10.1182/blood-2013-12-544924
Published: 2014
Includes: Supplemental data
Journal Articles

A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene

Vladimir T. Manchev, Morgane Hilpert, Eliane Berrou, Ziane Elaib, Achille Aouba, Siham Boukour, Sylvie Souquere, Gerard Pierron, Philippe Rameau, Robert Andrews, François Lanza, Regis Bobe, William Vainchenker, Jean-Philippe Rosa, Marijke Bryckaert, Najet Debili, Remi Favier, Hana Raslova
Journal: Blood
Blood (2014) 124 (16): 2554–2563.
https://doi.org/10.1182/blood-2014-01-551820
Published: 2014
Includes: Supplemental data
Journal Articles

JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation

Rodolphe Besancenot, Damien Roos-Weil, Carole Tonetti, Hadjer Abdelouahab, Catherine Lacout, Florence Pasquier, Christophe Willekens, Philippe Rameau, Yann Lecluse, Jean-Baptiste Micol, Stefan N. Constantinescu, William Vainchenker, Eric Solary, Stéphane Giraudier
Journal: Blood
Blood (2014) 124 (13): 2104–2115.
https://doi.org/10.1182/blood-2014-03-559815
Published: 2014
Includes: Supplemental data
Journal Articles

Clonal architecture of chronic myelomonocytic leukemias

Raphaël Itzykson, Olivier Kosmider, Aline Renneville, Margot Morabito, Claude Preudhomme, Céline Berthon, Lionel Adès, Pierre Fenaux, Uwe Platzbecker, Olivier Gagey, Philippe Rameau, Guillaume Meurice, Cédric Oréar, François Delhommeau, Olivier A. Bernard, Michaela Fontenay, William Vainchenker, Nathalie Droin, Eric Solary
Journal: Blood
Blood (2013) 121 (12): 2186–2198.
https://doi.org/10.1182/blood-2012-06-440347
Published: 2013
Includes: Supplemental data
Journal Articles

Two Distinct Mechanisms Contribute to Granulomonocytic Hyperplasia in Chronic Myelomonocytic Leukemias (CMML)

Raphael Itzykson, Olivier Kosmider, MD, PhD, Aline Renneville, Margot Morabito, Dorothee Buet, Claude Preudhomme, Céline Berthon, MD, PhD, Lionel Ades, MD, PhD, Pierre Fenaux, MD, PhD, Uwe Platzbecker, MD, Olivier Gagey, Philippe Rameau, Francois Delhommeau, PharmD, PHD, Olivier A. Bernard, PhD, Michaela Fontenay, MD, PhD, William Vainchenker, MD, PhD, Nathalie Droin, Ph.D, Eric Solary
Journal: Blood
Blood (2012) 120 (21): 309.
https://doi.org/10.1182/blood.V120.21.309.309
Published: 2012
Journal Articles

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression

Dominique Bluteau, Ana C. Glembotsky, Anna Raimbault, Nathalie Balayn, Laure Gilles, Philippe Rameau, Paquita Nurden, Marie Christine Alessi, Najet Debili, William Vainchenker, Paula G. Heller, Remi Favier, Hana Raslova
Journal: Blood
Blood (2012) 120 (13): 2708–2718.
https://doi.org/10.1182/blood-2012-04-422337
Published: 2012
Includes: Supplemental data
Journal Articles

Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome

Clinical Trials & Observations
Paquita Nurden, Najet Debili, Isabelle Coupry, Marijke Bryckaert, Ibtissam Youlyouz-Marfak, Guilhem Solé, Anne-Cécile Pons, Eliane Berrou, Frédéric Adam, Alexandre Kauskot, Jean-Marie Daniel Lamazière, Philippe Rameau, Patricia Fergelot, Caroline Rooryck, Dorothée Cailley, Benoît Arveiler, Didier Lacombe, William Vainchenker, Alan Nurden, Cyril Goizet
Journal: Blood
Blood (2011) 118 (22): 5928–5937.
https://doi.org/10.1182/blood-2011-07-365601
Published: 2011
Includes: Supplemental data
Journal Articles

RUNX1-Induced Silencing of Non-Muscle Myosin Iib (MYH10) Is Required for Megakaryocyte Polyploidization

Dominique Bluteau, PhD, Larissa Lordier, PhD, Iléana Antony-Debré, Abdelali Jalil, Céline Legrand, Philippe Rameau, Olivier Bluteau, PhD, Dima Jouni, Thomas Mercher, PhD, Catherine Leon, Christian Gachet, MD, PhD, Najet Debili, PhD, William Vainchenker, MD., Ph.D, Yunhua Chang, PhD, Hana Raslova, PhD
Journal: Blood
Blood (2011) 118 (21): 1308.
https://doi.org/10.1182/blood.V118.21.1308.1308
Published: 2011
Journal Articles

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification

Melanie G. Cornejo, Vinciane Mabialah, Stephen M. Sykes, Tulasi Khandan, Cristina Lo Celso, Cécile K. Lopez, Paola Rivera-Muñoz, Philippe Rameau, Zuzana Tothova, Jon C. Aster, Ronald A. DePinho, David T. Scadden, D. Gary Gilliland, Thomas Mercher
Journal: Blood
Blood (2011) 118 (5): 1264–1273.
https://doi.org/10.1182/blood-2011-01-328567
Published: 2011
Includes: Supplemental data
Journal Articles

Thrombospondin-1 is not the major activator of TGF-β1 in thrombopoietin-induced myelofibrosis

Brief Report
Solène Evrard, Olivier Bluteau, Micheline Tulliez, Philippe Rameau, Patrick Gonin, Eva Zetterberg, Jan Palmblad, Arnaud Bonnefoy, Jean-Luc Villeval, William Vainchenker, Stéphane Giraudier, Orianne Wagner-Ballon
Journal: Blood
Blood (2011) 117 (1): 246–249.
https://doi.org/10.1182/blood-2010-07-294447
Published: 2011
Includes: Supplemental data
Journal Articles

Myeloid-Derived Suppressive Cells Belonging to the Leukemic Clone Account for Immunosuppression In CMML

Nathalie Droin, Raphael Itzykson, Philippe Rameau, Margot Morabito, Thorsten Braun, Fawzia Louache, Yanyan Zhang, Stephane De Botton, Catherine Cordonnier, Bruno Quesnel, Pierre Fenaux, MD, PhD, William Vainchenker, Eric Solary
Journal: Blood
Blood (2010) 116 (21): 3997.
https://doi.org/10.1182/blood.V116.21.3997.3997
Published: 2010
Journal Articles

Interferon-Alpha Preferentially Targets JAK2V617F-Positive Rather Than Wild-Type Early Progenitor Cells in Myeloproliferative Disorders.

Florence Pasquier, Carole Tonetti, Rodolphe Besancenot, Bruno Cassinat, Pharm.D, Jean-Jacques Kiladjian, MD, PhD, Olivier Herault, MD, PhD, MSc, Philippe Rameau, Catherine Lacout, Jean-Luc Villeval, William Vainchenker, MD, PhD, Ronan Chaligné, Stephane Giraudier
Journal: Blood
Blood (2009) 114 (22): 436.
https://doi.org/10.1182/blood.V114.22.436.436
Published: 2009