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Journal Articles

Mitochondrial dysfunction as a key factor in the predisposition to 14q32-related myeloid hematological malignancies

Blood (2025) 146 (Supplement 1): 3212.

https://doi.org/10.1182/blood-2025-3212

Published: 2025

Journal Articles

INCB160058 selectively targets JAK2V617F-driven hematopoiesis in diverse and drug-resistant models of myeloproliferative neoplasms

Hamza Celik, Gaurang Trivedi, Angelo Albertoni, Brittney Wass, Eddy Yue, Yanran Ai, Caroline Marty, Elodie Rosa, Maxime Evrard, William Vainchenker, Florence Pasquier, Cynthia Timmers, Sunkyu Kim, Ricardo Macarron, Isabelle Plo, Matthew Stubbs

Blood (2025) 146 (Supplement 1): 3275.

https://doi.org/10.1182/blood-2025-3275

Published: 2025

Journal Articles

Extracellular matrix-targeting oligonucleotide reverses marrow fibrosis

Francesca Calledda, Vittorio Abbonante, Delfina Tosi, Umberto Gianelli, Caroline Marty, Isabelle Plo, Hana Raslova, Dario Balestra, Mirko Pinotti, Alessandra Balduini, Alessandro Malara

Blood (2025) 146 (Supplement 1): 1976.

https://doi.org/10.1182/blood-2025-1976

Published: 2025

Journal Articles

Type 2 calreticulin mutations activate ATF6 to promote BCL-xL–mediated survival in myeloproliferative neoplasms

Blood (2025) 146 (8): 971–983.

https://doi.org/10.1182/blood.2024026940

Published: 2025

Includes: Supplemental data

Journal Articles

Dissecting JAK2V617F’s double life with and without MPL

Isabelle Plo, Caroline Marty

Blood (2025) 146 (4): 406–408.

https://doi.org/10.1182/blood.2025029479

Published: 2025

Journal Articles

Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN

Blood (2024) 144 (22): 2336–2348.

https://doi.org/10.1182/blood.2024024373

Published: 2024

Includes: Supplemental data

Journal Articles

Amplification of Von Willebrand Factor-Positive CALR mut Disease-Initiating Hematopoietic Stem Cells Is Associated to the Activation of the PERK/EiF2a Branch of Unfolded Protein Response

Camelia Benlabiod, Gurvan Hermange, Laetitia Borderon, Quentin Blampey, Maxime Evrard, Antonio Rodriguez Romera, Stéphanie G. Moreno, Nathalie Gault, Philippe Rameau, Cyril Catelain, Elodie Rosa, Bethan Psaila, Claus Nerlov, Sten Eirik Waelgaard Jacobsen, William Vainchenker, Hana Raslova, Paul-Henry Cournède, Isabelle Plo, Caroline Marty

Blood (2024) 144 (Supplement 1): 752.

https://doi.org/10.1182/blood-2024-205477

Published: 2024

Journal Articles

An Atypical Somatic Calr Variant Acquired in Cis to a Germline Calr variant Induces Constitutive Signaling of the Thrombopoietin Receptor and Results in Essential Thrombocythemia

Laetitia Borderon, Jihyun Song, Soo Jin Kim, Christophe Marzac, Christine Bellanné-Chantelot, Nicolas Papadopoulos, Stefan N. Constantinescu, William Vainchenker, Isabelle Plo, Josef T. Prchal, Caroline Marty

Blood (2023) 142 (Supplement 1): 3161.

https://doi.org/10.1182/blood-2023-179381

Published: 2023

Journal Articles

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Blood (2023) 141 (8): 917–929.

https://doi.org/10.1182/blood.2022016846

Published: 2023

Includes: Supplemental data

Journal Articles

Discovery of INCA033989, a Monoclonal Antibody That Selectively Antagonizes Mutant Calreticulin Oncogenic Function in Myeloproliferative Neoplasms (MPNs)

Edimara Reis, Rebecca Buonpane, Hamza Celik, Caroline Marty, Angela Lei, Fatoumata Jobe, Mark Rupar, Yue Zhang, Darlise DiMatteo, Rahel Awdew, William Vainchenker, Jing Zhou, Ian Hitchcock, Isabelle Plo, Horacio Nastri, Patrick Mayes

Blood (2022) 140 (Supplement 1): 14–15.

https://doi.org/10.1182/blood-2022-159435

Published: 2022

Journal Articles

Oral SGLT2 Inhibitors in Glycogen Storage Disease Type Ib and G6PC3-Deficiency. Preliminary Results from an Off-Label Study of 21 Patients

Blood (2022) 140 (Supplement 1): 8320–8322.

https://doi.org/10.1182/blood-2022-169243

Published: 2022

Journal Articles

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

Blood (2021) 138 (22): 2231–2243.

https://doi.org/10.1182/blood.2021010986

Published: 2021

Includes: Supplemental data

Journal Articles

SRSF2-P95Hdelays Myelofibrosis Development through Altered JAK/STAT Signaling in JAK2-V617F Megakaryocytes

Blood (2021) 138 (Supplement 1): 2544.

https://doi.org/10.1182/blood-2021-149757

Published: 2021

Journal Articles

CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag

Francesca Basso-Valentina, Gabriel Levy, Leila N. Varghese, Myriam Oufadem, Benedicte Neven, Charlotte Boussard, Nathalie Balayn, Caroline Marty, William Vainchenker, Isabelle Plo, Paola Ballerini, Stefan N. Constantinescu, Remi Favier, Hana Raslova

Blood (2021) 138 (6): 480–485.

https://doi.org/10.1182/blood.2020010567

Published: 2021

Includes: Supplemental data

Journal Articles

Palbociclib Prevents CDK4/6 Dependent-Myeloproliferation and Myelofibrosis

Helene Duparc, Delphine Muller, Ileana Antony-Debre, PhD PharmD, Caroline Marty, PhD, Najet Debili, Jean-Luc Villeval, PhD, Isabelle Plo, William Vainchenker, Laure Gilles, PhD, Hana Raslova

Blood (2020) 136 (Supplement 1): 25.

https://doi.org/10.1182/blood-2020-141092

Published: 2020

Journal Articles

Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms

Christian A. Di Buduo, Vittorio Abbonante, Caroline Marty, Francesco Moccia, Elisa Rumi, Daniela Pietra, Paolo M. Soprano, Dmitry Lim, Daniele Cattaneo, Alessandra Iurlo, Umberto Gianelli, Giovanni Barosi, Vittorio Rosti, Isabelle Plo, Mario Cazzola, Alessandra Balduini

Blood (2020) 135 (2): 133–144.

https://doi.org/10.1182/blood.2019001103

Published: 2020

Includes: Supplemental data

Journal Articles

Description of a knock-in mouse model of JAK2 V617F MPN emerging from a minority of mutated hematopoietic stem cells

Olivier Mansier, Badr Kilani, Amélie V. Guitart, Alexandre Guy, Virginie Gourdou-Latyszenok, Caroline Marty, Marie Parrens, Isabelle Plo, William Vainchenker, Chloé James

Blood (2019) 134 (26): 2383–2387.

https://doi.org/10.1182/blood.2019001163

Published: 2019

Includes: Supplemental data

Journal Articles

Not just another kinase mutation!

Isabelle Plo, Caroline Marty

Blood (2019) 134 (26): 2335–2337.

https://doi.org/10.1182/blood.2019003650

Published: 2019

Journal Articles

Predicting the Long-Term Efficacy of Ifnα in JAK2 V617F and Calr -Mutated MPN Patients

Blood (2019) 134 (Supplement_1): 4196.

https://doi.org/10.1182/blood-2019-127903

Published: 2019

Journal Articles

Disease Phenotype and Clonal Amplification in Calreticulin del52 and ins5 Knock-in Mice Are Dependent on the Type of Mutations and Gene Dosage

Camélia Benlabiod, Maira da Costa Cacemiro, PhD, Thomas Balligand, MD, Barbara Panneau-Schmaltz, PhD, Delphine Muller, Laure Touchard, Patrick Gonin, DVM, Jean-Luc Villeval, PhD, Stefan N Constantinescu, MD PhD, Hana Raslova, PhD, William Vainchenker, MD PhD, Isabelle Plo, Caroline Marty, PhD

Blood (2019) 134 (Supplement_1): 311.

https://doi.org/10.1182/blood-2019-127918

Published: 2019

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Mitochondrial dysfunction as a key factor in the predisposition to 14q32-related myeloid hematological malignancies

INCB160058 selectively targets JAK2V617F-driven hematopoiesis in diverse and drug-resistant models of myeloproliferative neoplasms

Extracellular matrix-targeting oligonucleotide reverses marrow fibrosis

Type 2 calreticulin mutations activate ATF6 to promote BCL-xL–mediated survival in myeloproliferative neoplasms

Dissecting JAK2V617F’s double life with and without MPL

Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN

Amplification of Von Willebrand Factor-Positive CALR mut Disease-Initiating Hematopoietic Stem Cells Is Associated to the Activation of the PERK/EiF2a Branch of Unfolded Protein Response

An Atypical Somatic Calr Variant Acquired in Cis to a Germline Calr variant Induces Constitutive Signaling of the Thrombopoietin Receptor and Results in Essential Thrombocythemia

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Discovery of INCA033989, a Monoclonal Antibody That Selectively Antagonizes Mutant Calreticulin Oncogenic Function in Myeloproliferative Neoplasms (MPNs)

Oral SGLT2 Inhibitors in Glycogen Storage Disease Type Ib and G6PC3-Deficiency. Preliminary Results from an Off-Label Study of 21 Patients

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

SRSF2-P95Hdelays Myelofibrosis Development through Altered JAK/STAT Signaling in JAK2-V617F Megakaryocytes

CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag

Palbociclib Prevents CDK4/6 Dependent-Myeloproliferation and Myelofibrosis

Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms

Description of a knock-in mouse model of JAK2 V617F MPN emerging from a minority of mutated hematopoietic stem cells

Not just another kinase mutation!

Predicting the Long-Term Efficacy of Ifnα in JAK2 V617F and Calr -Mutated MPN Patients

Disease Phenotype and Clonal Amplification in Calreticulin del52 and ins5 Knock-in Mice Are Dependent on the Type of Mutations and Gene Dosage

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American Society of Hematology

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