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Journal Articles

Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN

Blood (2024) 144 (22): 2336–2348.

https://doi.org/10.1182/blood.2024024373

Published: 2024

Includes: Supplemental data

Journal Articles

In Vivo and Ex Vivo Expansion of Functional Human Repopulating Cells through JARID2 Inhibition

Wentao Han, Hassan Bjeije, Hamza Celik, Michael P. Rettig, Yanan Li, Andrew L Young, Christine RC Zhang, Infencia Xavier Raj, Saranajith Dunuwille, Grant A Challen

Blood (2024) 144 (Supplement 1): 3398.

https://doi.org/10.1182/blood-2024-211397

Published: 2024

Journal Articles

EZH2-Mediated Methylation Regulates JARID2 Protein Stability in Normal and Neoplastic Hematopoiesis

Hassan Bjeije, Wentao Han, Hamza Celik, Yanan Li, Michael P. Rettig, Andrew L Young, Saranajith Dunuwille, Nancy Issa, Wei Yang, Jeffrey A. Magee, Grant A Challen

Blood (2024) 144 (Supplement 1): 628.

https://doi.org/10.1182/blood-2024-202827

Published: 2024

Journal Articles

Preclinical Evaluation of INCB160058 - a Novel and Potentially Disease-Modifying Therapy for JAK2V617F Mutant Myeloproliferative Neoplasms

Blood (2023) 142 (Supplement 1): 860.

https://doi.org/10.1182/blood-2023-179369

Published: 2023

Journal Articles

Comparison of the Enzymatic and Cellular Profiles of Clinical JAK2 Inhibitors for the Treatment of Myelofibrosis

Hamza Celik, Maryanne Covington, Katherine Drake, Kamna Katiyar, Alex Margulis, Amanda Smith, Gaurang Trivedi, Brittney Wass, Guofeng Zhang, Nina Zolotarjova, Sunkyu Kim, Ricardo Macarrón

Blood (2023) 142 (Supplement 1): 4532.

https://doi.org/10.1182/blood-2023-174917

Published: 2023

Journal Articles

Discovery of INCA033989, a Monoclonal Antibody That Selectively Antagonizes Mutant Calreticulin Oncogenic Function in Myeloproliferative Neoplasms (MPNs)

Edimara Reis, Rebecca Buonpane, Hamza Celik, Caroline Marty, Angela Lei, Fatoumata Jobe, Mark Rupar, Yue Zhang, Darlise DiMatteo, Rahel Awdew, William Vainchenker, Jing Zhou, Ian Hitchcock, Isabelle Plo, Horacio Nastri, Patrick Mayes

Blood (2022) 140 (Supplement 1): 14–15.

https://doi.org/10.1182/blood-2022-159435

Published: 2022

Journal Articles

The PRC2 Co-Factor JARID2 Regulates Hematopoiesis through Non-Canonical Mechanisms

Hassan Bjeije, Infencia Xavier Raj, Hamza Celik, Nancy Issa, Wentao Han, Jason Arand, Grant A Challen

Blood (2022) 140 (Supplement 1): 8578–8579.

https://doi.org/10.1182/blood-2022-164743

Published: 2022

Journal Articles

DUSP6 Mediates Resistance to JAK2 Inhibition and Drives Myeloproliferative Neoplasm Disease Progression

Tim Kong, Angelo BA Laranjeira, Kangning Yang, Daniel AC Fisher, LaYow Yu, Anthony Z Wang, Marianna B. Ruzinova, Jared S. Fowles, Maggie J. Allen, Hamza Celik, Grant A. Challen, Sidong Huang, Stephen T. Oh

Blood (2021) 138 (Supplement 1): 55.

https://doi.org/10.1182/blood-2021-147455

Published: 2021

Journal Articles

The Histone Demethylase KDM6B Is a Genetic Dependency of NOTCH1-Driven T-ALL

Nancy Issa, Hamza Celik, Hassan Bjeije, Wangisa M.B. Dunuwille, Won Kyun Koh, Tyler Parsons, Christine R Zhang, Wentao Han, Grant A. Challen

Blood (2021) 138 (Supplement 1): 782.

https://doi.org/10.1182/blood-2021-150790

Published: 2021

Journal Articles

DNMT3A Regulates Hematopoietic Stem Cell Function Via DNA Methylation-Independent Functions

Won Kyun Koh, Hamza Celik, Jacob Tao, Jake Fairchild, Ostap Kukhar, Christine R Zhang, Paul Gontarz, Grant A. Challen

Blood (2021) 138 (Supplement 1): 24.

https://doi.org/10.1182/blood-2021-153759

Published: 2021

Journal Articles

Txnip enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells Via p21

Christine R Zhang, Elizabeth Leigh Ostrander, Jiameng Sun, Cates Mallaney, Hamza Celik, Won Kyun Koh, Katherine Y. King, Paul Gontarz, Grant A. Challen

Blood (2021) 138 (Supplement 1): 600.

https://doi.org/10.1182/blood-2021-146667

Published: 2021

Journal Articles

Loss of LKB1/ STK11 Facilitates Leukemic Progression of the Myeloproliferative Neoplasms

Christian Marinaccio, MSc, Praveen K Suraneni, PhD, Hamza Celik, PhD, Andrew Volk, PhD, Jeremy Q. Wen, MD PhD, Te Ling, PhD, Terra Lasho, PhD, Richard P. Koche, PhD, Christopher Famulare, MS, Brady L. Stein, MD, Sandeep Gurbuxani, MBBS, PhD, Ronald Hoffman, MD, Naseema Gangat, MBBS, Navdeep Chandel, Ross L. Levine, MD, Raajit K. Rampal, MD PhD, Grant Challen, Ayalew Tefferi, MD, John D. Crispino, PhD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-140557

Published: 2020

Journal Articles

A Novel Humanized Animal Model Reveals Clonal Architecture and Therapeutic Vulnerabilities in Myelofibrosis

Hamza Celik, PhD, Ethan Krug, Hassan Bjeije, PhD, Nancy Issa, MD, Wentao Han, Won Kyun Koh, Ruochao CZ Zhang, PhD, Maggie J. Allen, Terrence N Wong, MD PhD, Daniel AC Fisher, PhD, Tiandao Li, Stephen T. Oh, MD PhD, Grant A. Challen, PhD

Blood (2020) 136 (Supplement 1): 17–18.

https://doi.org/10.1182/blood-2020-143034

Published: 2020

Journal Articles

TGF-β Signaling in Fetal Mesenchymal Progenitor Cells Plays an Essential Role in the Emergence of Bone Marrow Hematopoietic Niches

Grazia Abou Ezzi, PhD, Teerawit Supakorndej, BS, Jingzhu Zhang, BS, Joseph R. Krambs, BS, Hamza Celik, PhD, Daniel C. Link, MD

Blood (2018) 132 (Supplement 1): 3847.

https://doi.org/10.1182/blood-2018-99-117396

Published: 2018

Journal Articles

Jarid2 Restricts Long-Term Repopulating Stem Cell Capacity in Multipotent Progenitors and Acts As Tumor Suppressor in Chronic Myeloid Neoplasms

Hamza Celik, PhD, Won Kyun Koh, MS, Elizabeth Leigh Ostrander, BS, Ashley C. Kramer, BS, William C Wilson, PhD, Greg Fishberger, BS, Cates Mallaney, MS, BS, Alok Kothari, MD, Grant Anthony Challen, PhD

Blood (2017) 130 (Supplement 1): 488.

https://doi.org/10.1182/blood.V130.Suppl_1.488.488

Published: 2017

Journal Articles

The Role of JARID2 in Normal and Malignant Hematopoiesis

Hamza Celik, PhD, Kramer C Ashley, BS, Martens Andy, BS, Elizabeth Eultgen, Cates Mallaney, BS, Alok Kothari, MD, Elizabeth Ostrander, BS, Grant A. Challen, PhD

Blood (2016) 128 (22): 793.

https://doi.org/10.1182/blood.V128.22.793.793

Published: 2016

Journal Articles

The Role of Jarid2 in Leukemic Transformation of Chronic Myeloid Neoplasms

Hamza Celik, PhD, Andrew Martens, Cates Mallaney, Elizabeth Eultgen, Alok Kothari, MD, Gregory Fishberger, Grant A. Challen, PhD

Blood (2015) 126 (23): 1245.

https://doi.org/10.1182/blood.V126.23.1245.1245

Published: 2015

Journal Articles

Pathways for Oncogenesis in T-Cell Acute Lymphoblastic Leukemia Driven By DNA Methylation and Notch Signaling

Alok Kothari, MD, Hamza Celik, PhD, Andrew Martens, Cates Mallaney, Elizabeth L Ostrander, Elizabeth Eultgen, Grant A. Challen, PhD

Blood (2015) 126 (23): 1226.

https://doi.org/10.1182/blood.V126.23.1226.1226

Published: 2015

Journal Articles

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

Hamza Celik, Cates Mallaney, Alok Kothari, Elizabeth L. Ostrander, Elizabeth Eultgen, Andrew Martens, Christopher A. Miller, Jasreet Hundal, Jeffery M. Klco, Grant A. Challen

Blood (2015) 125 (4): 619–628.

https://doi.org/10.1182/blood-2014-08-594564

Published: 2015

Includes: Supplemental data

Journal Articles

Enforced Differentiation of Dnmt3a-Null Bone Marrow Leads to Failure with c-Kit Mutations Driving Leukemic Transformation

Hamza Celik, Cates Mallaney, Alok Kothari, Christopher A Miller, PhD, Jasreet Hundal, MS, Jeffery M. Klco, MDPhD, Grant A Challen, PhD

Blood (2014) 124 (21): 837.

https://doi.org/10.1182/blood.V124.21.837.837

Published: 2014

NARROW

Selective targeting of mutated calreticulin by the monoclonal antibody INCA033989 inhibits oncogenic function of MPN

In Vivo and Ex Vivo Expansion of Functional Human Repopulating Cells through JARID2 Inhibition

EZH2-Mediated Methylation Regulates JARID2 Protein Stability in Normal and Neoplastic Hematopoiesis

Preclinical Evaluation of INCB160058 - a Novel and Potentially Disease-Modifying Therapy for JAK2V617F Mutant Myeloproliferative Neoplasms

Comparison of the Enzymatic and Cellular Profiles of Clinical JAK2 Inhibitors for the Treatment of Myelofibrosis

Discovery of INCA033989, a Monoclonal Antibody That Selectively Antagonizes Mutant Calreticulin Oncogenic Function in Myeloproliferative Neoplasms (MPNs)

The PRC2 Co-Factor JARID2 Regulates Hematopoiesis through Non-Canonical Mechanisms

DUSP6 Mediates Resistance to JAK2 Inhibition and Drives Myeloproliferative Neoplasm Disease Progression

The Histone Demethylase KDM6B Is a Genetic Dependency of NOTCH1-Driven T-ALL

DNMT3A Regulates Hematopoietic Stem Cell Function Via DNA Methylation-Independent Functions

Txnip enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells Via p21

Loss of LKB1/ STK11 Facilitates Leukemic Progression of the Myeloproliferative Neoplasms

A Novel Humanized Animal Model Reveals Clonal Architecture and Therapeutic Vulnerabilities in Myelofibrosis

TGF-β Signaling in Fetal Mesenchymal Progenitor Cells Plays an Essential Role in the Emergence of Bone Marrow Hematopoietic Niches

Jarid2 Restricts Long-Term Repopulating Stem Cell Capacity in Multipotent Progenitors and Acts As Tumor Suppressor in Chronic Myeloid Neoplasms

The Role of JARID2 in Normal and Malignant Hematopoiesis

The Role of Jarid2 in Leukemic Transformation of Chronic Myeloid Neoplasms

Pathways for Oncogenesis in T-Cell Acute Lymphoblastic Leukemia Driven By DNA Methylation and Notch Signaling

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

Enforced Differentiation of Dnmt3a-Null Bone Marrow Leads to Failure with c-Kit Mutations Driving Leukemic Transformation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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