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William L. Heaton
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Journal Articles

SIRT5 As a Therapeutic Target in Acute Myeloid Leukemia

Dongqing Yan, Anthony D. Pomicter, MS, William L. Heaton, MS, Clint C. Mason, PhD, Jonathan Ahmann, BS, Anna Senina, MS, Anca Franzini, PhD, Brayden Halverson, Hein Than, MD FRCPath, MRCP, Phillip M. Clair, MS, Jamshid S Khorashad, MD PhD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 907.
https://doi.org/10.1182/blood-2018-99-115468
Published: 2018
Journal Articles

Inhibition of Nucleocytoplasmic Export Enhances Selective Elimination of Leukemic Stem Cells in Chronic Myeloid Leukemia

Hein Than, MD FRCPath, MRCP, Anthony D. Pomicter, MS, Clinton C. Mason, PhD, Anna M. Eiring, PhD, William L. Heaton, MS, Dongqing Yan, Anna Senina, MS, Phillip M. Clair, MS, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 42.
https://doi.org/10.1182/blood.V130.Suppl_1.42.42
Published: 2017
Journal Articles

Selective Inhibition of Nucleocytoplasmic Transport Overcomes Ruxolitinib Resistance in Myelofibrosis

Dongqing Yan, Srinivas K. Tantravahi, MBBS, Anthony D. Pomicter, MS, Clinton C. Mason, PhD, Anna Senina, MS, Qiang Wang, PhD, Jamshid Sorouri Khorashad, MD PhD FRCPath, Hein Than, MD FRCPath, MRCP, Phillip M. Clair, MS, William L. Heaton, MS, Anna M. Eiring, PhD, Josef T. Prchal, MD, Sabina I. Swierczek, PhD, Erkan Baloglu, Sharon Shacham, PhD MBA, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1660.
https://doi.org/10.1182/blood.V130.Suppl_1.1660.1660
Published: 2017
Journal Articles

TNFR2 Signaling Promotes Myeloproliferative Disease Progression: A Role for MAPK8?

William L. Heaton, MS, Anna Senina, MS, Anthony D. Pomicter, MS, James Marvin, Josef T. Prchal, MD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1962.
https://doi.org/10.1182/blood.V128.22.1962.1962
Published: 2016
Journal Articles

The Nitric Oxide-Generating Prodrug Js-K Is Selectively Toxic Towards AML Compared to Normal Human Hematopoietic Cells

Kristi J. Smock, MD, William L. Heaton, MS, Anthony D. Pomicter, MS, Ronda A Crist, MT, Ken M Kosak, BS, Kenneth M Boucher, PhD, George M. Rodgers, MD PhD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD, Paul J Shami, MD
Journal: Blood
Blood (2016) 128 (22): 5217.
https://doi.org/10.1182/blood.V128.22.5217.5217
Published: 2016
Journal Articles

Stroma-Based Activation of pSTAT3 Y705 Confers Resistance to FLT3 Inhibitors in FLT3 ITD-Positive AML

Ami Patel, MD, Anthony D. Pomicter, MS, Anna M. Eiring, PhD, Than Hein, MBBS, William L. Heaton, MS, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2016) 128 (22): 34.
https://doi.org/10.1182/blood.V128.22.34.34
Published: 2016
Journal Articles

shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance

Jamshid S. Khorashad, Anna M. Eiring, Clinton C. Mason, Kevin C. Gantz, Amber D. Bowler, Hannah M. Redwine, Fan Yu, Ira L. Kraft, Anthony D. Pomicter, Kimberly R. Reynolds, Anthony J. Iovino, Matthew S. Zabriskie, William L. Heaton, Srinivas K. Tantravahi, Michael Kauffman, Sharon Shacham, Alex Chenchik, Kyle Bonneau, Katharine S. Ullman, Thomas O’Hare, Michael W. Deininger
Journal: Blood
Blood (2015) 125 (11): 1772–1781.
https://doi.org/10.1182/blood-2014-08-588855
Published: 2015
Includes: Supplemental data
Journal Articles

Design, Optimization, and Pre-Clinical Evaluation of Direct, Mechanism-Based STAT3 Inhibitors for Treating Myeloid Disorders

William L. Heaton, M.S., Anna M. Eiring, PhD, Nadeem A. Vellore, PhD, Diana Resetca, B.S., Sina Haftchenary, PhD, David Rosa, PhD, Ahmed M. Ali, Anna V. Senina, M.S., Anthony D. Pomicter, M.S., Brent D.G. Page, PhD, Ira L. Kraft, B.S., Kimberly R. Reynolds, M.S., Derek J. Wilson, PhD, Riccardo Baron, PhD, Thomas O'Hare, PhD, Patrick T. Gunning, PhD, Michael W. Deininger
Journal: Blood
Blood (2014) 124 (21): 4816.
https://doi.org/10.1182/blood.V124.21.4816.4816
Published: 2014
Journal Articles

Effect of a TNFα Blocker and Peginfa on Polycythemia Vera Clonal Hematopoiesis and Suppressed Normal Dormant Hematopoiesis

Sabina Swierczek, PhD, Soo Jin Kim, MS, Mohamed E Salama, MD, William L. Heaton, M.S., Michael W. Deininger, Josef T. Prchal, MD
Journal: Blood
Blood (2014) 124 (21): 1820.
https://doi.org/10.1182/blood.V124.21.1820.1820
Published: 2014
Journal Articles

Autocrine TNF-α Signaling in Hematopoietic Stem Cells Promotes Myeloproliferative Disease Progression through Activation of TNFR2

William L. Heaton, M.S., Anna V. Senina, M.S., Anthony D. Pomicter, M.S., James E Marvin, M.S., Sabina Swierczek, PhD, Anna M. Eiring, PhD, Josef T. Prchal, MD, Thomas O'Hare, Michael W. Deininger
Journal: Blood
Blood (2014) 124 (21): 1888.
https://doi.org/10.1182/blood.V124.21.1888.1888
Published: 2014