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Journal Articles

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Blood (2023) 141 (8): 917–929.

https://doi.org/10.1182/blood.2022016846

Published: 2023

Includes: Supplemental data

Journal Articles

Use of Ppmx-T003 As a Potent Inhibitor of Erythrocytosis in Polycythemia Vera

Nami Masubuchi, PhD, Marito Araki, PhD, Kaho Shioiri, Sota Kitazawa, Yoshihiko Kihara, Yuta Ohira, Fumiko Nomura, Tadashi Matsuura, Norio Komatsu, MD PhD

Blood (2020) 136 (Supplement 1): 31.

https://doi.org/10.1182/blood-2020-138387

Published: 2020

Journal Articles

MPL Overexpression Induces a High Level of Mutant-Calr/MPL Complex: A Novel Mechanism of Ruxolitinib Resistance in Myeloproliferative Neoplasms with Calr Mutations

Shunichiro Yasuda, MD, Satoru Aoyama, MD, Ryoto Yoshimoto, Student, Daisuke Watanabe, MD, PhD, Hiroki Akiyama, MD, PhD, Kouhei Yamamoto, Takeo Fujiwara, MD, Emiko Sakaida, MDPhD, Yoko Edahiro, MD PhD, Misa Imai, PhD, Marito Araki, PhD, Norio Komatsu, MD PhD, Norihiko Kawamata, MD, PhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-139162

Published: 2020

Journal Articles

Concomitant Occurrence of Polyclonal Hematopoiesis and Cell-Autonomous Megakaryopoiesis in Triple-Negative Essential Thrombocythemia

Tadaaki Inano, MDPhD, Marito Araki, PhD, Soji Morishita, PhD, Misa Imai, PhD, Yoshihiko Kihara, Maho Okuda, PhD, Masafumi Ito, MD PhD, Satoshi Osaga, Yinjie Yang, PhD, Yoko Edahiro, MD PhD, Tomonori Ochiai, MDPhD, Kyohei Misawa, MDPhD, Yasutaka Fukuda, MDPhD, Akimichi Ohsaka, MD PhD, Norio Komatsu, MD PhD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-134494

Published: 2020

Journal Articles

CREB3L1 Overexpression Can Reliably Discriminate Ph-MPNs from Reactive Cases

Soji Morishita, PhD, Hajime Yasuda, MD PhD, Saya Yamawaki, Hideya Kawaji, PhD, Masayoshi Itoh, PhD, Yoko Edahiro, MD PhD, Misa Imai, PhD, Yasushi Kogo, PhD, Satoshi Tsuneda, PhD, Akimichi Ohsaka, MD PhD, Yoshihide Hayashizaki, MD PhD, Marito Araki, PhD, Norio Komatsu, MD PhD

Blood (2020) 136 (Supplement 1): 41.

https://doi.org/10.1182/blood-2020-137325

Published: 2020

Journal Articles

Therapeutic Potential of an Antibody Targeting the Cleaved Form of Mutant Calreticulin in Myeloproliferative Neoplasms

Yoshihiko Kihara, Marito Araki, PhD, Misa Imai, PhD, Yosuke Mori, MD, Mei Horino, Satoko Ogata, PhD, Syunpei Yoshikawa, Teppei Taguchi, Nami Masubuchi, PhD, Yo Mabuchi, PhD, Yinjie Yang, PhD, Yasutaka Fukuda, MDPhD, Soji Morishita, PhD, Takehiro Suzuki, PhD, Naoshi Domae, PhD, Motoyuki Shimonaka, PhD, Chihiro Akazawa, MD PhD, Akimichi Ohsaka, MD PhD, Norio Komatsu, MD PhD

Blood (2020) 136 (Supplement 1): 9–10.

https://doi.org/10.1182/blood-2020-141159

Published: 2020

Journal Articles

Chitinase 3-like 1 Produced By Fibrocytes Promotes Myelofibrosis

Blood (2019) 134 (Supplement_1): 4197.

https://doi.org/10.1182/blood-2019-125525

Published: 2019

Journal Articles

Overexpression of MPL Causes Ruxolitinib-Resistance in Myeloproliferative Neoplasms with Calreticulin Frame-Shift Mutations

Shunichiro Yasuda, MD, Satoru Aoyama, MD, Ryoto Yoshimoto, Student, Watanabe Daisuke, MD, Hiroki Akiyama, MD, PhD, Yoshihiro Umezawa, MD, PhD, Ayako Nogami, MD PhD BPharm, Kouhei Yamamoto, Takeo Fujiwara, MD, Yoko Edahiro, MD PhD, Marito Araki, PhD, Norio Komatsu, MD PhD, Tetsuya Fukuda, MD PhD, Ayako Arai, MD PhD, Osamu Miura, MD, PhD, Norihiko Kawamata

Blood (2019) 134 (Supplement_1): 1690.

https://doi.org/10.1182/blood-2019-122652

Published: 2019

Journal Articles

Increased SLAMF7 high monocytes in myelofibrosis patients harboring JAK2 V617F provide a therapeutic target of elotuzumab

Blood (2019) 134 (10): 814–825.

https://doi.org/10.1182/blood.2019000051

Published: 2019

Includes: Supplemental data

Journal Articles

SLAMF7 high CD16 negative Monocytes Increase in Peripheral Blood of Patients with Myelofibrosis in Correlation with JAK2V617F Mutation

Takaaki Maekawa, MD, Shoichiro Kato, MD, Yosuke Okada, MD, Noriaki Tachi, MD, Masahiro Teramoto, MD, Toshikuni Kawamura, MD, Yukiko Osawa, PhD, Shinichi Kobayashi, MD PhD, Ken Sato, MD PhD, Michihiro Hashimoto, PhD, Shinya Suzu, PhD, Kensuke Usuki, MD PhD, Soji Morishita, PhD, Marito Araki, PhD, Norio Komatsu, MD PhD, Fumihiko Kimura, Prof, MD PhD

Blood (2018) 132 (Supplement 1): 4330.

https://doi.org/10.1182/blood-2018-99-110916

Published: 2018

Journal Articles

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Blood (2018) 132 (Supplement 1): 4.

https://doi.org/10.1182/blood-2018-99-118348

Published: 2018

Journal Articles

The Zygosity of JAK2 V617F Determines the Disease Entities of Myeloproliferative Neoplasms By Modulating Erythropoiesis but Not Megakaryopoiesis

Hiraku Takei, MS, Yoko Edahiro, MD PhD, Lihua Li, PhD, Yoshihisa Mizukami, PhD, Misa Imai, PhD, Soji Morishita, PhD, Akimichi Ohsaka, MD PhD, Marito Araki, PhD, Norio Komatsu, MD PhD

Blood (2018) 132 (Supplement 1): 3068.

https://doi.org/10.1182/blood-2018-99-112419

Published: 2018

Journal Articles

Localization of Mutant Calreticulin in the Golgi Apparatus Is Required for Its Oncogenic Capacity

Nami Masubuchi, Marito Araki, PhD, Erina Hayashi, BS, Yinjie Yang, PhD, Misa Imai, PhD, Yoshihiko Kihara, PhD, Yoshihisa Mizukami, PhD, Yumi Hironaka, BS, Hiraku Takei, MS, Yoko Edahiro, PhD, Akimichi Ohsaka, MD PhD, Norio Komatsu, MD

Blood (2017) 130 (Supplement 1): 1656.

https://doi.org/10.1182/blood.V130.Suppl_1.1656.1656

Published: 2017

Journal Articles

Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms

Marito Araki, Yinjie Yang, Nami Masubuchi, Yumi Hironaka, Hiraku Takei, Soji Morishita, Yoshihisa Mizukami, Shin Kan, Shuichi Shirane, Yoko Edahiro, Yoshitaka Sunami, Akimichi Ohsaka, Norio Komatsu

Blood (2016) 127 (10): 1307–1316.

https://doi.org/10.1182/blood-2015-09-671172

Published: 2016

Includes: Supplemental data

Journal Articles

Activation of AP-1 By JAK2V617F through Induction and Stabilization of c-FOS

Yoko Edahiro, MD PhD, Marito Araki, PhD, Yumi Hironaka, Yinjie Yang, PhD, Soji Morishita, PhD, Yoshitaka Sunami, MD PhD, Akimichi Ohsaka, MD PhD, Norio Komatsu, MD PhD

Blood (2015) 126 (23): 4098.

https://doi.org/10.1182/blood.V126.23.4098.4098

Published: 2015

Journal Articles

Histone Acetyltransferase Pcaf Is Required for ATRA-Induced Granulocytic Differentiation in Acute Promyelocytic Leukemia Cells

Yoshitaka Sunami, MD PhD, Marito Araki, PhD, Akihiro Ito, PhD, Yumi Hironaka, Minoru Yoshida, PhD, Akimichi Ohsaka, MD PhD, Norio Komatsu, MD PhD

Blood (2014) 124 (21): 617.

https://doi.org/10.1182/blood.V124.21.617.617

Published: 2014

Journal Articles

Dynamic Increase in JAK2V617F Allele Burden Is a Predictive Parameter for the Transformation into Myelofibrosis from Polycythemia Vera and Essential Thrombocytosis

Shuichi Shirane, Marito Araki, PhD, Soji Morishita, PhD, Yumi Hironaka, Masaaki Noguchi, MD PhD, Michiaki Koike, MD PhD, Takao Hirano, MD, Akimichi Ohsaka, MD PhD, Norio Komatsu, MD PhD

Blood (2014) 124 (21): 1832.

https://doi.org/10.1182/blood.V124.21.1832.1832

Published: 2014

Journal Articles

Identification Of FOXO3A As a Key Downstream Target For The Oncogenic JAK2V617F

Masaki Kobayashi, Marito Araki, PhD, Yumi Hironaka, Akimichi Ohsaka, MD, PhD, Norio Komatsu, MD, PhD

Blood (2013) 122 (21): 4108.

https://doi.org/10.1182/blood.V122.21.4108.4108

Published: 2013

Journal Articles

The SirT1 Inhibitor Tenovin-6 Induces Monocytic Differentiation in APL Cells

Yoshitaka Sunami, Marito Araki, Soji Morishita, Yumi Hironaka, Yoko Edahiro, Norio Komatsu, Akimichi Ohsaka, MD, PhD

Blood (2011) 118 (21): 1542.

https://doi.org/10.1182/blood.V118.21.1542.1542

Published: 2011

NARROW

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Use of Ppmx-T003 As a Potent Inhibitor of Erythrocytosis in Polycythemia Vera

MPL Overexpression Induces a High Level of Mutant-Calr/MPL Complex: A Novel Mechanism of Ruxolitinib Resistance in Myeloproliferative Neoplasms with Calr Mutations

Concomitant Occurrence of Polyclonal Hematopoiesis and Cell-Autonomous Megakaryopoiesis in Triple-Negative Essential Thrombocythemia

CREB3L1 Overexpression Can Reliably Discriminate Ph-MPNs from Reactive Cases

Therapeutic Potential of an Antibody Targeting the Cleaved Form of Mutant Calreticulin in Myeloproliferative Neoplasms

Chitinase 3-like 1 Produced By Fibrocytes Promotes Myelofibrosis

Overexpression of MPL Causes Ruxolitinib-Resistance in Myeloproliferative Neoplasms with Calreticulin Frame-Shift Mutations

Increased SLAMF7 high monocytes in myelofibrosis patients harboring JAK2 V617F provide a therapeutic target of elotuzumab

SLAMF7 high CD16 negative Monocytes Increase in Peripheral Blood of Patients with Myelofibrosis in Correlation with JAK2V617F Mutation

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

The Zygosity of JAK2 V617F Determines the Disease Entities of Myeloproliferative Neoplasms By Modulating Erythropoiesis but Not Megakaryopoiesis

Localization of Mutant Calreticulin in the Golgi Apparatus Is Required for Its Oncogenic Capacity

Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms

Activation of AP-1 By JAK2V617F through Induction and Stabilization of c-FOS

Histone Acetyltransferase Pcaf Is Required for ATRA-Induced Granulocytic Differentiation in Acute Promyelocytic Leukemia Cells

Dynamic Increase in JAK2V617F Allele Burden Is a Predictive Parameter for the Transformation into Myelofibrosis from Polycythemia Vera and Essential Thrombocytosis

Identification Of FOXO3A As a Key Downstream Target For The Oncogenic JAK2V617F

The SirT1 Inhibitor Tenovin-6 Induces Monocytic Differentiation in APL Cells

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American Society of Hematology

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American Society of Hematology

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