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Journal Articles

Discovery of JNJ-88549968, a Novel, First-in-Class CALRmutxCD3 T-Cell Redirecting Antibody for the Treatment of Myeloproliferative Neoplasms

Anna Kuchnio, Elsie Samakai, Eva Hug, Meritxell Balmaña, Lut Janssen, Ricardo Amorim, Ivo Cornelissen, Andrea Majoros, Michaël Broux, Isha Taneja, Vince Torti, Azra Agic, Stefan Moritsch, Filippo Benedetti, Felix Rosebrock, Kathryn Packman, Janine Arts, Sonal Patel, Oliver Christopher Lomas, M. Phillip Deyoung, Oleh Zagrijtschuk, Yusri Elsayed, Stefan Constantinescu, Robert Kralovics, Ulrike Philippar
Journal: Blood
Blood (2023) 142 (Supplement 1): 1777.
https://doi.org/10.1182/blood-2023-173430
Published: 2023
Journal Articles

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Christian Pecquet, Nicolas Papadopoulos, Thomas Balligand, Ilyas Chachoua, Amandine Tisserand, Gaëlle Vertenoeil, Audrey Nédélec, Didier Vertommen, Anita Roy, Caroline Marty, Harini Nivarthi, Jean-Philippe Defour, Mira El-Khoury, Eva Hug, Andrea Majoros, Erica Xu, Oleh Zagrijtschuk, Tudor E. Fertig, Daciana S. Marta, Heinz Gisslinger, Bettina Gisslinger, Martin Schalling, Ilaria Casetti, Elisa Rumi, Daniela Pietra, Chiara Cavalloni, Luca Arcaini, Mario Cazzola, Norio Komatsu, Yoshihiko Kihara, Yoshitaka Sunami, Yoko Edahiro, Marito Araki, Roman Lesyk, Veronika Buxhofer-Ausch, Sonja Heibl, Florence Pasquier, Violaine Havelange, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N. Constantinescu
Journal: Blood
Blood (2023) 141 (8): 917–929.
https://doi.org/10.1182/blood.2022016846
Published: 2023
Includes: Supplemental data
Journal Articles

Ifnα Attenuates the Disease Phenotype and Extends Survival in Mouse Models of MPN

Harini Nivarthi, PhD, Andrea Majoros, PhD, Eva Hug, PhD, Ruochen Jia, PhD, Sarada Achyutuni, Roland Jäger, PhD, Raimund Holly, Beatrice Grabner, Felix Rosebrock, Shin-Jye Lee, Chung-Wei Lee, Robert Kralovics, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 53.
https://doi.org/10.1182/blood-2020-138813
Published: 2020
Journal Articles

Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms

Fiorella Schischlik, Roland Jäger, Felix Rosebrock, Eva Hug, Michael Schuster, Raimund Holly, Elisabeth Fuchs, Jelena D. Milosevic Feenstra, Edith Bogner, Bettina Gisslinger, Martin Schalling, Elisa Rumi, Daniela Pietra, Gottfried Fischer, Ingrid Faé, Loan Vulliard, Jörg Menche, Torsten Haferlach, Manja Meggendorfer, Anna Stengel, Christoph Bock, Mario Cazzola, Heinz Gisslinger, Robert Kralovics
Journal: Blood
Blood (2019) 134 (2): 199–210.
https://doi.org/10.1182/blood.2019000519
Published: 2019
Includes: Supplemental data
Journal Articles

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Christian Pecquet, Ilyas Chachoua, Anita Roy, Thomas Balligand, Gaëlle Vertenoeil, Emilie Leroy, Roxana-Irina Albu, Jean-Philippe Defour, Harini Nivarthi, Eva Hug, Erica Xu, Yasmine Ould-Amer, Céline Mouton, Didier Colau, Didier Vertommen, Myat Marlar Shwe, Caroline Marty, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N. Constantinescu
Journal: Blood
Blood (2019) 133 (25): 2669–2681.
https://doi.org/10.1182/blood-2018-09-874578
Published: 2019
Includes: Supplemental data
Journal Articles

Mutational Landscape of the Transcriptome Offers a Rich Neoantigen Resource for Immunotherapy of Myeloproliferative Neoplasms

Fiorella Schischlik, MSc, Roland Jäger, PhD, Felix Rosebrock, Eva Hug, PhD, Michael Schuster, PhD, Raimund Holly, Elisabeth Fuchs, Jelena D. Milosevic Feenstra, PhD, Edith Bogner, Bettina Gisslinger, Martin Schalling, MSc, Elisa Rumi, MD, Daniela Pietra, PhD, Gottfried Fischer, MD, Ingrid Faé, Vulliard Loan, Jörg Menche, PhD, Torsten Haferlach, MD, Manja Meggendorfer, PhD, Anna Stengel, PhD, Christoph Bock, PhD, Mario Cazzola, Heinz Gisslinger, Robert Kralovics, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3058.
https://doi.org/10.1182/blood-2018-99-118049
Published: 2018
Journal Articles

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Christian Pecquet, PhD, Thomas Balligand, MD, Ilyas Chachoua, PhD, Anita Roy, PhD, Gaelle Vertenoeil, MD, Didier Colau, PhD, Emanuel Fertig, MD, Caroline Marty, PhD, Harini Nivarthi, PhD, Jean-Philippe Defour, BPharm, PhD, Erica Xu, Eva Hug, PhD, Heinz Gisslinger, Bettina Gisslinger, Martin Schalling, MSc, Ilaria Carola Casetti, MD, Elisa Rumi, MD, Daniela Pietra, PhD, Chiara Cavalloni, MD, Luca Arcaini, MD, Mario Cazzola, Norio Komatsu, MD PhD, Yoshihiko Kihara, PhD, Yoshitaka Sunami, MD PhD, Yoko Edahiro, MD PhD, Marito Araki, PhD, Isabelle Plo, PhD, William Vainchenker, MD PhD, Robert Kralovics, PhD, Stefan N Constantinescu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4.
https://doi.org/10.1182/blood-2018-99-118348
Published: 2018
Journal Articles

Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL

Stefano Iacovelli, Eva Hug, Sara Bennardo, Marcus Duehren-von Minden, Stefania Gobessi, Andrea Rinaldi, Mirza Suljagic, Daniel Bilbao, Giulia Bolasco, Julia Eckl-Dorna, Verena Niederberger, Francesco Autore, Simona Sica, Luca Laurenti, Hongsheng Wang, Richard J. Cornall, Stephen H. Clarke, Carlo M. Croce, Francesco Bertoni, Hassan Jumaa, Dimitar G. Efremov
Journal: Blood
Blood (2015) 125 (10): 1578–1588.
https://doi.org/10.1182/blood-2014-07-587790
Published: 2015
Includes: Supplemental data