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Journal Articles

Preclinical Proof of Concept for Decentralized Manufacturing of a MAGE-A4/CD8α-Expressing Autologous T-Cell Therapy for Solid Tumors

Melissa Herman, Stefania Gobessi, Laurens Sand, Karolin Wagner, Ryan Yuan, Sterenn Davis, Ian Donaldson, Megan Butler, Natalie Bath, Robert Harris, Nathaniel Golden, Alex Tipping, Joseph Sanderson, John Mellors, Phillip Debnam

Blood (2024) 144 (Supplement 1): 2100.

https://doi.org/10.1182/blood-2024-199551

Published: 2024

Journal Articles

Macrophage- and BCR-derived but not TLR-derived signals support the growth of CLL and Richter syndrome murine models in vivo

Claudio Martines, Supriya Chakraborty, Marija Vujovikj, Stefania Gobessi, Tiziana Vaisitti, Silvia Deaglio, Luca Laurenti, Aleksandar J. Dimovski, Dimitar G. Efremov

Blood (2022) 140 (22): 2335–2347.

https://doi.org/10.1182/blood.2022016272

Published: 2022

Includes: Supplemental data

Journal Articles

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Stefania Gobessi, PhD, Luca Laurenti, MD, Fabiola Porro, MS, Claudio Martines, MS, Rosa Fazio, BS, Elena Xerxa, PhD, Idanna Innocenti, MD PhD, Antonella Zucchetto, Shih-Shih Chen, PhD, Xiao-Jie Yan, MD PhD, Nicholas Chiorazzi, MD, Valter Gattei, MD, Dimitar G Efremov, MD PhD

Blood (2018) 132 (Supplement 1): 4409.

https://doi.org/10.1182/blood-2018-99-118562

Published: 2018

Journal Articles

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

Tiziana Vaisitti, PhD, Sara Serra, PhD, Cinzia Bologna, PhD, Nicoletta Vitale, PhD, Stefania Gobessi, PhD BS, Dimitar G Efremov, MD PhD, Silvia Deaglio, MD

Blood (2017) 130 (Supplement 1): 1721.

https://doi.org/10.1182/blood.V130.Suppl_1.1721.1721

Published: 2017

Journal Articles

The Bcl-2 BH4 Antagonist Bda-366 Induces Apoptosis in CLL and DLBCL Cells through a Bcl-2 Independent Mechanism

Binu K Sasi, PhD, Tamara Vervloessem, PhD, Stefania Gobessi, PhD, Idanna Innocenti, MD, Luca Laurenti, Geert Bultynck, PhD, Dimitar G Efremov, MD PhD

Blood (2016) 128 (22): 2014.

https://doi.org/10.1182/blood.V128.22.2014.2014

Published: 2016

Journal Articles

FcμR Triggering Activates BCR Signaling Pathways and Increases Survival of CLL Cells

Stefania Gobessi, PhD, Binu K Sasi, PhD, Gabriele Pozzato, MD, Idanna Innocenti, MD, Luca Laurenti, Dimitar G Efremov, MD PhD

Blood (2016) 128 (22): 2015.

https://doi.org/10.1182/blood.V128.22.2015.2015

Published: 2016

Journal Articles

BCR signaling inhibitors differ in their ability to overcome Mcl-1–mediated resistance of CLL B cells to ABT-199

Kamil Bojarczuk, Binu K. Sasi, Stefania Gobessi, Idanna Innocenti, Gabriele Pozzato, Luca Laurenti, Dimitar G. Efremov

Blood (2016) 127 (25): 3192–3201.

https://doi.org/10.1182/blood-2015-10-675009

Published: 2016

Includes: Supplemental data

Journal Articles

Serum IgM Activates BCR Signaling Pathways and Increases Survival of Chronic Lymphocytic Leukemia B Cells

Stefania Gobessi, PhD, Binu K Sasi, PhD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD

Blood (2015) 126 (23): 4131.

https://doi.org/10.1182/blood.V126.23.4131.4131

Published: 2015

Journal Articles

Inhibition of SYK More Effectively Overcomes MCL-1 Mediated ABT-199 Resistance of BCR-Stimulated CLL Cells Than Inhibition of BTK or PI3Kdelta

Kamil Bojarczuk, PhD, Binu K Sasi, PhD, Stefania Gobessi, PhD, Idanna Innocenti, MD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD

Blood (2015) 126 (23): 489.

https://doi.org/10.1182/blood.V126.23.489.489

Published: 2015

Journal Articles

Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL

Blood (2015) 125 (10): 1578–1588.

https://doi.org/10.1182/blood-2014-07-587790

Published: 2015

Includes: Supplemental data

Journal Articles

Bruton’s tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

Jennifer A. Woyach, Engin Bojnik, Amy S. Ruppert, Matthew R. Stefanovski, Virginia M. Goettl, Kelly A. Smucker, Lisa L. Smith, Jason A. Dubovsky, William H. Towns, Jessica MacMurray, Bonnie K. Harrington, Melanie E. Davis, Stefania Gobessi, Luca Laurenti, Betty Y. Chang, Joseph J. Buggy, Dimitar G. Efremov, John C. Byrd, Amy J. Johnson

Blood (2014) 123 (8): 1207–1213.

https://doi.org/10.1182/blood-2013-07-515361

Published: 2014

Includes: Supplemental data

Journal Articles

The Nature of the Antigen Determines Leukemia Development and Behavior in the Eμ-TCL1 Transgenic Mouse Model of CLL

Sara Bennardo, BS, Stefano Iacovelli, BS, Stefania Gobessi, PhD, Mirza Suljagic, DVM, PhD, Daniel Bilbao, PhD, Julia Eckl-Dorna, MD, PhD, Hongsheng Wang, MD, PhD, Richard J. Cornall, MD, PhD, Stephen H Clarke, PhD, Carlo M. Croce, MD, Dimitar G Efremov, MD, PhD

Blood (2012) 120 (21): 181.

https://doi.org/10.1182/blood.V120.21.181.181

Published: 2012

Journal Articles

Expression of ZAP-70 Does Not Accelerate Leukemia Development and Progression in the Eμ-TCL1 Transgenic Mouse Model of Chronic Lymphocytic Leukemia

Stefania Gobessi, PhD, Francesca Belfiore, PhD, Sara Bennardo, BS, Brendan Doe, BS, Luca Laurenti, MD, Dimitar G Efremov, MD, PhD

Blood (2012) 120 (21): 925.

https://doi.org/10.1182/blood.V120.21.925.925

Published: 2012

Journal Articles

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT

Roberto Negro, Stefania Gobessi, Pablo G. Longo, Yantao He, Zhong-Yin Zhang, Luca Laurenti, Dimitar G. Efremov

Blood (2012) 119 (26): 6278–6287.

https://doi.org/10.1182/blood-2012-01-403162

Published: 2012

Includes: Supplemental data

Journal Articles

Development of a Transgenic Mouse Model to Study the Role of ZAP-70 in the Development and Progression of Chronic Lymphocytic Leukemia

Stefania Gobessi, PhD, Sara Bennardo, BS, Pablo G Longo, MD, Brendan Doe, BS, Dimitar G Efremov, MD, PhD

Blood (2011) 118 (21): 2830.

https://doi.org/10.1182/blood.V118.21.2830.2830

Published: 2011

Journal Articles

Overexpression of the Autoimmunity-Associated Tyrosine Phosphatase PTPN22 in CLL Cells Enhances Antiapoptotic B-Cell Receptor Signals Through Selective Activation of the AKT Pathway

Roberto Negro, PhD, Stefania Gobessi, PhD, Pablo G Longo, MD, Luca Laurenti, Dimitar G Efremov, MD, PhD

Blood (2011) 118 (21): 619.

https://doi.org/10.1182/blood.V118.21.619.619

Published: 2011

Journal Articles

The Mir-17~92 Cluster Family Determines the Responsiveness of CLL Cells with Unmutated IGHV Genes to Toll-Like Receptor 9 Triggering

Riccardo Bomben, Stefano Volinia, Stefania Gobessi, Daniela Marconi, Michele Dal Bo, Dania Benedetti, Giovanni Del Poeta, Luca Laurenti, Dimitar G Efremov, Valter Gattei

Blood (2010) 116 (21): 2407.

https://doi.org/10.1182/blood.V116.21.2407.2407

Published: 2010

Journal Articles

Overexpression of the Protein Tyrosine Phosphatase Lyp Reduces the Responsiveness of Chronic Lymphocytic Leukemia B-Cells to B-Cell Receptor Ligation.

Roberto Negro, PhD, Pablo G Longo, MD, Michela Tarnani, MD, Stefania Gobessi, PhD, Luca Laurenti, MD, Dimitar G Efremov, MD, PhD

Blood (2009) 114 (22): 800.

https://doi.org/10.1182/blood.V114.22.800.800

Published: 2009

Journal Articles

Molecular Requirements for Syk-Mediated Intracellular Signaling and B-Cell Transformation

Laura Carsetti, BS, Luca Laurenti, MD, Stefania Gobessi, PhD, Pablo G Longo, MD, Giuseppe Leone, MD, Dimitar G Efremov, MD, PhD

Blood (2008) 112 (11): 2837.

https://doi.org/10.1182/blood.V112.11.2837.2837

Published: 2008

Journal Articles

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

Pablo G. Longo, Luca Laurenti, Stefania Gobessi, Simona Sica, Giuseppe Leone, Dimitar G. Efremov

Blood (2008) 111 (2): 846–855.

https://doi.org/10.1182/blood-2007-05-089037

Published: 2008

Includes: Supplemental data

NARROW

Preclinical Proof of Concept for Decentralized Manufacturing of a MAGE-A4/CD8α-Expressing Autologous T-Cell Therapy for Solid Tumors

Macrophage- and BCR-derived but not TLR-derived signals support the growth of CLL and Richter syndrome murine models in vivo

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

The Bcl-2 BH4 Antagonist Bda-366 Induces Apoptosis in CLL and DLBCL Cells through a Bcl-2 Independent Mechanism

FcμR Triggering Activates BCR Signaling Pathways and Increases Survival of CLL Cells

BCR signaling inhibitors differ in their ability to overcome Mcl-1–mediated resistance of CLL B cells to ABT-199

Serum IgM Activates BCR Signaling Pathways and Increases Survival of Chronic Lymphocytic Leukemia B Cells

Inhibition of SYK More Effectively Overcomes MCL-1 Mediated ABT-199 Resistance of BCR-Stimulated CLL Cells Than Inhibition of BTK or PI3Kdelta

Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL

Bruton’s tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

The Nature of the Antigen Determines Leukemia Development and Behavior in the Eμ-TCL1 Transgenic Mouse Model of CLL

Expression of ZAP-70 Does Not Accelerate Leukemia Development and Progression in the Eμ-TCL1 Transgenic Mouse Model of Chronic Lymphocytic Leukemia

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT

Development of a Transgenic Mouse Model to Study the Role of ZAP-70 in the Development and Progression of Chronic Lymphocytic Leukemia

Overexpression of the Autoimmunity-Associated Tyrosine Phosphatase PTPN22 in CLL Cells Enhances Antiapoptotic B-Cell Receptor Signals Through Selective Activation of the AKT Pathway

The Mir-17~92 Cluster Family Determines the Responsiveness of CLL Cells with Unmutated IGHV Genes to Toll-Like Receptor 9 Triggering

Overexpression of the Protein Tyrosine Phosphatase Lyp Reduces the Responsiveness of Chronic Lymphocytic Leukemia B-Cells to B-Cell Receptor Ligation.

Molecular Requirements for Syk-Mediated Intracellular Signaling and B-Cell Transformation

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

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American Society of Hematology

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American Society of Hematology

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