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Melanie E. Davis
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Journal Articles

Bruton’s tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

Jennifer A. Woyach, Engin Bojnik, Amy S. Ruppert, Matthew R. Stefanovski, Virginia M. Goettl, Kelly A. Smucker, Lisa L. Smith, Jason A. Dubovsky, William H. Towns, Jessica MacMurray, Bonnie K. Harrington, Melanie E. Davis, Stefania Gobessi, Luca Laurenti, Betty Y. Chang, Joseph J. Buggy, Dimitar G. Efremov, John C. Byrd, Amy J. Johnson
Journal: Blood
Blood (2014) 123 (8): 1207–1213.
https://doi.org/10.1182/blood-2013-07-515361
Published: 2014
Includes: Supplemental data
Journal Articles

Global Inhibition of Bruton's Tyrosine Kinase (BTK) Delays the Development and Expansion of Chronic Lymphocytic Leukemia (CLL) in the TCL1 Mouse Model of Disease

Jennifer A. Woyach, MD, Matthew R Stefanovski, B.S., Virginia Goettl, Amy S. Ruppert, MAS, Kelly A Smucker, Lisa L. Smith, Jason A Dubovsky, Ph.D, William H. Towns, Jessica MacMurray, Melanie E. Davis, Yicheng Mao, Betty Y. Chang, PhD, Joseph J. Buggy, PhD, John C. Byrd, MD, Amy J Johnson, PhD
Journal: Blood
Blood (2012) 120 (21): 183.
https://doi.org/10.1182/blood.V120.21.183.183
Published: 2012
Journal Articles

The Novel Proteasome Inhibitor Carfilzomib Functions Independently of p53 to Induce Potent Cytotoxicity in Primary Chronic Lymphocytic Leukemia Cells and a Defective NF-κB Response,

Sneha V. Gupta, Erin K Hertlein, PhD, Jennifer A. Woyach, MD, Ellen J. Sass, Melanie E. Davis, John C. Byrd, MD, David M. Lucas, PhD
Journal: Blood
Blood (2011) 118 (21): 3510.
https://doi.org/10.1182/blood.V118.21.3510.3510
Published: 2011
Journal Articles

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

David M. Lucas, Ryan B. Edwards, Gerard Lozanski, Derek A. West, Jungook D. Shin, Melissa A. Vargo, Melanie E. Davis, Darlene M. Rozewski, Amy J. Johnson, Bao-Ning Su, Virginia M. Goettl, Nyla A. Heerema, Thomas S. Lin, Amy Lehman, Xiaoli Zhang, David Jarjoura, David J. Newman, John C. Byrd, A. Douglas Kinghorn, Michael R. Grever
Journal: Blood
Blood (2009) 113 (19): 4656–4666.
https://doi.org/10.1182/blood-2008-09-175430
Published: 2009
Journal Articles

Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab

Brief Report
Farrukh T. Awan, Neil E. Kay, Melanie E. Davis, Wenting Wu, Susan M. Geyer, Nelson Leung, Diane F. Jelinek, Renee C. Tschumper, Charla R. Secreto, Thomas S. Lin, Michael R. Grever, Tait D. Shanafelt, Clive S. Zent, Timothy G. Call, Nyla A. Heerema, Gerard Lozanski, John C. Byrd, David M. Lucas
Journal: Blood
Blood (2009) 113 (3): 535–537.
https://doi.org/10.1182/blood-2008-08-173450
Published: 2009
Journal Articles

The Novel Histone Deacetylase Inhibitor OSU-HDAC42 Has Class I and II Histone Deacetylase (HDAC) Inhibitory Activity and Represents a Novel Therapy for Chronic Lymphocytic Leukemia.

Derek A. West, BS, David M. Lucas, PhD, Melanie E. Davis, PhD, Michael D. De Lay, BA, Amy J. Johnson, PhD, Sara E. Guster, MS/MBA, Michael A. Freitas, PhD, Mark R. Parthun, PhD, Dasheng Wang, PhD, Samuel K. Kulp, PhD/DVM, Michael R. Grever, MD, Ching-Shih Chen, PhD, John C. Byrd, MD
Journal: Blood
Blood (2006) 108 (11): 2807.
https://doi.org/10.1182/blood.V108.11.2807.2807
Published: 2006
Journal Articles

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia

Clinical Trials & Observations
John C. Byrd, Guido Marcucci, Mark R. Parthun, Jim J. Xiao, Rebecca B. Klisovic, Mollie Moran, Thomas S. Lin, Shujun Liu, Amy R. Sklenar, Melanie E. Davis, David M. Lucas, Beth Fischer, Roshini Shank, Sooraj L. Tejaswi, Philip Binkley, John Wright, Kenneth K. Chan, Michael R. Grever
Journal: Blood
Blood (2005) 105 (3): 959–967.
https://doi.org/10.1182/blood-2004-05-1693
Published: 2005
Journal Articles

The Histone Deacetylase Inhibitor Depsipeptide Mediates Distinct Patterns of Histone Acetylation in Cells Overexpressing Bcl-2.

David M. Lucas, PhD, Liwen Zhang, PhD, Melanie E. Davis, PhD, Xiaodan Su, Amy Sklenar, Mark R. Parthun, PhD, Michael A. Freitas, PhD, Shinichi Kitada, PhD, John C. Reed, MD, PhD, Guido Marcucci, MD, Michael R. Grever, MD, John C. Byrd, MD
Journal: Blood
Blood (2004) 104 (11): 2802.
https://doi.org/10.1182/blood.V104.11.2802.2802
Published: 2004
Journal Articles

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8–mediated apoptosis and down-regulation of c-FLIP protein

Jennifer L. Aron, Mark R. Parthun, Guido Marcucci, Shinichi Kitada, Andrew P. Mone, Melanie E. Davis, Tiansheng Shen, Timothy Murphy, Joseph Wickham, Chris Kanakry, David M. Lucas, John C. Reed, Michael R. Grever, John C. Byrd
Journal: Blood
Blood (2003) 102 (2): 652–658.
https://doi.org/10.1182/blood-2002-12-3794
Published: 2003