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Mark R. Parthun
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Journal Articles

The Novel Histone Deacetylase Inhibitor OSU-HDAC42 Has Class I and II Histone Deacetylase (HDAC) Inhibitory Activity and Represents a Novel Therapy for Chronic Lymphocytic Leukemia.

Derek A. West, BS, David M. Lucas, PhD, Melanie E. Davis, PhD, Michael D. De Lay, BA, Amy J. Johnson, PhD, Sara E. Guster, MS/MBA, Michael A. Freitas, PhD, Mark R. Parthun, PhD, Dasheng Wang, PhD, Samuel K. Kulp, PhD/DVM, Michael R. Grever, MD, Ching-Shih Chen, PhD, John C. Byrd, MD
Journal: Blood
Blood (2006) 108 (11): 2807.
https://doi.org/10.1182/blood.V108.11.2807.2807
Published: 2006
Journal Articles

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia

Clinical Trials & Observations
John C. Byrd, Guido Marcucci, Mark R. Parthun, Jim J. Xiao, Rebecca B. Klisovic, Mollie Moran, Thomas S. Lin, Shujun Liu, Amy R. Sklenar, Melanie E. Davis, David M. Lucas, Beth Fischer, Roshini Shank, Sooraj L. Tejaswi, Philip Binkley, John Wright, Kenneth K. Chan, Michael R. Grever
Journal: Blood
Blood (2005) 105 (3): 959–967.
https://doi.org/10.1182/blood-2004-05-1693
Published: 2005
Journal Articles

The Histone Deacetylase Inhibitor Depsipeptide Mediates Distinct Patterns of Histone Acetylation in Cells Overexpressing Bcl-2.

David M. Lucas, PhD, Liwen Zhang, PhD, Melanie E. Davis, PhD, Xiaodan Su, Amy Sklenar, Mark R. Parthun, PhD, Michael A. Freitas, PhD, Shinichi Kitada, PhD, John C. Reed, MD, PhD, Guido Marcucci, MD, Michael R. Grever, MD, John C. Byrd, MD
Journal: Blood
Blood (2004) 104 (11): 2802.
https://doi.org/10.1182/blood.V104.11.2802.2802
Published: 2004
Journal Articles

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8–mediated apoptosis and down-regulation of c-FLIP protein

Jennifer L. Aron, Mark R. Parthun, Guido Marcucci, Shinichi Kitada, Andrew P. Mone, Melanie E. Davis, Tiansheng Shen, Timothy Murphy, Joseph Wickham, Chris Kanakry, David M. Lucas, John C. Reed, Michael R. Grever, John C. Byrd
Journal: Blood
Blood (2003) 102 (2): 652–658.
https://doi.org/10.1182/blood-2002-12-3794
Published: 2003