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Journal Articles

Protein Tyrosine Phosphatase PRL2 Promotes MLL -Rearranged Acute Myeloid Leukemia Development through Inhibiting the p53 Pathway

Shiyu Xiao, Hongxia Chen, Michihiro Kobayashi, Yunpeng Bai, Sergio Barajas, Wenjie Cai, Zhong-Yin Zhang, Yan Liu
Journal: Blood
Blood (2024) 144 (Supplement 1): 4109.
https://doi.org/10.1182/blood-2024-198244
Published: 2024
Journal Articles

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371

Hongxia Chen, Yunpeng Bai, Michihiro Kobayashi, Shiyu Xiao, Wenjie Cai, Sergio Barajas, Sisi Chen, Jinmin Miao, Frederick Nguele Meke, Sasidhar Vemula, James P. Ropa, James M. Croop, H. Scott Boswell, Jun Wan, Yuzhi Jia, Huiping Liu, Loretta S. Li, Jessica K. Altman, Elizabeth A. Eklund, Peng Ji, Wei Tong, Hamid Band, Danny T. Huang, Leonidas C. Platanias, Zhong-Yin Zhang, Yan Liu
Journal: Blood
Blood (2023) 141 (3): 244–259.
https://doi.org/10.1182/blood.2022016580
Published: 2023
Includes: Supplemental data
Journal Articles

PRL2 Phosphatase Is a Key Mediator of Oncogenic Cytokine Signaling in Leukemia Stem Cells

Michihiro Kobayashi, MD PhD, Yunpeng Bai, PhD, Sisi Chen, BS, Sarah C Nabinger, PhD, Chonghua Yao, MD, Zhong-Yin Zhang, PhD, Yan Liu, PhD
Journal: Blood
Blood (2016) 128 (22): 724.
https://doi.org/10.1182/blood.V128.22.724.724
Published: 2016
Journal Articles

PRL2 Maintains Hematopoietic Stem and Progenitor Cells Through Regulating SCF/KIT Signaling

Michihiro Kobayashi, MD, PhD, Yuanshu Dong, Ph.D., Hao Yu, Ph.D., Yunpeng Bai, Sisi Chen, Rui Gao, PhD, Mervin C. Yoder, MD, Reuben Kapur, PhD, Zhong-Yin Zhang, PhD, Yan Liu, PhD
Journal: Blood
Blood (2013) 122 (21): 3674.
https://doi.org/10.1182/blood.V122.21.3674.3674
Published: 2013
Journal Articles

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

Sarah C Nabinger, PhD, Xing Jun Li, MD, PhD, Baskar Ramdas, Ph.D., Yantao He, PhD, Xian Zhang, Ph.D., Briana Richine, Joshua Bowling, Seiji Fukuda, MD, PhD, Shreevrat Goenka, Ph.D., Ziyue Liu, Ph.D., Gen-Sheng Feng, PhD, Menggang Yu, Ph.D., George Sandusky, MD, H. Scott Boswell, MD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2420.
https://doi.org/10.1182/blood.V120.21.2420.2420
Published: 2012
Journal Articles

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Raghuveer Singh Mali, Peilin Ma, Li-Fan Zeng, Holly Martin, Baskar Ramdas, Yantao He, Emily Sims, Sarah Nabinger, Joydeep Ghosh, Namit Sharma, Veerendra Munugalavadla, Anindya Chatterjee, Shuo Li, George Sandusky, Andrew W. Craig, Kevin D. Bunting, Gen-Sheng Feng, Rebecca J. Chan, Zhong-Yin Zhang, Reuben Kapur
Journal: Blood
Blood (2012) 120 (13): 2669–2678.
https://doi.org/10.1182/blood-2011-08-375873
Published: 2012
Includes: Supplemental data
Journal Articles

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT

Roberto Negro, Stefania Gobessi, Pablo G. Longo, Yantao He, Zhong-Yin Zhang, Luca Laurenti, Dimitar G. Efremov
Journal: Blood
Blood (2012) 119 (26): 6278–6287.
https://doi.org/10.1182/blood-2012-01-403162
Published: 2012
Includes: Supplemental data
Journal Articles

KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML

Peilin Ma, MD, PhD, Raghuveer Mali, Ph.D., Li-Fan Zeng, PhD, Holly Martin, Baskar Ramdas, Ph.D., Yantao He, PhD, Emily Sims, Joydeep Ghosh, Ph.D, Sarah C Nabinger, Shuo Li, Veerendra Munugalavadla, PhD, Anindya Chatterjee, PhD, George Sandusky, MD, Andrew Craig, PhD, Kevin D. Bunting, PhD, Gen-Sheng Feng, Rebecca J. Chan, MD, PhD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD
Journal: Blood
Blood (2011) 118 (21): 868.
https://doi.org/10.1182/blood.V118.21.868.868
Published: 2011
Journal Articles

Targeting the Protein Phosphatase, Shp2, Reduces FLT3-ITD-Induced Hyperproliferation of Murine Hematopoietic Progenitors.

Sarah C Nabinger, Yantao He, Fuqin Yin, Xian Zhang, Linda Senbanjo, Seiji Fukuda, MD, PhD, Menggang Yu, Gen-Sheng Feng, Zhong-Yin Zhang, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 827.
https://doi.org/10.1182/blood.V114.22.827.827
Published: 2009