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Emily Sims
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Journal Articles

Role of p21 Activated Kinase and Specific Guanine Exchange Factors of Rac Gtpases in Oncogenic KIT Induced Systemic Mastocytosis and Acute Myeloid Leukemia

Free
Holly Martin, Peilin Ma, MD, PhD, Anindya Chatterjee, MS, PhD, Baskar Ramdas, Ph.D., Emily Sims, Cornelis Vlaar, PhD, Suraganie Dharmawardhane, PhD, Reuben Kapur, PhD
Journal: Blood
Blood (2012) 120 (21): 810.
https://doi.org/10.1182/blood.V120.21.810.810
Published: 2012
Journal Articles

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Free
Raghuveer Singh Mali, Peilin Ma, Li-Fan Zeng, Holly Martin, Baskar Ramdas, Yantao He, Emily Sims, Sarah Nabinger, Joydeep Ghosh, Namit Sharma, Veerendra Munugalavadla, Anindya Chatterjee, Shuo Li, George Sandusky, Andrew W. Craig, Kevin D. Bunting, Gen-Sheng Feng, Rebecca J. Chan, Zhong-Yin Zhang, Reuben Kapur
Journal: Blood
Blood (2012) 120 (13): 2669–2678.
https://doi.org/10.1182/blood-2011-08-375873
Published: 2012
Includes: Supplemental data
Journal Articles

p85β regulatory subunit of class I A PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

Free
Subha Krishnan, Raghuveer Singh Mali, Baskar Ramdas, Emily Sims, Peilin Ma, Joydeep Ghosh, Veerendra Munugalavadla, Philip Hanneman, Joal D. Beane, Reuben Kapur
Journal: Blood
Blood (2012) 119 (17): 3951–3961.
https://doi.org/10.1182/blood-2011-05-355602
Published: 2012
Journal Articles

KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML

Free
Peilin Ma, MD, PhD, Raghuveer Mali, Ph.D., Li-Fan Zeng, PhD, Holly Martin, Baskar Ramdas, Ph.D., Yantao He, PhD, Emily Sims, Joydeep Ghosh, Ph.D, Sarah C Nabinger, Shuo Li, Veerendra Munugalavadla, PhD, Anindya Chatterjee, PhD, George Sandusky, MD, Andrew Craig, PhD, Kevin D. Bunting, PhD, Gen-Sheng Feng, Rebecca J. Chan, MD, PhD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD
Journal: Blood
Blood (2011) 118 (21): 868.
https://doi.org/10.1182/blood.V118.21.868.868
Published: 2011
Journal Articles

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Free
Peilin Ma, Raghuveer Singh Mali, Veerendra Munugalavadla, Subha Krishnan, Baskar Ramdas, Emily Sims, Holly Martin, Joydeep Ghosh, Shuo Li, Rebecca J. Chan, Gerald Krystal, Andrew W. Craig, Clifford Takemoto, Reuben Kapur
Journal: Blood
Blood (2011) 118 (13): 3459–3469.
https://doi.org/10.1182/blood-2011-04-351809
Published: 2011
Journal Articles

Role of Intracellular Tyrosine Residues in Oncogenic KIT- Induced Transformamtion.

Free
Peilin Ma, PhD, Holly Martin, Emily Sims, Ramdas Baskar, PhD, Joy Ghosh, Reuben Kapur, PhD
Journal: Blood
Blood (2009) 114 (22): 1435.
https://doi.org/10.1182/blood.V114.22.1435.1435
Published: 2009
Journal Articles

Differential Role of Class 1A PI 3-Kinase Regulatory Subunits in Mast Cell Growth, Maturation and Survival.

Free
Raghuveer Mali, Ph.D., Subha Krishnan, Ramdas Baskar, PhD, Veerendra Munugalavadla, hD, Emily Sims, Philip Hanneman, Reuben Kapur, PhD
Journal: Blood
Blood (2009) 114 (22): 77.
https://doi.org/10.1182/blood.V114.22.77.77
Published: 2009
Journal Articles

Rho Kinase Inhibitors as Potential Therapeutic Agents for Oncogenic KIT, FLT3, and BCR-ABL Induced Leukemogenesis.

Free
Raghuveer Mali, Ph.D., Baskar Ramdas, Ph.D., Veerendra Munugalavadla, Emily Sims, Reuben Kapur, PhD
Journal: Blood
Blood (2009) 114 (22): 3909.
https://doi.org/10.1182/blood.V114.22.3909.3909
Published: 2009
Journal Articles

ROCKI Regulates Growth, Maturation and Migration of Mast Cells.

Free
Veerendra Munugalavadla, PhD, Emily Sims, BS, Jianjian Shi, PhD, Lei Wei, MD/PhD, Reuben Kapur, PhD
Journal: Blood
Blood (2007) 110 (11): 2191.
https://doi.org/10.1182/blood.V110.11.2191.2191
Published: 2007
Journal Articles

p85α Regulatory Subunit of Class IA PI-3Kinase Regulates Osteoclast Function(s) and Bone Mass.

Free
Veerendra Munugalavadla, PhD, Emily Sims, BS, David A. Ingram, MD, Alexander Robling, PhD, Reuben Kapur, PhD
Journal: Blood
Blood (2005) 106 (11): 2223.
https://doi.org/10.1182/blood.V106.11.2223.2223
Published: 2005
Journal Articles

Gleevec Resistant Activating Mutation of c-Kit (D816V) Demonstrates Ligand Independent Growth and Promiscuous Cooperation with Multiple Cytokine Receptors Via the p85α Subunit of Class IA PI-3Kinase.

Free
Veerendra Munugalavadla, PhD, Emily Sims, BS, Jovencio Borneo, BS, Reuben Kapur, PhD
Journal: Blood
Blood (2005) 106 (11): 3530.
https://doi.org/10.1182/blood.V106.11.3530.3530
Published: 2005