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Journal Articles

Comparison of Familial Versus Sporadic Forms of Chronic Lymphocytic Leukemia: An Italian Multicenter Case-Control Study

Blood (2024) 144 (Supplement 1): 4621.

https://doi.org/10.1182/blood-2024-205215

Published: 2024

Journal Articles

Adaptation of Chronic Lymphocytic Leukemia to Ibrutinib Is Mediated By Epigenetic Plasticity of Residual Disease and By-Pass Signaling Via MAPK Pathway

Blood (2024) 144 (Supplement 1): 73.

https://doi.org/10.1182/blood-2024-205557

Published: 2024

Journal Articles

Richter Syndrome-Associated Genetic Lesions in TP53 and the Cell Cycle Inhibitors CDKN2A and CDKN2B Induce Transformation of a CD5+ B Cell Subset Characterized By a Restricted IGHV Repertoire, Autoreactivity and BCR Dependence

Claudio Martines, Supriya Chakraborty, Giulia Felician, Karin Hofmann, Sasha Blasutig, Ivan Negara, Alice Bonato, Marija Vujovikj, Alberto Zamò, Andreas Rosenwald, Aleksandar J Dimovski, Dimitar G Efremov

Blood (2024) 144 (Supplement 1): 759.

https://doi.org/10.1182/blood-2024-207095

Published: 2024

Journal Articles

T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia

Blood (2024) 144 (5): 510–524.

https://doi.org/10.1182/blood.2023021990

Published: 2024

Includes: Supplemental data

Journal Articles

CXCR4 Loss Reduces the Local Growth of Richter Syndrome Murine and Patient-Derived Xenograft Models and Impairs BCR and VLA-4 Activation

Claudio Martines, Supriya Chakraborty, Antonella Zucchetto, Erika Tissino, Vincenzo Guastafierro, Marija Vujovikj, Tiziana Vaisitti, Silvia Deaglio, Luca Laurenti, Aleksandar J Dimovski, Valter Gattei, Dimitar G Efremov

Blood (2023) 142 (Supplement 1): 80.

https://doi.org/10.1182/blood-2023-179183

Published: 2023

Journal Articles

Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL

Blood (2023) 141 (26): 3166–3183.

https://doi.org/10.1182/blood.2022017839

Published: 2023

Includes: Supplemental data

Journal Articles

Macrophage- and BCR-derived but not TLR-derived signals support the growth of CLL and Richter syndrome murine models in vivo

Claudio Martines, Supriya Chakraborty, Marija Vujovikj, Stefania Gobessi, Tiziana Vaisitti, Silvia Deaglio, Luca Laurenti, Aleksandar J. Dimovski, Dimitar G. Efremov

Blood (2022) 140 (22): 2335–2347.

https://doi.org/10.1182/blood.2022016272

Published: 2022

Includes: Supplemental data

Journal Articles

Predictive and Prognostic Molecular Biomarkers in Familial Chronic Lymphocytic Leukemia: A Pilot Monocentric Study

Giulia Benintende, Idanna Innocenti, Alberto Fresa, Francesco Autore, Annamaria Tomasso, Florenzia Vuono, Luca Stirparo, Antonio Mosca, Dimitar G Efremov, Andrea Bacigalupo, Luca Laurenti

Blood (2022) 140 (Supplement 1): 7018–7019.

https://doi.org/10.1182/blood-2022-169897

Published: 2022

Journal Articles

VEGF and IL-6 As Markers of Severity and Response to Treatment in Waldenstrom Macroglobulinemia and IgM-Monoclonal Gammopathy of Undetermined Significance: A Monocentric Experience

Annamaria Tomasso, Idanna Innocenti, Giulia Benintende, Francesco Autore, Alberto Fresa, Florenzia Vuono, Luca Stirparo, Antonio Mosca, Claudia Giannotta, Dimitar G Efremov, Marco Luigetti, Silvia Baroni, Luca Laurenti

Blood (2022) 140 (Supplement 1): 12498–12500.

https://doi.org/10.1182/blood-2022-165487

Published: 2022

Journal Articles

Rapid Generation of Murine CLL/Richter Syndrome Models By Multiplexed CRISPR/Cas9 Editing of Common CLL Driver Genes

Supriya Chakraborty, Giulia Felician, Claudio Martines, Alice Bonato, Ana Colado, Marija Vujovic, Aleksandar J. Dimovski, Dimitar G Efremov

Blood (2022) 140 (Supplement 1): 1536–1537.

https://doi.org/10.1182/blood-2022-163067

Published: 2022

Journal Articles

Prevalence of Allelic Variants and Clonality of IGHV1-69 Expressing B-Cells in Patients with Different Severity of COVID 19 Disease

Irina Panovska-Stavridis, Nevenka Ridova, Simona Stojanovska, Milena Stevanovic, Tatjana Stojanoska, Ilir Demiri, Nadica Matevska-Geshkovska, Marija Vujovic, Hristina Markoska, Venko Filipce, Aleksandar J. Dimovski, Dimitar G Efremov

Blood (2021) 138 (Supplement 1): 994.

https://doi.org/10.1182/blood-2021-153487

Published: 2021

Journal Articles

Chronic Lymphocytic Leukemia Cells with Mutated Nfkbie Are Positively Selected By Microenvironmental Signals and Display Reduced Sensitivity to Ibrutinib Treatment

Alice Bonato, Riccardo Bomben, Supriya Chakraborty, Giulia Felician, Claudio Martines, Antonella Zucchetto, Annalisa Chiarenza, Giovanni Del Poeta, Roberto Marasca, Agostino Tafuri, Luca Laurenti, Aleksandar J. Dimovski, Valter Gattei, Dimitar G Efremov

Blood (2021) 138 (Supplement 1): 248.

https://doi.org/10.1182/blood-2021-149442

Published: 2021

Journal Articles

B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation

Supriya Chakraborty, Claudio Martines, Fabiola Porro, Ilaria Fortunati, Alice Bonato, Marija Dimishkovska, Silvano Piazza, Brijesh S. Yadav, Idanna Innocenti, Rosa Fazio, Tiziana Vaisitti, Silvia Deaglio, Alberto Zamò, Aleksandar J. Dimovski, Luca Laurenti, Dimitar G. Efremov

Blood (2021) 138 (12): 1053–1066.

https://doi.org/10.1182/blood.2020008276

Published: 2021

Includes: Supplemental data

Journal Articles

Combined Genetic Lesions in TP53 and CDKN2A/CDKN2B Drive B Cell Receptor-Dependent/Costimulatory Signal-Independent Proliferation in Richter Syndrome

Supriya Chakraborty, PhD, Claudio Martines, MS, Fabiola Porro, MS, Ilaria Fortunati, BS, Alice Bonato, BA, Marija Dimishkovska, PhD, Brijesh Yadav, PhD, Idanna Innocenti, MDPhD, Rosa Fazio, BA, Tizianna Vaisitti, PhD, Silvia Deaglio, MD, Alberto Zamò, MD PhD, Aleksandar Dimovski, MD PhD, Luca Laurenti, MD, Dimitar G Efremov, MDPhD

Blood (2020) 136 (Supplement 1): 5–6.

https://doi.org/10.1182/blood-2020-136668

Published: 2020

Journal Articles

A CRISPR/Cas9-Generated Murine Model Reveals Cooperation between BCR Signaling and CDKN2A/2B and TP53 Disruption in Richter Syndrome

Supriya Chakraborty, PhD, Ilaria Fortunati, BS, Claudio Martines, MS, Brijesh Yadav, PhD, Marija Dimishkovska, PhD, Idanna Innocenti, MD PhD, Rosa Fazio, BS, Giovanni D'Arena, MD, Aleksandar Dimovski, MD PhD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD

Blood (2019) 134 (Supplement_1): 4278.

https://doi.org/10.1182/blood-2019-128425

Published: 2019

Journal Articles

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Binu K Sasi, PhD, Sven Turkalj, BS, Hilal Kalkan, BS, Fabiola Porro, MS, Engin Bojnik, PhD, Beata Pyrzynska, PhD, Abdessamad Zerrouqi, PhD, Malgorzata Bobrowicz, PhD, Magdalena Winiarska, PhD, Valdemar Priebe, MS, Francesco Bertoni, MD, Larry Mansouri, PhD, Richard Rosenquist, MD PhD, Dimitar G Efremov, MD PhD

Blood (2018) 132 (Supplement 1): 2860.

https://doi.org/10.1182/blood-2018-99-118120

Published: 2018

Journal Articles

Targeting the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Novel Therapeutic Opportunities

Andrea Papait, PhD, Tiziana Vaisitti, PhD, Sara Serra, PhD, Valentina Audrito, PhD, Francesco Tito, Giulia Guerra, Dimitar G Efremov, MDPhD, Silvia Deaglio, MD PhD

Blood (2018) 132 (Supplement 1): 240.

https://doi.org/10.1182/blood-2018-99-118057

Published: 2018

Journal Articles

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Stefania Gobessi, PhD, Luca Laurenti, MD, Fabiola Porro, MS, Claudio Martines, MS, Rosa Fazio, BS, Elena Xerxa, PhD, Idanna Innocenti, MD PhD, Antonella Zucchetto, Shih-Shih Chen, PhD, Xiao-Jie Yan, MD PhD, Nicholas Chiorazzi, MD, Valter Gattei, MD, Dimitar G Efremov, MD PhD

Blood (2018) 132 (Supplement 1): 4409.

https://doi.org/10.1182/blood-2018-99-118562

Published: 2018

Journal Articles

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

Tiziana Vaisitti, PhD, Sara Serra, PhD, Cinzia Bologna, PhD, Nicoletta Vitale, PhD, Stefania Gobessi, PhD BS, Dimitar G Efremov, MD PhD, Silvia Deaglio, MD

Blood (2017) 130 (Supplement 1): 1721.

https://doi.org/10.1182/blood.V130.Suppl_1.1721.1721

Published: 2017

Journal Articles

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Blood (2017) 130 (14): 1628–1638.

https://doi.org/10.1182/blood-2016-08-736066

Published: 2017

Includes: Supplemental data

NARROW

Comparison of Familial Versus Sporadic Forms of Chronic Lymphocytic Leukemia: An Italian Multicenter Case-Control Study

Adaptation of Chronic Lymphocytic Leukemia to Ibrutinib Is Mediated By Epigenetic Plasticity of Residual Disease and By-Pass Signaling Via MAPK Pathway

Richter Syndrome-Associated Genetic Lesions in TP53 and the Cell Cycle Inhibitors CDKN2A and CDKN2B Induce Transformation of a CD5+ B Cell Subset Characterized By a Restricted IGHV Repertoire, Autoreactivity and BCR Dependence

T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia

CXCR4 Loss Reduces the Local Growth of Richter Syndrome Murine and Patient-Derived Xenograft Models and Impairs BCR and VLA-4 Activation

Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL

Macrophage- and BCR-derived but not TLR-derived signals support the growth of CLL and Richter syndrome murine models in vivo

Predictive and Prognostic Molecular Biomarkers in Familial Chronic Lymphocytic Leukemia: A Pilot Monocentric Study

VEGF and IL-6 As Markers of Severity and Response to Treatment in Waldenstrom Macroglobulinemia and IgM-Monoclonal Gammopathy of Undetermined Significance: A Monocentric Experience

Rapid Generation of Murine CLL/Richter Syndrome Models By Multiplexed CRISPR/Cas9 Editing of Common CLL Driver Genes

Prevalence of Allelic Variants and Clonality of IGHV1-69 Expressing B-Cells in Patients with Different Severity of COVID 19 Disease

Chronic Lymphocytic Leukemia Cells with Mutated Nfkbie Are Positively Selected By Microenvironmental Signals and Display Reduced Sensitivity to Ibrutinib Treatment

B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation

Combined Genetic Lesions in TP53 and CDKN2A/CDKN2B Drive B Cell Receptor-Dependent/Costimulatory Signal-Independent Proliferation in Richter Syndrome

A CRISPR/Cas9-Generated Murine Model Reveals Cooperation between BCR Signaling and CDKN2A/2B and TP53 Disruption in Richter Syndrome

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Targeting the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Novel Therapeutic Opportunities

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

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American Society of Hematology

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American Society of Hematology

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