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Peter Lichter
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Journal Articles

T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia

Philipp M. Roessner, Isabelle Seufert, Vicente Chapaprieta, Ruparoshni Jayabalan, Hannah Briesch, Ramon Massoni-Badosa, Pavle Boskovic, Julian Benckendorff, Tobias Roider, Lavinia Arseni, Mariana Coelho, Supriya Chakraborty, Alicia M. Vaca, Mariela Sivina, Markus Muckenhuber, Sonia Rodriguez-Rodriguez, Alice Bonato, Sophie A. Herbst, Marc Zapatka, Clare Sun, Helene Kretzmer, Thomas Naake, Peter-Martin Bruch, Felix Czernilofsky, Elisa ten Hacken, Martin Schneider, Dominic Helm, Deyan Y. Yosifov, Joseph Kauer, Alexey V. Danilov, Moritz Bewarder, Kristina Heyne, Christof Schneider, Stephan Stilgenbauer, Adrian Wiestner, Jan-Philipp Mallm, Jan A. Burger, Dimitar G. Efremov, Peter Lichter, Sascha Dietrich, José I. Martin-Subero, Karsten Rippe, Martina Seiffert
Journal: Blood
Blood (2024) 144 (5): 510–524.
https://doi.org/10.1182/blood.2023021990
Published: 2024
Includes: Supplemental data
Journal Articles

Single-Cell Omics Analyses Identify the TIM-3 Ligand Galectin-9 As Novel Immunotherapy Target for Chronic Lymphocytic Leukemia

Laura Llaó Cid, John KL Wong, Marina Wierz, Yashna Paul, Tobias Roider, Iria Fernandez Botana, Susanne Gonder, Alessia Floerchinger, Dolors Colomer, Elías Campo, Sascha Dietrich, Peter Lichter, Marc Zapatka, Etienne Moussay, Jérôme Paggetti, Martina Seiffert
Journal: Blood
Blood (2022) 140 (Supplement 1): 1805–1806.
https://doi.org/10.1182/blood-2022-167183
Published: 2022
Journal Articles

Longitudinal Omics Data Followed By Preclinical Treatment Studies Identify Proteasome Inhibition As Effective Therapy for Ibrutinib-Resistant Chronic Lymphocytic Leukemia

Lavinia Arseni, Gianluca Sigismondo, Johanne U Hermansen, Sigrid S Skånland, Eugen Tausch, Stephan Stilgenbauer, Jeroen Krijgsveld, Peter Lichter, Marc Zapatka, Martina Seiffert
Journal: Blood
Blood (2022) 140 (Supplement 1): 4107–4108.
https://doi.org/10.1182/blood-2022-166999
Published: 2022
Journal Articles

Modelling Single Cell B-Cell Receptor Signaling Reveals Enhanced Activity in Primary CLL Cells Compared to Non-Malignant Cells While Fundamental Network Circuit Topology Remains Stable Even with Novel Therapeutic Inhibitors

Daniel Mertens, PhD, Christine Wolf, PhD, Carsten Maus, PhD, Michael Persicke, Katharina Filarsky, PhD, Hartmut Döhner, Peter Lichter, PhD, Thomas Höfer, PhD, Stephan Stilgenbauer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4275.
https://doi.org/10.1182/blood-2019-127837
Published: 2019
Journal Articles

IL-10 Receptor Deficiency Aggravates Exhaustion of CD8 + T-Cells and Impedes Their Control of Chronic Lymphocytic Leukemia

Bola S Hanna, PhD, Philipp M Röβner, Murat Iskar, PhD, Norman Mack, Verena Kalter, Manfred Schmidt, PhD, Marc Zapatka, PhD, Markus Feuerer, MD, Richard Gabriel, PhD, Peter Lichter, PhD, Martina Seiffert
Journal: Blood
Blood (2017) 130 (Supplement 1): 385.
https://doi.org/10.1182/blood.V130.Suppl_1.385.385
Published: 2017
Journal Articles

Exhausted PD-1 hi T-Cells Are Enriched in Secondary Lymphoid Organs of CLL Patients

Philipp M Rößner, Bola S Hanna, PhD, Colomer Dolors, PhD, Elias Campo, MD PhD, Stephan Stilgenbauer, MD PhD, Peter Lichter, PhD, Martina Seiffert
Journal: Blood
Blood (2017) 130 (Supplement 1): 4281.
https://doi.org/10.1182/blood.V130.Suppl_1.4281.4281
Published: 2017
Journal Articles

PI3K-δ Inhibition Influences T-Cell Populations and Anti-Tumoral Immune Function in Preclinical Models

Annika Scheffold, Bola S Hanna, PhD, Philipp Roeßner, Yasmin Demerdash, Billy Michael Chelliah Jebaraj, PhD, Peter Lichter, PhD, Stephan Stilgenbauer, MD PhD, Martina Seiffert
Journal: Blood
Blood (2017) 130 (Supplement 1): 2998.
https://doi.org/10.1182/blood.V130.Suppl_1.2998.2998
Published: 2017
Journal Articles

CLL Exosome-Derived Y RNA hY4 Induces TLR7/8-Mediated Inflammation and PD-L1 Expression in Monocytes

Franziska Haderk, MSc, Laura Llao Cid, MSc, Murat Iskar, PhD, Ralph Schulz, MSc, Maria Goebel, MD, Jan Duerig, MD, Stephan Stilgenbauer, Marc Zapatka, Peter Lichter, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2016) 128 (22): 3217.
https://doi.org/10.1182/blood.V128.22.3217.3217
Published: 2016
Journal Articles

Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic Leukemia

Christopher C. Oakes, PhD, Marc Seifert, Yassen Assenov, Lei Gu, Martina Przekopowitz, Amy S. Ruppert, MAS, Qi Wang, Charles Imbusch, Andrius Serva, Sandra Koser, David Brocks, Daniel B Lipka, Olga Bogatyrova, Benedikt Brors, Dieter Weichenhan, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Daniel Mertens, PhD, Marc Zapatka, Peter Lichter, Hartmut Döhner, MD, Ralf Kueppers, Thorsten Zenz, Stephan Stilgenbauer, MD, John C Byrd, MD, Christoph Plass, PhD
Journal: Blood
Blood (2015) 126 (23): 2436.
https://doi.org/10.1182/blood.V126.23.2436.2436
Published: 2015
Journal Articles

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

Jerome Paggetti, Franziska Haderk, Martina Seiffert, Bassam Janji, Ute Distler, Wim Ammerlaan, Yeoun Jin Kim, Julien Adam, Peter Lichter, Eric Solary, Guy Berchem, Etienne Moussay
Journal: Blood
Blood (2015) 126 (9): 1106–1117.
https://doi.org/10.1182/blood-2014-12-618025
Published: 2015
Includes: Supplemental data
Journal Articles

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Fabienne McClanahan, Bola Hanna, Shaun Miller, Andrew James Clear, Peter Lichter, John G. Gribben, Martina Seiffert
Journal: Blood
Blood (2015) 126 (2): 203–211.
https://doi.org/10.1182/blood-2015-01-622936
Published: 2015
Includes: Supplemental data
Journal Articles

Chronic Lymphocytic Leukemia-Exosomes Switch Endothelial and Mesenchymal Stromal Cells into Cancer-Associated Fibroblasts to Sustain Leukemic Cell Survival

Jerome Paggetti, Franziska Haderk, Martina Seiffert, Bassam Janji, Yeoun Jin Kim, Ute Diestler, Wim Ammerlaan, Peter Lichter, Eric Solary, Guy Berchem, Etienne Moussay
Journal: Blood
Blood (2014) 124 (21): 2927.
https://doi.org/10.1182/blood.V124.21.2927.2927
Published: 2014
Journal Articles

Targeting Dysfunctional Myeloid Cells Delays Disease Development and Improves Immune Function in a CLL Mouse Model

Bola Hanna, Fabienne McClanahan, MD, Nadja Zaborsky, PhD, Claudia Dürr, Verena Kalter, Alexander Egle, MD, John G. Gribben, MD DSc, Peter Lichter, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2014) 124 (21): 3298.
https://doi.org/10.1182/blood.V124.21.3298.3298
Published: 2014
Journal Articles

Immune Checkpoint Blockade with Anti-PD-L1 Prevents Immune Dysfuntion and CLL Development in the TCL1 Adoptive Transfer Mouse Model

Bola Hanna, Fabienne McClanahan, MD, Andrew James Clear, BSc, Shaun Miller, Peter Lichter, PhD, Martina Seiffert, PhD, John G. Gribben, MD DSc
Journal: Blood
Blood (2014) 124 (21): 717.
https://doi.org/10.1182/blood.V124.21.717.717
Published: 2014
Journal Articles

The Flavonoid Wogonin Reduces CLL Cell Survival in Vitro and Leukemia Development in Eµ-TCL1 Mice By Targeting Aberrant TNF Receptor Signaling

Claudia Dürr, Bola Hanna, Fabienne McClanahan, MD, Andrew James Clear, BSc, Thorsten Zenz, MD, Stephan Stilgenbauer, MD, John G. Gribben, MD DSc, Peter Lichter, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2014) 124 (21): 1966.
https://doi.org/10.1182/blood.V124.21.1966.1966
Published: 2014
Journal Articles

Chronic Lymphocytic Leukemia-Derived Extracellular Vesicles Contain a Distinctive Proteome, As Well As Specific Micro RNAs and Y RNAs

Franziska Haderk, Etienne Moussay, Jerome Paggetti, Maria Göbel, Jan Dürig, MD, Thorsten Zenz, MD, Stephan Stilgenbauer, MD, Peter Lichter, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2014) 124 (21): 1968.
https://doi.org/10.1182/blood.V124.21.1968.1968
Published: 2014
Journal Articles

NFATc1 Is Transcriptionally Activated in Chronic Lymphocytic Leukemia (CLL) By Promotor DNA-Hypomethylation Which Correlates with in-Vitro Vulnerability to Calcineurin Inhibitors

Christine Wolf, Katharina Filarsky, Angela Garding, PhD, Rainer Claus, MD, Christopher C Oakes, PhD, Irina Idler, PhD, Christoph Plass, PhD, Peter Lichter, PhD, Hartmut Doehner, MD, Stephan Stilgenbauer, MD, Daniel Mertens, PhD
Journal: Blood
Blood (2014) 124 (21): 1941.
https://doi.org/10.1182/blood.V124.21.1941.1941
Published: 2014
Journal Articles

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial

Clinical Trials & Observations
Stephan Stilgenbauer, Andrea Schnaiter, Peter Paschka, Thorsten Zenz, Marianna Rossi, Konstanze Döhner, Andreas Bühler, Sebastian Böttcher, Matthias Ritgen, Michael Kneba, Dirk Winkler, Eugen Tausch, Patrick Hoth, Jennifer Edelmann, Daniel Mertens, Lars Bullinger, Manuela Bergmann, Sabrina Kless, Silja Mack, Ulrich Jäger, Nancy Patten, Lin Wu, Michael K. Wenger, Günter Fingerle-Rowson, Peter Lichter, Mario Cazzola, Clemens M. Wendtner, Anna M. Fink, Kirsten Fischer, Raymonde Busch, Michael Hallek, Hartmut Döhner
Journal: Blood
Blood (2014) 123 (21): 3247–3254.
https://doi.org/10.1182/blood-2014-01-546150
Published: 2014
Includes: Supplemental data
Journal Articles

Heterogeneity and Evolution Of DNA Methylation In Chronic Lymphocytic Leukemia

Christopher C Oakes, Ph.D, Rainer Claus, MD, Lei Gu, Yassen Assenov, Jennifer Hüllein, Manuela Zucknick, David Brocks, Olga Bogatyrova, Christopher R. Schmidt, Laura Rassenti, PhD, Thomas J. Kipps, MD, PhD, Daniel Mertens, PhD, Peter Lichter, PhD, Hartmut Döhner, MD, Stephan Stilgenbauer, MD, John C. Byrd, MD, Thorsten Zenz, MD, Christoph Plass, PhD
Journal: Blood
Blood (2013) 122 (21): 1626.
https://doi.org/10.1182/blood.V122.21.1626.1626
Published: 2013
Journal Articles

Microenvironmental Factors and The Role Of Tumor Necrosis Factor Receptor Type 1 (TNFR-1) In Chronic Lymphocytic Leukemia

Claudia Duerr, Angela Schulz, PhD, Sibylle Ohl, Thorsten Zenz, MD, Stephan Stilgenbauer, MD, Peter Lichter, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2013) 122 (21): 4149.
https://doi.org/10.1182/blood.V122.21.4149.4149
Published: 2013