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David Brocks
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Journal Articles

Recurrent Mutations in EGR2 Direct Specific Epigenetic Reconfiguration in Chronic Lymphocytic Leukemia

Christoph Weigel, PhD, Yassen Assenov, Charles Imbusch, Qi Wang, Renée Beekman, Brian Giacopelli, BS, Yue-zhong Wu, MSc, David Brocks, Weichenhan Dieter, Popanda Odilia, Peter Schmezer, Benedikt Brors, Daniel Mertens, Karsten Rippe, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Jennifer A. Woyach, MD, James S. Blachly, MD, Elias Campo, Thorsten Zenz, MD, John C. Byrd, MD, José I. Martin-Subero, PhD, Christoph Plass, Christopher C. Oakes
Journal: Blood
Blood (2018) 132 (Supplement 1): 650.
https://doi.org/10.1182/blood-2018-99-119070
Published: 2018
Journal Articles

Epigenetic Drug Treatment Globally Induces Cryptic Transcription Start Sites Encoded in Long Terminal Repeats

Michael Daskalakis, David Brocks, Christopher Schmidt, Daofeng Li, Jing Li, Hyo S. Jang, Bo Zhang, Daniel B Lipka, Johanna Schott, Holger Bierhoff, Yassen Assenov, Monika Helf, Alzbeta Ressnerova, Anders Lindroth, Simon Haas, Marieke A. G. Essers, Charles D. Imbusch, Benedikt Brors, Ina Oehme, Olaf Witt, Michael Lübbert, MD, Georg Stoecklin, Clarissa Gerhäuser, Christopher C Oakes, PhD, Ting Wang, Christoph Plass
Journal: Blood
Blood (2016) 128 (22): 3931.
https://doi.org/10.1182/blood.V128.22.3931.3931
Published: 2016
Journal Articles

Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic Leukemia

Christopher C. Oakes, PhD, Marc Seifert, Yassen Assenov, Lei Gu, Martina Przekopowitz, Amy S. Ruppert, MAS, Qi Wang, Charles Imbusch, Andrius Serva, Sandra Koser, David Brocks, Daniel B Lipka, Olga Bogatyrova, Benedikt Brors, Dieter Weichenhan, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Daniel Mertens, PhD, Marc Zapatka, Peter Lichter, Hartmut Döhner, MD, Ralf Kueppers, Thorsten Zenz, Stephan Stilgenbauer, MD, John C Byrd, MD, Christoph Plass, PhD
Journal: Blood
Blood (2015) 126 (23): 2436.
https://doi.org/10.1182/blood.V126.23.2436.2436
Published: 2015
Journal Articles

Altered HSC Metabolism in Response to Stress Leads to De Novo dna Damage and Cellular Attrition

Anja Geiselhart, Dagmar Walter, PhD, Amelie Lier, Frederic B. Thalheimer, Sina Huntscha, David Brocks, Irem Bayindir, Paul Kaschutnig, Katja Müdder, Mirko Sobotta, PhD, Tobias Dick, PhD, Tim Holland-Letz, PhD, Peter Schmezer, PhD, Timm Schröder, PhD, Steven W Lane, MD PhD, Marieke Essers, PhD, Michael A. Rieger, PhD, David A. Williams, MD, Andreas Trumpp, PhD, Michael D. Milsom, PhD
Journal: Blood
Blood (2014) 124 (21): 255.
https://doi.org/10.1182/blood.V124.21.255.255
Published: 2014
Journal Articles

Heterogeneity and Evolution Of DNA Methylation In Chronic Lymphocytic Leukemia

Christopher C Oakes, Ph.D, Rainer Claus, MD, Lei Gu, Yassen Assenov, Jennifer Hüllein, Manuela Zucknick, David Brocks, Olga Bogatyrova, Christopher R. Schmidt, Laura Rassenti, PhD, Thomas J. Kipps, MD, PhD, Daniel Mertens, PhD, Peter Lichter, PhD, Hartmut Döhner, MD, Stephan Stilgenbauer, MD, John C. Byrd, MD, Thorsten Zenz, MD, Christoph Plass, PhD
Journal: Blood
Blood (2013) 122 (21): 1626.
https://doi.org/10.1182/blood.V122.21.1626.1626
Published: 2013
Journal Articles

HSC Exit From Dormancy Provokes De Novo DNA Damage, Leading To Bone Marrow Failure If Unresolved By The Fanconi Anemia Pathway

Dagmar Walter, PhD, Amelie Lier, Anja Geiselhart, Sina Huntscha, David Brocks, Irem Bayindir, Paul Kaschutnig, Peter Schmezer, PhD, Steven W Lane, MD, PhD, Marieke Essers, PhD, David A. Williams, MD, Andreas Trumpp, PhD, Michael D. Milsom, PhD
Journal: Blood
Blood (2013) 122 (21): 799.
https://doi.org/10.1182/blood.V122.21.799.799
Published: 2013