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Marc Zapatka
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Journal Articles

T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia

Philipp M. Roessner, Isabelle Seufert, Vicente Chapaprieta, Ruparoshni Jayabalan, Hannah Briesch, Ramon Massoni-Badosa, Pavle Boskovic, Julian Benckendorff, Tobias Roider, Lavinia Arseni, Mariana Coelho, Supriya Chakraborty, Alicia M. Vaca, Mariela Sivina, Markus Muckenhuber, Sonia Rodriguez-Rodriguez, Alice Bonato, Sophie A. Herbst, Marc Zapatka, Clare Sun, Helene Kretzmer, Thomas Naake, Peter-Martin Bruch, Felix Czernilofsky, Elisa ten Hacken, Martin Schneider, Dominic Helm, Deyan Y. Yosifov, Joseph Kauer, Alexey V. Danilov, Moritz Bewarder, Kristina Heyne, Christof Schneider, Stephan Stilgenbauer, Adrian Wiestner, Jan-Philipp Mallm, Jan A. Burger, Dimitar G. Efremov, Peter Lichter, Sascha Dietrich, José I. Martin-Subero, Karsten Rippe, Martina Seiffert
Journal: Blood
Blood (2024) 144 (5): 510–524.
https://doi.org/10.1182/blood.2023021990
Published: 2024
Includes: Supplemental data
Journal Articles

Longitudinal Omics Data Followed By Preclinical Treatment Studies Identify Proteasome Inhibition As Effective Therapy for Ibrutinib-Resistant Chronic Lymphocytic Leukemia

Lavinia Arseni, Gianluca Sigismondo, Johanne U Hermansen, Sigrid S Skånland, Eugen Tausch, Stephan Stilgenbauer, Jeroen Krijgsveld, Peter Lichter, Marc Zapatka, Martina Seiffert
Journal: Blood
Blood (2022) 140 (Supplement 1): 4107–4108.
https://doi.org/10.1182/blood-2022-166999
Published: 2022
Journal Articles

Single-Cell Omics Analyses Identify the TIM-3 Ligand Galectin-9 As Novel Immunotherapy Target for Chronic Lymphocytic Leukemia

Laura Llaó Cid, John KL Wong, Marina Wierz, Yashna Paul, Tobias Roider, Iria Fernandez Botana, Susanne Gonder, Alessia Floerchinger, Dolors Colomer, Elías Campo, Sascha Dietrich, Peter Lichter, Marc Zapatka, Etienne Moussay, Jérôme Paggetti, Martina Seiffert
Journal: Blood
Blood (2022) 140 (Supplement 1): 1805–1806.
https://doi.org/10.1182/blood-2022-167183
Published: 2022
Journal Articles

Secondary resistance to idelalisib is characterized by upregulation of IGF1R rather than by MAPK/ERK pathway mutations

Eugen Tausch, Viktor Ljungström, Andreas Agathangelidis, Marc Zapatka, Lydia Scarfò, Billy Michael Chelliah Jebaraj, Deyan Y. Yosifov, Annika Müller, Veerendra Munugalavadla, Jeremiah D. Degenhardt, Paolo Ghia, Richard Rosenquist, Stephan Stilgenbauer
Journal: Blood
Blood (2022) 139 (22): 3340–3344.
https://doi.org/10.1182/blood.2021014550
Published: 2022
Includes: Supplemental data
Journal Articles

Immune Suppression in CLL Is Mediated By the L-Amino Acid Oxidase IL4I1, a Reason for the Treatment Failure of IDO1 Inhibitors

Selcen Öztürk, PhD, Murat Iskar, PhD, Murat Sunbul, PhD, Philipp M Rößner, MD, Marc Zapatka, PhD, Martina Seiffert
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-141317
Published: 2020
Journal Articles

Proteogenomic Subtyping of Chronic Lymphocytic Leukemia Identifies a Novel Poor Outcome Subgroup with a Distinct Drug Response Profile

Sophie A. Herbst, MSc, Mattias Vesterlund, Rozbeh Jafari, PhD, Ioannis Siavelis, Matthias Stahl, Eva Schitter, Alexander J. Helmboldt, Murat Iskar, Nora Liebers, MD, Felix Czernilofsky, Tobias Roider, MD, Peter-Martin Bruch, Junyan Lu, Sarah Richter, Georgios Mermelekas, Husen Muhammad Umer, Mareike Knoll, Carolin Kolb, Angela Lenze, Xiaofang Cao, Cecilia Österholm-Corbascio, Sebastian Scheinost, Matthias Ganzinger, Larry Mansouri, PhD, Katharina Kriegsmann, MD, Mark Kriegsmann, MD, Carsten Mueller-Tidow, MD, Peter Dreger, MD, Simon Anders, PhD, Marc Zapatka, Marco Herling, MD, Richard Rosenquist, MD, Stephan Stilgenbauer, MD, Thorsten Zenz, Wolfgang Huber, PhD, Eugen Tausch, MD, Janne Lehtiö, Sascha Dietrich, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-137528
Published: 2020
Journal Articles

IL-10 Receptor Deficiency Aggravates Exhaustion of CD8 + T-Cells and Impedes Their Control of Chronic Lymphocytic Leukemia

Bola S Hanna, PhD, Philipp M Röβner, Murat Iskar, PhD, Norman Mack, Verena Kalter, Manfred Schmidt, PhD, Marc Zapatka, PhD, Markus Feuerer, MD, Richard Gabriel, PhD, Peter Lichter, PhD, Martina Seiffert
Journal: Blood
Blood (2017) 130 (Supplement 1): 385.
https://doi.org/10.1182/blood.V130.Suppl_1.385.385
Published: 2017
Journal Articles

Whole-Exome Sequencing Revealed No Recurrent Mutations within the PI3K Pathway in Relapsed Chronic Lymphocytic Leukemia Patients Progressing Under Idelalisib Treatment

Paolo Ghia, Viktor Ljungström, Eugen Tausch, Andreas Agathangelidis, Annika Scheffold, Lydia Scarfo, Billy Michael Chelliah Jebaraj, Carolyn J. Owen, MD MDes(UK), FRCPC, Jacqueline C. Barrientos, MD, Marc Zapatka, Veerendra Munugalavadla, Jeremiah D. Degenhardt, Yeonhee Kim, Ronald L. Dubowy, Lyndah K. Dreiling, Richard Rosenquist, Stephan Stilgenbauer
Journal: Blood
Blood (2016) 128 (22): 2770.
https://doi.org/10.1182/blood.V128.22.2770.2770
Published: 2016
Journal Articles

CLL Exosome-Derived Y RNA hY4 Induces TLR7/8-Mediated Inflammation and PD-L1 Expression in Monocytes

Franziska Haderk, MSc, Laura Llao Cid, MSc, Murat Iskar, PhD, Ralph Schulz, MSc, Maria Goebel, MD, Jan Duerig, MD, Stephan Stilgenbauer, Marc Zapatka, Peter Lichter, PhD, Martina Seiffert, PhD
Journal: Blood
Blood (2016) 128 (22): 3217.
https://doi.org/10.1182/blood.V128.22.3217.3217
Published: 2016
Journal Articles

Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic Leukemia

Christopher C. Oakes, PhD, Marc Seifert, Yassen Assenov, Lei Gu, Martina Przekopowitz, Amy S. Ruppert, MAS, Qi Wang, Charles Imbusch, Andrius Serva, Sandra Koser, David Brocks, Daniel B Lipka, Olga Bogatyrova, Benedikt Brors, Dieter Weichenhan, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Daniel Mertens, PhD, Marc Zapatka, Peter Lichter, Hartmut Döhner, MD, Ralf Kueppers, Thorsten Zenz, Stephan Stilgenbauer, MD, John C Byrd, MD, Christoph Plass, PhD
Journal: Blood
Blood (2015) 126 (23): 2436.
https://doi.org/10.1182/blood.V126.23.2436.2436
Published: 2015