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Journal Articles

BRAF V600E Accelerates Disease Progression and Increases Immune Suppression in a Mouse Model of B-Cell Leukemia

Yo-Ting Tsai, MS, Aparna Lakshmanan, PhD, Amy M. Lehman, MAS, Ellen J. Sass, Minh Tran, Fabienne McClanahan, MD PhD, Meixiao Long, MD PhD, Bonnie K. Harrington, DVM, Krista La Perle, DVM, PhD, Vincenzo Coppola, MD, Gerard Lozanski, MD, Natarajan Muthusamy, DVM, PhD, John C. Byrd, MD, Michael R. Grever, MD, David M. Lucas, PhD

Blood (2016) 128 (22): 1206.

https://doi.org/10.1182/blood.V128.22.1206.1206

Published: 2016

Journal Articles

Exploring the Functional Relevance of BTK Beyond Chronic Lymphocytic Leukemia (CLL) Cells: BTK Expression in Non-Malignant Immune Cells of the Microenvironment Mediates CLL Development and Progression In Vivo

Fabienne McClanahan, MD PhD, Sean D. Reiff, Daphne Guinn, PhD, Minh Tran, Larry Beaver, Samantha McWorther, Rose Mantel, Lisa L. Smith, MS, Amy J. Johnson, PhD, John C. Byrd, MD, Jennifer A. Woyach, MD

Blood (2016) 128 (22): 352.

https://doi.org/10.1182/blood.V128.22.352.352

Published: 2016

Journal Articles

REDX08608, a Novel, Potent and Selective, Reversible BTK Inhibitor with Efficacy and Equivalent Potency Against Wild-Type and Mutant C481S BTK

Blood (2016) 128 (22): 4399.

https://doi.org/10.1182/blood.V128.22.4399.4399

Published: 2016

Journal Articles

Minimal Renal Toxicity after Rituximab DHAP with a Modified Cisplatin Application Scheme in Patients with Relapsed and Refractory Diffuse Large B-Cell Lymphoma

Katharina Lisenko, MD, Fabienne McClanahan, MD PhD, Tilman Schöning, MD, Mark-Alexander Schwarzbich, MD, Martin Cremer, MD, Tobias Dittrich, MD, Anthony D. Ho, MD, Mathias Witzens-Harig, MD

Blood (2015) 126 (23): 1506.

https://doi.org/10.1182/blood.V126.23.1506.1506

Published: 2015

Journal Articles

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Fabienne McClanahan, Bola Hanna, Shaun Miller, Andrew James Clear, Peter Lichter, John G. Gribben, Martina Seiffert

Blood (2015) 126 (2): 203–211.

https://doi.org/10.1182/blood-2015-01-622936

Published: 2015

Includes: Supplemental data

Journal Articles

Mechanisms of PD-L1/PD-1–mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model

Fabienne McClanahan, John C. Riches, Shaun Miller, William P. Day, Eleni Kotsiou, Donna Neuberg, Carlo M. Croce, Melania Capasso, John G. Gribben

Blood (2015) 126 (2): 212–221.

https://doi.org/10.1182/blood-2015-02-626754

Published: 2015

Includes: Supplemental data

Journal Articles

Targeting Dysfunctional Myeloid Cells Delays Disease Development and Improves Immune Function in a CLL Mouse Model

Bola Hanna, Fabienne McClanahan, MD, Nadja Zaborsky, PhD, Claudia Dürr, Verena Kalter, Alexander Egle, MD, John G. Gribben, MD DSc, Peter Lichter, PhD, Martina Seiffert, PhD

Blood (2014) 124 (21): 3298.

https://doi.org/10.1182/blood.V124.21.3298.3298

Published: 2014

Journal Articles

Aberrant PD-L1 Expression in CLL As a Result of Adaptive Immune Resistance Mediated By Tumor-Secreted Circulating miRNA Binding to Toll-like Receptor 7

Fabienne McClanahan, MD, Federica Calore, PhD, Nicola Zanesi, PhD, John G. Gribben, MD DSc, Carlo M. Croce, MD

Blood (2014) 124 (21): 716.

https://doi.org/10.1182/blood.V124.21.716.716

Published: 2014

Journal Articles

Immune Checkpoint Blockade with Anti-PD-L1 Prevents Immune Dysfuntion and CLL Development in the TCL1 Adoptive Transfer Mouse Model

Bola Hanna, Fabienne McClanahan, MD, Andrew James Clear, BSc, Shaun Miller, Peter Lichter, PhD, Martina Seiffert, PhD, John G. Gribben, MD DSc

Blood (2014) 124 (21): 717.

https://doi.org/10.1182/blood.V124.21.717.717

Published: 2014

Journal Articles

The Flavonoid Wogonin Reduces CLL Cell Survival in Vitro and Leukemia Development in Eµ-TCL1 Mice By Targeting Aberrant TNF Receptor Signaling

Claudia Dürr, Bola Hanna, Fabienne McClanahan, MD, Andrew James Clear, BSc, Thorsten Zenz, MD, Stephan Stilgenbauer, MD, John G. Gribben, MD DSc, Peter Lichter, PhD, Martina Seiffert, PhD

Blood (2014) 124 (21): 1966.

https://doi.org/10.1182/blood.V124.21.1966.1966

Published: 2014

Journal Articles

Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations

John C. Riches, Conor J. O’Donovan, Sarah J. Kingdon, Fabienne McClanahan, Andrew J. Clear, Donna S. Neuberg, Lillian Werner, Carlo M. Croce, Alan G. Ramsay, Laura Z. Rassenti, Thomas J. Kipps, John G. Gribben

Blood (2014) 123 (26): 4101–4110.

https://doi.org/10.1182/blood-2014-01-552307

Published: 2014

Includes: Supplemental data

Journal Articles

NK Cells From CLL Patients Exhibit Down-Regulation Of Interferon Response Genes That Can Be Reversed With Lenalidomide

John C. Riches, MD, Ajanthah Sangaralingam, PhD, Tracy Chaplin, Fabienne McClanahan, MD, Sameena Iqbal, Samir G. Agrawal, Alan G. Ramsay, PhD, John Gribben, MD, DSc

Blood (2013) 122 (21): 4131.

https://doi.org/10.1182/blood.V122.21.4131.4131

Published: 2013

Journal Articles

Trisomy 12 CLL Cells Have High Surface Expression Of Integrins Involved In Lymphocyte Trafficking But This Does Not Translate Into Improved LFA-1-Mediated Motility

Conor J. O'Donovan, Alan G. Ramsay, PhD, Fabienne McClanahan, MD, Laura Rassenti, PhD, Thomas J. Kipps, MD, PhD, John Gribben, MD, DSc, John C. Riches, MD

Blood (2013) 122 (21): 4159.

https://doi.org/10.1182/blood.V122.21.4159.4159

Published: 2013

Journal Articles

T-Cell Dysfunction In CLL Is Mediated Not Only By PD-1/PD-L1 But Also By PD-1/PD-L2 Interactions - Partial Functionality Is Maintained In PD-1 Defined CD8 Subsets and This Can Be Further Promoted By Ibrutinib Treatment

Fabienne McClanahan, MD, Shaun Miller, John C. Riches, MD, Essam Ghazaly, MD, PhD, William P. Day, Melania Capasso, PhD, John Gribben, MD, DSc

Blood (2013) 122 (21): 4120.

https://doi.org/10.1182/blood.V122.21.4120.4120

Published: 2013

Journal Articles

Intraclonal Complexity Of CLL Fractions In Cell Proliferation Rates, Gene Expression Signatures, and Responses To Autologous T-Cell Help In Peripheral blood and Secondary Lymphoid Tissues

Shih-Shih Chen, Thomas M. Herndon, MD, Claire Emson, PhD, John C. Riches, MD, Fabienne McClanahan, MD, Timothy Tong, Xiao-Jie Yan, MD PhD, Piers E.M. Patten, MD, PhD, John Gribben, MD, DSc, Adrian Wiestner, MD, PhD, Nicholas Chiorazzi, MD

Blood (2013) 122 (21): 115.

https://doi.org/10.1182/blood.V122.21.115.115

Published: 2013

Journal Articles

T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production

John C. Riches, Jeffrey K. Davies, Fabienne McClanahan, Rewas Fatah, Sameena Iqbal, Samir Agrawal, Alan G. Ramsay, John G. Gribben

Blood (2013) 121 (9): 1612–1621.

https://doi.org/10.1182/blood-2012-09-457531

Published: 2013

Includes: Supplemental data

Journal Articles

Inhibitory Ligands CD200, CD270, CD274 and CD276 Are Expressed On Eμ-TCL1 Transgenic Mouse Splenocytes and Are of Potential Relevance to Impaired T-Cell Function in Vivo

Fabienne McClanahan, MD, Cristina Ghirelli, PhD, Paul Greaves, MD, John C. Riches, MD, Rita Coutinho, MD, Alan G. Ramsay, PhD, John G Gribben

Blood (2012) 120 (21): 313.

https://doi.org/10.1182/blood.V120.21.313.313

Published: 2012

Journal Articles

Characterizing Immunophenotypic and Functional Pseudo-Exhaustion in T Cells From CLL Patients: The Impact of Lenalidomide

John C. Riches, MD, Jeff K. Davies, MD, PhD, Fabienne McClanahan, Rewas Fatah, Sameena Iqbal, Samir Agrawal, Alan G. Ramsay, PhD, John G Gribben

Blood (2012) 120 (21): 564.

https://doi.org/10.1182/blood.V120.21.564.564

Published: 2012

Journal Articles

Early autologous stem cell transplantation for chronic lymphocytic leukemia: long-term follow-up of the German CLL Study Group CLL3 trial

Blood (2012) 119 (21): 4851–4859.

https://doi.org/10.1182/blood-2011-09-378505

Published: 2012

Includes: Supplemental data

Journal Articles

Rituximab Maintenance Therapy in Diffuse Large B-Cell Lymphoma in a Multicenter Prospective Randomised Phase II Study,

Mathias Witzens-Harig, MD, Axel Benner, Michael Rieger, MD, Fabienne McClanahan, MD, Manfred Hensel, MD, Kai Neben, MD, Peter Dreger, MD, Eva Lengfelder, MD, Ingo Schmidt-Wolf, MD, Alwin Krämer, MD, PhD, Anthony D. Ho, MD

Blood (2011) 118 (21): 3700.

https://doi.org/10.1182/blood.V118.21.3700.3700

Published: 2011

NARROW

BRAF V600E Accelerates Disease Progression and Increases Immune Suppression in a Mouse Model of B-Cell Leukemia

Exploring the Functional Relevance of BTK Beyond Chronic Lymphocytic Leukemia (CLL) Cells: BTK Expression in Non-Malignant Immune Cells of the Microenvironment Mediates CLL Development and Progression In Vivo

REDX08608, a Novel, Potent and Selective, Reversible BTK Inhibitor with Efficacy and Equivalent Potency Against Wild-Type and Mutant C481S BTK

Minimal Renal Toxicity after Rituximab DHAP with a Modified Cisplatin Application Scheme in Patients with Relapsed and Refractory Diffuse Large B-Cell Lymphoma

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Mechanisms of PD-L1/PD-1–mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model

Targeting Dysfunctional Myeloid Cells Delays Disease Development and Improves Immune Function in a CLL Mouse Model

Aberrant PD-L1 Expression in CLL As a Result of Adaptive Immune Resistance Mediated By Tumor-Secreted Circulating miRNA Binding to Toll-like Receptor 7

Immune Checkpoint Blockade with Anti-PD-L1 Prevents Immune Dysfuntion and CLL Development in the TCL1 Adoptive Transfer Mouse Model

The Flavonoid Wogonin Reduces CLL Cell Survival in Vitro and Leukemia Development in Eµ-TCL1 Mice By Targeting Aberrant TNF Receptor Signaling

Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations

NK Cells From CLL Patients Exhibit Down-Regulation Of Interferon Response Genes That Can Be Reversed With Lenalidomide

Trisomy 12 CLL Cells Have High Surface Expression Of Integrins Involved In Lymphocyte Trafficking But This Does Not Translate Into Improved LFA-1-Mediated Motility

T-Cell Dysfunction In CLL Is Mediated Not Only By PD-1/PD-L1 But Also By PD-1/PD-L2 Interactions - Partial Functionality Is Maintained In PD-1 Defined CD8 Subsets and This Can Be Further Promoted By Ibrutinib Treatment

Intraclonal Complexity Of CLL Fractions In Cell Proliferation Rates, Gene Expression Signatures, and Responses To Autologous T-Cell Help In Peripheral blood and Secondary Lymphoid Tissues

T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production

Inhibitory Ligands CD200, CD270, CD274 and CD276 Are Expressed On Eμ-TCL1 Transgenic Mouse Splenocytes and Are of Potential Relevance to Impaired T-Cell Function in Vivo

Characterizing Immunophenotypic and Functional Pseudo-Exhaustion in T Cells From CLL Patients: The Impact of Lenalidomide

Early autologous stem cell transplantation for chronic lymphocytic leukemia: long-term follow-up of the German CLL Study Group CLL3 trial

Rituximab Maintenance Therapy in Diffuse Large B-Cell Lymphoma in a Multicenter Prospective Randomised Phase II Study,

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American Society of Hematology

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American Society of Hematology

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