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Leila N. Varghese
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Journal Articles

CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag

Francesca Basso-Valentina, Gabriel Levy, Leila N. Varghese, Myriam Oufadem, Benedicte Neven, Charlotte Boussard, Nathalie Balayn, Caroline Marty, William Vainchenker, Isabelle Plo, Paola Ballerini, Stefan N. Constantinescu, Remi Favier, Hana Raslova
Journal: Blood
Blood (2021) 138 (6): 480–485.
https://doi.org/10.1182/blood.2020010567
Published: 2021
Includes: Supplemental data
Journal Articles

MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491

Brief Report
Gabriel Levy, Serge Carillo, Benjamin Papoular, Bruno Cassinat, Jean-Marc Zini, Emilie Leroy, Leila N. Varghese, Ilyas Chachoua, Jean-Philippe Defour, Steven O. Smith, Stefan N. Constantinescu
Journal: Blood
Blood (2020) 135 (12): 948–953.
https://doi.org/10.1182/blood.2019003240
Published: 2020
Includes: Supplemental data
Journal Articles

MPL membrane domain sequencing goes deep

Stefan N. Constantinescu, Leila N. Varghese
Journal: Blood
Blood (2020) 135 (4): 236–237.
https://doi.org/10.1182/blood.2019003482
Published: 2020
Journal Articles

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L

Fabrizia Favale, Kahia Messaoudi, Leila N. Varghese, Siham Boukour, Christian Pecquet, Vitalina Gryshkova, Jean Philippe Defour, Roxana-Irina Albu, Olivier Bluteau, Paola Ballerini, Guy Leverger, Isabelle Plo, Najet Debili, Hana Raslova, Remi Favier, Stefan N. Constantinescu, William Vainchenker
Journal: Blood
Blood (2016) 128 (26): 3146–3158.
https://doi.org/10.1182/blood-2016-06-722058
Published: 2016
Includes: Supplemental data