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Steven O. Smith
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Journal Articles

MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491

Brief Report
Gabriel Levy, Serge Carillo, Benjamin Papoular, Bruno Cassinat, Jean-Marc Zini, Emilie Leroy, Leila N. Varghese, Ilyas Chachoua, Jean-Philippe Defour, Steven O. Smith, Stefan N. Constantinescu
Journal: Blood
Blood (2020) 135 (12): 948–953.
https://doi.org/10.1182/blood.2019003240
Published: 2020
Includes: Supplemental data
Journal Articles

Controlling Thrombopoietin Receptor Dimerization, Orientation and Activation Via Tryptophan 515

Jean-Philippe Defour, BPharm, Miki Itaya, MSc., Vitalina Gryshkova, PhD, Ian Brett, MSc., Christian Pecquet, PhD, Takeshi Sato, PhD, Steven O. Smith, PhD, Stefan N. Constantinescu, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3449.
https://doi.org/10.1182/blood.V120.21.3449.3449
Published: 2012
Journal Articles

An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor

Judith Staerk, Catherine Lacout, Takeshi Sato, Steven O. Smith, William Vainchenker, Stefan N. Constantinescu
Journal: Blood
Blood (2006) 107 (5): 1864–1871.
https://doi.org/10.1182/blood-2005-06-2600
Published: 2006