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D. Gary Gilliland
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Journal Articles

Integrated Immunological Analysis of the Bone Marrow Tumor Microenvironment in Myeloproliferative Neoplasms to Determine Potential Efficacy of Immune Checkpoint Blockade

Robert Orlowski, MD, Alexander Huang, Mercy Gohil, James Mangan, MD PhD, Marissa Vignali, PhD, Ryan O Emerson, PhD, Harlan Robins, PhD, Erik Yusko, PhD, Martha S Jordan, PhD, Martin Carroll, MD, D. Gary Gilliland, MD PhD, Elizabeth O Hexner, MD
Journal: Blood
Blood (2015) 126 (23): 2766.
https://doi.org/10.1182/blood.V126.23.2766.2766
Published: 2015
Journal Articles

An ENU Mutagenesis Screen of FLT3-ITD Knock-in Mice Identifies Novel Gene Mutations That Lead to an Exacerbated Myeloproliferative Neoplasm

Anna L Brown, PhD, Teresa Sadras, PhD, Grant A Engler, BSc (Hons), Robert Tunningley, PhD, Jennifer Kofler, BSc, Paul J Leo, PhD, Jesse Cheah, BSc, Adrienne Laskowski, BSc, Ann Frazier, PhD, David Stroud, PhD, Michael Ryan, PhD, David Thorburn, PhDFHGSA FFSc(RCPA), D Gary Gilliland, MDPhD, Ian D Lewis, MBBS, PhD, Thomas J Gonda, PhD, Richard J D'Andrea, PhD
Journal: Blood
Blood (2014) 124 (21): 3591.
https://doi.org/10.1182/blood.V124.21.3591.3591
Published: 2014
Journal Articles

Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis

e-blood
Raajit Rampal, Fatima Al-Shahrour, Omar Abdel-Wahab, Jay P. Patel, Jean-Philippe Brunel, Craig H. Mermel, Adam J. Bass, Jennifer Pretz, Jihae Ahn, Todd Hricik, Outi Kilpivaara, Martha Wadleigh, Lambert Busque, D. Gary Gilliland, Todd R. Golub, Benjamin L. Ebert, Ross L. Levine
Journal: Blood
Blood (2014) 123 (22): e123–e133.
https://doi.org/10.1182/blood-2014-02-554634
Published: 2014
Includes: Supplemental data
Journal Articles

The p110alpha and p110delta Isoforms of PI3 Kinase Are Dispensable for Hematopoietic Stem Cell Self-Renewal but Have Redundant Roles in B Cell Differentiation.

Kira Gritsman, MD, PhD, Linda Clayton, PhD, D. Gary Gilliland, MD, PhD, Thomas M. Roberts, PhD, Jean Zhao, PhD
Journal: Blood
Blood (2012) 120 (21): 2322.
https://doi.org/10.1182/blood.V120.21.2322.2322
Published: 2012
Journal Articles

KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice

Ling Zhao, Jan J. Melenhorst, Lemlem Alemu, Martha Kirby, Stacie Anderson, Maggie Kench, Shelley Hoogstraten-Miller, Lauren Brinster, Yasuhiko Kamikubo, D. Gary Gilliland, P. Paul Liu
Journal: Blood
Blood (2012) 119 (6): 1511–1521.
https://doi.org/10.1182/blood-2011-02-338210
Published: 2012
Includes: Supplemental data
Journal Articles

Mtor Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

Demetrios Kalaitzidis, PhD, Stephen M. Sykes, Natalie Punt, Yuefeng Tang, PhD, Steven W. Lane, Clary Clish, PhD, D. Gary Gilliland, MD, PhD, David T. Scadden, MD, David Guertin, PhD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 391.
https://doi.org/10.1182/blood.V118.21.391.391
Published: 2011
Journal Articles

An ENU Mutagenesis Screen to Identify Genes Involved in the Induction of FLT3-ITD Positive Acute Myeloid Leukemia

Anna L Brown, PhD, Robert Tunningley, PhD, Grant A Engler, BSc(Hons), D. Gary Gilliland, MD, PhD, Ian D Lewis, MBBS, PhD, Thomas Gonda, PhD, Richard J D'Andrea, PhD
Journal: Blood
Blood (2011) 118 (21): 1400.
https://doi.org/10.1182/blood.V118.21.1400.1400
Published: 2011
Journal Articles

KIT with D816 Mutations Cooperates with CBFB-MYH11 for Leukemogenesis in Mice

Ling Zhao, MD, PhD, J. Joseph Melenhorst, PhD, Lemlem Alemu, Stacie Anderson, Martha Kirby, Shelley Hoogstraten-Miller, Lauren Brinster, Maggie Kench, Yasuhiko Kamikubo, D. Gary Gilliland, MD, PhD, Pu Paul Liu, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 867.
https://doi.org/10.1182/blood.V118.21.867.867
Published: 2011
Journal Articles

Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q− syndrome

Madhu S. Kumar, Anupama Narla, Atsushi Nonami, Ann Mullally, Nadya Dimitrova, Brian Ball, J. Randall McAuley, Luke Poveromo, Jeffrey L. Kutok, Naomi Galili, Azra Raza, Eyal Attar, D. Gary Gilliland, Tyler Jacks, Benjamin L. Ebert
Journal: Blood
Blood (2011) 118 (17): 4666–4673.
https://doi.org/10.1182/blood-2010-12-324715
Published: 2011
Includes: Supplemental data
Journal Articles

Differential niche and Wnt requirements during acute myeloid leukemia progression

Steven W. Lane, Yingzi J. Wang, Cristina Lo Celso, Christine Ragu, Lars Bullinger, Stephen M. Sykes, Francesca Ferraro, Sebastian Shterental, Charles P. Lin, D. Gary Gilliland, David T. Scadden, Scott A. Armstrong, David A. Williams
Journal: Blood
Blood (2011) 118 (10): 2849–2856.
https://doi.org/10.1182/blood-2011-03-345165
Published: 2011
Includes: Supplemental data
Journal Articles

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification

Melanie G. Cornejo, Vinciane Mabialah, Stephen M. Sykes, Tulasi Khandan, Cristina Lo Celso, Cécile K. Lopez, Paola Rivera-Muñoz, Philippe Rameau, Zuzana Tothova, Jon C. Aster, Ronald A. DePinho, David T. Scadden, D. Gary Gilliland, Thomas Mercher
Journal: Blood
Blood (2011) 118 (5): 1264–1273.
https://doi.org/10.1182/blood-2011-01-328567
Published: 2011
Includes: Supplemental data
Journal Articles

Leukemogenic Tyrosine Kinases Inhibit PKM2 to Promote the Warburg Effect and Tumor Growth

Taro Hitosugi, PhD, Sumin Kang, PhD, Matthew Vander Heiden, MD/PhD, Tea-wook Chung, PhD, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, PhD, Sagar Lonial, MD, Xu Wang, PhD, Georgia Chen, PhD, Jianxin Xie, PhD, Ting-Lei Gu, PhD, Roberto Polakiewicz, PhD, Johannes L. Roesel, PhD, Titus Boggon, PhD, Fadlo Khuri, MD, D. Gary Gilliland, MD, PhD, Lewis Cantley, PhD, Jonathan L. Kaufman, MD, Jing Chen, PhD
Journal: Blood
Blood (2010) 116 (21): 3142.
https://doi.org/10.1182/blood.V116.21.3142.3142
Published: 2010
Journal Articles

Longer-Term Follow up with TG101348 Therapy In Myelofibrosis Confirms Sustained Improvement In Splenomegaly, Disease-Related Symptoms, and JAK2 V617F Allele Burden

Animesh Pardanani, MBBS, PhD, Jason R Gotlib, MD, MS, Catriona Jamieson, MD, PhD, Jorge E. Cortes, MD, Moshe Talpaz, MD, Richard M Stone, M.D., Michael H Silverman, MD, FACP, Jolene Shorr, D. Gary Gilliland, MD, PhD, Ayalew Tefferi, MD
Journal: Blood
Blood (2010) 116 (21): 459.
https://doi.org/10.1182/blood.V116.21.459.459
Published: 2010
Journal Articles

The Apc min mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

Steven W. Lane, Stephen M. Sykes, Fatima Al-Shahrour, Sebastian Shterental, Mahnaz Paktinat, Cristina Lo Celso, Jonathan L. Jesneck, Benjamin L. Ebert, David A. Williams, D. Gary Gilliland
Journal: Blood
Blood (2010) 115 (17): 3489–3497.
https://doi.org/10.1182/blood-2009-11-251728
Published: 2010
Includes: Supplemental data
Journal Articles

Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome–negative myeloproliferative neoplasms

Nils H. Thoennissen, Utz O. Krug, Dhong Hyun Tony Lee, Norihiko Kawamata, Gabriela B. Iwanski, Terra Lasho, Tamara Weiss, Daniel Nowak, Maya Koren-Michowitz, Motohiro Kato, Masashi Sanada, Lee-Yung Shih, Arnon Nagler, Sophie D. Raynaud, Carsten Müller-Tidow, Ruben Mesa, Torsten Haferlach, D. Gary Gilliland, Ayalew Tefferi, Seishi Ogawa, H. Phillip Koeffler
Journal: Blood
Blood (2010) 115 (14): 2882–2890.
https://doi.org/10.1182/blood-2009-07-235119
Published: 2010
Includes: Supplemental data
Journal Articles

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

Michael G. Kharas, Rachel Okabe, Jared J. Ganis, Maricel Gozo, Tulasi Khandan, Mahnaz Paktinat, D. Gary Gilliland, Kira Gritsman
Journal: Blood
Blood (2010) 115 (7): 1406–1415.
https://doi.org/10.1182/blood-2009-06-229443
Published: 2010
Includes: Supplemental data
Journal Articles

Leukemia Stem Cells Are Resistant to In Vivo, Cell Non-Autonomous Wnt Inhibition.

Steven W. Lane, MD, Cristina Lo Celso, Stephen M Sykes, Sebastian Shterental, Mahnaz Paktinat, Charles P Lin, David A. Williams, MD, David T. Scadden, MD, D. Gary Gilliland, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 1025.
https://doi.org/10.1182/blood.V114.22.1025.1025
Published: 2009
Journal Articles

Prevalence and Prognostic Impact of Allelic Imbalances Associated with Leukemic Transformation of Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.

Nils Heinrich Thoennissen, Utz O. Krug, Dhong Hyun Lee, Norohiko Kawamata, Terra L Lasho, MT(ASCP), Tamara Weiss, Daniel Nowak, Gabriela B. Iwanski, Motohiro Kato, Lee-Yung Shih, Maya Koren-Michowitz, Arnon Nagler, Sophie Raynaud, MD, PHD, Carsten Müller-Tidow, Ruben A. Mesa, MD, Torsten Haferlach, MD, D. Gary Gilliland, MD, PhD, Ayalew Tefferi, MD, Seishi Ogawa, MD, PhD, H. Phillip Koeffler, MD
Journal: Blood
Blood (2009) 114 (22): 1280.
https://doi.org/10.1182/blood.V114.22.1280.1280
Published: 2009
Journal Articles

Coordinate Loss of a MicroRNA Mir 145 and a Protein-Coding Gene RPS14 Cooperate in the Pathogenesis of 5q- Syndrome.

Madhu Kumar, PhD, Anupama Narla, MD, Atsushi Nonami, MD, PhD, Brian Ball, Christine Chin, Cindy Chen, Jeffery Lorne Kutok, MD, PhD, Naomi Galili, PhD, Azra Raza, MD, Eyal C. Attar, MD, D. Gary GIlliland, Tyler Jacks, Benjamin L. Ebert, MD, DPhil
Journal: Blood
Blood (2009) 114 (22): 947.
https://doi.org/10.1182/blood.V114.22.947.947
Published: 2009
Journal Articles

A Phase I Evaluation of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis: Clinical Response Is Accompanied by Significant Reduction in JAK2 V617F Allele Burden.

Animesh D. Pardanani, MBBS, PhD, Jason R Gotlib, MD, MS, Catriona Jamieson, MD, PhD, Jorge Cortes, MD, Moshe Talpaz, MD, Richard Stone, MD, Michael H Silverman, MD, FACP, Jolene Shorr, D. Gary Gilliland, MD, PhD, Ayalew Tefferi, MD
Journal: Blood
Blood (2009) 114 (22): 755.
https://doi.org/10.1182/blood.V114.22.755.755
Published: 2009