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Journal Articles

Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis

Yiqing Yang, Melanie Mumau, Joanna Tober, Qin Zhu, Laura Bennett, Courtney Hong, Derek Sung, Thomas Keller, Yasin Uzun, Peng Gao, Swapnil Shewale, Mei Chen, Jisheng Yang, Xiaowen Chen, Steven A. Thomas, Kai Tan, Nancy A. Speck, Mark L. Kahn

Blood (2022) 139 (19): 2942–2957.

https://doi.org/10.1182/blood.2021013934

Published: 2022

Includes: Supplemental data

Journal Articles

Developmental trajectory of prehematopoietic stem cell formation from endothelium

Qin Zhu, Peng Gao, Joanna Tober, Laura Bennett, Changya Chen, Yasin Uzun, Yan Li, Elizabeth D. Howell, Melanie Mumau, Wenbao Yu, Bing He, Nancy A. Speck, Kai Tan

Blood (2020) 136 (7): 845–856.

https://doi.org/10.1182/blood.2020004801

Published: 2020

Includes: Supplemental data

Journal Articles

Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11

Tao Zhen, Erika M. Kwon, Ling Zhao, Jingmei Hsu, R. Katherine Hyde, Ying Lu, Lemlem Alemu, Nancy A. Speck, P. Paul Liu

Blood (2017) 130 (22): 2431–2442.

https://doi.org/10.1182/blood-2017-04-780106

Published: 2017

Includes: Supplemental data

Journal Articles

CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells

Yan Li, Long Gao, Brandon Hadland, Kai Tan, Nancy A. Speck

Blood (2017) 130 (3): 372–376.

https://doi.org/10.1182/blood-2017-03-776849

Published: 2017

Includes: Supplemental data

Journal Articles

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Xiongwei Cai, PhD, Yoshihiro Hayashi, MD PhD, Mark Wunderlich, MS, Nancy A. Speck, PhD, James C. Mulloy, PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2016) 128 (22): 3860.

https://doi.org/10.1182/blood.V128.22.3860.3860

Published: 2016

Journal Articles

Direct Conversion of Adult Endothelial Cells into Immunecompetent Long-Term Engraftable Clinically Scalable Hematopoietic Stem Cells: Pathway to Therapeutic Translation

Raphael Lis, PhD, Charles Harrasch, Michael Gustave Poulos, PhD, Jose Gabriel Duran, William Schachterle, PhD, Michael Ginsberg, PhD, Arash Rafii, Koji Shido, Nancy A. Speck, PhD, Jason M. Butler, PhD, Joseph M. Scandura, MD PhD, Shahin Rafii

Blood (2016) 128 (22): 372.

https://doi.org/10.1182/blood.V128.22.372.372

Published: 2016

Journal Articles

Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Lymphoid Progenitor Cell Formation

Yan Li, Virginie Esain, PhD, Li Teng, Jian Xu, PhD, Isaura Frost, Wanda Kwan, PhD, Amanda D Yzaguirre, Marijke W Maijenberg, Stuart H. Orkin, MD, Kai Tan, PhD, Trista E North, PhD, Nancy A. Speck, PhD

Blood (2014) 124 (21): 2902.

https://doi.org/10.1182/blood.V124.21.2902.2902

Published: 2014

Journal Articles

Runx1 and Cbfβ regulate the development of Flt3 + dendritic cell progenitors and restrict myeloproliferative disorder

Ansuman T. Satpathy, Carlos G. Briseño, Xiongwei Cai, Drew G. Michael, Chun Chou, Sunnie Hsiung, Deepta Bhattacharya, Nancy A. Speck, Takeshi Egawa

Blood (2014) 123 (19): 2968–2977.

https://doi.org/10.1182/blood-2013-11-539643

Published: 2014

Includes: Supplemental data

Journal Articles

Inherited and Acquired RUNX1 Mutations in Hematologic Disorders

Nancy A. Speck, PhD, Xiongwei Cai, Ph.D., Jingping Ge, Philip J. Mason

Blood (2013) 122 (21): SCI-5.

https://doi.org/10.1182/blood.V122.21.SCI-5.SCI-5

Published: 2013

Journal Articles

Chromatin Remodeling Enzyme CHD7 Negatively Regulate Hematopoietic Stem Cell Function

Jingmei Hsu, MD, PhD, Hsuan-Ting Huang, Ph.D, Chung-Tsai Lee, Shuqian Yu, MS, Leonard I. Zon, MD, Nancy A. Speck, PhD

Blood (2013) 122 (21): 2413.

https://doi.org/10.1182/blood.V122.21.2413.2413

Published: 2013

Journal Articles

Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential

Russell C. DeKelver, Ming Yan, Eun-Young Ahn, Wei-Jong Shia, Nancy A. Speck, Dong-Er Zhang

Blood (2013) 121 (18): 3714–3717.

https://doi.org/10.1182/blood-2012-11-465641

Published: 2013

Includes: Supplemental data

Journal Articles

CHD7 Negatively Regulates Hematopoietic Stem Cell Potency

Jingmei Hsu, MD, PhD, Hsuan-Ting Huang, Chung-Tsai Lee, Shuqian Yu, MS, Scott Gerber, PhD, Leonard I. Zon, MD, Nancy A. Speck, PhD

Blood (2012) 120 (21): 850.

https://doi.org/10.1182/blood.V120.21.850.850

Published: 2012

Journal Articles

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

Hong Guo, Ou Ma, Nancy A. Speck, Alan D. Friedman

Blood (2012) 119 (19): 4408–4418.

https://doi.org/10.1182/blood-2011-12-397091

Published: 2012

Includes: Supplemental data

Journal Articles

Runx1-Cbfb Interacts with CHD7, a Chromatin Modifying Enzyme with a Potential Role in Hematopoiesis

Jingmei Hsu, MD, PhD, Chung-Tsai Lee, Scott Gerber, PhD, Shuqian Yu, MS, Nancy A. Speck, PhD

Blood (2011) 118 (21): 1300.

https://doi.org/10.1182/blood.V118.21.1300.1300

Published: 2011

Journal Articles

Genetic manipulation of AML1-ETO–induced expansion of hematopoietic precursors in a Drosophila model

Sergey A. Sinenko, Tony Hung, Tatiana Moroz, Quynh-Minh Tran, Sohrab Sidhu, Matthew D. Cheney, Nancy A. Speck, Utpal Banerjee

Blood (2010) 116 (22): 4612–4620.

https://doi.org/10.1182/blood-2010-03-276998

Published: 2010

Includes: Supplemental data

Journal Articles

Hemogenic Endothelium

Nancy A. Speck, PhD, Joanna Tober, Ph.D., Michael Chen, Ph.D., Marella de Bruijn, Ph.D., Mun Chiang Chan

Blood (2010) 116 (21): SCI-44.

https://doi.org/10.1182/blood.V116.21.SCI-44.SCI-44

Published: 2010

Journal Articles

The role of CBFβ in AML1-ETO's activity

Sangho Park, Nancy A. Speck, John H. Bushweller

Blood (2009) 114 (13): 2849–2850.

https://doi.org/10.1182/blood-2009-07-231233

Published: 2009

Journal Articles

Structure of the AML1-ETO eTAFH domain–HEB peptide complex and its contribution to AML1-ETO activity

Sangho Park, Wei Chen, Tomasz Cierpicki, Marco Tonelli, Xiongwei Cai, Nancy A. Speck, John H. Bushweller

Blood (2009) 113 (15): 3558–3567.

https://doi.org/10.1182/blood-2008-06-161307

Published: 2009

Includes: Supplemental data

Journal Articles

CBFβ is critical for AML1-ETO and TEL-AML1 activity

Liya Roudaia, Matthew D. Cheney, Ekaterina Manuylova, Wei Chen, Michelle Morrow, Sangho Park, Chung-Tsai Lee, Prabhjot Kaur, Owen Williams, John H. Bushweller, Nancy A. Speck

Blood (2009) 113 (13): 3070–3079.

https://doi.org/10.1182/blood-2008-03-147207

Published: 2009

Journal Articles

Runx1 Interactions in Stem Cell Biology.

Nancy A. Speck, PhD, Michael Chen, Tomomasa Yokomizo, Brandon Zeigler, Elaine Dzierzak

Blood (2008) 112 (11): sci-15.

https://doi.org/10.1182/blood.V112.11.sci-15.sci-15

Published: 2008

NARROW

Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis

Developmental trajectory of prehematopoietic stem cell formation from endothelium

Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11

CD27 marks murine embryonic hematopoietic stem cells and type II prehematopoietic stem cells

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Direct Conversion of Adult Endothelial Cells into Immunecompetent Long-Term Engraftable Clinically Scalable Hematopoietic Stem Cells: Pathway to Therapeutic Translation

Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Lymphoid Progenitor Cell Formation

Runx1 and Cbfβ regulate the development of Flt3 + dendritic cell progenitors and restrict myeloproliferative disorder

Inherited and Acquired RUNX1 Mutations in Hematologic Disorders

Chromatin Remodeling Enzyme CHD7 Negatively Regulate Hematopoietic Stem Cell Function

Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential

CHD7 Negatively Regulates Hematopoietic Stem Cell Potency

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

Runx1-Cbfb Interacts with CHD7, a Chromatin Modifying Enzyme with a Potential Role in Hematopoiesis

Genetic manipulation of AML1-ETO–induced expansion of hematopoietic precursors in a Drosophila model

Hemogenic Endothelium

The role of CBFβ in AML1-ETO's activity

Structure of the AML1-ETO eTAFH domain–HEB peptide complex and its contribution to AML1-ETO activity

CBFβ is critical for AML1-ETO and TEL-AML1 activity

Runx1 Interactions in Stem Cell Biology.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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