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Shahin Rafii
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Journal Articles

Capturing Endothelial-to-Hematopoietic Transition Using a Highly Efficient in Vitro Platform

Nassima Messali, Mia Yabut, Pouneh Kermani, Shahin Rafii, Joseph M. Scandura
Journal: Blood
Blood (2023) 142 (Supplement 1): 2670.
https://doi.org/10.1182/blood-2023-190072
Published: 2023
Journal Articles

Endothelial cell–leukemia interactions remodel drug responses, uncovering T-ALL vulnerabilities

Luca Vincenzo Cappelli, Danilo Fiore, Jude M. Phillip, Liron Yoffe, Filomena Di Giacomo, William Chiu, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, Jose Gabriel Barcia Duran, Nahuel Zamponi, Ari M. Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foà, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Journal: Blood
Blood (2023) 141 (5): 503–518.
https://doi.org/10.1182/blood.2022015414
Published: 2023
Includes: Supplemental data
Journal Articles

Clonal Analysis Reveals Functional and Transcriptional Heterogeneity of Self-Renewing Fetal Liver Hematopoietic Stem Cells

Takashi Ishida, Adam M Heck, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-Mckay, Katie Kraskouskas, Rachel Wellington, Olivia Waltner, Christina Root, Dana L Jackson, Cole Trapnell, Shahin Rafii, Irwin D. Bernstein, Brandon Hadland
Journal: Blood
Blood (2022) 140 (Supplement 1): 8574–8575.
https://doi.org/10.1182/blood-2022-156513
Published: 2022
Journal Articles

Angiocrine ANGPTL2 executes HSC functions in endothelial niche

Shahin Rafii, Raphael Lis
Journal: Blood
Blood (2022) 139 (10): 1433–1434.
https://doi.org/10.1182/blood.2021015198
Published: 2022
Journal Articles

A Predictive Endothelial-Leukemia Pre-Clinical Platform to Uncover Drug Vulnerabilities for Personalized Treatments

Luca Vincenzo Cappelli, Danilo Fiore, Jude M Phillip, Liron Yoffe, Filomena Di Giacomo, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, José Gabriel Barcia Durán, Nahuel Zamponi, Ari Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foa, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Journal: Blood
Blood (2021) 138 (Supplement 1): 704.
https://doi.org/10.1182/blood-2021-153300
Published: 2021
Journal Articles

Distinct Transcriptional Signatures Distinguish the Emergence of Multipotent Progenitors and Hematopoietic Stem Cells from Endothelial Precursors in the Murine Embryo

Tessa Dignum, BS, Barbara Varnum-Finney, PhD, Sanjay Srivatsan, Stacey Dozono, Olivia Waltner, Adam Heck, PhD, Cynthia Nourigat-Mckay, Dana Jackson, Shahin Rafii, MD, Irwin D. Bernstein, MD, Cole Trapnell, PhD, Brandon Hadland, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-142607
Published: 2020
Journal Articles

Megakaryocyte TGFβ1 partitions erythropoiesis into immature progenitor/stem cells and maturing precursors

Silvana Di Giandomenico, Pouneh Kermani, Nicole Mollé, Maria Mia Yabut, Ghaith Abu-Zeinah, Thomas Stephens, Nassima Messali, Ryan Schreiner, Fabienne Brenet, Shahin Rafii, Joseph M. Scandura
Journal: Blood
Blood (2020) 136 (9): 1044–1054.
https://doi.org/10.1182/blood.2019003276
Published: 2020
Includes: Supplemental data
Journal Articles

Transcription Factor Induction of Ectopic Vascular Blood Stem Cell Niches In Vivo

Elliott J. Hagedorn, PhD, Julie R. Perlin, PhD, Rebecca J. Freeman, BS, Clara Mao, BS, Inés Fernández-Maestre, BS, Madeleine L. Daily, B.S., Christopher R. D'Amato, B.S., Samuel J. Wattrus, B.S., Tianxiao Han, BS, Michael J. Fairchild, PhD, Raquel Riquelme, Brian Li, B.S., Shelby E. Redfield, B.S., Samantha H. Collins, B.S., Asher Lichtig, BS, Song Yang, PhD, Yi Zhou, Balvir Kunar, Jesus M Gomez-Salinero, PhD, Theresa T. Dinh, PhD, Junliang Pan, MD PhD, Karoline Holler, B.S., Eugene Butcher, Alexander Van Oudenaarden, Shahin Rafii, MD, Jan Philipp Junker, PhD, Leonard I Zon, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 525.
https://doi.org/10.1182/blood-2019-127219
Published: 2019
Journal Articles

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo

Brandon Hadland, MD PhD, Barbara Varnum-Finney, PhD, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-Mckay, Dana Jackson, Shahin Rafii, MD, Cole Trapnell, PhD, Irwin D. Bernstein, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3699.
https://doi.org/10.1182/blood-2019-126109
Published: 2019
Journal Articles

Fli-1 Transcriptionally Integrates Microenvironmental Cues Sensing By Self-Renewing Hematopoietic Stem and Progenitor Cells

Tomer Itkin, PhD, Chaitanya R Badwe, PhD, Sean Houghton, MSc, Yang Lin, PhD, Ying Liu, PhD, Peipei Guo, PhD, Jesus M Gomez-Salinero, PhD, Fuqiang Geng, PhD, Jae-Hung Shieh, PhD, David Redmond, PhD, Yen-Michael S. Hsu, MD PhD, Brandon Hadland, MD PhD, Shahin Rafii, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 725.
https://doi.org/10.1182/blood-2019-126190
Published: 2019
Journal Articles

Single Cell Transcriptomics Maps the Embryonic Emergence of HSC and Identifies Intercellular Interactions Regulating HSC Genesis

Brandon Hadland, MD PhD, Barbara Varnum-Finney, Stacey Dozono, Dana Jackson, Shahin Rafii, MD, Irwin D. Bernstein, MD, Cole Trapnell, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5086.
https://doi.org/10.1182/blood-2018-99-118772
Published: 2018
Journal Articles

Reprogrammed Adult Human Endothelium into Hematopoietic Stem Cells Yields Functional T Cells In Vivo

José Gabriel Barcia Durán, BS, Tyler M. Lu, BS, Raphael Lis, PhD, Shahin Rafii, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 169.
https://doi.org/10.1182/blood-2018-169
Published: 2018
Journal Articles

Generation and Application of T-Cell Lymphoma Patient Derived Tumor Xenograft Models

Danilo Fiore, PhD, Xujun Wang, Inna Khodos, Filomena Di Giacomo, PhD, Marcello Gaudiano, BS, Jude M Phillip, DPhil, Rui Wang, Zhiwei Yang, Michael Ginsberg, Andrew M Intlekofer, MD PhD, Craig B. Thompson, MD, Jon C. Aster, MD PhD, Jia Ruan, MD PhD, Samuel Y. Ng, MDPhD, Eric Jacobsen, MD, Ahmet Dogan, MD PhD, Elisa de Stanchina, Marissa Mattar, Leandro Cerchietti, MD, Rohan Bareja, Olivier Elemento, PhD, Wayne Tam, MD PhD, David M. Weinstock, MD, Shahin Rafii, MD, Steven M. Horwitz, MD, Giorgio Inghirami, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 109.
https://doi.org/10.1182/blood.V130.Suppl_1.109.109
Published: 2017
Journal Articles

Megakaryocytic TGFβ1 Partitions Hematopoiesis into Amplifying Stem and Progenitor Cells and Maturing Effector Cells

Silvana Di Giandomenico, PhD, Pouneh Kermani, PhD, Nicole Molle, BS, Mia Yabut, BS, Fabienne Brenet, PhD, Shahin Rafii, MD, Joseph Scandura, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 81.
https://doi.org/10.1182/blood.V130.Suppl_1.81.81
Published: 2017
Journal Articles

Mechanisms Governing Endogenous Thymic Regeneration

Tobias Wertheimer, Enrico Velardi, PhD BS, Jennifer Tsai, MD PhD, Kirsten Cooper, Katja J Ottmüller, Zeinab Mokthari, Jason M. Butler, PhD, Shahin Rafii, MD, Marcel R.M. van den Brink, MD PhD, Jarrod A Dudakov, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 66.
https://doi.org/10.1182/blood.V130.Suppl_1.66.66
Published: 2017
Journal Articles

Fli1 Is Essential for the Maintenance of Hematopoietic Stem Cell Homeostasis and Function

Chaitanya R Badwe, MS, Raphael Lis, PhD, Jose Gabriel Barcia Duran, Balvir Kunar, Shahin Rafii, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3769.
https://doi.org/10.1182/blood.V130.Suppl_1.3769.3769
Published: 2017
Journal Articles

Conversion of Adult Human Endothelium to Lymphoid Competent Haematopoietic Stem Cells

Raphael Lis, PhD, Tomer Itkin, PhD, Shahin Rafii, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4941.
https://doi.org/10.1182/blood.V130.Suppl_1.4941.4941
Published: 2017
Journal Articles

Plasmin regulation of acute cytokine storm

Jesus Maria Gomez-Salinero, Shahin Rafii
Journal: Blood
Blood (2017) 130 (1): 5–6.
https://doi.org/10.1182/blood-2017-04-776385
Published: 2017
Journal Articles

The Pro-Tumorigenic Vascular Niche Sustains the T-Cell Acute Lymphoblastic Leukemia Phenotype and Fosters Resistance to Therapy

Filomena Di Giacomo, Xujun Wang, Danilo Fiore, Lorena Consolino, Jude Phillip, Marcello Gaudiano, Lydia Roman-Gonzalez, Ramona Crescenzo, Sabina Chiaretti, Valentina Gianfelici, Ginsberg Michael, Jose Gabriel Barcia Duran, Jesus Maria Gomez Salinero, Rohan Bareja, Olivier Elemento, PhD, Anna Guarini, Robin Foà, Leandro Cerchietti, MD, Shahin Rafii, Giorgio Inghirami
Journal: Blood
Blood (2016) 128 (22): 279.
https://doi.org/10.1182/blood.V128.22.279.279
Published: 2016
Journal Articles

Direct Conversion of Adult Endothelial Cells into Immunecompetent Long-Term Engraftable Clinically Scalable Hematopoietic Stem Cells: Pathway to Therapeutic Translation

Raphael Lis, PhD, Charles Harrasch, Michael Gustave Poulos, PhD, Jose Gabriel Duran, William Schachterle, PhD, Michael Ginsberg, PhD, Arash Rafii, Koji Shido, Nancy A. Speck, PhD, Jason M. Butler, PhD, Joseph M. Scandura, MD PhD, Shahin Rafii
Journal: Blood
Blood (2016) 128 (22): 372.
https://doi.org/10.1182/blood.V128.22.372.372
Published: 2016