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Journal Articles

Clonal Analysis Reveals Functional and Transcriptional Heterogeneity of Self-Renewing Fetal Liver Hematopoietic Stem Cells

Takashi Ishida, Adam M Heck, Barbara Varnum-Finney, Stacey Dozono, Cynthia Nourigat-Mckay, Katie Kraskouskas, Rachel Wellington, Olivia Waltner, Christina Root, Dana L Jackson, Cole Trapnell, Shahin Rafii, Irwin D. Bernstein, Brandon Hadland

Blood (2022) 140 (Supplement 1): 8574–8575.

https://doi.org/10.1182/blood-2022-156513

Published: 2022

Journal Articles

Distinct Transcriptional Signatures Distinguish the Emergence of Multipotent Progenitors and Hematopoietic Stem Cells from Endothelial Precursors in the Murine Embryo

Tessa Dignum, BS, Barbara Varnum-Finney, PhD, Sanjay Srivatsan, Stacey Dozono, Olivia Waltner, Adam Heck, PhD, Cynthia Nourigat-Mckay, Dana Jackson, Shahin Rafii, MD, Irwin D. Bernstein, MD, Cole Trapnell, PhD, Brandon Hadland, MD PhD

Blood (2020) 136 (Supplement 1): 7–8.

https://doi.org/10.1182/blood-2020-142607

Published: 2020

Journal Articles

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo

Brandon Hadland, MD PhD, Barbara Varnum-Finney, PhD, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-Mckay, Dana Jackson, Shahin Rafii, MD, Cole Trapnell, PhD, Irwin D. Bernstein, MD

Blood (2019) 134 (Supplement_1): 3699.

https://doi.org/10.1182/blood-2019-126109

Published: 2019

Journal Articles

Single Cell Transcriptomics Maps the Embryonic Emergence of HSC and Identifies Intercellular Interactions Regulating HSC Genesis

Brandon Hadland, MD PhD, Barbara Varnum-Finney, Stacey Dozono, Dana Jackson, Shahin Rafii, MD, Irwin D. Bernstein, MD, Cole Trapnell, PhD

Blood (2018) 132 (Supplement 1): 5086.

https://doi.org/10.1182/blood-2018-99-118772

Published: 2018

Journal Articles

Notch Signaling By Either Notch1 or Notch2 Mediates Expansion of AGM-Derived Long-Term HSC Populations in Vitro

Brandon K Hadland, MD PhD, Barbara Varnum-Finney, Randall T Moon, PhD, Michael Gustave Poulos, PhD, Jason M. Butler, PhD, Shahin Rafii, MD, Irwin D. Bernstein, MD

Blood (2014) 124 (21): 2897.

https://doi.org/10.1182/blood.V124.21.2897.2897

Published: 2014

Journal Articles

AGM-Derived Endothelial Cells and Notch Ligands Provide Embryonic Hematopoietic Stem Cell-Supportive Niches In Vitro

Brandon K Hadland, MD, PhD, Barbara Varnum-Finney, Ph.D., Randall T Moon, PHD, Jason M Butler, PhD, Shahin Rafii, MD, Irwin D. Bernstein, MD

Blood (2013) 122 (21): 1167.

https://doi.org/10.1182/blood.V122.21.1167.1167

Published: 2013

Journal Articles

Activation of Notch Signaling Mediates Ex Vivo Expansion of Multilineage, Engrafting Murine Hematopoietic Progenitors From Embryonic Sources.

Brandon K Hadland, MD, PhD, Barbara Varnum-Finney, Ph.D., Irwin D. Bernstein, MD

Blood (2012) 120 (21): 2321.

https://doi.org/10.1182/blood.V120.21.2321.2321

Published: 2012

Journal Articles

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice

Vid Leko, Barbara Varnum-Finney, Hongzhe Li, Yansong Gu, David Flowers, Cynthia Nourigat, Irwin D. Bernstein, Antonio Bedalov

Blood (2012) 119 (8): 1856–1860.

https://doi.org/10.1182/blood-2011-09-377077

Published: 2012

Journal Articles

Notch2 Signaling Inhibits Differentiation and Promotes Self Renewal of Hematopoietic Stem and Progenitor Cells During Marrow Regeneration.

Barbara Varnum-Finney, Ph.D., Irwin D. Bernstein, MD

Blood (2009) 114 (22): 2544.

https://doi.org/10.1182/blood.V114.22.2544.2544

Published: 2009

Journal Articles

Facilitation of Thymic and Bone Marrow Engraftment by Hematopoietic Progenitors Expanded Ex-Vivo Using the Notch Ligand Delta1

Mari Dallas, MD, Colleen Delaney, MD, MSC, Barbara Varnum-Finney, Ph.D., Irwin D. Bernstein, MD

Blood (2008) 112 (11): 3498.

https://doi.org/10.1182/blood.V112.11.3498.3498

Published: 2008

Journal Articles

Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus

Barbara Varnum-Finney, Mari H. Dallas, Keizo Kato, Irwin D. Bernstein

Blood (2008) 111 (5): 2615–2620.

https://doi.org/10.1182/blood-2007-03-079855

Published: 2008

Journal Articles

Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1

Mari H. Dallas, Barbara Varnum-Finney, Paul J. Martin, Irwin D. Bernstein

Blood (2007) 109 (8): 3579–3587.

https://doi.org/10.1182/blood-2006-08-039842

Published: 2007

Journal Articles

Enhanced T Cell Reconstitution by Hematopoietic Progenitors Expanded Ex-Vivo Using the Notch Ligand Delta1.

Mari H. Dallas, MD, Barbara Varnum-Finney, PhD, Paul J. Martin, MD, Irwin D. Bernstein, MD

Blood (2006) 108 (11): 67.

https://doi.org/10.1182/blood.V108.11.67.67

Published: 2006

Journal Articles

The Interaction of the Wnt and Notch Pathways Modulates NK vs. T Cell Commitment.

Keisuke Aoyama, MD, Barbara Varnum-Finney, PhD, Randall T. Moon, PhD, Irwin D. Bernstein, MD

Blood (2005) 106 (11): 765.

https://doi.org/10.1182/blood.V106.11.765.765

Published: 2005

Journal Articles

Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells

Colleen Delaney, Barbara Varnum-Finney, Keisuke Aoyama, Carolyn Brashem-Stein, Irwin D. Bernstein

Blood (2005) 106 (8): 2693–2699.

https://doi.org/10.1182/blood-2005-03-1131

Published: 2005

Journal Articles

Notch Signaling in Hematopoietic Precursor Cells Maintains the Expression of Genes Required for Stem Cell Self-Renewal and Promotes the Expression of Genes Associated with T cell Differentiation.

Keizo Kato, MD, PhD, Barbara Varnum-Finney, PhD, Irwin D. Bernstein, MD

Blood (2004) 104 (11): 1699.

https://doi.org/10.1182/blood.V104.11.1699.1699

Published: 2004

Journal Articles

Density-Dependent Regulation of Hematopoietic Stem Cell Fate by the Notch Ligand, Delta1.

Mari H. Dallas, MD, Colleen Delaney, MD, Barbara Varnum-Finney, PhD, Irwin D. Bernstein, MD

Blood (2004) 104 (11): 1700.

https://doi.org/10.1182/blood.V104.11.1700.1700

Published: 2004

Journal Articles

Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability

Barbara Varnum-Finney, Carolyn Brashem-Stein, Irwin D. Bernstein

Blood (2003) 101 (5): 1784–1789.

https://doi.org/10.1182/blood-2002-06-1862

Published: 2003

Journal Articles

The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells

Kohshi Ohishi, Barbara Varnum-Finney, Rita E. Serda, Claudio Anasetti, Irwin D. Bernstein

Blood (2001) 98 (5): 1402–1407.

https://doi.org/10.1182/blood.V98.5.1402

Published: 2001

Journal Articles

Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1

Kohshi Ohishi, Barbara Varnum-Finney, David Flowers, Claudio Anasetti, David Myerson, Irwin D. Bernstein

Blood (2000) 95 (9): 2847–2854.

https://doi.org/10.1182/blood.V95.9.2847.009k19_2847_2854

Published: 2000

NARROW

Clonal Analysis Reveals Functional and Transcriptional Heterogeneity of Self-Renewing Fetal Liver Hematopoietic Stem Cells

Distinct Transcriptional Signatures Distinguish the Emergence of Multipotent Progenitors and Hematopoietic Stem Cells from Endothelial Precursors in the Murine Embryo

Integrated Single Cell Transcriptomics Defines an Engineered Niche Supporting Hematopoietic Stem Cell Development Ex Vivo

Single Cell Transcriptomics Maps the Embryonic Emergence of HSC and Identifies Intercellular Interactions Regulating HSC Genesis

Notch Signaling By Either Notch1 or Notch2 Mediates Expansion of AGM-Derived Long-Term HSC Populations in Vitro

AGM-Derived Endothelial Cells and Notch Ligands Provide Embryonic Hematopoietic Stem Cell-Supportive Niches In Vitro

Activation of Notch Signaling Mediates Ex Vivo Expansion of Multilineage, Engrafting Murine Hematopoietic Progenitors From Embryonic Sources.

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice

Notch2 Signaling Inhibits Differentiation and Promotes Self Renewal of Hematopoietic Stem and Progenitor Cells During Marrow Regeneration.

Facilitation of Thymic and Bone Marrow Engraftment by Hematopoietic Progenitors Expanded Ex-Vivo Using the Notch Ligand Delta1

Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus

Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1

Enhanced T Cell Reconstitution by Hematopoietic Progenitors Expanded Ex-Vivo Using the Notch Ligand Delta1.

The Interaction of the Wnt and Notch Pathways Modulates NK vs. T Cell Commitment.

Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells

Notch Signaling in Hematopoietic Precursor Cells Maintains the Expression of Genes Required for Stem Cell Self-Renewal and Promotes the Expression of Genes Associated with T cell Differentiation.

Density-Dependent Regulation of Hematopoietic Stem Cell Fate by the Notch Ligand, Delta1.

Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability

The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells

Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1

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American Society of Hematology

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ASH Publications

American Society of Hematology

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