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Journal Articles

Pathways Relevant to AML Pathogenesis Targeting the Hematopoietic-Specific Cebpa +37 Kb Enhancer

Stacy Cooper, MD, Hong Guo, MD PhD, Justin Thomas, Jay L. Hess, MD PhD, Peter D. Aplan, MD, Donald Small, MD PhD, Alan D. Friedman, MD
Journal: Blood
Blood (2016) 128 (22): 2691.
https://doi.org/10.1182/blood.V128.22.2691.2691
Published: 2016
Journal Articles

In Vivo Deletion of the Cebpa +37 Kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis

Alan D. Friedman, MD, Hong Guo, MD PhD, Stacy Cooper, MD
Journal: Blood
Blood (2015) 126 (23): 1178.
https://doi.org/10.1182/blood.V126.23.1178.1178
Published: 2015
Journal Articles

A multicenter randomized open-label study of rituximab plus rhTPO vs rituximab in corticosteroid-resistant or relapsed ITP

Clinical Trials & Observations
Hai Zhou, Miao Xu, Ping Qin, Hai-yan Zhang, Cheng-lu Yuan, Hong-guo Zhao, Zhong-guang Cui, Yue-sheng Meng, Lei Wang, Fang Zhou, Xin Wang, Da-qi Li, Ke-hong Bi, Chuan-sheng Zhu, Cheng-shan Guo, Xiao-xia Chu, Qing-chao Wu, Xin-guang Liu, Xiao-yuan Dong, Jie Li, Jun Peng, Ming Hou
Journal: Blood
Blood (2015) 125 (10): 1541–1547.
https://doi.org/10.1182/blood-2014-06-581868
Published: 2015
Journal Articles

The RUNX1-Regulated Cebpa +37 Kb Enhancer Directs Human CD4 Transgene Expression To Long-Term Hematopoietic Stem Cells and Preferentially To Myeloid Compared With Lymphoid Or Erythroid Progenitors

Alan D. Friedman, M.D., Hong Guo, M.D., Ph.D., Ou Ma, Ph.D., Leonard I. Zon, MD, Ilya Shestopalov, Ph.D., Dan S. Kaufman, M.D., Ph.D., Patrick I Ferrell, B.S.
Journal: Blood
Blood (2013) 122 (21): 2442.
https://doi.org/10.1182/blood.V122.21.2442.2442
Published: 2013
Journal Articles

Src Kinase Can Activate RUNX1 Activity Via Phosphorylation Of C-Terminal Tyrosines and Activated RUNX1 Stimulates Granulopoiesis

Alan D. Friedman, M.D., Wan Yee Leong, M.Sc., Hong Guo, M.D., Ph.D., Ou Ma, Ph.D., Alan B. Cantor, M.D., Ph.D., Hui Huang, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1210.
https://doi.org/10.1182/blood.V122.21.1210.1210
Published: 2013
Journal Articles

Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

Hong Guo, Ou Ma, Nancy A. Speck, Alan D. Friedman
Journal: Blood
Blood (2012) 119 (19): 4408–4418.
https://doi.org/10.1182/blood-2011-12-397091
Published: 2012
Includes: Supplemental data
Journal Articles

Myeloid Expansion In the Absence of RUNX1 Is Associated with Increased Monopoiesis, Reduced Granulopoiesis, and Diminished CEBPA Gene Expression, Effects of Potential Relevance to Myeloid Transformation

Hong Guo, M.D., Ph.D., Alan D. Friedman, M.D.
Journal: Blood
Blood (2010) 116 (21): 3147.
https://doi.org/10.1182/blood.V116.21.3147.3147
Published: 2010
Journal Articles

Phosphorylation of RUNX1 by Cyclin-Dependent Kinase Reduces Direct Interaction with HDAC1 and HDAC3 and Stimulates Marrow Progenitor Proliferation.

Hong Guo, M.D., Ph.D., Alan D. Friedman, MD
Journal: Blood
Blood (2009) 114 (22): 2508.
https://doi.org/10.1182/blood.V114.22.2508.2508
Published: 2009
Journal Articles

Phosphorylation of Runx1 by Cyclin-Dependent Kinases Regulates Its Interaction with HDAC1 and HDAC3.

Hong Guo, M.D., Ph.D., Alan D. Friedman, M.D.
Journal: Blood
Blood (2008) 112 (11): 1381.
https://doi.org/10.1182/blood.V112.11.1381.1381
Published: 2008
Journal Articles

Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation

Linsheng Zhang, Florence B. Fried, Hong Guo, Alan D. Friedman
Journal: Blood
Blood (2008) 111 (3): 1193–1200.
https://doi.org/10.1182/blood-2007-08-109702
Published: 2008