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Journal Articles

A Non-Canonical Lymphoblast in Refractory Childhood T-Cell Acute Lymphoblastic Leukemia

Bram S.J. Lim, Holly J. Whitfield, Mi K. Trinh, Gianna Bloye, Rebecca Thomas, Nathaniel D. Anderson, Anna Wenger, Angus Hodder, Taryn D. Treger, Henry Lee-Six, Tim H.H. Coorens, Conor Parks, Toochi Ogbonnah, Petri Pölönen, Charles G. Mullighan, David T. Teachey, Melanie M Hagleitner, Lennart A. Kester, Frank N. van Leeuwen, Gordon Beattie, Marc R. Mansour, Owen Williams, Jack Bartram, Stuart Adams, Laura Jardine, Sam Behjati, David O'Connor
Journal: Blood
Blood (2024) 144 (Supplement 1): 2830.
https://doi.org/10.1182/blood-2024-198354
Published: 2024
Journal Articles

A human genome editing–based MLL :: AF4 ALL model recapitulates key cellular and molecular leukemogenic features

Clara Bueno, Raul Torres-Ruiz, Talia Velasco-Hernandez, Oscar Molina, Paolo Petazzi, Alba Martinez, Virginia Rodriguez, Meritxell Vinyoles, Sandra Cantilena, Owen Williams, Nerea Vega-Garcia, Sandra Rodriguez-Perales, Jose C. Segovia, Oscar Quintana-Bustamante, Anindita Roy, Claus Meyer, Rolf Marschalek, Alastair L. Smith, Thomas A. Milne, Mario F. Fraga, Juan Ramón Tejedor, Pablo Menéndez
Journal: Blood
Blood (2023) 142 (20): 1752–1756.
https://doi.org/10.1182/blood.2023020858
Published: 2023
Includes: Supplemental data
Journal Articles

Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia

Paul M. Maciocia, Patrycja A. Wawrzyniecka, Nicola C. Maciocia, Amy Burley, Thaneswari Karpanasamy, Sam Devereaux, Malika Hoekx, David O’Connor, Theresa Leon, Tanya Rapoz-D’Silva, Rachael Pocock, Sunniyat Rahman, Giuseppe Gritti, Diana C. Yánez, Susan Ross, Tessa Crompton, Owen Williams, Lydia Lee, Martin A. Pule, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (1): 25–37.
https://doi.org/10.1182/blood.2021013648
Published: 2022
Includes: Supplemental data
Journal Articles

Targeted Inactivation of the c-Myb Oncogene through Integrated Network Analysis

Jasper de Boer, PhD, Vanessa Walf-Vorderwuelbecke, PhD, Gareth Williams, PhD, Sujith Samarasinghe, MD PhD, Phil Ancliff, MD, Nicholas Goulden, MD PhD, Owen Williams, PhD
Journal: Blood
Blood (2015) 126 (23): 2561.
https://doi.org/10.1182/blood.V126.23.2561.2561
Published: 2015
Journal Articles

The Role of SMAD7 Downstream of TEL-AML1 Signalling in t(12;21) Acute Lymphoblastic Leukemia

Aishwarya Sundaresh, Miss, Maurizio Mangolini, Dr, Jasper de Boer, Dr, Mike Hubank, Dr, Nicholas Goulden, Dr, Owen Williams, PhD
Journal: Blood
Blood (2015) 126 (23): 4823.
https://doi.org/10.1182/blood.V126.23.4823.4823
Published: 2015
Journal Articles

Targeting Reptin Function in Acute Myeloid Leukaemia

Elena Armenteros-Monterroso, M.Phil., Lu Zhao, Dr, Jasper de Boer, PhD, Owen Williams, PhD
Journal: Blood
Blood (2015) 126 (23): 4824.
https://doi.org/10.1182/blood.V126.23.4824.4824
Published: 2015
Journal Articles

Drug Induced MLL Fusion Degradation Via Hsp90 Inhibition

Sandra Cantilena, MPhil, Nicholas Goulden, MD PhD, Owen Williams, PhD, Jasper de Boer, PhD
Journal: Blood
Blood (2015) 126 (23): 4850.
https://doi.org/10.1182/blood.V126.23.4850.4850
Published: 2015
Journal Articles

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurens T van der Meer, PhD, Simone de Rijk, BSc, Owen Williams, PhD, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 5193.
https://doi.org/10.1182/blood.V124.21.5193.5193
Published: 2014
Journal Articles

Loss Of BTG1 Function Promotes ETV6-RUNX1 -Mediated Leukemic Transformation

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Dorette van Ingen Schenau, Msc, Laurens T. van der Meer, PhD, Owen Williams, PhD, Peter M. Hoogerbrugge, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2013) 122 (21): 2545.
https://doi.org/10.1182/blood.V122.21.2545.2545
Published: 2013
Journal Articles

STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia

Maurizio Mangolini, Jasper de Boer, Vanessa Walf-Vorderwülbecke, Rob Pieters, Monique L. den Boer, Owen Williams
Journal: Blood
Blood (2013) 122 (4): 542–549.
https://doi.org/10.1182/blood-2012-11-465252
Published: 2013
Includes: Supplemental data
Journal Articles

Frat2 mediates the oncogenic activation of Rac by MLL fusions

Vanessa Walf-Vorderwülbecke, Jasper de Boer, Sarah J. Horton, Renée van Amerongen, Natalie Proost, Anton Berns, Owen Williams
Journal: Blood
Blood (2012) 120 (24): 4819–4828.
https://doi.org/10.1182/blood-2012-05-432534
Published: 2012
Includes: Supplemental data
Journal Articles

PAX5 Is a Frequently Altered Transcription Factor In Genetically Unclassified Childhood Common/B-Cell Precursor Acute Lymphoblastic Leukemia

Iryna Stasevich, Sarah Inglott, Philip Ancliff, Owen Williams, Helena Kempski
Journal: Blood
Blood (2011) 118 (21): 1458.
https://doi.org/10.1182/blood.V118.21.1458.1458
Published: 2011
Journal Articles

Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension

Jonathan Bond, Daniel P. Gale, Thomas Connor, Stuart Adams, Jasper de Boer, Duncan M. Gascoyne, Owen Williams, Patrick H. Maxwell, Philip J. Ancliff
Journal: Blood
Blood (2011) 117 (13): 3699–3701.
https://doi.org/10.1182/blood-2010-12-327569
Published: 2011
Journal Articles

Connectivity Mapping Identifies HDAC Inhibitors as Suitable Candidates for the Treatment of t(4;11)-Positive Acute Lymphoblastic Leukemia In Infants

Dominique JPM Stumpel, Pauline Schneider, Lidija Seslija, Hikari Osaki, Owen Williams, Rob Pieters, MD, PhD, Ronald Stam, PhD
Journal: Blood
Blood (2010) 116 (21): 3222.
https://doi.org/10.1182/blood.V116.21.3222.3222
Published: 2010
Journal Articles

High Expression of the Ca 2+ -Binding Proteins S100A8 and S100A9 Cause Glucocorticoid Resistance in MLL -Rearranged Infant Acute Lymphoblastic Leukemia.

Jill Hagelstein, Pauline Schneider, Jasper de Boer, Esther Hulleman, PhD, Owen Williams, Rob Pieters, Ronald W. Stam, Ph.D.
Journal: Blood
Blood (2009) 114 (22): 729.
https://doi.org/10.1182/blood.V114.22.729.729
Published: 2009
Journal Articles

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

Sarah J. Horton, Vanessa Walf-Vorderwülbecke, Steve J. Chatters, Neil J. Sebire, Jasper de Boer, Owen Williams
Journal: Blood
Blood (2009) 113 (20): 4922–4929.
https://doi.org/10.1182/blood-2008-07-170480
Published: 2009
Includes: Supplemental data
Journal Articles

CBFβ is critical for AML1-ETO and TEL-AML1 activity

Liya Roudaia, Matthew D. Cheney, Ekaterina Manuylova, Wei Chen, Michelle Morrow, Sangho Park, Chung-Tsai Lee, Prabhjot Kaur, Owen Williams, John H. Bushweller, Nancy A. Speck
Journal: Blood
Blood (2009) 113 (13): 3070–3079.
https://doi.org/10.1182/blood-2008-03-147207
Published: 2009
Journal Articles

Acute Myeloid Leukemia Induced by MLL-ENL Is Cured by Oncogene Ablation despite Acquisition of Complex Genetic Abnormalities

Sarah J. Horton, Vanessa Walf-Vorderwülbecke, Steve J. Chatters, Neil J. Sebire, Jasper de Boer, Owen Williams
Journal: Blood
Blood (2008) 112 (11): 3109.
https://doi.org/10.1182/blood.V112.11.3109.3109
Published: 2008
Journal Articles

TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity

Michelle Morrow, Sarah Horton, Dimitris Kioussis, Hugh J. M. Brady, Owen Williams
Journal: Blood
Blood (2004) 103 (10): 3890–3896.
https://doi.org/10.1182/blood-2003-10-3695
Published: 2004
Includes: Supplemental data