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Jasper de Boer
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Journal Articles

Interaction with the DNA Binding Domain of MLL and a Small Molecular Drug Induces Proteolysis of MLL-Fusion Proteins and Ablates Leukemic Stem Cell Activity

Jasper de Boer, PhD, Sandra Cantilena, MPhil
Journal: Blood
Blood (2016) 128 (22): 1549.
https://doi.org/10.1182/blood.V128.22.1549.1549
Published: 2016
Journal Articles

Targeted Inactivation of the c-Myb Oncogene through Integrated Network Analysis

Jasper de Boer, PhD, Vanessa Walf-Vorderwuelbecke, PhD, Gareth Williams, PhD, Sujith Samarasinghe, MD PhD, Phil Ancliff, MD, Nicholas Goulden, MD PhD, Owen Williams, PhD
Journal: Blood
Blood (2015) 126 (23): 2561.
https://doi.org/10.1182/blood.V126.23.2561.2561
Published: 2015
Journal Articles

The Role of SMAD7 Downstream of TEL-AML1 Signalling in t(12;21) Acute Lymphoblastic Leukemia

Aishwarya Sundaresh, Miss, Maurizio Mangolini, Dr, Jasper de Boer, Dr, Mike Hubank, Dr, Nicholas Goulden, Dr, Owen Williams, PhD
Journal: Blood
Blood (2015) 126 (23): 4823.
https://doi.org/10.1182/blood.V126.23.4823.4823
Published: 2015
Journal Articles

Targeting Reptin Function in Acute Myeloid Leukaemia

Elena Armenteros-Monterroso, M.Phil., Lu Zhao, Dr, Jasper de Boer, PhD, Owen Williams, PhD
Journal: Blood
Blood (2015) 126 (23): 4824.
https://doi.org/10.1182/blood.V126.23.4824.4824
Published: 2015
Journal Articles

Drug Induced MLL Fusion Degradation Via Hsp90 Inhibition

Sandra Cantilena, MPhil, Nicholas Goulden, MD PhD, Owen Williams, PhD, Jasper de Boer, PhD
Journal: Blood
Blood (2015) 126 (23): 4850.
https://doi.org/10.1182/blood.V126.23.4850.4850
Published: 2015
Journal Articles

STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia

Maurizio Mangolini, Jasper de Boer, Vanessa Walf-Vorderwülbecke, Rob Pieters, Monique L. den Boer, Owen Williams
Journal: Blood
Blood (2013) 122 (4): 542–549.
https://doi.org/10.1182/blood-2012-11-465252
Published: 2013
Includes: Supplemental data
Journal Articles

Frat2 mediates the oncogenic activation of Rac by MLL fusions

Vanessa Walf-Vorderwülbecke, Jasper de Boer, Sarah J. Horton, Renée van Amerongen, Natalie Proost, Anton Berns, Owen Williams
Journal: Blood
Blood (2012) 120 (24): 4819–4828.
https://doi.org/10.1182/blood-2012-05-432534
Published: 2012
Includes: Supplemental data
Journal Articles

Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension

Jonathan Bond, Daniel P. Gale, Thomas Connor, Stuart Adams, Jasper de Boer, Duncan M. Gascoyne, Owen Williams, Patrick H. Maxwell, Philip J. Ancliff
Journal: Blood
Blood (2011) 117 (13): 3699–3701.
https://doi.org/10.1182/blood-2010-12-327569
Published: 2011
Journal Articles

Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL -rearranged infant acute lymphoblastic leukemia

Ronald W. Stam, Monique L. Den Boer, Pauline Schneider, Jasper de Boer, Jill Hagelstein, Maria G. Valsecchi, Paola de Lorenzo, Stephen E. Sallan, Hugh J. M. Brady, Scott A. Armstrong, Rob Pieters
Journal: Blood
Blood (2010) 115 (5): 1018–1025.
https://doi.org/10.1182/blood-2009-02-205963
Published: 2010
Journal Articles

High Expression of the Ca 2+ -Binding Proteins S100A8 and S100A9 Cause Glucocorticoid Resistance in MLL -Rearranged Infant Acute Lymphoblastic Leukemia.

Jill Hagelstein, Pauline Schneider, Jasper de Boer, Esther Hulleman, PhD, Owen Williams, Rob Pieters, Ronald W. Stam, Ph.D.
Journal: Blood
Blood (2009) 114 (22): 729.
https://doi.org/10.1182/blood.V114.22.729.729
Published: 2009
Journal Articles

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

Sarah J. Horton, Vanessa Walf-Vorderwülbecke, Steve J. Chatters, Neil J. Sebire, Jasper de Boer, Owen Williams
Journal: Blood
Blood (2009) 113 (20): 4922–4929.
https://doi.org/10.1182/blood-2008-07-170480
Published: 2009
Includes: Supplemental data
Journal Articles

Rac GTPases play critical roles in early T-cell development

Celine Dumont, Agnieszka Corsoni-Tadrzak, Sandra Ruf, Jasper de Boer, Adam Williams, Martin Turner, Dimitris Kioussis, Victor L. J. Tybulewicz
Journal: Blood
Blood (2009) 113 (17): 3990–3998.
https://doi.org/10.1182/blood-2008-09-181180
Published: 2009
Journal Articles

Acute Myeloid Leukemia Induced by MLL-ENL Is Cured by Oncogene Ablation despite Acquisition of Complex Genetic Abnormalities

Sarah J. Horton, Vanessa Walf-Vorderwülbecke, Steve J. Chatters, Neil J. Sebire, Jasper de Boer, Owen Williams
Journal: Blood
Blood (2008) 112 (11): 3109.
https://doi.org/10.1182/blood.V112.11.3109.3109
Published: 2008
Journal Articles

Rearranged Infant Acute Lymphoblastic Leukemia.

Ronald W. Stam, PhD, Monique L. Den Boer, PhD, Pauline Schneider, Jasper de Boer, PhD, Jill Hagelstein, MSc, Stephen E. Sallan, MD, Hugh J.M. Brady, PhD, Scott Armstrong, MD, PhD, Rob Pieters, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1913.
https://doi.org/10.1182/blood.V112.11.1913.1913
Published: 2008