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Sarah J. Horton
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Journal Articles

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation

Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Aaron Gallego-Crespo, Malte Andreas Behrendt, Maria Saura-Pañella, Aarti Tarkar, Benedict Schubert, Haiyang Yun, Sarah J. Horton, Shuchi Agrawal-Singh, Dr, Patricia S Hähnel, Faisal Basheer, Dave Lugo, Ioanna Eleftheriadou, Olena Barbash, Arindam Dhar, Michael Kühn, Borhane Guezguez, Matthias Theobald, Thomas Kindler, Paolo Gallipoli, Paul Sung-Hao Yeh, Mark A. Dawson, Rab K Prinjha, Brian JP Huntly, Daniel Sasca
Journal: Blood
Blood blood.2022019306.
https://doi.org/10.1182/blood.2022019306
Published: 2024
Includes: Supplemental data
Journal Articles

Delayed Trp53 Activation Protects Dnmt3a -Mutant Haematopoietic Stem Cells from Inflammatory Attrition

Ludovica Marando, George Giotopoulos, Pedro Madrigal, Dhoyazan M A Azazi, Ryan Asby, Maria Erendira Calleja-Cervantes, David Lara-Astiaso, Nicola K. Wilson, Rebecca Hannah, Jaana Bagri, Elsa Barnard, Sarah J Horton, Berthold Gottgens, Elli Papaemmanuil, Shuchi Agrawal Singh, Malgorzata Gozdecka, George S Vassiliou, Brian J P Huntly
Journal: Blood
Blood (2024) 144 (Supplement 1): 190.
https://doi.org/10.1182/blood-2024-201612
Published: 2024
Journal Articles

Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation

Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Aarón Gallego-Crespo, Malte Andreas Behrendt, Maria Saura-Pañella, Benedict Schubert, Haiyang Yun, Sarah J Horton, Shuchi Agrawal Singh, Patricia S Hähnel, Faisal Basheer, Dave Lugo, Michael Kühn, Borhane Guezguez, Matthias Theobald, Thomas Kindler, Paolo Gallipoli, Paul Yeh, Mark A. Dawson, Rab Prinjha, Brian J P Huntly, Daniel Sasca
Journal: Blood
Blood (2024) 144 (Supplement 1): 722.
https://doi.org/10.1182/blood-2024-202515
Published: 2024
Journal Articles

HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia

Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan M. A. Azazi, Sarah J. Horton, Cecile K. Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W. Houghton, George S. Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D. Whetton, Brian J. P. Huntly
Journal: Blood
Blood (2023) 141 (14): 1737–1754.
https://doi.org/10.1182/blood.2022016528
Published: 2023
Includes: Supplemental data
Journal Articles

HOXA9 Nucleates a Repressive Chromatin Complex with Nuclear Matrix-Associated Protein- Safb to Maintain Acute Myeloid Leukemia

Shuchi Agrawal Singh, Jaana Bagri, George Giotopoulos, Eshwar Meduri, Shubha Anad, Sarah J. Horton, Daniel Sasca, Haiyang Yun, Anthony Whetton, Brian James Patrick Huntly
Journal: Blood
Blood (2022) 140 (Supplement 1): 720–721.
https://doi.org/10.1182/blood-2022-156341
Published: 2022
Journal Articles

Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction

Haiyang Yun, PhD, Shabana Vohra, PhD, Annalisa Mupo, PhD, George Giotopoulos, PhD, Daniel Sasca, MD, Sarah J. Horton, PhD, Shuchi Agrawal-Singh, PhD, Eshwar Meduri, PhD, Faisal Basheer, MBBChir, MA, PhD, Ludovica Marando, Malgorzata Gozdecka, PhD, Oliver M. Dovey, PhD, Xiaonan Wang, PhD, Paolo Gallipoli, PhD, Cameron Osborne, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 278.
https://doi.org/10.1182/blood-2019-122413
Published: 2019
Journal Articles

Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition

Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S. H. Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M. L. Dias, Haiyang Yun, Daniel Sasca, Sarah J. Horton, George Vassiliou, Christian Frezza, Brian J. P. Huntly
Journal: Blood
Blood (2018) 131 (15): 1639–1653.
https://doi.org/10.1182/blood-2017-12-820035
Published: 2018
Includes: Supplemental data
Journal Articles

Frat2 mediates the oncogenic activation of Rac by MLL fusions

Vanessa Walf-Vorderwülbecke, Jasper de Boer, Sarah J. Horton, Renée van Amerongen, Natalie Proost, Anton Berns, Owen Williams
Journal: Blood
Blood (2012) 120 (24): 4819–4828.
https://doi.org/10.1182/blood-2012-05-432534
Published: 2012
Includes: Supplemental data
Journal Articles

BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34 + cells

Aleksandra Rizo, Sarah J. Horton, Sandra Olthof, Bert Dontje, Albertina Ausema, Ronald van Os, Vincent van den Boom, Edo Vellenga, Gerald de Haan, Jan Jacob Schuringa
Journal: Blood
Blood (2010) 116 (22): 4621–4630.
https://doi.org/10.1182/blood-2010-02-270660
Published: 2010
Includes: Supplemental data
Journal Articles

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

Sarah J. Horton, Vanessa Walf-Vorderwülbecke, Steve J. Chatters, Neil J. Sebire, Jasper de Boer, Owen Williams
Journal: Blood
Blood (2009) 113 (20): 4922–4929.
https://doi.org/10.1182/blood-2008-07-170480
Published: 2009
Includes: Supplemental data
Journal Articles

Acute Myeloid Leukemia Induced by MLL-ENL Is Cured by Oncogene Ablation despite Acquisition of Complex Genetic Abnormalities

Sarah J. Horton, Vanessa Walf-Vorderwülbecke, Steve J. Chatters, Neil J. Sebire, Jasper de Boer, Owen Williams
Journal: Blood
Blood (2008) 112 (11): 3109.
https://doi.org/10.1182/blood.V112.11.3109.3109
Published: 2008