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Olena Barbash
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Journal Articles

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation

Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Aaron Gallego-Crespo, Malte Andreas Behrendt, Maria Saura-Pañella, Aarti Tarkar, Benedict Schubert, Haiyang Yun, Sarah J. Horton, Shuchi Agrawal-Singh, Dr, Patricia S Hähnel, Faisal Basheer, Dave Lugo, Ioanna Eleftheriadou, Olena Barbash, Arindam Dhar, Michael Kühn, Borhane Guezguez, Matthias Theobald, Thomas Kindler, Paolo Gallipoli, Paul Sung-Hao Yeh, Mark A. Dawson, Rab K Prinjha, Brian JP Huntly, Daniel Sasca
Journal: Blood
Blood blood.2022019306.
https://doi.org/10.1182/blood.2022019306
Published: 2024
Includes: Supplemental data
Journal Articles

TP53 Mutations and RNA Binding Protein Musashi 2 Drive Resistance to PRMT5-Targeted Therapy in B-Cell Lymphoma

Ingrid Tatiana Erazo, Chiara M Evans, Daniel Zakheim, Karen L Chu, Olena Barbash, Alice Yunsi Refermat, Connie Lee Batlevi, Anas Younes, Michael G Kharas
Journal: Blood
Blood (2021) 138 (Supplement 1): 788.
https://doi.org/10.1182/blood-2021-151280
Published: 2021
Journal Articles

A Phase I/II Study to Investigate the Safety and Clinical Activity of the Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 in Subjects with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Justin M. Watts, MD, Terrence J Bradley, MD, Amber Thomassen, Andrew M. Brunner, MD, Mark D. Minden, MD PhD, Nikolaos Papadantonakis, MDPhDMSc, Sameem Abedin, MD, Amanda J Baines, Olena Barbash, PhD, Shelby Gorman, Brandon E Kremer, MD PhD, Gautam M. Borthakur, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2656.
https://doi.org/10.1182/blood-2019-130337
Published: 2019
Journal Articles

Identification of a First-in-Class PRMT5 Inhibitor with Potent in Vitro and in Vivo Activity in Preclinical Models of Mantle Cell Lymphoma

Elayne Penebre, PhD, Kristy G Kuplast, Christina R Majer, L. Danielle Johnston, MS, Nathalie Rioux, PhD, Michael Munchhof, PhD, Lei Jin, PhD, P. Ann Boriak-Sjodin, PhD, Tim J Wigle, PhD, Suzanne L Jacques, PhD, Kip A West, PhD, Trupti Lingaraj, Kimberly Stickland, PhD, Scott A Ribich, PhD, Alejandra Raimondi, MS, Margaret Porter-Scott, PhD, Nigel J Waters, PhD, Roy M Pollock, PhD, Jesse J Smith, PhD, Olena Barbash, PhD, Ryan G. Kruger, PhD, Robert A Copeland, PhD, Mikel P Moyer, PhD, Richard Chesworth, DPhil, Kenneth W Duncan, PhD
Journal: Blood
Blood (2014) 124 (21): 438.
https://doi.org/10.1182/blood.V124.21.438.438
Published: 2014
Journal Articles

Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762

Aristeidis Chaidos, Valentina Caputo, Katerina Gouvedenou, Binbin Liu, Ilaria Marigo, Mohammed Suhail Chaudhry, Antonia Rotolo, David F. Tough, Nicholas N. Smithers, Anna K. Bassil, Trevor D. Chapman, Nicola R. Harker, Olena Barbash, Peter Tummino, Niam Al-Mahdi, Andrea C. Haynes, Leanne Cutler, BaoChau Le, Amin Rahemtulla, Irene Roberts, Maurits Kleijnen, Jason J. Witherington, Nigel J. Parr, Rab K. Prinjha, Anastasios Karadimitris
Journal: Blood
Blood (2014) 123 (5): 697–705.
https://doi.org/10.1182/blood-2013-01-478420
Published: 2014
Includes: Supplemental data
Journal Articles

Potent Anti-Myeloma Activity Of The Novel Bromodomain Inhibitors I-BET151 and I-BET762

Aristeidis Chaidos, Valentina Caputo, Ilaria Marigo, Binbin Liu, Suhail Chaudhry, Katerina Goudevenou, Antonia Rotolo, David F Tough, Nicholas N Smithers, Anna K Bassil, Trevor D Chapman, Nicola R Harker, Olena Barbash, Peter Tummino, Ph.D., Niam Al-Mahdi, Andrea C Haynes, Leanne Cutler, BaoChau Le, Amin Rahemtulla, Irene Roberts, Maurits Kleijnen, Jason Witherington, Nigel J Parr, Rab K Prinjha, Anastasios Karadimitris
Journal: Blood
Blood (2013) 122 (21): 878.
https://doi.org/10.1182/blood.V122.21.878.878
Published: 2013