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Journal Articles

Immune Graft Composition Is Important for Deepening Response and Outcome after Autologous Stem Cell Transplantation in Patients with Multiple Myeloma Who Do Not Receive Maintenance Therapy

Yeasung Lee, Francesca Bladt, Dimitrios Leonardos, Chira Mustafa, Alexia Katsarou, Maria Atta, Marco Bua, Ian Gabriel, Jose Ros-Soto, Alexandra Bazeos, Jiri Pavlu, Sandra Loaiza, Emma Bray, Farah O'Boyle, Elisabet Nadal, Richard Szydlo, Nicholas Crump, Anastasios Karadimitris, Aristeidis Chaidos
Journal: Blood
Blood (2023) 142 (Supplement 1): 759.
https://doi.org/10.1182/blood-2023-188912
Published: 2023
Journal Articles

Development of Novel Invariant TCR-Anchored Bispecific Engagers to Enhance Anti-Cancer Activity of iNKT Cells

Klesti Karaxhuku, Kanagaraju Ponnusamy, Hongwei Ren, Bryan Lye, Ilia Leontari, Mehmood Zaidi, Farah Sabrin, Marco Bua, Maria Atta, Alexia Katsarou, Irene Roberts, Aristeidis Chaidos, Anastasios Karadimitris
Journal: Blood
Blood (2023) 142 (Supplement 1): 4828.
https://doi.org/10.1182/blood-2023-190598
Published: 2023
Journal Articles

Bispecific CAR-iNKT Immunotherapy for High Risk MLL-Rearranged Acute Lymphoblastic Leukemia

Hongwei Ren, Natalina Elliott, Bryan Lye, Joe Cross, Lucy Field, Kanagaraju Ponnusamy, Irene Roberts, Christina Halsey, Thomas Arthur Milne, Anindita Roy, Anastasios Karadimitris
Journal: Blood
Blood (2023) 142 (Supplement 1): 766.
https://doi.org/10.1182/blood-2023-186442
Published: 2023
Journal Articles

Optimal, Off-the-Shelf, CAR-iNKT Cell Platform-Based Immunotherapy for Multiple Myeloma

Kanagaraju Ponnusamy, Lyra Randzavola, Hongwei Ren, Klesti Karaxhuku, Bryan Lye, Dimitrios Leonardos, Reza Nadafi, Irene Sarkar, Ilia Leontari, Farah Sabrin, Mehmood Zaidi, Marco Bua, Maria Atta, Alexia Katsarou, Irene Roberts, Aristeidis Chaidos, Anastasios Karadimitris
Journal: Blood
Blood (2023) 142 (Supplement 1): 3459.
https://doi.org/10.1182/blood-2023-189905
Published: 2023
Journal Articles

Anti-T Cell Receptor Vβ Chain-Specific CAR-iNKT Cells As a Precise Strategy to Treat Mature T Cell Lymphomas

Aileen G Rowan, Kanagaraju Ponnusamy, Hongwei Ren, Graham Phillip Taylor, Lucy Cook, Anastasios Karadimitris
Journal: Blood
Blood (2022) 140 (Supplement 1): 10257–10258.
https://doi.org/10.1182/blood-2022-165271
Published: 2022
Journal Articles

Pre-Clinical Evaluation of Allogeneic 'Off-the-Shelf' CAR-iNKT Cells Targeting CD19 (ALA-101)-Expressing Hematological Malignancies

Kanagaraju Ponnusamy, Janani Kanagaraju, Yingxin Wang, Bryan Lye, Hongwei Ren, Uthayamalar Armugam, Sandhya Buchanan, Michael J Baker, Mini Bharathan, Anastasios Karadimitris
Journal: Blood
Blood (2022) 140 (Supplement 1): 12699–12700.
https://doi.org/10.1182/blood-2022-165516
Published: 2022
Journal Articles

Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma

Nikolaos Trasanidis, Alexia Katsarou, Kanagaraju Ponnusamy, Yao-An Shen, Ioannis V. Kostopoulos, Bien Bergonia, Keren Keren, Paudel Reema, Xiaolin Xiao, Richard M. Szydlo, Pierangela M. R. Sabbattini, Irene A. G. Roberts, Holger W. Auner, Kikkeri N. Naresh, Aristeidis Chaidos, Tian-Li Wang, Luca Magnani, Valentina S. Caputo, Anastasios Karadimitris
Journal: Blood
Blood (2022) 139 (13): 1939–1953.
https://doi.org/10.1182/blood.2021014391
Published: 2022
Includes: Supplemental data
Journal Articles

Single-Cell Transcriptional Landscapes of Human Bone Marrow Reveal Distinct Erythroid Phenotypes Underpinned By Genotype in Diamond-Blackfan Anemia

Deena Iskander, MD, Guanlin Wang, PhD, Elisabeth F Heuston, PhD, Chrysi Christodoulidou, Bethan Psaila, MD PhD, Mark E Robinson, PhD, Aristeidis Chaidos, MD PhD, Pritesh Trivedi, MSc, Nikolaos Trasanidis, PhD, Alexia Katsarou, MD, Richard Szydlo, PhD, NISC Comparative SequencingProgram, Qais Al-Oqaily, MD PhD, Valentina S Caputo, PhD, Kanagaraju Ponnusamy, PhD, Anindita Roy, MD PhD, Leena Karnik, FRCPath, MRCP, Kikkeri Naresh, MD, Adam J. Mead, MD PhD, Supat Thongjuea, PhD, Marjorie Brand, PhD, Josu de la Fuente, David M. Bodine, PhD, Irene Roberts, MD PhD, Anastasios Karadimitris, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-141535
Published: 2020
Journal Articles

Myc and Bet Proteins Orchestrate the Early Regulatory Genome Changes Required for Osteoclast Lineage Commitment

Valentina S Caputo, Nikolaos Trasanidis, Xiaolin Xiao, Mark E Robinson, Alexia Katsarou, Kanagaraju Ponnusamy, Aristeidis Chaidos, Holger W Auner, MD PhD, Irene Roberts, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 4329.
https://doi.org/10.1182/blood-2019-125047
Published: 2019
Journal Articles

Oncogenic MAF in Co-Operation with IRF4 Confers Extensive Chromatin Re-Arrangement in Plasma Cells and Generates 'Neo-Enhancers' That Regulate Genes Critical for Myeloma Biology

Alexia Katsarou, Nikolaos Trasanidis, Jaime Alvarez-Benayas, Foteini Papaleonidopoulou, Keren Keren, Ioannis V. Kostopoulos, Kanagaraju Ponnusamy, Xiaolin Xiao, Niklas Feldhahn, Irene Roberts, Evdoxia Hatjiharissi, Maria Papaioannou, Ian Sudbery, Aristeidis Chaidos, Valentina S Caputo, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 3783.
https://doi.org/10.1182/blood-2019-122371
Published: 2019
Journal Articles

PBX1 Co-Operates with FOXM1 to Regulate Myeloma Cell Proliferation and to Define an Ultra High-Risk chr1q Gain Myeloma Patient Subgroup

Nikolaos Trasanidis, Alexia Katsarou, Bien Bergonia, Keren Keren, Ioannis V. Kostopoulos, Kanagaraju Ponnusamy, Reema Paudel, Xiaolin Xiao, Holger W Auner, MD PhD, Irene Roberts, Kikkeri Naresh, MD, Aristeidis Chaidos, Luca Magnani, Valentina S Caputo, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 3760.
https://doi.org/10.1182/blood-2019-124109
Published: 2019
Journal Articles

Novel ZBP1-IRF3 Dependency in Multiple Myeloma Mediated By IRF3-Driven Regulation of Cell Cycle Genes

Kanagaraju Ponnusamy, Maria-Myrsini Tzioni, MS, Murshida Begum, MS, Mark E Robinson, Valentina S Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, MD, Irene Roberts, Pritesh Trivedi, MSc, Holger W Auner, MD PhD, Kikkeri Naresh, MD, Aristeidis Chaidos, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 2521.
https://doi.org/10.1182/blood-2019-125768
Published: 2019
Journal Articles

Distinct Chromatin Accessibility Changes, Aberrant Transcription Factor Networks Combined with Novel Oncogenic Enhancers Characterise Myeloma-Initiating Genetic Events

Nikolaos Trasanidis, Jaime Alvarez-Benayas, Alexia Katsarou, Aristeidis Chaidos, Philippa C May, Kanagaraju Ponnusamy, Xiaolin Xiao, Marco Bua, MD, Maria Atta, MD, Irene Roberts, Holger W Auner, MD PhD, Evdoxia Hatjiharissi, Maria Papaioannou, Valentina S Caputo, Ian Sudbery, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 1769.
https://doi.org/10.1182/blood-2019-124761
Published: 2019
Journal Articles

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Sorcha O’Byrne, Natalina Elliott, Siobhan Rice, Gemma Buck, Nicholas Fordham, Catherine Garnett, Laura Godfrey, Nicholas T. Crump, Gary Wright, Sarah Inglott, Peng Hua, Bethan Psaila, Benjamin Povinelli, David J. H. F. Knapp, Antonio Agraz-Doblas, Clara Bueno, Ignacio Varela, Phillip Bennett, Hashem Koohy, Suzanne M. Watt, Anastasios Karadimitris, Adam J. Mead, Phillip Ancliff, Paresh Vyas, Pablo Menendez, Thomas A. Milne, Irene Roberts, Anindita Roy
Journal: Blood
Blood (2019) 134 (13): 1059–1071.
https://doi.org/10.1182/blood.2019001289
Published: 2019
Includes: Supplemental data
Journal Articles

Clustering Analysis of Myeloma Clone Phenotype Is Informative for Disease Heterogeneity and Prognosis at Relapse

Syeda Maheen Ahsan, Elisabet Nadal-Melsio, MD, Mark E Robinson, PhD, Richard Syzdlo, PhD, Eva Yebra-Fernandez, MD, Holger W Auner, MD PhD, Maria Atta, MD, Marco Bua, MD, Farah O'Boyle, PhD, Kikkeri Naresh, Jane Apperley, MB ChB MD, Anastasios Karadimitris, FRCPath, PhD, Aristeidis Chaidos, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4492.
https://doi.org/10.1182/blood-2018-99-117460
Published: 2018
Journal Articles

A Phase I Study of Molibresib (GSK525762), a Selective Bromodomain (BRD) and Extra Terminal Protein (BET) Inhibitor: Results from Part 1 of a Phase I/II Open Label Single Agent Study in Subjects with Non-Hodgkin's Lymphoma (NHL)

Michael Dickinson, MD, Manali Kamdar, MD, Brian J.P Huntly, Carlos Fernández De Larrea, MD PhD, Raul Cordoba, MD PhD, Maria-Victoria Mateos, MD PhD, Adrián Alegre, MD, Won-Seog Kim, MD PhD, Jin Seok Kim, MD PhD, Mark Dawson, MD PhD, Paul Sung-Hao Yeh, MBBS, FRCPA, FRACP, Faisal Basheer, MBBChir, MA, Paolo Gallipoli, PhD, Aristeidis Chaidos, MD PhD, Alejandro Martín, MD, Thierry Horner, PhD, James Winnberg, MS, Lijoy K Mathew, PhD, Jeffrey Botbyl, MS, Natalie Karpinich, PhD, Brandon E. Kremer, MD PhD, Arindam Dhar, MBBS,MDPhD, Anastasios Karadimitris, FRCPath, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1682.
https://doi.org/10.1182/blood-2018-99-117089
Published: 2018
Journal Articles

Myeloma Cell Addiction to the Transcription Factor TCF11

Valentina Caputo, PhD, Katerina Goudevenou, PhD, Nikolaos Trasanidis, BSc, MSc, Kyriaki Petevi, MD, Xiaolin Xiao, PhD, Kanagaraju Ponnusamy, PhD, Deena Iskander, MD, David Pitcher, PhD, Antonia Rotolo, MD, Holger W. Auner, MD PhD, Aristeidis Chaidos, MD PhD, Anastasios Karadimitris, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1194.
https://doi.org/10.1182/blood.V130.Suppl_1.1194.1194
Published: 2017
Journal Articles

Invariant NKT Are a More Effective and Versatile Platform Than T Cells for CAR Immunotherapy of CD1d-Expressing B Lineage Malignancies: Cellular and Molecular Mechanisms

Antonia Rotolo, MD, Olivier Dubois, Nicoleta Baxan, PhD, Suhail Chaudhry, PhD, Valentina Caputo, PhD, Katerina Goudevenou, PhD, Kyriaki Petevi, MD, Gordon W Cheung, Martin Pule, PhD, John Maher, PhD, Anastasios Karadimitris, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4613.
https://doi.org/10.1182/blood.V130.Suppl_1.4613.4613
Published: 2017
Journal Articles

A Phase I Study of GSK525762, a Selective Bromodomain (BRD) and Extra Terminal Protein (BET) Inhibitor: Results from Part 1 of Phase I/II Open Label Single Agent Study in Patients with Acute Myeloid Leukemia (AML)

Mark Dawson, MD PhD, Eytan M. Stein, MD, Brian J.P Huntly, Anastasios Karadimitris, PhD, Manali Kamdar, Carlos Fernandez de Larrea, Michael J. Dickinson, Paul Sung-Hao Yeh, MBBS, FRCPA, FRACP, Naval Daver, MD, Aristeidis Chaidos, MD PhD, Martin S. Tallman, MD, Raquel Jiménez, MD, Thierry Horner, PhD, January Baron, MS, John Brennan, Geraldine Ferron-Brady, Yuehui Wu, PhD, Natalie Karpinich, Brandon Kremer, Arindam Dhar, MBBS,MDPhD, Gautam Borthakur, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1377.
https://doi.org/10.1182/blood.V130.Suppl_1.1377.1377
Published: 2017
Journal Articles

High Resolution Igh Repertoire Analysis Reveals the Human Fetal Liver As the Origin of Life-Long, Innate B Lymphopoiesis

Anindita Roy, MDPhD, Vojtech Bystry, Georg Bohn, Katerina Goudevenou, Tomas Reigl, Maria Papaioannou, Adam Krejci, Sorcha O'Byrne, Aristeidis Chaidos, Andrea Grioni, Nikos Darzentas, Irene Roberts, Anastasios Karadimitris
Journal: Blood
Blood (2016) 128 (22): 127.
https://doi.org/10.1182/blood.V128.22.127.127
Published: 2016