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David J. H. F. Knapp
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Journal Articles

The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML

Hanyang Lin, Katharina Rothe, Min Chen, Andrew Wu, Artem Babaian, Ryan Yen, Jonathan Zeng, Jens Ruschmann, Oleh I. Petriv, Kieran O'Neill, Tobias Maetzig, David J. H. F. Knapp, Naoto Nakamichi, Ryan Brinkman, Inanc Birol, Donna L. Forrest, Carl Hansen, R. Keith Humphries, Connie J. Eaves, Xiaoyan Jiang
Journal: Blood
Blood (2020) 136 (5): 596–609.
https://doi.org/10.1182/blood.2019003636
Published: 2020
Includes: Supplemental data
Journal Articles

Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy in humans and mice

Jennifer M. Grants, Joanna Wegrzyn, Tony Hui, Kieran O’Neill, Marion Shadbolt, David J. H. F. Knapp, Jeremy Parker, Yu Deng, Aparna Gopal, T. Roderick Docking, Megan Fuller, Jenny Li, Mark Boldin, Connie J. Eaves, Martin Hirst, Aly Karsan
Journal: Blood
Blood (2020) 135 (25): 2235–2251.
https://doi.org/10.1182/blood.2019003105
Published: 2020
Includes: Supplemental data
Journal Articles

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Sorcha O’Byrne, Natalina Elliott, Siobhan Rice, Gemma Buck, Nicholas Fordham, Catherine Garnett, Laura Godfrey, Nicholas T. Crump, Gary Wright, Sarah Inglott, Peng Hua, Bethan Psaila, Benjamin Povinelli, David J. H. F. Knapp, Antonio Agraz-Doblas, Clara Bueno, Ignacio Varela, Phillip Bennett, Hashem Koohy, Suzanne M. Watt, Anastasios Karadimitris, Adam J. Mead, Phillip Ancliff, Paresh Vyas, Pablo Menendez, Thomas A. Milne, Irene Roberts, Anindita Roy
Journal: Blood
Blood (2019) 134 (13): 1059–1071.
https://doi.org/10.1182/blood.2019001289
Published: 2019
Includes: Supplemental data
Journal Articles

A topological view of human CD34 + cell state trajectories from integrated single-cell output and proteomic data

David J. H. F. Knapp, Colin A. Hammond, Fangwu Wang, Nima Aghaeepour, Paul H. Miller, Philip A. Beer, Davide Pellacani, Michael VanInsberghe, Carl Hansen, Sean C. Bendall, Garry P. Nolan, Connie J. Eaves
Journal: Blood
Blood (2019) 133 (9): 927–939.
https://doi.org/10.1182/blood-2018-10-878025
Published: 2019
Includes: Supplemental data
Journal Articles

Distinct signaling programs control human hematopoietic stem cell survival and proliferation

David J. H. F. Knapp, Colin A. Hammond, Nima Aghaeepour, Paul H. Miller, Davide Pellacani, Philip A. Beer, Karen Sachs, Wenlian Qiao, WeiJia Wang, R. Keith Humphries, Guy Sauvageau, Peter W. Zandstra, Sean C. Bendall, Garry P. Nolan, Carl Hansen, Connie J. Eaves
Journal: Blood
Blood (2017) 129 (3): 307–318.
https://doi.org/10.1182/blood-2016-09-740654
Published: 2017
Includes: Supplemental data
Journal Articles

Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression

Philip A. Beer, David J. H. F. Knapp, Paul H. Miller, Nagarajan Kannan, Ivan Sloma, Kathy Heel, Sonja Babovic, Elizabeth Bulaeva, Gabrielle Rabu, Jefferson Terry, Brian J. Druker, Marc M. Loriaux, Keith R. Loeb, Jerald P. Radich, Wendy N. Erber, Connie J. Eaves
Journal: Blood
Blood (2015) 125 (3): 504–515.
https://doi.org/10.1182/blood-2014-06-581173
Published: 2015
Includes: Supplemental data
Journal Articles

Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice

Alice M. S. Cheung, Long V. Nguyen, Annaick Carles, Philip Beer, Paul H. Miller, David J. H. F. Knapp, Kiran Dhillon, Martin Hirst, Connie J. Eaves
Journal: Blood
Blood (2013) 122 (18): 3129–3137.
https://doi.org/10.1182/blood-2013-06-508432
Published: 2013
Includes: Supplemental data
Journal Articles

Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors

e-blood
Paul H. Miller, Alice M. S. Cheung, Philip A. Beer, David J. H. F. Knapp, Kiran Dhillon, Gabrielle Rabu, Shabnam Rostamirad, R. Keith Humphries, Connie J. Eaves
Journal: Blood
Blood (2013) 121 (5): e1–e4.
https://doi.org/10.1182/blood-2012-09-456566
Published: 2013
Includes: Supplemental data