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Journal Articles

KMT2C Mutations Co-Operate with KMT2A-MLLT1 Fusion to Inhibit Hematopoietic Differentiation in a Zebrafish Model of Infant Leukemia

Sarada Ketharnathan, Keon Collett, Anna Pawelko, Benno Orr, Sergey V Prykhozhij, Martin Hirst, Jason N. Berman

Blood (2024) 144 (Supplement 1): 1342.

https://doi.org/10.1182/blood-2024-211039

Published: 2024

Journal Articles

Single-Cell Revelation of Extensive Heterogeneity in the Human Lymphocyte and Neutrophil/Monocyte Lineage Restriction Process Despite Highly Co-Regulated Changes in Cell Cycle Control

Fangwu Wang, Laura Gonzalez, Martin Hirst, Benjamin D. Simons, Connie J. Eaves

Blood (2023) 142 (Supplement 1): 5581.

https://doi.org/10.1182/blood-2023-190863

Published: 2023

Journal Articles

MYCN Is Required in Immature T-ALL and Bears Epigenetic Marks Associated with Cell Identity

Gabriela Cristina Segat, Ann Chong Sun, Alice C Zhu, Marissa Foo, Claudia V Barreto Rodriguez, Rachel Wong, Samuel Gusscott, Martin Hirst, Andrew P. Weng

Blood (2022) 140 (Supplement 1): 8752–8753.

https://doi.org/10.1182/blood-2022-167375

Published: 2022

Journal Articles

DNMT3A Limits Myeloid Signaling Responses in Committed T Cells during Normal and Leukemic Development

Rachel Wong, Samuel Gusscott, Gabriela Cristina Segat, Annaick Carles, Reanne Bowlby, Martin Hirst, Andrew P. Weng

Blood (2022) 140 (Supplement 1): 5914.

https://doi.org/10.1182/blood-2022-171228

Published: 2022

Journal Articles

Single-Cell Profiling Reveals Clinically Relevant Evolutionary Trajectories and Alternate Biologies in Human Follicular Lymphoma

Blood (2021) 138 (Supplement 1): 450.

https://doi.org/10.1182/blood-2021-153237

Published: 2021

Journal Articles

Elucidating the Importance and Regulation of Key Enhancers for Human MEIS1 Expression

Xining Yang, Ping Xiang, Leo Escano, Ishpreet Dhillon, Edith Schneider, Jack Clemans-Gibbon, Wei Wei, Jasper Wong, Simon Xufeng Wang, Gregg Morin, Pamela A Hoodless, Martin Hirst, Aly Karsan, Florian Kuchenbauer, R. Keith Humphries, Arefeh Rouhi

Blood (2021) 138 (Supplement 1): 3302.

https://doi.org/10.1182/blood-2021-151467

Published: 2021

Journal Articles

MYC-induced human acute myeloid leukemia requires a continuing IL-3/GM-CSF costimulus

Elizabeth Bulaeva, Davide Pellacani, Naoto Nakamichi, Colin A. Hammond, Philip A. Beer, Alireza Lorzadeh, Michelle Moksa, Annaïck Carles, Misha Bilenky, Sylvain Lefort, Jeremy Shu, Brian T. Wilhelm, Andrew P. Weng, Martin Hirst, Connie J. Eaves

Blood (2020) 136 (24): 2764–2773.

https://doi.org/10.1182/blood.2020006374

Published: 2020

Includes: Supplemental data

Journal Articles

Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy in humans and mice

Jennifer M. Grants, Joanna Wegrzyn, Tony Hui, Kieran O’Neill, Marion Shadbolt, David J. H. F. Knapp, Jeremy Parker, Yu Deng, Aparna Gopal, T. Roderick Docking, Megan Fuller, Jenny Li, Mark Boldin, Connie J. Eaves, Martin Hirst, Aly Karsan

Blood (2020) 135 (25): 2235–2251.

https://doi.org/10.1182/blood.2019003105

Published: 2020

Includes: Supplemental data

Journal Articles

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

Ivan Sloma, PharmD, PhD, Philip Beer, PhD FRCPath, MRCP, Christophe Desterke, PhD, Elizabeth Bulaeva, Misha Bilenky, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G Turhan, MD PhD, Orianne Wagner-Ballon, MD PhD, Philippe Gaulard, MD PhD, R. Keith Humphries, MD PhD, Martin Hirst, PhD BS, Connie J. Eaves, PhD

Blood (2019) 134 (Supplement_1): 4139.

https://doi.org/10.1182/blood-2019-127839

Published: 2019

Journal Articles

Growth Factor-Dependent Activation of a MYC-Induced Latent AML Program in Human Hematopoietic Cells

Elizabeth Bulaeva, Davide Pellacani, PhD, Naoto Nakamichi, MD PhD, Philip Beer, MD PhD, Colin Hammond, Alireza Lorzadeh, Michelle Moksa, Annaick Carles, Misha Bilenky, Sylvain Lefort, PhD, Jeremy Shu, Brian T. Wilhelm, PhDBSc, Andrew P. Weng, MD PhD, Martin Hirst, PhD, Connie J. Eaves, PhD

Blood (2019) 134 (Supplement_1): 2533.

https://doi.org/10.1182/blood-2019-122768

Published: 2019

Journal Articles

Synthetic De Novo Modeling of Human T-Cell Acute Lymphoblastic Leukemia Reveals HOXB Genes Drive Expansion of Leukemia Cells-of-Origin and Established Tumor Clones

Blood (2018) 132 (Supplement 1): 1322.

https://doi.org/10.1182/blood-2018-99-120120

Published: 2018

Journal Articles

Single Cell-Resolution Analysis of HSC Dysfunction in Mir-146a knockout Mice

Jennifer Grants, PhD, Joanna Wegrzyn, PhD, David Knapp, PhD, Tony Hui, Kieran O'Neill, PhD, Jeremy Parker, PhD, Deborah Deng, Mark Boldin, PhD, Martin Hirst, PhD, Connie J. Eaves, PhD, Aly Karsan, MD

Blood (2017) 130 (Supplement 1): 714.

https://doi.org/10.1182/blood.V130.Suppl_1.714.714

Published: 2017

Journal Articles

NOTCH1 Induces Differential Epigenomic Patterning and Genomic Organization in Fetal Liver- and Adult Bone Marrow-Derived Hematopoietic Progentiors

Vincenzo Giambra, PhD, Sonya H Lam, Miriam Belmonte, Sam Gusscott, Sohrab Salehi, Fong Chun Chan, Robert Kridel, MD MPH, Alireza Lorzadeh, Catherine Hoofd, PhD, Christian Steidl, MD, Connie J. Eaves, PhD, Martin Hirst, PhD, Andrew P. Weng, MD PhD

Blood (2015) 126 (23): 3637.

https://doi.org/10.1182/blood.V126.23.3637.3637

Published: 2015

Journal Articles

Preclinical Determination of the Efficacy of Epigenetic Therapy in High Risk Myeloid Disease Using the Zebrafish Model

Adam Deveau, BSc, MSc, Alexander Michael Forrester, BSc, PhD, Andrew J Coombs, BScH, Gretchen S Wagner, BScH, Clemens Grabher, PhD, Ian Chute, MSc, Daniel Leger, MSc, Stephen Lewis, PhD, Matthew Mingay, BSc, Martin Hirst, PhD, A. Thomas Look, MD, Jason N. Berman, MD

Blood (2014) 124 (21): 436.

https://doi.org/10.1182/blood.V124.21.436.436

Published: 2014

Journal Articles

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

Blood (2014) 123 (25): 3914–3924.

https://doi.org/10.1182/blood-2012-12-473439

Published: 2014

Includes: Supplemental data

Journal Articles

Characterization Of The Effects Of Mutated EZH2 On Expression and Epigenome In a Mouse Lymphoma Model

Blood (2013) 122 (21): 346.

https://doi.org/10.1182/blood.V122.21.346.346

Published: 2013

Journal Articles

Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice

Alice M. S. Cheung, Long V. Nguyen, Annaick Carles, Philip Beer, Paul H. Miller, David J. H. F. Knapp, Kiran Dhillon, Martin Hirst, Connie J. Eaves

Blood (2013) 122 (18): 3129–3137.

https://doi.org/10.1182/blood-2013-06-508432

Published: 2013

Includes: Supplemental data

Journal Articles

Time Course Studies of the Progeny of Barcoded CD34 + Human Cord Blood Cells Generated in Transplanted NOD/SCID-IL2Rγ −/− Mice Unveil the Clonal Dynamics of Short Term, Intermediate Term and Long Term Repopulating Cells

Alice M.S. Cheung, PhD, Long V. Nguyen, Annaick Carles, Paul H. Miller, Philip A Beer, BM, MRCP, MRCPath, Pawan Pandoh, David Knapp, Kiran Dhillon, Kane Tse, Thomas Zeng, Yongjun Zhao, Martin Hirst, Ph.D., Connie J. Eaves, PhD

Blood (2012) 120 (21): 28.

https://doi.org/10.1182/blood.V120.21.28.28

Published: 2012

Journal Articles

Identification and characterization of Hoxa9 binding sites in hematopoietic cells

Yongsheng Huang, Kajal Sitwala, Joel Bronstein, Daniel Sanders, Monisha Dandekar, Cailin Collins, Gordon Robertson, James MacDonald, Timothee Cezard, Misha Bilenky, Nina Thiessen, Yongjun Zhao, Thomas Zeng, Martin Hirst, Alfred Hero, Steven Jones, Jay L. Hess

Blood (2012) 119 (2): 388–398.

https://doi.org/10.1182/blood-2011-03-341081

Published: 2012

Includes: Supplemental data

Journal Articles

Novel Chromosomal Rearrangements and Sequence Mutations in High-Risk Ph-Like Acute Lymphoblastic Leukemia

Blood (2011) 118 (21): 67.

https://doi.org/10.1182/blood.V118.21.67.67

Published: 2011

NARROW

KMT2C Mutations Co-Operate with KMT2A-MLLT1 Fusion to Inhibit Hematopoietic Differentiation in a Zebrafish Model of Infant Leukemia

Single-Cell Revelation of Extensive Heterogeneity in the Human Lymphocyte and Neutrophil/Monocyte Lineage Restriction Process Despite Highly Co-Regulated Changes in Cell Cycle Control

MYCN Is Required in Immature T-ALL and Bears Epigenetic Marks Associated with Cell Identity

DNMT3A Limits Myeloid Signaling Responses in Committed T Cells during Normal and Leukemic Development

Single-Cell Profiling Reveals Clinically Relevant Evolutionary Trajectories and Alternate Biologies in Human Follicular Lymphoma

Elucidating the Importance and Regulation of Key Enhancers for Human MEIS1 Expression

MYC-induced human acute myeloid leukemia requires a continuing IL-3/GM-CSF costimulus

Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy in humans and mice

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

Growth Factor-Dependent Activation of a MYC-Induced Latent AML Program in Human Hematopoietic Cells

Synthetic De Novo Modeling of Human T-Cell Acute Lymphoblastic Leukemia Reveals HOXB Genes Drive Expansion of Leukemia Cells-of-Origin and Established Tumor Clones

Single Cell-Resolution Analysis of HSC Dysfunction in Mir-146a knockout Mice

NOTCH1 Induces Differential Epigenomic Patterning and Genomic Organization in Fetal Liver- and Adult Bone Marrow-Derived Hematopoietic Progentiors

Preclinical Determination of the Efficacy of Epigenetic Therapy in High Risk Myeloid Disease Using the Zebrafish Model

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

Characterization Of The Effects Of Mutated EZH2 On Expression and Epigenome In a Mouse Lymphoma Model

Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice

Time Course Studies of the Progeny of Barcoded CD34 + Human Cord Blood Cells Generated in Transplanted NOD/SCID-IL2Rγ −/− Mice Unveil the Clonal Dynamics of Short Term, Intermediate Term and Long Term Repopulating Cells

Identification and characterization of Hoxa9 binding sites in hematopoietic cells

Novel Chromosomal Rearrangements and Sequence Mutations in High-Risk Ph-Like Acute Lymphoblastic Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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