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Gerben Duns
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Journal Articles

CSF2RB Mutations Result in Cytokine-Dependent Gain-of-Function Phenotypes in Classic Hodgkin Lymphoma

Shinya Rai, Tomohiro Aoki, Gerben Duns, Aixiang Jiang, Andrew Lytle, Yifan Yin, Makoto Kishida, Michael Yu Li, Denise Smorra, Cecilia Lee, Katy Milne, Adele Telenius, Luke O'Brien, Katsuyoshi Takata, Tomoko Miyata-Takata, Merrill Boyle, Susana Ben-Neriah, Andrew P. Weng, Andrew Roth, Brad H NelsonH, Laura K. Hilton, Pedro Farinha, Kerry J. Savage, David W. Scott, Christian Steidl
Journal: Blood
Blood (2024) 144 (Supplement 1): 855.
https://doi.org/10.1182/blood-2024-199981
Published: 2024
Journal Articles

Multiomic Profiling Reveals Pleiotropic Effects of Somatic IRF4-C99R Mutations in Primary Mediastinal Large B-Cell Lymphomas

Shinya Rai, Gerben Duns, Fabian Frontzek, Jasper Wong, Yifan Yin, Shannon Healy, Michael Yu Li, Makoto Kishida, Elena Viganò, Manabu Fujisawa, Bruce Woolcock, Adele Telenius, Barbara Meissner, Merrill Boyle, Hisae Nakamura, Luke O'Brien, Andrew Lytle, Pedro Farinha, Graham W. Slack, Laura K. Hilton, Ryan Morin, Leandro Venturutti, Tomohiro Aoki, Kerry J. Savage, David W. Scott, Christian Steidl
Journal: Blood
Blood (2024) 144 (Supplement 1): 2966.
https://doi.org/10.1182/blood-2024-199227
Published: 2024
Journal Articles

Identification of a Novel Function of B2M Involving T-Cell Exhaustion Via P-Selectin Ligand Upregulation in Diffuse Large B-Cell Lymphoma

Katsuyoshi Takata, Hidekazu IIoka, Shuta Tomida, Yuting Liu, Shujiro Okuda, Hiroyuki Usuda, Takashi Kawasaki, Akihiro Kitadate, Naoto Takahashi, Gerben Duns, Yasuharu Sato, Christian Steidl, Daisuke Ennishi
Journal: Blood
Blood (2024) 144 (Supplement 1): 331.
https://doi.org/10.1182/blood-2024-202199
Published: 2024
Journal Articles

A CD5 Gene Signature Identifies Diffuse Large B-Cell Lymphomas Sensitive to Brutonʼs Tyrosine Kinase Inhibition

Alan Cooper, Sravya Tumuluru, Kyle Kissick, Girish Venkataraman, Joo Y Song, Andrew Lytle, Gerben Duns, Jovian Yu, Nikita Kotlov, Alexander Bagaev, Brendan Paul Hodkinson, Srimathi Srinivasan, Sonali M. Smith, David W. Scott, Christian Steidl, James Godfrey, Justin Kline
Journal: Blood
Blood (2023) 142 (Supplement 1): 851.
https://doi.org/10.1182/blood-2023-182390
Published: 2023
Journal Articles

Identification and Clinical Characterization of CNS Relapse in DLBCL Patients across 19 Prospective Phase 2 and 3 Trials - a GLA/ DSHNHL and LYSA Collaboration

Fabian Frontzek, Loïc Renaud, Ulrich Duehrsen, Viola Poeschel, Sophie Bernard, Loïc Chartier, Nicolas Ketterer, Christian Recher, Olivier Fitoussi, Gerhard Held, Rene-Olivier Casasnovas, Corinne Haioun, Nicolas Mounier, Hervé Tilly, Franck Morschhauser, Steven Le Gouill, Imke E. Karsten, Gerben Duns, Christian Steidl, David W. Scott, Wolfram Klapper, Andreas Rosenwald, German Ott, Thierry Jo Molina, Georg Lenz, Marita Ziepert, Bettina Altmann, Catherine Thieblemont, Norbert Schmitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 71.
https://doi.org/10.1182/blood-2023-178815
Published: 2023
Journal Articles

Multi-Dimensional Molecular and Tumor-Microenvironment Analysis of Classic Hodgkin Lymphoma

Tomohiro Aoki, Gerben Duns, Shinya Rai, Andrew Lytle, Yifan Yin, Clementine Sarkozy, Stacy Hung, Katy Milne, Adele Telenius, Luke O'Brien, Celia Strong, Talia Goodyear, Shaocheng Wu, Katsuyoshi Takata, Tomoko Miyata-Takata, Merrill Boyle, Susana Ben-Neriah, Andrew P. Weng, Andrew Roth, Anca Prica, Robert Kridel, Brad Nelson, Pedro Farinha, Kerry J. Savage, David W. Scott, Christian Steidl
Journal: Blood
Blood (2023) 142 (Supplement 1): 172.
https://doi.org/10.1182/blood-2023-174139
Published: 2023
Journal Articles

Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns

Kostiantyn Dreval, Laura K. Hilton, Manuela Cruz, Haya Shaalan, Susana Ben-Neriah, Merrill Boyle, Brett Collinge, Krysta M. Coyle, Gerben Duns, Pedro Farinha, Bruno M. Grande, Barbara Meissner, Prasath Pararajalingam, Christopher K. Rushton, Graham W. Slack, Jasper Wong, Andrew J. Mungall, Marco A. Marra, Joseph M. Connors, Christian Steidl, David W. Scott, Ryan D. Morin
Journal: Blood
Blood (2023) 142 (6): 561–573.
https://doi.org/10.1182/blood.2022018719
Published: 2023
Includes: Supplemental data
Journal Articles

Loss of FBXO11 Function Establishes a Stem Cell Program in Acute Myeloid Leukemia through Dysregulation of the Mitochondrial Protease LONP1

Angela Mo, Hayle Kincross, Xuan Wang, Linda Ya-Ting Chang, Gerben Duns, Harwood Kwan, Tammy Lau, Rod Docking, Se-Wing Grace Cheng, Shujun Huang, Nadia Gharaee, Elijah Willie, Jihong Jiang, Jeremy Parker, Josh Bridgers, Gregg Morin, Aly Karsan
Journal: Blood
Blood (2022) 140 (Supplement 1): 8688–8689.
https://doi.org/10.1182/blood-2022-170689
Published: 2022
Journal Articles

Constrained FL: A Genetically Distinct Subgroup of Follicular Lymphoma with Low Rates of Somatic Hypermutation and a Reduced Propensity for Histologic Transformation

Laura K Hilton, Kostiantyn Dreval, Shaghayegh Soudi, Susana Ben-Neriah, Manuela Cruz, Brett Collinge, Krysta M. Coyle, Bruno M. Grande, Gerben Duns, Christopher K Rushton, Merrill Boyle, Barbara Meissner, Pedro Farinha, Graham W Slack, Andrew J. Mungall, Marco A. Marra, Joseph M. Connors, Christian Steidl, David W. Scott, Ryan D Morin
Journal: Blood
Blood (2021) 138 (Supplement 1): 807.
https://doi.org/10.1182/blood-2021-153445
Published: 2021
Journal Articles

Transformation of Follicular Lymphoma into Primary Mediastinal B-Cell Lymphoma-like Large B-Cell Lymphoma

Tristan Loveday, Gerben Duns, Lisa M. Rimsza, Karen Rech, James R. Cook, Ryan S. Robetorye, Allison C. Rosenthal, Colleen Ramsower, Tameson Yip, Catherine McKinney, Steven H. Swerdlow, Shweta Bhavsar, Christian Steidl, Sarah E. Gibson
Journal: Blood
Blood (2021) 138 (Supplement 1): 4479.
https://doi.org/10.1182/blood-2021-144892
Published: 2021
Journal Articles

Elucidating the Mechanisms of Leukemogenesis Driven By FBXO11 Depletion

Angela Mo, Linda Ya-Ting Chang, Gerben Duns, Xuan Wang, Gregg Morin, Tammy Lau, Rod Docking, Shane Colborne, Se-Wing Grace Cheng, Shujun Huang, Hayle Kincross, Nadia Gharaee, Elijah Willie, Jihong Jiang, Jeremy Parker, Aly Karsan
Journal: Blood
Blood (2021) 138 (Supplement 1): 3328.
https://doi.org/10.1182/blood-2021-145384
Published: 2021
Journal Articles

Single-Cell Profiling Reveals Clinically Relevant Evolutionary Trajectories and Alternate Biologies in Human Follicular Lymphoma

Xuehai Wang, Michael Nissen, Deanne Gracias, Manabu Kusakabe, Guillermo Simkin, Gerben Duns, Clementine Sarkozy, Elizabeth Chavez, Gabriela Cristina Segat, Jubin Kim, Aixiang Jiang, Tomohiro Aoki, Rashedul Islam, Christina May, Stacy Hung, Kateryna Tyshchenko, Ryan Brinkman, Martin Hirst, Aly Karsan, Ciara L. Freeman, Laurie H. Sehn, Kerry J. Savage, Jeffrey W Craig, David W. Scott, Christian Steidl, Sohrab P Shah, Andrew P. Weng
Journal: Blood
Blood (2021) 138 (Supplement 1): 450.
https://doi.org/10.1182/blood-2021-153237
Published: 2021
Journal Articles

Integrative Genomic Analysis Uncovers Unique Diffuse Large B Cell Lymphoma (DLBCL) Immune Environments and Identifies Associations with Specific Oncogenic Alterations

Sravya Tumuluru, James Godfrey, Jovian Yu, Alan Cooper, Xiufen Chen, Gerben Duns, Sonali M. Smith, Christian Steidl, Justin Kline
Journal: Blood
Blood (2021) 138 (Supplement 1): 449.
https://doi.org/10.1182/blood-2021-153724
Published: 2021
Journal Articles

Characterization of DLBCL with a PMBL gene expression signature

Gerben Duns, Elena Viganò, Daisuke Ennishi, Clementine Sarkozy, Stacy S. Hung, Elizabeth Chavez, Katsuyoshi Takata, Christopher Rushton, Aixiang Jiang, Susana Ben-Neriah, Bruce W. Woolcock, Graham W. Slack, Eric D. Hsi, Jeffrey W. Craig, Laura K. Hilton, Sohrab P. Shah, Pedro Farinha, Anja Mottok, Randy D. Gascoyne, Ryan D. Morin, Kerry J. Savage, David W. Scott, Christian Steidl
Journal: Blood
Blood (2021) 138 (2): 136–148.
https://doi.org/10.1182/blood.2020007683
Published: 2021
Includes: Supplemental data
Journal Articles

Mutational landscape of gray zone lymphoma

Clémentine Sarkozy, Stacy S. Hung, Elizabeth A. Chavez, Gerben Duns, Katsuyoshi Takata, Lauren C. Chong, Tomohiro Aoki, Aixiang Jiang, Tomoko Miyata-Takata, Adèle Telenius, Graham W. Slack, Thierry Jo Molina, Susana Ben-Neriah, Pedro Farinha, Peggy Dartigues, Diane Damotte, Anja Mottok, Gilles A. Salles, Rene-Olivier Casasnovas, Kerry J. Savage, Camille Laurent, David W. Scott, Alexandra Traverse-Glehen, Christian Steidl
Journal: Blood
Blood (2021) 137 (13): 1765–1776.
https://doi.org/10.1182/blood.2020007507
Published: 2021
Includes: Supplemental data
Journal Articles

Mutational Landscape of Grey Zone Lymphoma

Clementine Sarkozy, MD, Stacy Hung, Katsuyoshi Takata, MD PhD, Elizabeth Chavez, BSc, Cg RT, Tomohiro Aoki, MD PhD, Gerben Duns, PhD, Graham W Slack, MD PhD, Adele Telenius, Tomoko Miyata-Takata, Elena Viganò, PhD, Thierry Jo Molina, MDPhD, Diane Damotte, MDPhD, Susana Ben-Neriah, BSc, Christiane Copie-Bergman, MD PhD, Camille Laurent, MD PhD, Anja Mottok, MD PhD, Gilles Salles, MD PhD, Kerry J Savage, BSc, MD MSc, David W. Scott, MBChB, PhD, Alexandra Traverse-Glehen, MD PhD, Christian Steidl, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 21.
https://doi.org/10.1182/blood-2019-127375
Published: 2019
Journal Articles

Diffuse Large B-Cell Lymphomas with a Molecular PMBCL Expression Signature Represent a Distinct Molecular Subtype Associated with Poor Clinical Outcome

Gerben Duns, PhD, Elena Viganò, PhD, Daisuke Ennishi, MD PhD, Clementine Sarkozy, MD, Stacy Hung, Elizabeth Chavez, Katsuyoshi Takata, MD PhD, Anja Mottok, MD PhD, Randy D. Gascoyne, MD, Ryan D. Morin, PhD, Kerry J Savage, BSc, MD MSc, David W. Scott, MBChB, PhD, Christian Steidl, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 922.
https://doi.org/10.1182/blood-2019-131450
Published: 2019
Journal Articles

Recurrent IL4R Somatic Mutations in Diffuse Large B-Cell Lymphoma Lead to an Altered Gene Expression Profile and Changes in Tumor Microenvironment Composition

Elena Viganò, PhD, Gerben Duns, PhD, Daisuke Ennishi, MDPhD, Randy D. Gascoyne, MD, Ryan D. Morin, PhDBSc,MSc, David W. Scott, PhDMD,FRACP,FRCPA, Christian Steidl, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 669.
https://doi.org/10.1182/blood-2018-99-110473
Published: 2018
Journal Articles

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 As a Therapeutic Target for Restoring MHC Expression in Diffuse Large B-Cell Lymphoma

Daisuke Ennishi, MDPhD, Katsuyoshi Takata, MD PhD, Wendy Béguelin, PhD, Gerben Duns, PhD, Anja Mottok, Pedro Farinha, MD PhD, Ali Bashashati, David Scott, Merrill Boyle, BSc, Barbara Meissner, PhD, Susana Ben-Neriah, BSc, Bruce W Woolcock, Adele Telenius, Daniel Lai, Matthew R Teater, PhD, Robert Kridel, PhD MD, Kerry J Savage, BSc, MD MSc, Laurie H Sehn, MD MPH, Ryan D. Morin, PhD BSc MSc, Marco A. Marra, PhD, Sohrab P Shah, Joseph M. Connors, MD, Randy D. Gascoyne, MD, David W. Scott, PhD MD FRACP FRCPA, Ari M Melnick, MD, Christian Steidl, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2018-99-112010
Published: 2018
Journal Articles

Contribution of Deregulated miRNAs to the Phenotypic Characteristic of Hodgkin Lymphoma.

Lu Ping Tan, BSc,MSc, Bart-Jan Kroesen, PhD, Enrico Tiacci, PhD, Gerben Duns, Erwin Seinen, Ody Sibon, PhD, Klaas Kok, PhD, Sibrand Poppema, MD, PhD, Anke Van Den Berg, PhD
Journal: Blood
Blood (2009) 114 (22): 265.
https://doi.org/10.1182/blood.V114.22.265.265
Published: 2009