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Karen Rech
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Journal Articles

Efficacy of frontline fixed duration chemotherapy in MAPK-pathway altered adult langerhans cell histiocytosis: A multi-institutional international retrospective study

Free
Carla Isabel Borre, Mia Poleksic, Grant Spears, Dongni Yi, XI Yang, Haadi Ali, Brinda H Shukla, Jacquelyn Fitzgerald, Muhammad Azeem Khan, Aishwarya Pradeep, Mitali Sen, Diana Morlote, Aditi Saha, Shuko Harada, N. Nora Bennani, Lucy Bailey, Matthew J Koster, Brittany Wade, Robert Vassallo, Aishwarya Ravindran, Muhamad Alhaj Moustafa, Jason Young, Julio Sartori Valinotti, Aldo Acosta Medina, Mithun Shah, William Tobin, Daniel Sokolowski, Lucinda Gruber, Long Chang, Surendra Dasari, Talal Hilal, Karen Rech, Thomas Witzig, Asra Ahmed, Aki Sato, Gaurav Goyal, Ronald Go, Xin-Xin Cao, Jithma Abeykoon
Journal: Blood
Blood (2025) 146 (Supplement 1): 2999.
https://doi.org/10.1182/blood-2025-2999
Published: 2025
Journal Articles

KRAS mutations in histiocytic neoplasms: Mutation spectrum and response to MEK inhibition

Free
Dongni Yi, Carla Isabel Borre, Mia Poleksic, Brinda H Shukla, Jacquelyn Fitzgerald, Muhammad Azeem Khan, Pradeep Bhambhvani, Mitali Sen, Diana Morlote, Aditi Saha, Lucy Bailey, Daniel Sokolowski, Ubenthira Patgunarajah, William Tobin, Jason Young, Julio Sartori Valinotti, Matthew J Koster, Aldo Acosta Medina, Mithun Shah, N. Nora Bennani, Muhamad Alhaj Moustafa, Talal Hilal, Robert Vassallo, Lucinda Gruber, Surendra Dasari, Karen Rech, Thomas Witzig, Aishwarya Ravindran, Gaurav Goyal, Ronald Go, Jithma Abeykoon
Journal: Blood
Blood (2025) 146 (Supplement 1): 6760.
https://doi.org/10.1182/blood-2025-6760
Published: 2025
Journal Articles

Evolving insights and changes in survival of erdheim-chester disease over time

Free
Mia Poleksic, Grant Spears, Carla Isabel Borre, Dongni Yi, Brinda H Shukla, Jacquelyn Fitzgerald, Muhammad Azeem Khan, Pradeep Bhambhvani, Mitali Sen, Diana Morlote, Aditi Saha, Lucy Bailey, Daniel Sokolowski, William Tobin, Jason Young, Julio Sartori Valinotti, Matthew J Koster, Aldo Acosta Medina, Mithun Shah, N. Nora Bennani, Muhamad Alhaj Moustafa, Talal Hilal, Robert Vassallo, Lucinda Gruber, Surendra Dasari, Karen Rech, Thomas Witzig, Aishwarya Ravindran, Ronald Go, Gaurav Goyal, Jithma Abeykoon
Journal: Blood
Blood (2025) 146 (Supplement 1): 2990.
https://doi.org/10.1182/blood-2025-2990
Published: 2025
Journal Articles

The molecular landscape of patients with malignant histiocytosis

Free
Alanis Rodriguez-Rosario, Jithma Abeykoon, N. Nora Bennani, Karen Rech, Mithun Shah, Aishwarya Ravindran, Aldo Acosta Medina, Gordon Ruan, Dongni Yi, Saurabh Zanwar, Gaurav Goyal, Ronald Go
Journal: Blood
Blood (2025) 146 (Supplement 1): 7335.
https://doi.org/10.1182/blood-2025-7335
Published: 2025
Journal Articles

Mutational landscape of adult xanthogranuloma

Free
Muhammad Azeem Khan, Karen Rech, Dongni Yi, Carla Isabel Borre, Mia Poleksic, William Tobin, Jason Young, Julio Sartori Valinotti, Matthew J Koster, Aldo Acosta Medina, Mithun Shah, N. Nora Bennani, Muhamad Alhaj Moustafa, Talal Hilal, Robert Vassallo, Lucinda Gruber, Surendra Dasari, Thomas Witzig, Aishwarya Ravindran, Gaurav Goyal, Ronald Go, Jithma Abeykoon
Journal: Blood
Blood (2025) 146 (Supplement 1): 7339.
https://doi.org/10.1182/blood-2025-7339
Published: 2025
Journal Articles

BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Free
Clinical Trials & Observations
Aldo A. Acosta-Medina, Paul G. Kemps, Timo C. E. Zondag, Jithma P. Abeykoon, Jelske Forma-Borst, Eline C. Steenwijk, Elizabeth A. M. Feijen, Jop C. Teepen, N. Nora Bennani, Susan M. Schram, Mithun V. Shah, Caroline Davidge-Pitts, Matthew J. Koster, Jay H. Ryu, Robert Vassallo, W. Oliver Tobin, Jason R. Young, Surendra Dasari, Karen Rech, Aishwarya Ravindran, Arjen H. G. Cleven, Robert M. Verdijk, Carel J. M. van Noesel, Brian V. Balgobind, Gerrit Joan Bouma, Peerooz Saeed, Jos A. M. Bramer, Ruben A. L. de Groen, Joost S. P. Vermaat, Michiel A. J. van de Sande, Egbert F. Smit, Anton W. Langerak, Tom van Wezel, Sanne H. Tonino, Cor van den Bos, Jan A. M. van Laar, Ronald S. Go, Gaurav Goyal, Astrid G. S. van Halteren
Journal: Blood
Blood (2023) 142 (18): 1570–1575.
https://doi.org/10.1182/blood.2023021212
Published: 2023
Includes: Supplemental data
Journal Articles

Efficacy of MEK Inhibitors in Erdheim Chester Disease

Free
Aldo A. Acosta Medina, Saurabh Zanwar, Gordon Ruan, Jithma P. Abeykoon, Karen Rech, Aishwarya Ravindran, N. Nora Bennani, Caroline J Davidge-Pitts, Matthew Koster, Jay Ryu, Mithun V. Shah, W. Oliver Tobin, Robert Vassallo, Jason R. Young, Gaurav Goyal, Ronald Go
Journal: Blood
Blood (2022) 140 (Supplement 1): 9733–9734.
https://doi.org/10.1182/blood-2022-163674
Published: 2022
Journal Articles

High Prevalence of Epigenetic Mutations in Histiocytic and Dendritic Cell Disorders: Results from Molecular Analysis of a Large Cohort from Histiocytosis Working Group

Free
Gaurav Goyal, Jithma P. Abeykoon, Aldo A. Acosta Medina, Karen Rech, Saurabh Zanwar, Aishwarya Ravindran, Gordon Ruan, Matthew Koster, W. Oliver Tobin, Robert Vassallo, Jay Ryu, N. Nora Bennani, Mithun V. Shah, Liuyan Jiang, Lucinda Gruber, Caroline J Davidge-Pitts, Xiaosheng Wu, Jason R. Young, Colton M McNinch, Ronald Go, Surendra Dasari
Journal: Blood
Blood (2022) 140 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2022-162855
Published: 2022
Journal Articles

Gastrointestinal Manifestation of Langerhans Cell Histiocytosis

Free
Yuan Yao, Saurabh Zanwar, Aldo A. Acosta Medina, Gordon Ruan, Jithma P. Abeykoon, Jason R. Young, Karen Rech, Aishwarya Ravindran, Ronald Go
Journal: Blood
Blood (2022) 140 (Supplement 1): 12259–12260.
https://doi.org/10.1182/blood-2022-165511
Published: 2022
Journal Articles

Mutational Profiling of Rosai-Dorfman Disease and Association with Phenotype: A Multi-Institutional Study

Free
Gordon Ruan, Jithma P. Abeykoon, Aldo A. Acosta Medina, Saurabh Zanwar, Aishwarya Ravindran, Karen Rech, Jason R. Young, Jay Ryu, Matthew Koster, W. Oliver Tobin, Mithun V. Shah, N. Nora Bennani, Robert Vassallo, Baylie Brooks, Ginny-Tyler Meadows, Abby McCrory, Diana Morlote, Gaurav Goyal, Ronald Go
Journal: Blood
Blood (2022) 140 (Supplement 1): 3995–3996.
https://doi.org/10.1182/blood-2022-159714
Published: 2022
Journal Articles

BRAF Fusions in Histiocytic Disorders: Frequency and Clinical Characteristics

Free
Saurabh Zanwar, Jithma P. Abeykoon, Aldo A. Acosta-Medina, Aishwarya Ravindran, Karen Rech, Jonathan Schwartz, Nora Bennani, Mithun V. Shah, Diana Morlote, Gaurav Goyal, Ronald Go
Journal: Blood
Blood (2021) 138 (Supplement 1): 2582.
https://doi.org/10.1182/blood-2021-149802
Published: 2021
Journal Articles

Classical and Non-Classical Phenotypes of Erdheim-Chester Disease: Correlating Clinical, Radiographic, and Genotypic Findings

Free
Antonious Z. Hazim, Gordon Ruan, Aldo A. Acosta-Medina, Jithma P. Abeykoon, Aishwarya Ravindran, Robert Vassallo, Jay Ryu, W. Oliver Tobin, Matthew Koster, N Nora Bennani, Karen Rech, Mithun V. Shah, Jason R. Young, Gaurav Goyal, Ronald Go
Journal: Blood
Blood (2021) 138 (Supplement 1): 2566.
https://doi.org/10.1182/blood-2021-144786
Published: 2021
Journal Articles

Efficacy of Cobimetinib in Rosai-Dorfman Disease

Free
Jithma P. Abeykoon, Karen Rech, Aishwarya Ravindran, Aldo A. Acosta-Medina, Saurabh Zanwar, Jason R. Young, W. Oliver Tobin, Mithun V. Shah, Nora Bennani, Robert Vassallo, Jay Ryu, Matthew Koster, Caroline J Davidge-Pitts, Gaurav Goyal, Ronald Go
Journal: Blood
Blood (2021) 138 (Supplement 1): 1506.
https://doi.org/10.1182/blood-2021-149912
Published: 2021
Journal Articles

Transformation of Follicular Lymphoma into Primary Mediastinal B-Cell Lymphoma-like Large B-Cell Lymphoma

Free
Tristan Loveday, Gerben Duns, Lisa M. Rimsza, Karen Rech, James R. Cook, Ryan S. Robetorye, Allison C. Rosenthal, Colleen Ramsower, Tameson Yip, Catherine McKinney, Steven H. Swerdlow, Shweta Bhavsar, Christian Steidl, Sarah E. Gibson
Journal: Blood
Blood (2021) 138 (Supplement 1): 4479.
https://doi.org/10.1182/blood-2021-144892
Published: 2021
Journal Articles

Tumor Mutational Burden in Histiocytic Neoplasms

Free
Aldo A. Acosta-Medina, Jithma P. Abeykoon, Surendra Dasari, Antonious Z. Hazim, N. Nora Bennani, Terra Lasho, Aishwarya Ravindran, Karen Rech, Mithun V. Shah, Gaurav Goyal, Ronald Go
Journal: Blood
Blood (2021) 138 (Supplement 1): 3634.
https://doi.org/10.1182/blood-2021-153128
Published: 2021
Journal Articles

Striking Association of Lymphoid Enhancing Factor (LEF1) Overexpression and DUSP22 rearrangements in Anaplastic Large Cell Lymphoma

Free
Aishwarya Ravindran, MBBS, Andrew L. Feldman, MD, Rhett P. Ketterling, MD, Surendra Dasari, PhD, Karen Rech, MD, Ellen D. McPhail, MD, Paul J Kurtin, MD, Min Shi, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-134547
Published: 2020
Journal Articles

Identification of a Novel Role for PD-1 Signaling in Promotion Tumor Proliferation in B-Cell Lymphoma

Free
Sutapa Sinha, PhD, Wei Ding, MD PhD, Tammy Price-Troska, BS, Reona Sakemura, MDPhD, Shulan Tian, MS, PhD, Charla R. Secreto, Xiaosheng Wu, MD, Timothy G. Call, MD, Rong He, MD, Sameer A. Parikh, MD, Yucai Wang, MDPhD, Jose F. Leis, MD PhD, Huihuang Yan, PhD, Karen Rech, MD, Amber B. Koehler, PA-C, MS, Daniel L. Van Dyke, PhD, Minetta C. Liu, MD, Susan L. Slager, PhD, Esteban Braggio, PhD, Stephen M. Ansell, MD PhD, Saad S. Kenderian, MB, ChB, Neil E. Kay, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–12.
https://doi.org/10.1182/blood-2020-136550
Published: 2020
Journal Articles

The Role of Staging Evaluation at Initial Diagnosis of Adult Patients with Clinically Isolated Pulmonary Langerhans Cell Histiocytosis

Free
Antonious Hazim, Gordon Ruan, MD, Aishwarya Ravindran, MBBS, Jithma P. Abeykoon, MD, Caleb J Scheckel, DO, Robert Vassallo, MD, Jay Ryu, MD, W. Oliver Tobin, MB BCh, Matthew Koster, MD, Nabila Bennani, MD, Karen Rech, MD, Jason R Young, MD, Mithun Vinod Shah, MD PhD, Gaurav Goyal, MD, Ronald S. Go, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45.
https://doi.org/10.1182/blood-2020-136861
Published: 2020
Journal Articles

Low-Dose BRAF-Inhibitors in the Treatment of Histiocytic Disorders with the BRAF-V600E Mutation

Free
Gordon Ruan, MD, Gaurav Goyal, MBBS, Jithma P. Abeykoon, MD, N. Nora Bennani, MD, Karen Rech, MD, Jason Young, MD, Mithun Vinod Shah, MD PhD, Ronald S. Go, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5895.
https://doi.org/10.1182/blood-2019-124891
Published: 2019
Journal Articles

Clinical Features and Outcomes of Unifocal Adult Langerhans Cell Histiocytosis

Free
Marie Hu, MD, Gaurav Goyal, MBBS, Jason Young, MD, Karen Rech, MD, N. Nora Bennani, MD, Mithun Vinod Shah, MD PhD, Robert Vassallo, MD, Jay H Ryu, MD, Ronald S. Go, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1667.
https://doi.org/10.1182/blood-2019-132104
Published: 2019