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Journal Articles

Spen loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and TLR pathway therapeutic vulnerabilities

Free
Benedikt Pelzer, Cem Meydan, Isaac Spiegel, Ioannis Karagiannidis, Min Xia, Matthew Teater, Emma Welter, Zowie Searcy, Laura Hilton, Darko Barisic, Pengyan Fa, Shenon Sethi, Irem Isgor, Jessie Fielding, Alireza Karbalyhareh, Colin Burdette, Sravya Tumuluru, Sonia Debek, Sunjae Lee, Ramon Massoni-Badosa, Ceyda Durmaz, Eralda Salataj, Prasath Pararajalingam, Zhengming Chen, Richard Pelzl, Sanket Shah, Martin Rivas, Kenneth Hoehn, Coraline Mlynarczyk, Hannah Isles, Ahmet Dogan, Kojo Elenitoba-Johnson, David Scott, Kostiantyn Dreval, Ryan Morin, Christina Leslie, Rishi Puri, Jacob Geri, Christopher Chin, Amy Chadburn, Christopher Mason, Hans Christian Reinhardt, Montserrat Anguera, Wendy Béguelin, Leandro Venturutti, Ari Melnick
Journal: Blood
Blood (2025) 146 (Supplement 1): 140.
https://doi.org/10.1182/blood-2025-140
Published: 2025
Journal Articles

Sasp-driven immune evasion defines a novel African ancestry-associated DLBCL subtype with distinctive molecular and immune vulnerabilities

Free
Sanket Shah, Meng Li, Michelle Lee, Matthew Teater, Kumudha Balakrishnan, Vishal Sahu, Vignesh Shanmugam, Sunjae Lee, Isabella Kong, Ioannis Karagiannidis, Tania Sainz, Wilfred Leung, Andrea Orlando, Jongkuen Lee, Benedikt Pelzer, Dejauwne Young, Sravya Tumuluru, David Jaye, Mohamed Moustafa, Deniz Peker, Yusuke Isshiki, Daniela Magliulo, Hao Shen, Piali Mukherjee, Anthony Santella, Maneeza Bilal, Pengyan Fa, Lisa Roth, Giorgio Inghirami, Victoria Alagiozian-Angelova, Leandro Cerchietti, Simone Sidoli, Paul Rubinstein, Roberta Zappasodi, Wendy Béguelin, Yuri Fedoriw, Francisco Vega, Jean Koff, Christopher Flowers, Ari Melnick
Journal: Blood
Blood (2025) 146 (Supplement 1): 3.
https://doi.org/10.1182/blood-2025-3
Published: 2025
Journal Articles

Transcriptional profiling refines DLBCL classification and identifies subtypes with distinct therapeutic vulnerabilities

Free
James Godfrey, Sravya Tumuluru, Alan Cooper, Gilles Salles, Marek Trneny, Georg Lenz, Franck Morschhauser, Fabrice Jardin, Will Harris, Sandhya Balasubramanian, Matthew Sugidono, Connie Lee Batlevi, Yanwen Jiang, Justin Kline, Alex Herrera
Journal: Blood
Blood (2025) 146 (Supplement 1): 49.
https://doi.org/10.1182/blood-2025-49
Published: 2025
Journal Articles

Integrative genomic analysis of DLBCL identifies immune environments associated with bispecific antibody response

Open Access
Sravya Tumuluru, James K. Godfrey, Alan Cooper, Jovian Yu, Xiufen Chen, Brendan W. MacNabb, Girish Venkataraman, Yuanyuan Zha, Benedikt Pelzer, Joo Song, Gerben Duns, Brian J. Sworder, Sandeep Raj, Christopher Bolen, Elicia Penuel, Ekaterina Postovalova, Nikita Kotlov, Aleksander Bagaev, Nathan Fowler, Roni Shouval, Sonali M. Smith, Ash A. Alizadeh, Christian Steidl, Justin Kline
Journal: Blood
Blood (2025) 145 (21): 2460–2472.
https://doi.org/10.1182/blood.2024025355
Published: 2025
Includes: Supplemental data
Journal Articles

A CD5 Gene Signature Identifies Diffuse Large B-Cell Lymphomas Sensitive to Brutonʼs Tyrosine Kinase Inhibition

Free
Alan Cooper, Sravya Tumuluru, Kyle Kissick, Girish Venkataraman, Joo Y Song, Andrew Lytle, Gerben Duns, Jovian Yu, Nikita Kotlov, Alexander Bagaev, Brendan Paul Hodkinson, Srimathi Srinivasan, Sonali M. Smith, David W. Scott, Christian Steidl, James Godfrey, Justin Kline
Journal: Blood
Blood (2023) 142 (Supplement 1): 851.
https://doi.org/10.1182/blood-2023-182390
Published: 2023
Journal Articles

Integrative Genomic Analysis Uncovers Unique Diffuse Large B Cell Lymphoma (DLBCL) Immune Environments and Identifies Associations with Specific Oncogenic Alterations

Free
Sravya Tumuluru, James Godfrey, Jovian Yu, Alan Cooper, Xiufen Chen, Gerben Duns, Sonali M. Smith, Christian Steidl, Justin Kline
Journal: Blood
Blood (2021) 138 (Supplement 1): 449.
https://doi.org/10.1182/blood-2021-153724
Published: 2021
Journal Articles

Integrative Immunogenomic Characterization of Diffuse Large B-Cell Lymphoma (DLBCL) Identifies Four Molecular Subtypes with Distinct Immune Landscapes

Free
Michael Leukam, MDMS, James Godfrey, MD, Sravya Tumuluru, Girish Venkataraman, MD MBBS, Sonali M. Smith, MD, Riyue Bao, PhD, Justin Kline, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 924.
https://doi.org/10.1182/blood-2019-131562
Published: 2019
Journal Articles

PD-L1 gene alterations identify a subset of diffuse large B-cell lymphoma harboring a T-cell–inflamed phenotype

Free
James Godfrey, Sravya Tumuluru, Riyue Bao, Michael Leukam, Girish Venkataraman, John Phillip, Carrie Fitzpatrick, James McElherne, Brendan W. MacNabb, Robert Orlowski, Sonali M. Smith, Justin Kline
Journal: Blood
Blood (2019) 133 (21): 2279–2290.
https://doi.org/10.1182/blood-2018-10-879015
Published: 2019
Includes: Supplemental data
Journal Articles

PD-L1 Gene Alterations Identify a Unique Subset of Diffuse Large B Cell Lymphoma That Harbors a T Cell Inflamed Phenotype

Free
Justin Kline, MD, James Godfrey, MD, Sravya Tumuluru, Girish Venkataraman, MD MBBS, Robert J Orlowski, MD, Sonali M. Smith, MD, Riyue Bao, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 673.
https://doi.org/10.1182/blood-2018-99-117189
Published: 2018