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Journal Articles

Transcriptional control of leukemogenesis by the chromatin reader SGF29

Blood (2024) 143 (8): 697–712.

https://doi.org/10.1182/blood.2023021234

Published: 2024

Includes: Supplemental data

Journal Articles

Meis1 Establishes the Pre-Hemogenic Endothelial State Prior to Runx1 Expression

Grace Cole, Patrick Coulombe, Amanda Fentiman, Jeremy Parker, Eric Yung, Lemlem Degefie, Patrick Lac, Maggie Ling, Derek Tam, R. Keith Humphries, Aly Karsan

Blood (2022) 140 (Supplement 1): 2857–2858.

https://doi.org/10.1182/blood-2022-170397

Published: 2022

Journal Articles

Elucidating the Importance and Regulation of Key Enhancers for Human MEIS1 Expression

Xining Yang, Ping Xiang, Leo Escano, Ishpreet Dhillon, Edith Schneider, Jack Clemans-Gibbon, Wei Wei, Jasper Wong, Simon Xufeng Wang, Gregg Morin, Pamela A Hoodless, Martin Hirst, Aly Karsan, Florian Kuchenbauer, R. Keith Humphries, Arefeh Rouhi

Blood (2021) 138 (Supplement 1): 3302.

https://doi.org/10.1182/blood-2021-151467

Published: 2021

Journal Articles

High-Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of Hox/Meis Gene Expression in Acute Myeloid Leukemia

Karina Barbosa, BSc, Anagha Deshpande, PhD, Ping Xiang, PhD, Bo-Rui Chen, PhD, Adam Brown, MSc, Neil Robertson, Younguk Sun, PhD, John Doench, PhD, Peter D Adams, PhD, R. Keith Humphries, MD PhD, Prashant Mali, PhD, Aniruddha J. Deshpande, PhD

Blood (2020) 136 (Supplement 1): 2–3.

https://doi.org/10.1182/blood-2020-141412

Published: 2020

Journal Articles

The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML

Blood (2020) 136 (5): 596–609.

https://doi.org/10.1182/blood.2019003636

Published: 2020

Includes: Supplemental data

Journal Articles

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

Ivan Sloma, PharmD, PhD, Philip Beer, PhD FRCPath, MRCP, Christophe Desterke, PhD, Elizabeth Bulaeva, Misha Bilenky, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G Turhan, MD PhD, Orianne Wagner-Ballon, MD PhD, Philippe Gaulard, MD PhD, R. Keith Humphries, MD PhD, Martin Hirst, PhD BS, Connie J. Eaves, PhD

Blood (2019) 134 (Supplement_1): 4139.

https://doi.org/10.1182/blood-2019-127839

Published: 2019

Journal Articles

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

Blood (2019) 134 (3): 263–276.

https://doi.org/10.1182/blood.2018862383

Published: 2019

Includes: Supplemental data

Journal Articles

MiR-193a Is a Negative Regulator of Hematopoietic Stem Cells and Promotes Anti-Leukemic Effects in Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 2627.

https://doi.org/10.1182/blood-2018-99-116256

Published: 2018

Journal Articles

Global Transcriptome Profiling Identifies a Key Mir-185-PAK6 Axis That Promotes Survival of Leukemic Stem Cells and Drug-Insensitive Blasts in BCR-ABL + Human Leukemia

Andrew Wu, BSc, Lin Hanyang, PhD, Katharina Rothe, PhD, Min Chen, MD PhD, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, MD, David Knapp, PhD, Naoto Nakamichi, MD PhD, Ryan Brinkman, PhD, Inanc Birol, PhD, Donna L Forrest, MD, Carl Hansen, PhD, R. Keith Humphries, MD PhD, Connie J. Eaves, PhD, Xiaoyan Jiang, MD PhD

Blood (2018) 132 (Supplement 1): 931.

https://doi.org/10.1182/blood-2018-99-113559

Published: 2018

Journal Articles

Synthetic De Novo Modeling of Human T-Cell Acute Lymphoblastic Leukemia Reveals HOXB Genes Drive Expansion of Leukemia Cells-of-Origin and Established Tumor Clones

Blood (2018) 132 (Supplement 1): 1322.

https://doi.org/10.1182/blood-2018-99-120120

Published: 2018

Journal Articles

Serially Transplantable Patient-Derived Xenograft Model of Chronic Myelomonocytic Leukemia (CMML)

Arnold Kloos, PhD, Felicitas Thol, MD, Lina Winckler, Razif Gabdoulline, PhD, Konstantinos Mintzas, Nidhi Jyotsana, PhD, Renate Schottmann, Felix F. Adams, Adrian Schwarzer, MD PhD, Dirk Heckl, PhD, Suzan Imren, MD, R. Keith Humphries, Arnold Ganser, MD, Michael Heuser, MD

Blood (2017) 130 (Supplement 1): 4236.

https://doi.org/10.1182/blood.V130.Suppl_1.4236.4236

Published: 2017

Journal Articles

Distinct signaling programs control human hematopoietic stem cell survival and proliferation

David J. H. F. Knapp, Colin A. Hammond, Nima Aghaeepour, Paul H. Miller, Davide Pellacani, Philip A. Beer, Karen Sachs, Wenlian Qiao, WeiJia Wang, R. Keith Humphries, Guy Sauvageau, Peter W. Zandstra, Sean C. Bendall, Garry P. Nolan, Carl Hansen, Connie J. Eaves

Blood (2017) 129 (3): 307–318.

https://doi.org/10.1182/blood-2016-09-740654

Published: 2017

Includes: Supplemental data

Journal Articles

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling By Suppression of Mir-146a in Acute Myeloid Leukemia

Blood (2016) 128 (22): 1533.

https://doi.org/10.1182/blood.V128.22.1533.1533

Published: 2016

Journal Articles

The miRNA-193 Family Is a Potent Tumor-Suppressor and a Biomarker for Poor Prognosis in Acute Myeloid Leukemia

Blood (2016) 128 (22): 1534.

https://doi.org/10.1182/blood.V128.22.1534.1534

Published: 2016

Journal Articles

Modeling of Pediatric Acute Megakaryoblastic Leukemia Using Cord Blood Stem/Progenitor Cells

Sophie Cardin, PhD, Louise Laramee, Tara MacRae, M.Sc., Jalila Chagraoui, PhD, Guy Sauvageau, MD PhD, R. Keith Humphries, MD PhD, Josée Hébert, MD, Brian T. Wilhelm, PhD, Sonia Cellot, MD PhD

Blood (2016) 128 (22): 1535.

https://doi.org/10.1182/blood.V128.22.1535.1535

Published: 2016

Journal Articles

A Tumor Suppressor microRNA Defines the Leukemic Hierarchy in Acute Myeloid Leukemia

Edith Schneider, MSc, Anna Staffas, PhD, Linda Roehner, MSc, Christian Buske, Lars Bullinger, MD, Michael Heuser, MD, Hartmut Döhner, MD, Konstanze Döhner, MD, R. Keith Humphries, MD PhD, Arefeh Rouhi, PhD, Lars Palmqvist, MD PhD, Florian Kuchenbauer, MD PhD

Blood (2015) 126 (23): 3653.

https://doi.org/10.1182/blood.V126.23.3653.3653

Published: 2015

Journal Articles

The Mir-193 Family Antagonizes Stem Cell Pathways and Is a Potent Tumor Suppressor in Childhood and Adult Acute Myeloid Leukemia

Blood (2015) 126 (23): 1244.

https://doi.org/10.1182/blood.V126.23.1244.1244

Published: 2015

Journal Articles

Identification and Characterization of New Microrna Biomarkers and Target Genes in Drug-Insensitive CD34+ CML Stem/Progenitor Cells Using Global Comparative RNA-Seq Analyses

Hanyang Lin, BSc, MSc, Jonathan Zeng, Katharina Rothe, BSc, MSc, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, PhD, David Knapp, BSc, Ryan R. Brinkman, PhD, Inanc Birol, PhD, Donna L. Forrest, MD, Carl Hansen, PhD, Connie J. Eaves, PhD, R. Keith Humphries, MD PhD, Xiaoyan Jiang, MDPhD

Blood (2015) 126 (23): 1567.

https://doi.org/10.1182/blood.V126.23.1567.1567

Published: 2015

Journal Articles

Hoxa9/Meis1 Mediate Leukemic Programming through Microrna-155

Edith Schneider, M.Sc., Anna Staffas, PhD, Milijana Mirkovic-Hoesle, PhD, Bernhard Gentner, MD, Jens Ruschmann, Christian Buske, MD, Michael Heuser, MD, Konstanze Döhner, MD, Hartmut Döhner, MD, R. Keith Humphries, MD PhD, Arefeh Rouhi, PhD, Florian Kuchenbauer, MD PhD, Lars Palmqvist, MD PhD

Blood (2014) 124 (21): 884.

https://doi.org/10.1182/blood.V124.21.884.884

Published: 2014

Journal Articles

Pyrimido-Indole Derivatives Are Novel Agonists of Human Cord Blood Hematopoietic Stem Cell Self-Renewal

Iman Fares, Jalila Chagaroui, Yves Gareau, Stéphane Gingras, Nadine Mayotte, Elizabeth Csaszar, Hans-Peter Kiem, Norman N. Iscove, R. Keith Humphries, Connie J. Eaves, Sandra Cohen, Anne Marinier, PhD, Peter W. Zandstra, Guy Sauvageau, MD PhD

Blood (2014) 124 (21): 650.

https://doi.org/10.1182/blood.V124.21.650.650

Published: 2014

NARROW

Transcriptional control of leukemogenesis by the chromatin reader SGF29

Meis1 Establishes the Pre-Hemogenic Endothelial State Prior to Runx1 Expression

Elucidating the Importance and Regulation of Key Enhancers for Human MEIS1 Expression

High-Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of Hox/Meis Gene Expression in Acute Myeloid Leukemia

The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

MiR-193a Is a Negative Regulator of Hematopoietic Stem Cells and Promotes Anti-Leukemic Effects in Acute Myeloid Leukemia

Global Transcriptome Profiling Identifies a Key Mir-185-PAK6 Axis That Promotes Survival of Leukemic Stem Cells and Drug-Insensitive Blasts in BCR-ABL + Human Leukemia

Synthetic De Novo Modeling of Human T-Cell Acute Lymphoblastic Leukemia Reveals HOXB Genes Drive Expansion of Leukemia Cells-of-Origin and Established Tumor Clones

Serially Transplantable Patient-Derived Xenograft Model of Chronic Myelomonocytic Leukemia (CMML)

Distinct signaling programs control human hematopoietic stem cell survival and proliferation

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling By Suppression of Mir-146a in Acute Myeloid Leukemia

The miRNA-193 Family Is a Potent Tumor-Suppressor and a Biomarker for Poor Prognosis in Acute Myeloid Leukemia

Modeling of Pediatric Acute Megakaryoblastic Leukemia Using Cord Blood Stem/Progenitor Cells

A Tumor Suppressor microRNA Defines the Leukemic Hierarchy in Acute Myeloid Leukemia

The Mir-193 Family Antagonizes Stem Cell Pathways and Is a Potent Tumor Suppressor in Childhood and Adult Acute Myeloid Leukemia

Identification and Characterization of New Microrna Biomarkers and Target Genes in Drug-Insensitive CD34+ CML Stem/Progenitor Cells Using Global Comparative RNA-Seq Analyses

Hoxa9/Meis1 Mediate Leukemic Programming through Microrna-155

Pyrimido-Indole Derivatives Are Novel Agonists of Human Cord Blood Hematopoietic Stem Cell Self-Renewal

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American Society of Hematology

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American Society of Hematology

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