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Journal Articles

NRAS G12V -Mediated Self-Renewal Signaling in Self-Renewing AML Stem Cells.

Marie Lue Antony, PhD, Klara Noble-Orcutt, Karen Sachs, PhD, Anna Khoroshilov, Daniel Chang, Alexandria Hillesheim, Hesham Mohei, Merve Pamukcuoglu, MD, Christine Bergene, David A. Largaespada, PhD, Zohar Sachs, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2626.
https://doi.org/10.1182/blood-2018-99-119448
Published: 2018
Journal Articles

Single-Cell Transcriptional Profiling of Acute Myeloid Leukemia Identifies Prognostic Transcriptional Profiles at Diagnosis

Karen Sachs, PhD, Aaron Sarver, PhD, Klara Noble-Orcutt, Connor Navis, Alexandria Hillesheim, Ian Nykaza, Rebecca S. Larue, PhD, Conner Hansen, Nuri Temiz, Ngoc Ha, Michael A. Linden, MDPhD, David A. Largaespada, PhD, Zohar Sachs, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2704.
https://doi.org/10.1182/blood.V130.Suppl_1.2704.2704
Published: 2017
Journal Articles

Distinct signaling programs control human hematopoietic stem cell survival and proliferation

David J. H. F. Knapp, Colin A. Hammond, Nima Aghaeepour, Paul H. Miller, Davide Pellacani, Philip A. Beer, Karen Sachs, Wenlian Qiao, WeiJia Wang, R. Keith Humphries, Guy Sauvageau, Peter W. Zandstra, Sean C. Bendall, Garry P. Nolan, Carl Hansen, Connie J. Eaves
Journal: Blood
Blood (2017) 129 (3): 307–318.
https://doi.org/10.1182/blood-2016-09-740654
Published: 2017
Includes: Supplemental data
Journal Articles

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Zohar Sachs, Rebecca S. LaRue, Hanh T. Nguyen, Karen Sachs, Klara E. Noble, Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, Susan K. Rathe, Aaron L. Sarver, Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, Garry P. Nolan, Kevin M. Shannon, David A. Largaespada
Journal: Blood
Blood (2014) 124 (22): 3274–3283.
https://doi.org/10.1182/blood-2013-08-521708
Published: 2014
Includes: Supplemental data
Journal Articles

Ras-Pathway Inhibition With Targeted Therapies Abrogates Self-Renewal In Acute Myelogenous Leukemia

Rebecca S. LaRue, PhD, Hanh Nguyen, Karen Sachs, Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, PhD, Susan K. Rathe, Aaron G. Sarver, Ph.D., Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, B.S., Garry P. Nolan, PhD, Kevin Shannon, MD, Zohar Sachs, MD, PhD, David A. Largaespada, PhD
Journal: Blood
Blood (2013) 122 (21): 819.
https://doi.org/10.1182/blood.V122.21.819.819
Published: 2013
Journal Articles

Network-Based Discovery of Prognostic Markers in Pediatric AML by Multi-Dimensional Single Cell Mass Cytometry

Karen Sachs, PhD, Garry P. Nolan, PhD, Wendy J. Fantl, PhD, Erin F. Simonds, PhD, Sean C. Bendall, PhD, Kara L. Davis, DO
Journal: Blood
Blood (2012) 120 (21): 1411.
https://doi.org/10.1182/blood.V120.21.1411.1411
Published: 2012
Journal Articles

Activated NRAS Mediates Self-Renewal Capacity in AML by Facilitating the Mll/AF9 -Specified Gene Expression Signature

Zohar Sachs, MD, PhD, Hanh Nguyen, Nurul Azyan Mohd Hassan, Susan K Rathe, Karen Sachs, Ph. D., Ernesto Diaz-Flores, PhD, Sean C Bendall, PhD, Miechaleen D Diers, Garry P. Nolan, Ph. D., Kevin M. Shannon, MD, David A. Largaespada, PhD
Journal: Blood
Blood (2012) 120 (21): 5116.
https://doi.org/10.1182/blood.V120.21.5116.5116
Published: 2012
Journal Articles

Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments

Kenneth D. Gibbs, Jr, Penney M. Gilbert, Karen Sachs, Feifei Zhao, Helen M. Blau, Irving L. Weissman, Garry P. Nolan, Ravindra Majeti
Journal: Blood
Blood (2011) 117 (16): 4226–4233.
https://doi.org/10.1182/blood-2010-07-298232
Published: 2011
Includes: Supplemental data
Journal Articles

Oncogene Withdrawal Selectively Alters Phosphoprotein States and Shifts Differentiation Status In Myeloid Leukemia Subpopulations

Zohar Sachs, MD, PhD, Ernesto Diaz-Flores, PhD, Miechaleen D Diers, Karen Sachs, Sean C Bendall, PhD, Harris G Fienberg, Susan K Rathe, Garry P. Nolan, Ph.D., Kevin Shannon, MD, David Largaespada, PhD
Journal: Blood
Blood (2010) 116 (21): 3160.
https://doi.org/10.1182/blood.V116.21.3160.3160
Published: 2010