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NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Zohar Sachs, Rebecca S. LaRue, Hanh T. Nguyen, Karen Sachs, Klara E. Noble, Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, Susan K. Rathe, Aaron L. Sarver, Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, Garry P. Nolan, Kevin M. Shannon, David A. Largaespada
Journal: Blood
Blood (2014) 124 (22): 3274–3283.
https://doi.org/10.1182/blood-2013-08-521708
Published: 2014
Includes: Supplemental data
Journal Articles

Cellular Intrinsic Mechanism Affecting The Outcome Of AML Treatment With Ara-C In a Syngeneic Mouse Model

Zheng Chen, B.S., Dongming Tan, B.S., Wenjun Zhao, B.S., Guangsong Su, B.S., Yanwen Zheng, MS, Chao He, M.S., Miechaleen D Diers, B.S., Zhengwei Mao, BS, Timothy Singleton, MD, David A. Largaespada, PhD, Bin Yin, PhD
Journal: Blood
Blood (2013) 122 (21): 5025.
https://doi.org/10.1182/blood.V122.21.5025.5025
Published: 2013
Journal Articles

Ras-Pathway Inhibition With Targeted Therapies Abrogates Self-Renewal In Acute Myelogenous Leukemia

Rebecca S. LaRue, PhD, Hanh Nguyen, Karen Sachs, Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, PhD, Susan K. Rathe, Aaron G. Sarver, Ph.D., Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, B.S., Garry P. Nolan, PhD, Kevin Shannon, MD, Zohar Sachs, MD, PhD, David A. Largaespada, PhD
Journal: Blood
Blood (2013) 122 (21): 819.
https://doi.org/10.1182/blood.V122.21.819.819
Published: 2013
Journal Articles

Activated NRAS Mediates Self-Renewal Capacity in AML by Facilitating the Mll/AF9 -Specified Gene Expression Signature

Zohar Sachs, MD, PhD, Hanh Nguyen, Nurul Azyan Mohd Hassan, Susan K Rathe, Karen Sachs, Ph. D., Ernesto Diaz-Flores, PhD, Sean C Bendall, PhD, Miechaleen D Diers, Garry P. Nolan, Ph. D., Kevin M. Shannon, MD, David A. Largaespada, PhD
Journal: Blood
Blood (2012) 120 (21): 5116.
https://doi.org/10.1182/blood.V120.21.5116.5116
Published: 2012
Journal Articles

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

Rachel J. Bergerson, Lara S. Collier, Aaron L. Sarver, Raha A. Been, Sanne Lugthart, Miechaleen D. Diers, Johannes Zuber, Amy R. Rappaport, Molly J. Nixon, Kevin A. T. Silverstein, Danhua Fan, Anne-Francoise J. Lamblin, Linda Wolff, John H. Kersey, Ruud Delwel, Scott W. Lowe, M. Gerard O'Sullivan, Scott C. Kogan, David J. Adams, David A. Largaespada
Journal: Blood
Blood (2012) 119 (19): 4512–4523.
https://doi.org/10.1182/blood-2010-04-281428
Published: 2012
Includes: Supplemental data
Journal Articles

Delineating Critical Effectors of Remission Induction in a Mouse Model of AML

Zohar Sachs, MD, PhD, Susan K. Rathe, Ernesto Diaz-Flores, PhD, Miechaleen D Diers, Kevin M. Shannon, MD, David A. Largaespada, PhD
Journal: Blood
Blood (2011) 118 (21): 5232.
https://doi.org/10.1182/blood.V118.21.5232.5232
Published: 2011
Journal Articles

Oncogene Withdrawal Selectively Alters Phosphoprotein States and Shifts Differentiation Status In Myeloid Leukemia Subpopulations

Zohar Sachs, MD, PhD, Ernesto Diaz-Flores, PhD, Miechaleen D Diers, Karen Sachs, Sean C Bendall, PhD, Harris G Fienberg, Susan K Rathe, Garry P. Nolan, Ph.D., Kevin Shannon, MD, David Largaespada, PhD
Journal: Blood
Blood (2010) 116 (21): 3160.
https://doi.org/10.1182/blood.V116.21.3160.3160
Published: 2010
Journal Articles

RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia

Won-Il Kim, Ilze Matise, Miechaleen D. Diers, David A. Largaespada
Journal: Blood
Blood (2009) 113 (5): 1086–1096.
https://doi.org/10.1182/blood-2008-01-132316
Published: 2009
Includes: Supplemental data
Journal Articles

A Murine AML Model for the Development of Resistance to NRAS(G12V) Oncogene Repression and/or Ara-C Treatment in Vivo

Won-IL Kim, Ph.D., Susan K Rathe, Miechaleen D Diers, David A Largaespada, Ph.D
Journal: Blood
Blood (2008) 112 (11): 4030.
https://doi.org/10.1182/blood.V112.11.4030.4030
Published: 2008
Journal Articles

Genetic Mechanisms of Cytarabine Resistance in Leukemia: Cell Culture and Mouse Transplantation Models.

Bin Yin, PhD, Miechaleen D. Diers, Bachelor, Susan K. Rathe, Bachelor, Scott W. Lowe, PhD, David A. Largaespada, PhD
Journal: Blood
Blood (2006) 108 (11): 4374.
https://doi.org/10.1182/blood.V108.11.4374.4374
Published: 2006
Journal Articles

Bcl11a Causes Leukemia/Lymphoma in Cooperation with Nf1 Inactivation.

Bin Yin, PhD, Jennifer L. Jeske-Geurts, Miechaleen D. Diers, Kevin M. Shannon, MD, David A. Largaespada, PhD
Journal: Blood
Blood (2006) 108 (11): 387.
https://doi.org/10.1182/blood.V108.11.387.387
Published: 2006
Journal Articles

β common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice

Andrew Kim, Kelly Morgan, Diane E. Hasz, Stephen M. Wiesner, Jennifer O. Lauchle, Jennifer L. Geurts, Miechaleen D. Diers, Doan T. Le, Scott C. Kogan, Luis F. Parada, Kevin Shannon, David A. Largaespada
Journal: Blood
Blood (2006) 109 (4): 1687–1691.
https://doi.org/10.1182/blood-2006-05-025395
Published: 2006
Includes: Supplemental data
Journal Articles

Mild preconditioning and low-level engraftment confer methotrexate resistance in mice transplanted with marrow expressing drug-resistant dihydrofolate reductase activity

Rohaizah I. James, Christopher A. Warlick, Miechaleen D. Diers, Roland Gunther, R. Scott McIvor
Journal: Blood
Blood (2000) 96 (4): 1334–1341.
https://doi.org/10.1182/blood.V96.4.1334
Published: 2000