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Journal Articles

Comprehensive Genomic Landscape and Clonal Architecture in Pediatric Patients with Monosomy 7

Tamara Westover, Sherif Abdelhamed, Emily Xiong, Michael P Walsh, Jing Ma, Jasmine C. Wong, Astrid Behnert, Mignon L. Loh, Kevin M. Shannon, Jeffery M. Klco

Blood (2022) 140 (Supplement 1): 5837–5838.

https://doi.org/10.1182/blood-2022-166915

Published: 2022

Journal Articles

Opposing Effects of KDM6A and JDP2 on Glucocorticoid Sensitivity in T-ALL

Anya Levinson, Karensa Tjoa, Benjamin J. Huang, Lauren K. Meyer, Samuel W Brady, Jinghui Zhang, Kevin M. Shannon, Anica Wandler

Blood (2022) 140 (Supplement 1): 5973–5974.

https://doi.org/10.1182/blood-2022-170403

Published: 2022

Journal Articles

Co-Targeting BET Bromodomain Proteins and Aberrant Signaling in AML

Benjamin J. Huang, MD, Xinyue Wang, BA, Max Harris, BA, Anica Wandler, PhD, Eugene Hwang, BA, Michael R. Burgess, MD PhD, Qing Li, MD PhD, Paul Severson, PhD, Ben Powell, PhD, Edward A. Kolb, MD, Soheil Meshinchi, MDPhD, Barry S Taylor, PhD, Gideon Bollag, PhD, Kevin M. Shannon, MD

Blood (2020) 136 (Supplement 1): 5–6.

https://doi.org/10.1182/blood-2020-142921

Published: 2020

Journal Articles

Glucocorticoids Paradoxically Induce Intrinsic Steroid Resistance through a STAT5-Mediated Survival Mechanism in T-Cell Acute Lymphoblastic Leukemia

Lauren K. Meyer, Benjamin Huang, MD, Ritu Roy, PhD, Aaron Hechmer, PhD, Anica Wandler, PhD, Cristina Delgado-Martin, PhD, Adam B. Olshen, PhD, Terzah M. Horton, MD PhD, David T Teachey, MD, Kevin M. Shannon, MD, Michelle L. Hermiston, MD PhD

Blood (2018) 132 (Supplement 1): 913.

https://doi.org/10.1182/blood-2018-99-119930

Published: 2018

Journal Articles

Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo

Noemi A. Zambetti, PhD, Ari J. Firestone, PhD, Jasmine C. Wong, PhD, Amanda Long, BA, Anagha Inguva, BA, Radu M. Suciu, B.Sc., Benjamin F. Cravatt, PhD, Kevin M. Haigis, PhD, Kevin M. Shannon, MD

Blood (2017) 130 (Supplement 1): 1221.

https://doi.org/10.1182/blood.V130.Suppl_1.1221.1221

Published: 2017

Journal Articles

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Zohar Sachs, Rebecca S. LaRue, Hanh T. Nguyen, Karen Sachs, Klara E. Noble, Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, Susan K. Rathe, Aaron L. Sarver, Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, Garry P. Nolan, Kevin M. Shannon, David A. Largaespada

Blood (2014) 124 (22): 3274–3283.

https://doi.org/10.1182/blood-2013-08-521708

Published: 2014

Includes: Supplemental data

Journal Articles

Mutations in GATA2 are rare in juvenile myelomonocytic leukemia

Elliot Stieglitz, Y. Lucy Liu, Peter D. Emanuel, Robert P. Castleberry, Todd M. Cooper, Kevin M. Shannon, Mignon L. Loh

Blood (2014) 123 (9): 1426–1427.

https://doi.org/10.1182/blood-2013-11-531079

Published: 2014

Journal Articles

Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo

Angell Shieh, Ashley F. Ward, Kegan L. Donlan, Emily R. Harding-Theobald, Jin Xu, Charles G. Mullighan, Chao Zhang, Shann-Ching Chen, Xiaoping Su, James R. Downing, Gideon E. Bollag, Kevin M. Shannon

Blood (2013) 121 (24): 4884–4893.

https://doi.org/10.1182/blood-2012-05-432252

Published: 2013

Includes: Supplemental data

Journal Articles

Oncogenic Nras Increases Hematopoietic Stem Cell Proliferation and Self-Renewal Through a Bimodal Effect

Qing Li, M.D., Ph.D., Natacha Bohin, B.S., Tiffany Wen, B.S., Kevin M. Shannon, MD, Sean J. Morrison, Ph.D

Blood (2012) 120 (21): 119.

https://doi.org/10.1182/blood.V120.21.119.119

Published: 2012

Journal Articles

The PI3K Inhibitor GDC-0941 Attenuates Disease in a Kras G12D Mouse Model of CMML and JMML.

Jon Akutagawa, B.S., Monique Dail, PhD, Lori S Friedman, PhD, Kevin M. Shannon, MD, Deepak Sampath, PhD, Benjamin S. Braun, MD, PhD

Blood (2012) 120 (21): 2862.

https://doi.org/10.1182/blood.V120.21.2862.2862

Published: 2012

Journal Articles

Activated NRAS Mediates Self-Renewal Capacity in AML by Facilitating the Mll/AF9 -Specified Gene Expression Signature

Zohar Sachs, MD, PhD, Hanh Nguyen, Nurul Azyan Mohd Hassan, Susan K Rathe, Karen Sachs, Ph. D., Ernesto Diaz-Flores, PhD, Sean C Bendall, PhD, Miechaleen D Diers, Garry P. Nolan, Ph. D., Kevin M. Shannon, MD, David A. Largaespada, PhD

Blood (2012) 120 (21): 5116.

https://doi.org/10.1182/blood.V120.21.5116.5116

Published: 2012

Journal Articles

Targeting oncogenic Ras signaling in hematologic malignancies

Ashley F. Ward, Benjamin S. Braun, Kevin M. Shannon

Blood (2012) 120 (17): 3397–3406.

https://doi.org/10.1182/blood-2012-05-378596

Published: 2012

Includes: Supplemental data

Journal Articles

MEK Inhibition Modulates the Growth of Nf1 mutant Hematopoietic Cells and Induces Clinical Improvement in a Murine Model of Juvenile Myelomonocytic Leukemia (JMML)

Tiffany Y. Chang, MD, Kimberly Krisman, BA, Emily Rose Harding-Theobald, BA, Benjamin S. Braun, MD, PhD, Kevin M. Shannon, MD

Blood (2011) 118 (21): 797.

https://doi.org/10.1182/blood.V118.21.797.797

Published: 2011

Journal Articles

Delineating Critical Effectors of Remission Induction in a Mouse Model of AML

Zohar Sachs, MD, PhD, Susan K. Rathe, Ernesto Diaz-Flores, PhD, Miechaleen D Diers, Kevin M. Shannon, MD, David A. Largaespada, PhD

Blood (2011) 118 (21): 5232.

https://doi.org/10.1182/blood.V118.21.5232.5232

Published: 2011

Journal Articles

Mechanisms of Relapse Following Targeted Therapy in An NRAS G12V and Mll-AF9 Driven Mouse Model of AML

Craig E. Eckfeldt, MD, PhD, Ernesto Diaz-Flores, PhD, Michaeleen D. Diers, Susan K. Rathe, Kevin M. Shannon, MD, David A. Largaespada, PhD

Blood (2011) 118 (21): 2620.

https://doi.org/10.1182/blood.V118.21.2620.2620

Published: 2011

Journal Articles

Heterozygous Germ Line Deletion of a 2Mb Interval in Mice That Models Loss of 7q22 in Human Myeloid Malignancies Results in Defective Hematopoietic Stem Cell Function Reminiscent of Premature Aging

Jasmine C. Wong, PhD, Kelley Weinfurtner, BA, Yan Zhang, Ph.D., Pilar Alzamora, Eugene Hwang, BA, Scott C. Kogan, MD, Kevin M. Shannon, MD

Blood (2011) 118 (21): 2340.

https://doi.org/10.1182/blood.V118.21.2340.2340

Published: 2011

Journal Articles

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

Gordon Chan, Laurene S. Cheung, Wentian Yang, Michael Milyavsky, Ashley D. Sanders, Shengqing Gu, Wan Xing Hong, Aurora X. Liu, Xiaonan Wang, Mary Barbara, Tarun Sharma, Joehleen Gavin, Jeffery L. Kutok, Norman N. Iscove, Kevin M. Shannon, John E. Dick, Benjamin G. Neel, Benjamin S. Braun

Blood (2011) 117 (16): 4253–4261.

https://doi.org/10.1182/blood-2010-11-319517

Published: 2011

Includes: Supplemental data

Journal Articles

Mutations in CBL occur frequently in juvenile myelomonocytic leukemia

Blood (2009) 114 (9): 1859–1863.

https://doi.org/10.1182/blood-2009-01-198416

Published: 2009

Includes: Supplemental data

Journal Articles

Mll5 contributes to hematopoietic stem cell fitness and homeostasis

Yan Zhang, Jasmine Wong, Mark Klinger, Mary T. Tran, Kevin M. Shannon, Nigel Killeen

Blood (2009) 113 (7): 1455–1463.

https://doi.org/10.1182/blood-2008-05-159905

Published: 2009

Includes: Supplemental data

Journal Articles

A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene

Bin Yin, Ruud Delwel, Peter J. Valk, Margaret R. Wallace, Mignon L. Loh, Kevin M. Shannon, David A. Largaespada

Blood (2009) 113 (5): 1075–1085.

https://doi.org/10.1182/blood-2008-03-144436

Published: 2009

Includes: Supplemental data

NARROW

Comprehensive Genomic Landscape and Clonal Architecture in Pediatric Patients with Monosomy 7

Opposing Effects of KDM6A and JDP2 on Glucocorticoid Sensitivity in T-ALL

Co-Targeting BET Bromodomain Proteins and Aberrant Signaling in AML

Glucocorticoids Paradoxically Induce Intrinsic Steroid Resistance through a STAT5-Mediated Survival Mechanism in T-Cell Acute Lymphoblastic Leukemia

Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Mutations in GATA2 are rare in juvenile myelomonocytic leukemia

Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo

Oncogenic Nras Increases Hematopoietic Stem Cell Proliferation and Self-Renewal Through a Bimodal Effect

The PI3K Inhibitor GDC-0941 Attenuates Disease in a Kras G12D Mouse Model of CMML and JMML.

Activated NRAS Mediates Self-Renewal Capacity in AML by Facilitating the Mll/AF9 -Specified Gene Expression Signature

Targeting oncogenic Ras signaling in hematologic malignancies

MEK Inhibition Modulates the Growth of Nf1 mutant Hematopoietic Cells and Induces Clinical Improvement in a Murine Model of Juvenile Myelomonocytic Leukemia (JMML)

Delineating Critical Effectors of Remission Induction in a Mouse Model of AML

Mechanisms of Relapse Following Targeted Therapy in An NRAS G12V and Mll-AF9 Driven Mouse Model of AML

Heterozygous Germ Line Deletion of a 2Mb Interval in Mice That Models Loss of 7q22 in Human Myeloid Malignancies Results in Defective Hematopoietic Stem Cell Function Reminiscent of Premature Aging

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

Mutations in CBL occur frequently in juvenile myelomonocytic leukemia

Mll5 contributes to hematopoietic stem cell fitness and homeostasis

A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene

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American Society of Hematology

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ASH Publications

American Society of Hematology

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