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Journal Articles

Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms

Angela Stoddart, Joy Nakitandwe, Shann-Ching Chen, James R. Downing, Michelle M. Le Beau
Journal: Blood
Blood (2015) 126 (26): 2899–2901.
https://doi.org/10.1182/blood-2015-10-673228
Published: 2015
Journal Articles

Genomic Landscape of Relapsed Acute Lymphoblastic Leukemia

Esmé Waanders, PhD, Stephanie M Dobson, MSc, Xiaotu Ma, PhD, Debbie Payne-Turner, BS, Guangchun Song, PhD, Yiping Fan, Zhaohui Gu, PhD, Ying Shao, Michael Rusch, BA, Kelly McCastlain, BS, Ilaria Iacobucci, PhD, Kathryn G. Roberts, Shann-Ching Chen, PhD, Pankaj Gupta, Ji Wen, Gang Wu, PhD, Jing Ma, PhD, Colin Bailey, Matthew Lear, Scott Olsen, Deanna Naeve, Geoffrey A. Neale, PhD, John Easton, PhD, Sima Jeha, MD, Ching-Hon Pui, MD, James R. Downing, MD, William E. Evans, PharmD, Mary V. Relling, PharmD, Jun J Yang, PhD, John E. Dick, PhD, Jinghui Zhang, PhD, Charles G. Mullighan, MBBS, MSc, MD
Journal: Blood
Blood (2015) 126 (23): 692.
https://doi.org/10.1182/blood.V126.23.692.692
Published: 2015
Journal Articles

Aberrant Hematopoietic Stem Cell Function in Mice Haploinsufficient for a 2 Mb Deletion of Chromosome 5A3 Syntenic to a Region of Human 7q22 Frequently Deleted in Myelodysplastic Syndromes

Jasmine C. Wong, PhD, Kelley Weinfurtner, BA, Pilar Alzamora, Scott C. Kogan, MD, Michael R. Burgess, MD PhD, Yan Zhang, PhD, Joy Nakitandwe, PhD, Jing Ma, PhD, Jinjun Cheng, MB, MS, Shann-Ching Chen, PhD, Johanna Flach, Damien Reynaud, PhD, Emmanuelle Passegue, PhD, James R Downing, MD, Kevin Shannon, MD
Journal: Blood
Blood (2014) 124 (21): 3247.
https://doi.org/10.1182/blood.V124.21.3247.3247
Published: 2014
Journal Articles

Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones

Monique Dail, PhD, Jason Wong, Jessica Lawrence, Daniel O'Connor, Joy Nakitandwe, PhD., Shann-Ching Chen, PhD, Keiko Akagi, Leslie Lee, Jon C. Aster, MD, PhD, Warren S. Pear, MD, PhD, Deepak Sampath, PhD, James R. Downing, MD, Kevin Shannon, MD
Journal: Blood
Blood (2013) 122 (21): 2677.
https://doi.org/10.1182/blood.V122.21.2677.2677
Published: 2013
Journal Articles

Integrated Genomic and Mutational Profiling Of Adolescent and Young Adult ALL Identifies a High Frequency Of BCR-ABL1 -Like ALL with Very Poor Outcome

Kathryn G. Roberts, PhD, Debbie Payne-Turner, Deqing Pei, MS, Jared Becksfort, Richard C. Harvey, PhD, Yongjin Li, Guangchun Song, Jinjun Cheng, MD, Jing Ma, PhD, Jinghui Zhang, PhD, Cheng Cheng, PhD, Shann-Ching Chen, PhD, I-Ming L. Chen, Meenakshi Devidas, PhD, Eric C. Larsen, MD, William L. Carroll, MD, Naomi J. Winick, MD, Nyla A. Heerema, PhD, Andrew J. Carroll, PhD, Julie M. Gastier-Foster, PhD, Elizabeth A. Raetz, MD, Ching-Hon Pui, MD, Sima Jeha, MD, James R. Downing, MD, Elisabeth Paietta, PhD, Steven M. Kornblau, MD, Guido Marcucci, MD, Wendy Stock, MD, Clara D. Bloomfield, MD, Daniela S. Gerhard, Ph.D., Mignon L. Loh, MD, Stephen P. Hunger, MD, Cheryl L. Willman, MD, Charles G. Mullighan, MBBS, MSc, MD, FRACP, FRCPA
Journal: Blood
Blood (2013) 122 (21): 825.
https://doi.org/10.1182/blood.V122.21.825.825
Published: 2013
Journal Articles

Development and Validation Of a Highly Sensitive and Specific Gene Expression Classifier To Prospectively Screen and Identify B-Precursor Acute Lymphoblastic Leukemia (ALL) Patients With a Philadelphia Chromosome-Like (“ Ph-like ” or “ BCR-ABL1-Like ”) Signature For Therapeutic Targeting and Clinical Intervention

Richard C. Harvey, PhD, Huining Kang, PhD, Kathryn G. Roberts, PhD, I-Ming L. Chen, DVM, MS, Susan R. Atlas, PhD, Edward J. Bedrick, PhD, Julie M. Gastier-Foster, PhD, Jinghui Zhang, PhD, Daniela S. Gerhard, Ph.D., Malcolm A. Smith, MD, PhD, Eric C. Larsen, MD, Elizabeth A. Raetz, MD, Naomi J. Winick, MD, William L. Carroll, MD, Eileen Stonerock, Nyla A. Heerema, PhD, Andrew J. Carroll, PhD, Shann-Ching Chen, PhD, Guangchun Song, Jared Becksfort, Michael Rusch, BA, Yongjin Li, Jing Ma, PhD, Denise Ell, Shalini C. Reshmi, PhD, Mignon L. Loh, MD, Meenakshi Davidas, PhD, Stephen P. Hunger, MD, Charles G. Mullighan, MBBS, MSc, MD, FRACP, FRCPA, Cheryl L. Willman, MD
Journal: Blood
Blood (2013) 122 (21): 826.
https://doi.org/10.1182/blood.V122.21.826.826
Published: 2013
Journal Articles

Genomic Characterization and Experimental Modeling Of BCR-ABL1 -Like Acute Lymphoblastic Leukemia

Kathryn G. Roberts, PhD, Yongjin Li, Debbie Payne-Turner, Richard C. Harvey, PhD, Jinjun Cheng, MD, Jinghui Zhang, PhD, Guangchun Song, Yung-Li Yang, M.D, Natalia Santiago-Morales, Deqing Pei, MS, Cheng Cheng, PhD, Jing Ma, PhD, Shann-Ching Chen, PhD, Michael Rusch, BA, Pankaj Gupta, Meenakshi Devidas, PhD, I-Ming Chen, DVM, Eric C. Larsen, MD, Naomi J. Winick, MD, William L. Carroll, MD, Nyla A. Heerema, PhD, Andrew J. Carroll, PhD, Julie M. Gastier-Foster, PhD, Elizabeth A. Raetz, MD, Ching-Hon Pui, MD, Sima Jeha, MD, James R Downing, MD, Elisabeth Paietta, PhD, Steven M. Kornblau, MD, Guido Marcucci, MD, Clara D. Bloomfield, MD, Daniela S. Gerhard, Ph.D., Mignon L. Loh, MD, Cheryl L. Willman, MD, Stephen P. Hunger, MD, Charles G. Mullighan, MBBS, MSc, MD, FRACP, FRCPA
Journal: Blood
Blood (2013) 122 (21): 232.
https://doi.org/10.1182/blood.V122.21.232.232
Published: 2013
Journal Articles

High Content Screening Identifies Synthetic Lethality Of Retinoid Receptor Agonists In IKZF1 -Mutated BCR-ABL1 positive Acute Lymphoblastic Leukemia

Michelle Churchman, Ph.D., Jonathan Low, Ph.D., Debbie Payne-Turner, Shann-Ching Chen, PhD, Jing Ma, PhD, Mark J. Althoff, Faiyaz Notta, PhD, John E. Dick, PhD, Laura Janke, DVM, PhD, Rodney Kiplin Guy, Ph.D, Taosheng Chen, Ph.D., Charles G. Mullighan, MBBS, MSc, MD, FRACP, FRCPA
Journal: Blood
Blood (2013) 122 (21): 172.
https://doi.org/10.1182/blood.V122.21.172.172
Published: 2013
Journal Articles

Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo

Angell Shieh, Ashley F. Ward, Kegan L. Donlan, Emily R. Harding-Theobald, Jin Xu, Charles G. Mullighan, Chao Zhang, Shann-Ching Chen, Xiaoping Su, James R. Downing, Gideon E. Bollag, Kevin M. Shannon
Journal: Blood
Blood (2013) 121 (24): 4884–4893.
https://doi.org/10.1182/blood-2012-05-432252
Published: 2013
Includes: Supplemental data
Journal Articles

Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases: A Report From the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project

Tanja A Gruber, MD, PhD, Amanda Larson Gedman, PhD, Huy Q. Ta, PhD, Jinghui Zhang, PhD, Cary Koss, BS, Shann-Ching Chen, PhD, Xiaoping Su, PhD, Vedant Gupta, BS, Stacey Ogden, PhD, Anna K. Andersson, PhD, John Easton, PhD, Jianmin Wang, PhD, Michael Rusch, BA, Li Ding, PhD, Giovanni Cazzaniga, Andrea Biondi, MD, Steven M. Kornblau, MD, Farhad Ravandi, MD, Hagop M. Kantarjian, Stephen D. Nimer, MD, Konstanze Doehner, Prof., Hartmut Doehner, MD, Timothy J Ley, MD, Sheila Shurtleff, PhD, Jeffrey Rubnitz, MD, PhD, Ching-Hon Pui, MD, Elaine R. Mardis, PhD, Richard K. Wilson, PhD, James R. Downing, MD
Journal: Blood
Blood (2011) 118 (21): 757.
https://doi.org/10.1182/blood.V118.21.757.757
Published: 2011
Journal Articles

Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project

Jinghui Zhang, PhD, Li Ding, PhD, Linda Holmfeldt, PhD, Gang Wu, PhD, Susan L. Heatley, Ph.D., Debbie Payne-Turner, John Easton, PhD, Xiang Chen, PhD, Jianmin Wang, PhD, Michael Rusch, BA, Charles Lu, PhD, Shann-Ching Chen, PhD, Racquel Collins-Underwood, PhD, Jing Ma, PhD, Kathryn G. Roberts, PhD, Stanley Pounds, PhD, Lei Wei, PhD, Anatoly Ulyanov, PhD, Jared Becksfort, Pankaj Gupta, Robert Huether, PhD, Richard Kriwacki, PhD, Daniel McGoldrick, David Zhao, Daniel Alford, Stephen Espy, Kiran Chand Bobba, Guangchun Song, Deqing Pei, MS, Cheng Cheng, PhD, Stefan Roberts, Michael Barbato, Dario Campana, MD, PhD, Elaine Coustan-Smith, MS, William E. Evans, PharmD, Sheila A Shurtleff, PhD, Maria Kleppe, Jan Cools, PhD, Kristin Shimano, Michelle L. Hermiston, MD, PhD, Sergei Doulatov, PhD, Kolja Eppert, PhD, Elisa Laurenti, PhD, Faiyaz Notta, PhD, John E Dick, PhD, Giuseppe Basso, MD PhD, Stephen P. Hunger, MD, Mignon L Loh, MD, Meenakshi Devidas, PhD, Brent L. Wood, MD, PhD, Stuart S. Winter, MD, Kimberly Dunsmore, MD, Robert S. Fulton, MS, Lucinda A. Fulton, MS, Xin Hong, PhD, Christopher C. Harris, BS, David J. Dooling, PhD, Kerri Ochoa, Kimberly J Johnson, John C Obenauer, Ching-Hon Pui, MD, Susana C. Raimondi, PhD, Clayton W Naeve, PhD, Timothy J Ley, MD, Elaine R Mardis, PhD, Richard K Wilson, PhD, James R Downing, MD, Charles G Mullighan, MBBS, MD, FRACP, FRCPA, MSc
Journal: Blood
Blood (2011) 118 (21): 68.
https://doi.org/10.1182/blood.V118.21.68.68
Published: 2011
Journal Articles

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

Brief Report
Alejandro Gutierrez, Alex Kentsis, Takaomi Sanda, Linda Holmfeldt, Shann-Ching Chen, Jianhua Zhang, Alexei Protopopov, Lynda Chin, Suzanne E. Dahlberg, Donna S. Neuberg, Lewis B. Silverman, Stuart S. Winter, Stephen P. Hunger, Stephen E. Sallan, Shan Zha, Frederick W. Alt, James R. Downing, Charles G. Mullighan, A. Thomas Look
Journal: Blood
Blood (2011) 118 (15): 4169–4173.
https://doi.org/10.1182/blood-2010-11-318873
Published: 2011
Includes: Supplemental data
Journal Articles

Dominant-Negative Impact of PAX5/TEL on Downstream Targets of PAX5 and Essential Pre-B Cell Receptor Genes

Gabriela B. Iwanski, MD, Nils H. Thoennissen, MD, Joy Nakitandwe, BSc, MSc, PhD, Patricia Lin, Norihiko Kawamata, Rahul Nahar, Parham Ramezani-Rad, Shann-Ching Chen, Sheila Shurtleff, PhD, Daniel Nowak, MD, Christian Ruckert, Martin Dugas, MD, Carsten Bokemeyer, MD, Grazia Fazio, Andrea Biondi, Professor, MD, Giovanni Cazzaniga, PhD, James R. Downing, MD, Markus Müschen, H. Phillip Koeffler, MD
Journal: Blood
Blood (2010) 116 (21): 3231.
https://doi.org/10.1182/blood.V116.21.3231.3231
Published: 2010
Journal Articles

The Role of Dominant-Negative IKAROS Mutations In the Pathogenesis and Treatment Responsiveness of BCR-ABL1 positive Acute Lymphoblastic Leukemia

J. Racquel Collins-Underwood, PhD, Nidal Boulos, PhD, Debbie Payne-Turner, Shann-Ching Chen, Ph.D., Richard Williams, MD, PhD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc
Journal: Blood
Blood (2010) 116 (21): 540.
https://doi.org/10.1182/blood.V116.21.540.540
Published: 2010
Journal Articles

Integrated Genetic and Epigenetic Analysis of Childhood Acute Lymphoblastic Leukemia Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype

Maria E. Figueroa, MD, Shann-Ching Chen, Ph.D., Anna K. Andersson, PhD, Wei Liu, Ph.D., Cheng Cheng, Ph.D., Letha A Phillips, Yushan Li, James R. Downing, MD, Ari M. Melnick, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc
Journal: Blood
Blood (2010) 116 (21): 537.
https://doi.org/10.1182/blood.V116.21.537.537
Published: 2010
Journal Articles

Acute Lymphoblastic Leukemia-Associated PAX5 Mutations Induce Aberrant B Cell Development

Joy Nakitandwe, PhD., Shann-Ching Chen, PhD., Noel T. Lenny, PhD., Christopher B. Miller, PhD., Xiaoping Su, PhD., Charles G. Mullighan, MD, PhD., James R. Downing, MD.
Journal: Blood
Blood (2010) 116 (21): 10.
https://doi.org/10.1182/blood.V116.21.10.10
Published: 2010