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Gordon Chan
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Journal Articles

HSC-Independent Yolk Sac Progenitors Bear Hallmarks of JMML in a PTPN11 D61Y Mouse Model

Stefan Pasichnyk Tarnawsky, B.Sc., Momoko Yoshimoto, MD PhD, Gordon Chan, PhD, Benjamin Neel, MD PhD, Rebecca J. Chan, MD PhD, Mervin C. Yoder, MD
Journal: Blood
Blood (2014) 124 (21): 3236.
https://doi.org/10.1182/blood.V124.21.3236.3236
Published: 2014
Journal Articles

Macrophage NADPH Oxidase Activation and ROS Production Is Positively Regulated By Shp2 Phosphatase Function

XingJun Li, MD PhD, Charles Goodwin, BS, Zhenyun Yang, Sarah C Nabinger, PhD, Briana Richine, Gordon Chan, Helmut Hanenberg, Hiroaki Ohnishi, MD, Takashi Matozaki, MD PhD, Jamel El Benna, Gen-Sheng Feng, PhD, Benjamin Neel, MD PhD, Rebecca J. Chan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1397.
https://doi.org/10.1182/blood.V124.21.1397.1397
Published: 2014
Journal Articles

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Brief Report
Charles B Goodwin, Xing Jun Li, Raghuveer S. Mali, Gordon Chan, Michelle Kang, Ziyue Liu, Bart Vanhaesebroeck, Benjamin G. Neel, Mignon L. Loh, Brian J. Lannutti, Reuben Kapur, Rebecca J. Chan
Journal: Blood
Blood (2014) 123 (18): 2838–2842.
https://doi.org/10.1182/blood-2013-10-535104
Published: 2014
Journal Articles

Phosphatidylinositol-3-Kinase p110d Uniquely Promotes Gain-Of-Function PTPN11 -Induced GM-CSF Hypersensitivity In a Model Of Juvenile Myelomonocytic Leukemia

Charles B Goodwin, Raghuveer Mali, Ph.D., Gordon Chan, Benjamin Neel, Brian Lannutti, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3678.
https://doi.org/10.1182/blood.V122.21.3678.3678
Published: 2013
Journal Articles

Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis

Brief Report
Gordon Chan, Shengqing Gu, Benjamin G. Neel
Journal: Blood
Blood (2013) 121 (18): 3594–3598.
https://doi.org/10.1182/blood-2012-12-476200
Published: 2013
Includes: Supplemental data
Journal Articles

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

Gordon Chan, Laurene S. Cheung, Wentian Yang, Michael Milyavsky, Ashley D. Sanders, Shengqing Gu, Wan Xing Hong, Aurora X. Liu, Xiaonan Wang, Mary Barbara, Tarun Sharma, Joehleen Gavin, Jeffery L. Kutok, Norman N. Iscove, Kevin M. Shannon, John E. Dick, Benjamin G. Neel, Benjamin S. Braun
Journal: Blood
Blood (2011) 117 (16): 4253–4261.
https://doi.org/10.1182/blood-2010-11-319517
Published: 2011
Includes: Supplemental data
Journal Articles

Tyrosine Phosphorylation of Runx1 In Megakaryocytes by Src Family Kinases

Hui Huang, Zachary Waldon, Gordon Chan, Helen Zhu, Hanno Steen, Gen-Sheng Feng, Benjamin Neel, Alan Cantor
Journal: Blood
Blood (2010) 116 (21): 742.
https://doi.org/10.1182/blood.V116.21.742.742
Published: 2010
Journal Articles

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

Dan Xu, Siying Wang, Wen-Mei Yu, Gordon Chan, Toshiyuki Araki, Kevin D. Bunting, Benjamin G. Neel, Cheng-Kui Qu
Journal: Blood
Blood (2010) 116 (18): 3611–3621.
https://doi.org/10.1182/blood-2010-01-265652
Published: 2010
Includes: Supplemental data
Journal Articles

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

Gordon Chan, Demetrios Kalaitzidis, Tatiana Usenko, Jeffery L. Kutok, Wentian Yang, M. Golam Mohi, Benjamin G. Neel
Journal: Blood
Blood (2009) 113 (18): 4414–4424.
https://doi.org/10.1182/blood-2008-10-182626
Published: 2009
Includes: Supplemental data
Journal Articles

Expression of Leukemogenic Ptpn11 Causes a Fatal Myeloproliferative Disorder by Affecting Multiple Stages of Hematopoiesis

Gordon Chan, Demetrios Kalaitzidis, Tatiana Usenko, Jeffery Kutok, MD, PhD, Wentian Yang, Golam Mohi, Benjamin Neel, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 3733.
https://doi.org/10.1182/blood.V112.11.3733.3733
Published: 2008
Journal Articles

Inducible Expression of Leukemia-Associated Shp2 (Ptpn11) Affects Multiple Stages of Hematopoiesis and Causes a Fatal Myeloproliferative Disorder (MPD) in Mice

Gordon Chan, Demetrios Kalaitzidis, M. Golam Mohi, Wentian Yang, Jeffery Kutok, Benjamin Neel
Journal: Blood
Blood (2007) 110 (11): 1529.
https://doi.org/10.1182/blood.V110.11.1529.1529
Published: 2007
Journal Articles

Activating Shp2 Mutations Cause Progressive Myeloproliferative Disorder in Mice.

M. Golam Mohi, PhD, Gordon Chan, Ph.D, Toshiyuki Araki, Ph.D., Wentien Yang, Ph.D., Lily Pao, Ph.D., Demetrios Kalaitzidis, Ph.D., Benjamin G. Neel, M.D., Ph.D.
Journal: Blood
Blood (2006) 108 (11): 3614.
https://doi.org/10.1182/blood.V108.11.3614.3614
Published: 2006
Journal Articles

Myelopoiesis Requires a Noncatalytic, Ras-Independent Function of SHP-2.

Benjamin S. Braun, MD, PhD, Joehleen A. Archard, Wentian Yang, PhD, Gordon Chan, PhD, Benjamin G. Neel, MD, PhD, Kevin Shannon, MD
Journal: Blood
Blood (2006) 108 (11): 635.
https://doi.org/10.1182/blood.V108.11.635.635
Published: 2006
Journal Articles

Oncogenic Ras Requires SHP-2 To Induce Myeloproliferative Disease (MPD).

Benjamin S. Braun, MD, PhD, Joehleen Archard, Wentian Yang, PhD, Gordon Chan, PhD, Benjamin G. Neel, MD, PhD, Kevin M. Shannon, MD
Journal: Blood
Blood (2005) 106 (11): 3517.
https://doi.org/10.1182/blood.V106.11.3517.3517
Published: 2005