Page 1 | Search Results | Blood | American Society of Hematology

1-20 of 24

Sort by

Sort Order Select

Journal Articles

α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia

Scott Evan Millman, Almudena Chaves-Perez, Sudha Janaki-Raman, Yu-Jui Ho, John P Morris IV, Varun Narendra, Chi-Chao Chen, Benjamin T Jackson, Jossie J Yashinskie, Riccardo Mezzadra, Tessa I Devine, Valentin J. A. Barthet, Michelle Saoi, Timour Baslan, Sha Tian, Zohar Sachs, Lydia WS Finley, Justin R Cross, Scott W Lowe

Blood blood.2024025245.

https://doi.org/10.1182/blood.2024025245

Published: 2024

Includes: Supplemental data

Journal Articles

SCA-AD, a Novel Method to Uniformly Identify Cells across Single-Cell RNA Sequencing Datasets, Applied to Adult and Pediatric Self-Renewing AML Cells

Yoonkyu Lee, Wen Wang, Timothy K Starr, Klara E Noble-Orcutt, Chad L Myers, Zohar Sachs

Blood (2024) 144 (Supplement 1): 2218.

https://doi.org/10.1182/blood-2024-208337

Published: 2024

Journal Articles

Single Cell Correlation Analysis: A Novel Method to Analyze Single Cell RNA Sequencing Data Identifies a Self-Renewing Subpopulation of Human Acute Myeloid Leukemia Stem Cells

Yoonkyu Lee, Wen Wang, Timothy K Starr, Klara E Noble-Orcutt, Chad L Myers, Zohar Sachs

Blood (2023) 142 (Supplement 1): 241.

https://doi.org/10.1182/blood-2023-186606

Published: 2023

Journal Articles

TP53 -Mutated Acute Myeloid Leukemia Patients Treated with Intensive Therapies Have Superior Outcomes: A Single Institution, Retrospective Study

Nuttavut Sumransub, Gabriel K Steinwand, Yoonkyu Lee, Qing Cao, Jeremy R. Allred, Vidhyalakshmi Ramesh, Chad L Myers, Zohar Sachs

Blood (2023) 142 (Supplement 1): 1526.

https://doi.org/10.1182/blood-2023-177757

Published: 2023

Journal Articles

Forward Genetic Screen Implicates Drivers of Leukemic Progression in a Novel Model of Trp53 R270H myelodysplastic Syndrome

Daniel Chang, Klara E Noble-Orcutt, Wendy Hudson, Aishwarya Iyer, Emily Pomeroy, Craig E. Eckfeldt, Aaron Sarver, Nuri Alpay Temiz, Michael Linden, Chad L Myers, David A. Largaespada, Zohar Sachs

Blood (2023) 142 (Supplement 1): 315.

https://doi.org/10.1182/blood-2023-189336

Published: 2023

Journal Articles

Gene Expression Analysis Reveals a Subset of TP53mutant -like AML with Wild Type TP53 and Poor Prognosis

Yoonkyu Lee, Chad Myers, Zohar Sachs

Blood (2022) 140 (Supplement 1): 9108–9109.

https://doi.org/10.1182/blood-2022-167021

Published: 2022

Journal Articles

TP53 Altered Acute Myeloid Leukemia Stem Cells Hyperactivate Nuclear Factor-Kappa B

Marie Lue Antony, Klara E Noble-Orcutt, Jeffrey Lee Jensen, Fiona He, Zohar Sachs

Blood (2022) 140 (Supplement 1): 3399–3400.

https://doi.org/10.1182/blood-2022-170479

Published: 2022

Journal Articles

Proteasome Inhibition Attenuates Self-Renewal in Human Acute Myeloid Leukemia By Targeting NF-Kappa B in Leukemia Stem Cells

Marie Lue Antony, Klara Noble-Orcutt, Jeffrey Lee Jensen, Fiona He, Zohar Sachs

Blood (2021) 138 (Supplement 1): 3347.

https://doi.org/10.1182/blood-2021-153338

Published: 2021

Journal Articles

JAK/STAT Inhibition Targets TP53 altered Primary Human Acute Myeloid Leukemia Stem Cells

Marie Lue Antony, PhD, Klara Noble-Orcutt, BS, MS, Yoonku Lee, MS, Oluwateniayo Ogunsan, Jeffrey Lee Jensen, MD PhD, Fiona He, MD, Zohar Sachs, MD PhD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-142993

Published: 2020

Journal Articles

Clinical Value of Next Generation Sequencing in the Detection of Recurring Structural Rearrangements and Copy Number Abnormalities in Acute Myeloid Leukemia

Beth A Pitel, MS, Neeraj Sharma, PhD, Cinthya Zepeda-Mendoza, PhD, James B Smadbeck, PhD, Kathryn E. Pearce, MS, Stephanie A. Smoley, BA, Joselle Cook, MBBS, George Vasmatzis, PhD, Zohar Sachs, MD PhD, David S. Viswanatha, MD, Robert Jenkins, MD PhD, Xinjie Xu, PhD, Sheng Xiao, MD, Nicole Hoppman, PhD, Rhett P. Ketterling, MD, Jess Peterson, MD, Patricia Greipp, DO, Linda B Baughn, PhD

Blood (2020) 136 (Supplement 1): 21–22.

https://doi.org/10.1182/blood-2020-139691

Published: 2020

Journal Articles

Cell Type-Specific Effects of Crizotinib in Human Acute Myeloid Leukemia with TP53 Alterations

Marie Lue Antony, PhD, Klara Noble-Orcutt, Oluwateniayo Ogunsan, Fiona He, MD, Zohar Sachs, MD PhD

Blood (2019) 134 (Supplement_1): 2563.

https://doi.org/10.1182/blood-2019-130487

Published: 2019

Journal Articles

High Risk of Relapse with Intermediate Dose Cytarabine for Consolidation in Young Favorable Risk AML Patients Following Induction with 7+3

Bhaskar Kolla, MBBS, Nurul Aidah Abdul Halim, MBBS, Zohar Sachs, MD PhD, Erica D. Warlick, MD, Daniel J. Weisdorf, MD, Fiona He, MD, Lao Zhentang, MBBS, MRCP

Blood (2019) 134 (Supplement_1): 3432.

https://doi.org/10.1182/blood-2019-123306

Published: 2019

Journal Articles

NRAS G12V -Mediated Self-Renewal Signaling in Self-Renewing AML Stem Cells.

Marie Lue Antony, PhD, Klara Noble-Orcutt, Karen Sachs, PhD, Anna Khoroshilov, Daniel Chang, Alexandria Hillesheim, Hesham Mohei, Merve Pamukcuoglu, MD, Christine Bergene, David A. Largaespada, PhD, Zohar Sachs, MD PhD

Blood (2018) 132 (Supplement 1): 2626.

https://doi.org/10.1182/blood-2018-99-119448

Published: 2018

Journal Articles

Single-Cell Transcriptional Profiling of Acute Myeloid Leukemia Identifies Prognostic Transcriptional Profiles at Diagnosis

Karen Sachs, PhD, Aaron Sarver, PhD, Klara Noble-Orcutt, Connor Navis, Alexandria Hillesheim, Ian Nykaza, Rebecca S. Larue, PhD, Conner Hansen, Nuri Temiz, Ngoc Ha, Michael A. Linden, MDPhD, David A. Largaespada, PhD, Zohar Sachs, MD PhD

Blood (2017) 130 (Supplement 1): 2704.

https://doi.org/10.1182/blood.V130.Suppl_1.2704.2704

Published: 2017

Journal Articles

Germline Calr Mutation and Thrombocytosis Presenting with Concomitant BCR-ABL1+ CML

Linda B. Baughn, PhD, Scott Gilles, MD, Elizabeth L. Courville, MD, Andrew C. Nelson, MD PhD, Zohar Sachs, MD PhD

Blood (2016) 128 (22): 5494.

https://doi.org/10.1182/blood.V128.22.5494.5494

Published: 2016

Journal Articles

Immunoproteasome Inhibition to Target AML with Activated RAS Pathways

Connor Navis, Klara Noble-Orcutt, Rebecca S LaRue, PhD, Conner Hansen, B.S., Ngoc Ha, B.S., Alexandria Hillesheim, Ryan Schulz, Do-Hyung Kim, David A Largaespada, PhD, Zohar Sachs, MD PhD

Blood (2016) 128 (22): 577.

https://doi.org/10.1182/blood.V128.22.577.577

Published: 2016

Journal Articles

Single-Cell Analysis Reveals Molecular Mechanisms of NRAS-Mediated Leukemia Stem Cell Self-Renewal in a Murine Model of AML

Rebecca S. Larue, PhD, Klara E Noble, B.S., Conner Hansen, B.S., Ngoc Ha, B.S., David A Largaespada, PhD, Zohar Sachs, MD PhD

Blood (2015) 126 (23): 3060.

https://doi.org/10.1182/blood.V126.23.3060.3060

Published: 2015

Journal Articles

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Zohar Sachs, Rebecca S. LaRue, Hanh T. Nguyen, Karen Sachs, Klara E. Noble, Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, Susan K. Rathe, Aaron L. Sarver, Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, Garry P. Nolan, Kevin M. Shannon, David A. Largaespada

Blood (2014) 124 (22): 3274–3283.

https://doi.org/10.1182/blood-2013-08-521708

Published: 2014

Includes: Supplemental data

Journal Articles

Ras-Pathway Inhibition With Targeted Therapies Abrogates Self-Renewal In Acute Myelogenous Leukemia

Rebecca S. LaRue, PhD, Hanh Nguyen, Karen Sachs, Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, PhD, Susan K. Rathe, Aaron G. Sarver, Ph.D., Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, B.S., Garry P. Nolan, PhD, Kevin Shannon, MD, Zohar Sachs, MD, PhD, David A. Largaespada, PhD

Blood (2013) 122 (21): 819.

https://doi.org/10.1182/blood.V122.21.819.819

Published: 2013

Journal Articles

Are IPSS-R and IPSS Cytogenetic Risk Stratification Informative At the Time of Allogeneic Hematopoietic Cell Transplantation?

Zohar Sachs, MD, PhD, Michelle Dollan, MD, Todd E De For, Phd, Leyla Shune, MD, Sarah Cooley, MD, Daniel J. Weisdorf, MD, Erica D. Warlick, MD, Celalettin Ustun

Blood (2012) 120 (21): 1400.

https://doi.org/10.1182/blood.V120.21.1400.1400

Published: 2012

NARROW

α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia

SCA-AD, a Novel Method to Uniformly Identify Cells across Single-Cell RNA Sequencing Datasets, Applied to Adult and Pediatric Self-Renewing AML Cells

Single Cell Correlation Analysis: A Novel Method to Analyze Single Cell RNA Sequencing Data Identifies a Self-Renewing Subpopulation of Human Acute Myeloid Leukemia Stem Cells

TP53 -Mutated Acute Myeloid Leukemia Patients Treated with Intensive Therapies Have Superior Outcomes: A Single Institution, Retrospective Study

Forward Genetic Screen Implicates Drivers of Leukemic Progression in a Novel Model of Trp53 R270H myelodysplastic Syndrome

Gene Expression Analysis Reveals a Subset of TP53mutant -like AML with Wild Type TP53 and Poor Prognosis

TP53 Altered Acute Myeloid Leukemia Stem Cells Hyperactivate Nuclear Factor-Kappa B

Proteasome Inhibition Attenuates Self-Renewal in Human Acute Myeloid Leukemia By Targeting NF-Kappa B in Leukemia Stem Cells

JAK/STAT Inhibition Targets TP53 altered Primary Human Acute Myeloid Leukemia Stem Cells

Clinical Value of Next Generation Sequencing in the Detection of Recurring Structural Rearrangements and Copy Number Abnormalities in Acute Myeloid Leukemia

Cell Type-Specific Effects of Crizotinib in Human Acute Myeloid Leukemia with TP53 Alterations

High Risk of Relapse with Intermediate Dose Cytarabine for Consolidation in Young Favorable Risk AML Patients Following Induction with 7+3

NRAS G12V -Mediated Self-Renewal Signaling in Self-Renewing AML Stem Cells.

Single-Cell Transcriptional Profiling of Acute Myeloid Leukemia Identifies Prognostic Transcriptional Profiles at Diagnosis

Germline Calr Mutation and Thrombocytosis Presenting with Concomitant BCR-ABL1+ CML

Immunoproteasome Inhibition to Target AML with Activated RAS Pathways

Single-Cell Analysis Reveals Molecular Mechanisms of NRAS-Mediated Leukemia Stem Cell Self-Renewal in a Murine Model of AML

NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Ras-Pathway Inhibition With Targeted Therapies Abrogates Self-Renewal In Acute Myelogenous Leukemia

Are IPSS-R and IPSS Cytogenetic Risk Stratification Informative At the Time of Allogeneic Hematopoietic Cell Transplantation?

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only