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Journal Articles

CD39, CD73 and the Adenosine Pathway Mediate Immune Escape in Juvenile Myelomonocytic Leukemia (JMML)

Jovana Rajak, Ke Meng, Anna Lena Stippel, Jun Wang, Naile Koleci, Alexandra Emilia Schlaak, Hui Xiao, Christian Flotho, Charlotte Marie Niemeyer, Bertram Bengsch, Miriam Erlacher
Journal: Blood
Blood (2024) 144 (Supplement 1): 4514.
https://doi.org/10.1182/blood-2024-209744
Published: 2024
Journal Articles

Outcome of Oncologic Pediatric Patients Presenting with Febrile Neutropenia after Implementation of the Standard of Procedure in the Outpatient Department

Stefano Malvestiti, Brigitte Strahm, Christian Flotho, Simone Hettmer, Markus Hufnagel, Tobias Feuchtinger, Charlotte Marie Niemeyer, Alexander Puzik
Journal: Blood
Blood (2024) 144 (Supplement 1): 7625.
https://doi.org/10.1182/blood-2024-193894
Published: 2024
Journal Articles

Hypersensitivity Reactions to Native E. coli L-Asparaginase in Children with Acute Lymphoblastic Leukemia May Vary By Treatment Schedule and Type of Glucocorticoid in Induction: Results of Trial ALL-BFM 2000

Anja Möricke, Martin Schrappe, Carmelo Rizzari, Julia Alten, Andishe Attarbaschi, Rita Beier, Andrea Biondi, Birgit Burkhardt, Nicole Bodmer, Joachim Boos, Gunnar Cario, Valentino Conter, Christian Flotho, Andreas E. Kulozik, Claudia Lanvers-Kaminsky, Georg Mann, Felix Niggli, Daniela Silvestri, Arend von Stackelberg, Martin Stanulla, Maria Grazia Valsecchi, Martin Zimmermann
Journal: Blood
Blood (2022) 140 (Supplement 1): 11676–11678.
https://doi.org/10.1182/blood-2022-163142
Published: 2022
Journal Articles

Multi-Omics Profiling of JMML HSPCs Reveals Onco-Fetal Reprogramming and Identifies Novel Prognostic Biomarkers and Therapeutic Targets in High-Risk JMML

Mark Hartmann, Ling Hai, Joschka Hey, Maximilian Schönung, Valentin Maurer, Jovana Rajak, Sina Staeble, Jens Langstein, Katharina Bauer, Mariam Hakobyan, Laura Jardine, Sheila Bohler, Dominik Vonficht, Abdul-Habib Maag, Dirk Lebrecht, Kathrin M. Bernt, Roland Roelz, Tobias Boch, Eleonora Khabirova, Pavlo Lutsik, Oliver Stegle, Simon Haas, Muzlifah Haniffa, Sam Behjati, Jan-Philipp Mallm, Christian Buske, Stefan Fröhling, Christoph Plass, Charlotte M. Niemeyer, Christian Flotho, Marc Jan Bonder, Miriam Erlacher, Matthias Schlesner, Daniel B. Lipka
Journal: Blood
Blood (2022) 140 (Supplement 1): 8729–8730.
https://doi.org/10.1182/blood-2022-162224
Published: 2022
Journal Articles

Superior Overall Survival with Blinatumomab Versus Chemotherapy As Pre-Transplant Consolidation Treatment in Children with High-Risk First-Relapse B-Cell Precursor Acute Lymphoblastic Leukemia (B-ALL): Longer Follow-up (FU) of a Phase 3 Randomized Controlled Trial (RCT)

Franco Locatelli, Gerhard Zugmaier, Carmelo Rizzari, Joan D Morris, Bernd Gruhn, Thomas Klingebiel, Rosanna Parasole, Christin Linderkamp, Christian Flotho, Arnaud Petit, Concetta Micalizzi, Yi Zeng, Deepali Dilip Pilankar, William N Kormany, Cornelia Eckert, Anja Moericke, Mary Sartor, Ondrej Hrusak, Christina Peters, Vaskar Saha, Luciana Vinti, Arend von Stackelberg
Journal: Blood
Blood (2021) 138 (Supplement 1): 1231.
https://doi.org/10.1182/blood-2021-145476
Published: 2021
Journal Articles

NF1 Tumor Suppressor Gene Inactivation in Juvenile Myelomonocytic Leukemia: New Genetic Evidence and Consequences for Diagnostic Work-up

Senthilkumar Ramamoorthy, PhD, Dirk Lebrecht, PhD, Denny Schanze, PhD, Ina Schanze, MD, Ilse Wieland, PhD, Michael H. Albert, MD, Arndt Borkhardt, MD, Dorine Bresters, MD PhD, Jochen Büchner, MDPhD, Albert Catala, MD PhD, Valerie De Haas, MD PhD, Michael Dworzak, MD PhD, Miriam Erlacher, MD PhD, Henrik Hasle, PhD, Kirsi Jahnukainen, MD PhD, Franco Locatelli, MD PhD, Riccardo Masetti, MDPhD, Jan Stary, MD PhD, Dominik Turkiewicz, MD, Luca Vinci, MD, Marcin W. Wlodarski, MD PhD, Ayami Yoshimi, MD PhD, Maria Hess, Melanie Boerries, MD PhD, Charlotte M. Niemeyer, MD, Martin Zenker, MD, Christian Flotho, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136294
Published: 2020
Journal Articles

DNA Methylation As a Biomarker of Outcome in JMML: An International Effort Towards Clinical Implementation

Julia Meyer, PhD, Maximillian Schönung, Christian Flotho, MD PhD, Adam B. Olshen, PhD, Mark Hartmann, PhD, Christoph Plass, PhD, Yusuke Okuno, MD PhD, Yoshiyuki Takahashi, MD PhD, Norihiro Murakami, MD PhD, Manabu Wakamatsu, MD, Mignon L. Loh, MD, Charlotte M. Niemeyer, MD, Hideki Muramatsu, MD PhD, Daniel B. Lipka, MD, Elliot Stieglitz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1693.
https://doi.org/10.1182/blood-2019-131279
Published: 2019
Journal Articles

Long Non-Coding RNAs As Novel Therapeutic Targets in Juvenile Myelomonocytic Leukemia: Proof of Concept Study

Mattias Hofmans, MD, Barbara Depreter, PhD PharmD, Tim Lammens, PhD, Helene Cave, PharmD, PhD, Christian Flotho, MD PhD, Henrik Hasle, Valerie de Haas, MD PhD, Charlotte M. Niemeyer, MD, Jan Stary, Prof., MD PhD, Pieter Van Vlierberghe, PhD, Jan Philippé, MD PhD, Barbara De Moerloose, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1701.
https://doi.org/10.1182/blood-2019-123715
Published: 2019
Journal Articles

High-Throughput RNA Sequencing Analysis Reveals Distinct Molecular Signature in NRAS and PTPN11 JMML Patients

Pier Paolo Leoncini, PhD, Alessandro Domenico Silvestris, PhD, Patrizia Vitullo, PhD, Marco Zecca, MD, Christian Flotho, MD PhD, Charlotte M. Niemeyer, MD, Angela Gallo, PhD, Alice Bertaina, MD PhD, Franco Locatelli, MD PhD, Pietro Merli, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4229.
https://doi.org/10.1182/blood-2019-129965
Published: 2019
Journal Articles

Juvenile myelomonocytic leukemia: who’s the driver at the wheel?

Clinical Trials & Observations
Charlotte M. Niemeyer, Christian Flotho
Journal: Blood
Blood (2019) 133 (10): 1060–1070.
https://doi.org/10.1182/blood-2018-11-844688
Published: 2019
Journal Articles

SAMD9 and SAMD9L Germline Disorders in Patients Enrolled in Studies of the European Working Group of MDS in Childhood (EWOG-MDS): Prevalence, Outcome, Phenotype and Functional Characterisation

Sushree Sangita Sahoo, MSc, Victor Pastor Loyola, MSc, Pritam Kumar Panda, MSc, MS, BSc, Enikoe Amina Szvetnik, Emilia J. Kozyra, MSc, Rebecca K Voss, MD, Dirk Lebrecht, PhD, Shlomit Barzilai, MD, Jochen Büchner, MDPhD, Albert Catala, MD PhD, Barbara De Moerloose, MD PhD, Michael Dworzak, MD, Oksana Fabri, MD, Henrik Hasle, MD, Kirsi Jahnukainen, Krisztián Kállay, MD, Franco Locatelli, Riccardo Masetti, MDPhD, Sophia Polychronopoulou, MD PhD, Markus Schmugge, MD, Jan Stary, MD PhD, Owen P Smith, MD, Dominik Turkiewicz, Marek Ussowicz, Marry M. van den Heuvel-Eibrink, Prof, Peter Noellke, MPH, Gudrun Göhring, MD, Miriam Erlacher, MD PhD, Christian Flotho, Brigitte Strahm, PD Dr., Charlotte Niemeyer, MD, Marcin W. Wlodarski, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 643.
https://doi.org/10.1182/blood-2018-99-118389
Published: 2018
Journal Articles

5-Azacytidine Is Effective for Targeting Leukemia-Initiating Cells in Juvenile Myelomonocytic Leukemia

Christopher Felix Krombholz, PhD, Lorena Gallego Villar, PhD, Pritam Kumar Panda, MSc, MS, BSc, Sushree Sangita Sahoo, MSc, Marcin W. Wlodarski, MD PhD, Daniel B. Lipka, Christoph Plass, Charlotte Niemeyer, MD, Miriam Erlacher, MD PhD, Christian Flotho
Journal: Blood
Blood (2018) 132 (Supplement 1): 4342.
https://doi.org/10.1182/blood-2018-99-116594
Published: 2018
Journal Articles

Monosomy 7 As the Initial Hit Followed By Sequential Acquisition of SETBP1 and ASXL1 Driver Mutations in Childhood Myelodysplastic Syndromes

Victor Pastor Loyola, MSc, Pritam Kumar Panda, MSc, MS, BSc, Sushree Sangita Sahoo, MSc, Enikoe Amina Szvetnik, Emilia J. Kozyra, MSc, Rebecca K Voss, MD, Dirk Lebrecht, PhD, Julius Wehrle, MD, Miriam Erlacher, MD PhD, Jan Stary, MD PhD, Christian Flotho, Gudrun Göhring, MD, Brigitte Schlegelberger, MD PhD, Brigitte Strahm, PD Dr., Charlotte Niemeyer, MD, Marcin W. Wlodarski, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 105.
https://doi.org/10.1182/blood-2018-99-118910
Published: 2018
Journal Articles

DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia: An International Collaborative Analysis and Development of a Common Diagnostic Platform

Maximilian Schoenung, Elliot Stieglitz, Hideki Muramatsu, MD PhD, Norihiro Murakami, MD, Mark Hartmann, Manuel Wiesenfarth, Yusuke Okuno, MD PhD, Adam B. Olshen, PhD, Christoph Plass, Mignon L. Loh, MD, Charlotte Niemeyer, MD, Christian Flotho, Daniel B. Lipka
Journal: Blood
Blood (2018) 132 (Supplement 1): 3093.
https://doi.org/10.1182/blood-2018-99-114918
Published: 2018
Journal Articles

LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia

Hetty H. Helsmoortel, Silvia Bresolin, Tim Lammens, Hélène Cavé, Peter Noellke, Aurélie Caye, Farzaneh Ghazavi, Andrica de Vries, Henrik Hasle, Veerle Labarque, Riccardo Masetti, Jan Stary, Marry M. van den Heuvel-Eibrink, Jan Philippé, Nadine Van Roy, Yves Benoit, Frank Speleman, Charlotte Niemeyer, Christian Flotho, Giuseppe Basso, Geertruy te Kronnie, Pieter Van Vlierberghe, Barbara De Moerloose
Journal: Blood
Blood (2016) 127 (9): 1163–1172.
https://doi.org/10.1182/blood-2015-09-667808
Published: 2016
Includes: Supplemental data
Journal Articles

Microrna-150 Regulates STAT5b Levels in Juvenile Myelomonocytic Leukemia (JMML)

Pier Paolo Leoncini, PhD, Alice Bertaina, MDPhD, Dimitrios Papaioannou, MD, Christian Flotho, Riccardo Masetti, MD, Silvia Bresolin, PhD, Giuseppe Menna, MD, Nicola Santoro, Marco Zecca, MD, Giuseppe Basso, Prof, MD, Giovanni Nigita, PhD, Sara Pagotto, PhD, Katia D'Ovidio, PhD, Rossella Rota, Carlo M. Croce, MD, Charlotte Marie Niemeyer, Prof, MD, Franco Locatelli, MD PhD, Ramiro Garzon, MD
Journal: Blood
Blood (2015) 126 (23): 2851.
https://doi.org/10.1182/blood.V126.23.2851.2851
Published: 2015
Journal Articles

Epigenetic Changes Accompany Disordered Hemoglobin Regulation in Juvenile Myelomonocytic Leukemia

Silvia Fluhr, Christopher Felix Krombholz, Angelina Meier, Christoph Plass, Charlotte Niemeyer, Christian Flotho
Journal: Blood
Blood (2015) 126 (23): 438.
https://doi.org/10.1182/blood.V126.23.438.438
Published: 2015
Journal Articles

5-Azacytidine Reduces Leukemic Burden in a Xenograft Model of Juvenile Myelomonocytic Leukemia

Christopher Felix Krombholz, Angelina Meier, Konrad Aumann, Silvia Fluhr, Matthias Kollek, Daniel B Lipka, Christoph Plass, Tania Witte, Charlotte Niemeyer, Miriam Erlacher, Christian Flotho
Journal: Blood
Blood (2015) 126 (23): 1655.
https://doi.org/10.1182/blood.V126.23.1655.1655
Published: 2015
Journal Articles

Bridging to transplant with azacitidine in juvenile myelomonocytic leukemia: a retrospective analysis of the EWOG-MDS study group

Annamaria Cseh, Charlotte M. Niemeyer, Ayami Yoshimi, Michael Dworzak, Henrik Hasle, Marry M. van den Heuvel-Eibrink, Franco Locatelli, Riccardo Masetti, Markus Schmugge, Ute Groß-Wieltsch, Andrea Candás, Andreas E. Kulozik, Lale Olcay, Meinolf Suttorp, Ingrid Furlan, Brigitte Strahm, Christian Flotho
Journal: Blood
Blood (2015) 125 (14): 2311–2313.
https://doi.org/10.1182/blood-2015-01-619734
Published: 2015
Journal Articles

Tracing the development of acute myeloid leukemia in CBL syndrome

Brief Report
Heiko Becker, Kenichi Yoshida, Nadja Blagitko-Dorfs, Rainer Claus, Milena Pantic, Mahmoud Abdelkarim, Christoph Niemöller, Christine Greil, Björn Hackanson, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Konstanze Döhner, Susanne Schnittger, Philipp Henneke, Charlotte M. Niemeyer, Christian Flotho, Dietmar Pfeifer, Seishi Ogawa, Michael Lübbert
Journal: Blood
Blood (2014) 123 (12): 1883–1886.
https://doi.org/10.1182/blood-2013-10-533844
Published: 2014
Includes: Supplemental data