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Journal Articles

Identification of Multivariable microRNA and Clinical Biomarkers Panels to Predict Imatinib Response in Chronic Myeloid Leukemia at Diagnosis

Andrew Wu, Ryan Yen, Sarah Grasedieck, Hanyang Lin, Helen Nakamoto, Donna L. Forrest, Connie J. Eaves, Xiaoyan Jiang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4547.
https://doi.org/10.1182/blood-2023-180252
Published: 2023
Journal Articles

Identification of Key microRNAs As Predictive Biomarkers of Nilotinib Response in Chronic Myeloid Leukemia: A Sub-Analysis of the Enestxtnd Clinical Trial

Andrew Wu, Ryan Yen, Sarah Grasedieck, Hanyang Lin, Jiechuang Su, Katharina Rothe, Helen Nakamoto, Donna L. Forrest, Connie J. Eaves, Xiaoyan Jiang
Journal: Blood
Blood (2022) 140 (Supplement 1): 12169–12170.
https://doi.org/10.1182/blood-2022-168534
Published: 2022
Journal Articles

The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML

Hanyang Lin, Katharina Rothe, Min Chen, Andrew Wu, Artem Babaian, Ryan Yen, Jonathan Zeng, Jens Ruschmann, Oleh I. Petriv, Kieran O'Neill, Tobias Maetzig, David J. H. F. Knapp, Naoto Nakamichi, Ryan Brinkman, Inanc Birol, Donna L. Forrest, Carl Hansen, R. Keith Humphries, Connie J. Eaves, Xiaoyan Jiang
Journal: Blood
Blood (2020) 136 (5): 596–609.
https://doi.org/10.1182/blood.2019003636
Published: 2020
Includes: Supplemental data
Journal Articles

Inhibition of the MiR-185-PAK6-Mediated Survival and Metabolic Pathways Selectively Targets Drug-Resistant CML Stem/Progenitor Cells

Andrew Wu, BSc, Katharina Rothe, PhD, Min Chen, PhD, Hanyang Lin, PhD, Artem Babaian, PhD, Ryan Yen, BSc, Donna L. Forrest, MD, Xiaoyan Jiang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4138.
https://doi.org/10.1182/blood-2019-127826
Published: 2019
Journal Articles

Identification and Characterization of New Microrna Biomarkers and Target Genes in Drug-Insensitive CD34+ CML Stem/Progenitor Cells Using Global Comparative RNA-Seq Analyses

Hanyang Lin, BSc, MSc, Jonathan Zeng, Katharina Rothe, BSc, MSc, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, PhD, David Knapp, BSc, Ryan R. Brinkman, PhD, Inanc Birol, PhD, Donna L. Forrest, MD, Carl Hansen, PhD, Connie J. Eaves, PhD, R. Keith Humphries, MD PhD, Xiaoyan Jiang, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1567.
https://doi.org/10.1182/blood.V126.23.1567.1567
Published: 2015
Journal Articles

Identification of New microRNA Biomarkers and Candidate Target Genes in Primitive CML Cells Using Global Comparative RNA analyses

Hanyang Lin, Katharina Rothe, Jens Ruschmann, Oleh Petriv, Kieran O'Neill, David J.H.F. Knapp, Ryan R. Brinkman, Inanc Birol, Donna L. Forrest, MD, Carl Hansen, Connie J Eaves, R. Keith Humphries, MD PhD, Xiaoyan Jiang
Journal: Blood
Blood (2014) 124 (21): 3133.
https://doi.org/10.1182/blood.V124.21.3133.3133
Published: 2014
Journal Articles

The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells

Katharina Rothe, Hanyang Lin, Kevin B. L. Lin, Amy Leung, Hui Mi Wang, Mehrnoush Malekesmaeili, Ryan R. Brinkman, Donna L. Forrest, Sharon M. Gorski, Xiaoyan Jiang
Journal: Blood
Blood (2014) 123 (23): 3622–3634.
https://doi.org/10.1182/blood-2013-07-516807
Published: 2014
Includes: Supplemental data
Journal Articles

Effectively Targeting Treatment-Naïve CML Stem/Progenitor Cells From Imatinib-Nonresponders With Combination Treatments Of JAK2 and ABL Inhibitors In Vitro and In Vivo

Hanyang Lin, MSc, Min Chen, PhD, Katharina Rothe, MSc, Matthew V Lorenzi, PhD, Adrian Woolfson, BM BCh, PhD, Xiaoyan Jiang, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1474.
https://doi.org/10.1182/blood.V122.21.1474.1474
Published: 2013
Journal Articles

Identification of a Unique Autophagy Gene Expression Signature in CD34 + CML Stem/Progenitor Cells That Correlates with Clinical Response to Imatinib Mesylate

Katharina Rothe, Kevin B.L. Lin, Hanyang Lin, Amy Leung, Donna L. Forrest, MD, FRCPC, Sharon Gorski, Xiaoyan Jiang, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1662.
https://doi.org/10.1182/blood.V120.21.1662.1662
Published: 2012
Journal Articles

Targeting Treatment-Naïve CML Stem/Progenitor Cells From Imatinib-Nonresponders with JAK2 (BMS-911543)/ABL Inhibitor Combination Therapy

Hanyang Lin, Katharina Rothe, Matthew V Lorenzi, PhD, Adrian Woolfson, BM BCh, PhD, Xiaoyan Jiang, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1339.
https://doi.org/10.1182/blood.V120.21.1339.1339
Published: 2012
Journal Articles

Targeting the CML Stem/Progenitor Cell with JAK2 (BMS-911543)/ABL Inhibitor Combination Therapy

Hanyang Lin, Matthew Lorenzi, PhD, Adrian Woolfson, PhD, Xiaoyan Jiang, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2743.
https://doi.org/10.1182/blood.V118.21.2743.2743
Published: 2011