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Aniruddha J. Deshpande
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Journal Articles

Broken brakes: PRC loss foils menin inhibition

Nahal Azimi, Aniruddha J. Deshpande
Journal: Blood
Blood (2024) 144 (19): 1979–1980.
https://doi.org/10.1182/blood.2024026297
Published: 2024
Journal Articles

Transcriptional control of leukemogenesis by the chromatin reader SGF29

Karina Barbosa, Anagha Deshpande, Marlenne Perales, Ping Xiang, Rabi Murad, Akula Bala Pramod, Anna Minkina, Neil Robertson, Fiorella Schischlik, Xue Lei, Younguk Sun, Adam Brown, Diana Amend, Irmela Jeremias, John G. Doench, R. Keith Humphries, Eytan Ruppin, Jay Shendure, Prashant Mali, Peter D. Adams, Aniruddha J. Deshpande
Journal: Blood
Blood (2024) 143 (8): 697–712.
https://doi.org/10.1182/blood.2023021234
Published: 2024
Includes: Supplemental data
Journal Articles

Silencing with SAFB: a new role for HOXA9 in AML

Aniruddha J. Deshpande, Nan Zhu
Journal: Blood
Blood (2023) 141 (14): 1653–1655.
https://doi.org/10.1182/blood.2022019244
Published: 2023
Journal Articles

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML

Bo-Rui Chen, Anagha Deshpande, Karina Barbosa, Maria Kleppe, Xue Lei, Narayana Yeddula, Pablo Sánchez Vela, Alexandre Rosa Campos, Robert J. Wechsler-Reya, Anindya Bagchi, Soheil Meshinchi, Connie Eaves, Irmela Jeremias, Torsten Haferlach, David A. Frank, Ze’ev Ronai, Sumit Chanda, Scott A. Armstrong, Peter D. Adams, Ross L. Levine, Aniruddha J. Deshpande
Journal: Blood
Blood (2021) 137 (24): 3403–3415.
https://doi.org/10.1182/blood.2020009023
Published: 2021
Includes: Supplemental data
Journal Articles

RNF5 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

Ali Khateb, PhD, Anagha Deshpande, PhD, Yongmei Feng, PhD, Ikrame Lazar, PhD, Joo Sang Lee, PhD, Bertrand Fabre, PhD, Yan Li, PhD, Darren Finlay, PhD, Yu Fujita, PhD, Tongwu Zhang, PhD, Ian Pass, PhD, Ido Livneh, PhD, Carol Burian, James R. Mason, MD, Ronit Almog, MD, Nurit Horesh, MD, Yishai Ofran, MD, Kevin Brown, Kristiina Vuori, PhD, Michael Jackson, PhD, Eytan Ruppin, PhD, Aniruddha J. Deshpande, PhD, Ze'ev A. Ronai, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-143352
Published: 2020
Journal Articles

High-Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of Hox/Meis Gene Expression in Acute Myeloid Leukemia

Karina Barbosa, BSc, Anagha Deshpande, PhD, Ping Xiang, PhD, Bo-Rui Chen, PhD, Adam Brown, MSc, Neil Robertson, Younguk Sun, PhD, John Doench, PhD, Peter D Adams, PhD, R. Keith Humphries, MD PhD, Prashant Mali, PhD, Aniruddha J. Deshpande, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-141412
Published: 2020
Journal Articles

A Synthetic Lethal Approach to Eradicate AML Via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors

Sha Li, Anne-Louise Latif, Ashley Newcombe, Kathryn Gilrory, Neil Robertson, Xue Lei, Darren Finlay, PhD, Karina Barbosa, BSc, Helen Stewart, John Cole, Maria Terradas Terradas, Loveena Rishi Delori, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Andrew Davis, Jonathan Lopez, Jun-Ichi Sakamaki, Jennifer Morton, Kevin Ryan, Stephen Tait, Sheela Abraham, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Brian Higgins, Xu Huang, BSc, PhD, Karen Blyth, Mhairi Copland, PhD MBBChir, FRCP, FRCPath, Timothy Chevassut, Aniruddha J. Deshpande, PhD, Karen Keeshan, Peter Adams, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-143079
Published: 2020
Journal Articles

Structural Variants Involving MLLT10/AF10 Are Associated with Adverse Outcome in AML Regardless of the Partner Gene - a COG/Tpaml Study

Rhonda E. Ries, MA, Amanda R. Leonti, MS, Timothy Junius Triche, Jr., PhD, Robert B. Gerbing, Betsy A Hirsch, PhD, Susana C. Raimondi, PhD, Jenny L. Smith, MSc, MD, Todd M Cooper, DO, Jason E. Farrar, MD, Aniruddha J. Deshpande, E. Anders Kolb, MD, Alan S Gamis, MD MPH, Richard Aplenc, MD PhD, Todd A. Alonzo, PhD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 461.
https://doi.org/10.1182/blood-2019-125943
Published: 2019
Journal Articles

Selective Dependency of MLL-Rearranged Leukemia on Immunoproteasome Function

Nuria Tubío Santamaría, Jonas Tönsing, Tina M. Schnoeder, PhD, Ulrike Seifert, Clemens Cammann, Juliane Mohr, PhD, Aniruddha J. Deshpande, PhD, Joanna Kirkpatrick, Alessandro Ori, PhD, Florian Perner, MD, Florian H. Heidel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 529.
https://doi.org/10.1182/blood-2019-122100
Published: 2019
Journal Articles

Genomic and Proteomic Profiling of AF10-Fusion Oncoproteins Reveal Mechanisms of Leukemogenesis and Actionable Targets

Bo-Rui Chen, PhD, Anagha Deshpande, PhD, Maria Kleppe, PhD, Narayana Yeddula, PhD, Sunnie Yoh, PhD, Scott A. Armstrong, MD PhD, Ross L. Levine, MD, Sumit Chanda, PhD, Aniruddha J. Deshpande, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 544.
https://doi.org/10.1182/blood-2018-99-119210
Published: 2018
Journal Articles

Genetic or Pharmacological Inhibition of the Polycomb Group Protein BMI1 Impairs Leukemic Transformation Mediated By the CALM-AF10 Fusion Oncoprotein

Karina O. Barbosa, BSc, Anwesha Ghosh, PhD, Anagha Deshpande, PhD, Sayantanee Dutta, PhD, Scott A. Armstrong, MD PhD, Stefan K. Bohlander, MD, Aniruddha J. Deshpande, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 762.
https://doi.org/10.1182/blood-2018-99-115552
Published: 2018
Journal Articles

Targeting MYC-Driven B-Cell Lymphoma By Inhibition of the Histone Methyltransferase DOT1L

Anagha Deshpande, PhD, Benson Chen, Parham Ramezani-Rad, PhD, Alessandro Pastore, Luyi Zhao, M.S., Oliver Weigert, MD, Scott A. Armstrong, MD PhD, Robert C Rickert, PhD, Bing Ren, Aniruddha J. Deshpande, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2839.
https://doi.org/10.1182/blood-2018-99-115475
Published: 2018
Journal Articles

Controlled stem cell amplification by HOXB4 depends on its unique proline-rich region near the N terminus

Brief Report
Monica Cusan, Naidu M. Vegi, Medhanie A. Mulaw, Shiva Bamezai, Lisa M. Kaiser, Aniruddha J. Deshpande, Philipp A. Greif, Leticia Quintanilla-Fend, Stefanie Göllner, Carsten Müller-Tidow, Keith R. Humphries, Scott A. Armstrong, Wolfgang Hiddemann, Michaela Feuring-Buske, Christian Buske
Journal: Blood
Blood (2017) 129 (3): 319–323.
https://doi.org/10.1182/blood-2016-04-706978
Published: 2017
Includes: Supplemental data
Journal Articles

Regulation Of Normal and Malignant Hoxa Gene Expression Through Higher H3K79 Methylated States

Aniruddha J Deshpande, Ph.D, Liying Chen, Ph.D., Amit U. Sinha, PhD, Nan Zhu, PhD, David Chen, Ph.D., Jenny Chang, Andrei V. Krivtsov, PhD, Kathrin Bernt, MD, James E Bradner, MD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2492.
https://doi.org/10.1182/blood.V122.21.2492.2492
Published: 2013
Journal Articles

Genome-Wide RNAi Screen Identifies The Mechanistic Role For DOT1L In MLL -Rearranged Leukemia

Chun-Wei David Chen, Ph.D., Amit U. Sinha, PhD, Jun Qi, Ph.D., Aniruddha J Deshpande, Ph.D., Nan Zhu, PhD, Richard Koche, Ph.D., Rowena Eng, Jenny Chang, William C. Hahn, MD, PhD, James E Bradner, MD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 598.
https://doi.org/10.1182/blood.V122.21.598.598
Published: 2013
Journal Articles

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l

Aniruddha J. Deshpande, Liying Chen, Maurizio Fazio, Amit U. Sinha, Kathrin M. Bernt, Deepti Banka, Stuart Dias, Jenny Chang, Edward J. Olhava, Scott R. Daigle, Victoria M. Richon, Roy M. Pollock, Scott A. Armstrong
Journal: Blood
Blood (2013) 121 (13): 2533–2541.
https://doi.org/10.1182/blood-2012-11-465120
Published: 2013
Includes: Supplemental data
Journal Articles

Abrogation of MLL-AF10 and CALM-AF10 Mediated Transformation Through Genetic Inactivation or Pharmacological Inhibition of the H3K79 Methyltransferase DOT1L.

Liying Chen, Aniruddha J Deshpande, Deepti Banka, Bernt Kathrin, Stuart Dias, Christian Buske, MD, Edward J Olhava, PhD, Scott R Daigle, Victoria M Richon, PhD, Roy M Pollock, PhD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2384.
https://doi.org/10.1182/blood.V120.21.2384.2384
Published: 2012
Journal Articles

MLL-AF6 Mediated Transformation Is Dependent On the H3K79 Methyl-transferase Dot1l

Aniruddha J Deshpande, Liying Chen, Maurizio Fazio, Amit U. Sinha, Kathrin M Bernt, MD, Deepti Banka, Stuart Dias, Edward J Olhava, PhD, Scott R Daigle, Victoria M Richon, PhD, Roy M Pollock, PhD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3502.
https://doi.org/10.1182/blood.V120.21.3502.3502
Published: 2012
Journal Articles

The Interaction Between DOT1L and AF10 Is Required for H3K79 Dimethylation and MLL-AF9 Leukemia

Aniruddha J Deshpande, Liying Chen, Kathrin M Bernt, MD, Stuart Dias, Deepti Banka, Amit U. Sinha, David Chen, Natalie Punt, James E. Bradner, M.D., Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 401.
https://doi.org/10.1182/blood.V120.21.401.401
Published: 2012
Journal Articles

Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10–positive leukemias

Yi-Hui Lin, Purvi M. Kakadia, Ying Chen, Ya-Qiang Li, Aniruddha J. Deshpande, Christian Buske, Kang-Ling Zhang, Yi Zhang, Guo-Liang Xu, Stefan K. Bohlander
Journal: Blood
Blood (2009) 114 (3): 651–658.
https://doi.org/10.1182/blood-2009-03-209395
Published: 2009
Includes: Supplemental data