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Journal Articles

A Synthetic Lethal Approach to Eradicate AML Via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors

Sha Li, Anne-Louise Latif, Ashley Newcombe, Kathryn Gilrory, Neil Robertson, Xue Lei, Darren Finlay, PhD, Karina Barbosa, BSc, Helen Stewart, John Cole, Maria Terradas Terradas, Loveena Rishi Delori, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Andrew Davis, Jonathan Lopez, Jun-Ichi Sakamaki, Jennifer Morton, Kevin Ryan, Stephen Tait, Sheela Abraham, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Brian Higgins, Xu Huang, BSc, PhD, Karen Blyth, Mhairi Copland, PhD MBBChir, FRCP, FRCPath, Timothy Chevassut, Aniruddha J. Deshpande, PhD, Karen Keeshan, Peter Adams, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-143079
Published: 2020
Journal Articles

BET Inhibitors Potentiate Activation of p53 and Killing of AML By MDM2 Inhibitors — a Candidate Combination Therapy

Peter D Adams, Anne Louise Latif, Ashley Newcombe, Neil Robertson, Maria Terradas, Helen Stewart, Claire Reid, Loveena Rishi Delori, Timothy Chevassut, Xu Huang, BSc, PhD, Karen Keeshan, Karen Blyth, Mhairi Copland
Journal: Blood
Blood (2018) 132 (Supplement 1): 3912.
https://doi.org/10.1182/blood-2018-99-115509
Published: 2018
Journal Articles

Dual Inhibition of MDM2 and BET Cooperate to Eradicate Acute Myeloid Leukemia

Anne-Louise Latif, MBChB, John J Cole, Joana Monteiro Campos, William Clark, Lynn McGarry, PhD, Claire Brock, Ashley Newcombe, Karen Keeshan, PhD, Mhairi Copland, BSc (Hons) MB ChB PhDFRCP FRCPath, Peter D Adams, PhD
Journal: Blood
Blood (2015) 126 (23): 674.
https://doi.org/10.1182/blood.V126.23.674.674
Published: 2015