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Kristina Kirschner
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Journal Articles

A Prospective Cohort Study of Biologic and Chronologic Aging in 106 Patients with Age and Context-Relevant Clonal Hematopoiesis

Marissa Li, Jenna A. Fernandez, Kristina Kirschner, Tamir Chandra, Kristen B. McCullough, Sarah Aug, Terra L. Lasho, Christy Finke, Naseema Gangat, Abhishek A. Mangaonkar, Rachel A Simon, Alejandro Ferrer, Mrinal M. Patnaik, James M. Foran, Cecilia Y. Arana Yi, Yael Kusne, Talha Badar
Journal: Blood
Blood (2024) 144 (Supplement 1): 5632.
https://doi.org/10.1182/blood-2024-206069
Published: 2024
Journal Articles

B-Precursor Acute Lymphoblastic Leukaemia Causes Paracrine Senescence in Mesenchymal Stromal Cells to Subvert the Treatment Response in Adult Acute Lymphoblastic Leukaemia

Aditi Dey, Ruchi Kumari, Andrew J Innes, Emily A Cutler, Hermione E Allen, Jenny Chatzigerou, Rodothea Amerikanou, Juma Ward, Jesus Gil, Adele Kay Fielding, Kristina Kirschner
Journal: Blood
Blood (2024) 144 (Supplement 1): 5655.
https://doi.org/10.1182/blood-2024-205756
Published: 2024
Journal Articles

Mitochondrial dsRNA from B-Precursor Acute Lymphoblastic Leukemia Cells Induce Formation of Cancer Associated Fibroblast in the Bone Marrow Leading to Formation of a Chemoprotective Bone Marrow Niche

Aditi Dey, Richard Burt, Emily Annie Cutler, Hermione Elsie Allen, Jenny Chatzigerou, Rodothea Amerikanou, Samantha Atkinson, Ashish Dhir, Kristina Kirschner, Adele Kay Fielding
Journal: Blood
Blood (2023) 142 (Supplement 1): 4073.
https://doi.org/10.1182/blood-2023-178759
Published: 2023
Journal Articles

Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche

Martha M. Zarou, Amy Dawson, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Giovanny Rodriguez Blanco, Mary Scott, Karen Dunn, Vaidehi Krishnan, Mhairi Copland, David Vetrie, Ravi Bhatia, Seth Coffelt, S.Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G. Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 2704.
https://doi.org/10.1182/blood-2023-181630
Published: 2023
Journal Articles

The Role of Mitochondrial RNA from B-Precursor Acute Lymphoblastic Leukaemia Cells in Generating a Chemoprotective Bone Marrow Niche

Aditi Dey, Richard J. Burt, Emily A. Cutler, Hermione E. Allen, Ashish Dhir, Kristina Kirschner, Adele K. Fielding
Journal: Blood
Blood (2022) 140 (Supplement 1): 2895–2896.
https://doi.org/10.1182/blood-2022-162293
Published: 2022
Journal Articles

Metabolic profiling of myeloproliferative neoplasms reveals subtype specific metabolic traits

Kristina Kirschner, Kevin Rattigan, Vignir Helgason, Fei Yan
Journal: Blood
Blood (2022) 140 (Supplement 1): 12180.
https://doi.org/10.1182/blood-2022-166992
Published: 2022
Journal Articles

p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion

Chrysa Kapeni, Leslie Nitsche, Alastair M. Kilpatrick, Nicola K. Wilson, Kankan Xia, Bahar Mirshekar-Syahkal, Vashe Chandrakanthan, Camille Malouf, John E. Pimanda, Berthold Göttgens, Kristina Kirschner, Simon R. Tomlinson, Katrin Ottersbach
Journal: Blood
Blood (2022) 140 (5): 464–477.
https://doi.org/10.1182/blood.2021014853
Published: 2022
Includes: Supplemental data
Journal Articles

A Synthetic Lethal Approach to Eradicate AML Via Synergistic Activation of Pro-Apoptotic p53 By MDM2 and BET Inhibitors

Sha Li, Anne-Louise Latif, Ashley Newcombe, Kathryn Gilrory, Neil Robertson, Xue Lei, Darren Finlay, PhD, Karina Barbosa, BSc, Helen Stewart, John Cole, Maria Terradas Terradas, Loveena Rishi Delori, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Andrew Davis, Jonathan Lopez, Jun-Ichi Sakamaki, Jennifer Morton, Kevin Ryan, Stephen Tait, Sheela Abraham, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Brian Higgins, Xu Huang, BSc, PhD, Karen Blyth, Mhairi Copland, PhD MBBChir, FRCP, FRCPath, Timothy Chevassut, Aniruddha J. Deshpande, PhD, Karen Keeshan, Peter Adams, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
https://doi.org/10.1182/blood-2020-143079
Published: 2020
Journal Articles

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress

Richard Burt, Aditi Dey, Sarah Aref, Melanie Aguiar, Ayse Akarca, Katharine Bailey, William Day, Steven Hooper, Amy Kirkwood, Kristina Kirschner, Soo-Wah Lee, Cristina Lo Celso, Jiten Manji, Marc R. Mansour, Teresa Marafioti, Rachel J. Mitchell, Robert C. Muirhead, Kenton Cheuk Yan Ng, Constandina Pospori, Ignazio Puccio, Krisztina Zuborne-Alapi, Erik Sahai, Adele K. Fielding
Journal: Blood
Blood (2019) 134 (17): 1415–1429.
https://doi.org/10.1182/blood.2019001398
Published: 2019
Includes: Supplemental data