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Journal Articles

Novel Role of Mitochondrial Folate Metabolism in Cell Fate Decisions and Leukaemogenesis

Martha M. Zarou, Kevin Rattigan, Daniele Sarnello, Amy Dawson, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 1369.
https://doi.org/10.1182/blood-2023-185915
Published: 2023
Journal Articles

MLL-AF9-Induced Leukaemia Changes during Ontogenic Stages

Meaad Saeed Almowaled, Lijun Liu, Karen Dunn, Myint Myat Khine Aung, Gillian Horne, Juerg Schwaller, Karen Keeshan
Journal: Blood
Blood (2023) 142 (Supplement 1): 2761.
https://doi.org/10.1182/blood-2023-185911
Published: 2023
Journal Articles

Nutrient-Sensitising Drug Repurposing Screen Identifies Lomerizine As a Mitochondrial Metabolism Inhibitor in Chronic Myeloid Leukaemia

Ahmed Khalaf, Lucie de Beauchamp, Eric Kalkman, Kevin Rattigan, Ekaterini Himonas, Joe Jones, Daniel James, Engy Shokry Abd Shokry, Mary Scott, Karen Dunn, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 862.
https://doi.org/10.1182/blood-2023-186405
Published: 2023
Journal Articles

Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche

Martha M. Zarou, Amy Dawson, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Giovanny Rodriguez Blanco, Mary Scott, Karen Dunn, Vaidehi Krishnan, Mhairi Copland, David Vetrie, Ravi Bhatia, Seth Coffelt, S.Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G. Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 2704.
https://doi.org/10.1182/blood-2023-181630
Published: 2023
Journal Articles

Uncoupling p53 from an Embryonic Regulome Exhausts Quiescent CML Stem Cells through Inhibition of a HIF1alpha Molecular Program

Mary T Scott, Wei Liu, Rebecca Mitchell, Cassie Clarke, Hassan Almasoudi, Felix Warren, Ross Kinstrie, Karen Dunn, John Pritchard, Mark E Drotar, Alison M Michie, Heather G Jørgensen, Brian Higgins, Mhairi Copland, David Vetrie
Journal: Blood
Blood (2021) 138 (Supplement 1): 1541.
https://doi.org/10.1182/blood-2021-150372
Published: 2021
Journal Articles

Role of mTORC1 and mTORC2 during Chronic Lymphocytic Leukaemia (CLL) Initiation and Progression

Natasha Malik, BSc, Karen Dunn, Owen Sansom, Prof, Alison M Michie, BSc, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3123.
https://doi.org/10.1182/blood-2018-99-116614
Published: 2018
Journal Articles

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells

Amy Sinclair, Laura Park, Mansi Shah, Mark Drotar, Simon Calaminus, Lisa E. M. Hopcroft, Ross Kinstrie, Amelie V. Guitart, Karen Dunn, Sheela A. Abraham, Owen Sansom, Alison M. Michie, Laura Machesky, Kamil R. Kranc, Gerard J. Graham, Francesca Pellicano, Tessa L. Holyoake
Journal: Blood
Blood (2016) 128 (3): 371–383.
https://doi.org/10.1182/blood-2015-08-661785
Published: 2016
Includes: Supplemental data
Journal Articles

CD93 Is a Novel Biomarker of Leukemia Stem Cells in Chronic Myeloid Leukemia

Ross Kinstrie, PhD BSc, Gillian A. Horne, BSc hons, MBChB, MRCP, MRES, Heather Morrison, BSc hons, Hothri A. Moka, BSc hons, Jennifer Cassels, BSc hons, Karen Dunn, BSc hons, Pawel Herzyk, MSc, PhD, David A. Irvine, BSc, MBBChir, MRCP, FRCPath, PhD, Mhairi Copland, BSc (Hons) MB ChB PhDFRCP FRCPath
Journal: Blood
Blood (2015) 126 (23): 49.
https://doi.org/10.1182/blood.V126.23.49.49
Published: 2015
Journal Articles

Subversion of Pkca and Pkcbii Upregulation Play an Essential Role in Chronic Lymphocytic Leukaemia Development, Inducing Constitutive B Cell Receptor-Mediated Signals

Anuradha Tarafdar, PhD, Ashfia Fatima Khan, M Pharm, Emilio Cosimo, Bsc, PhD, Hothri A. Moka, BSc hons, Karen Dunn, BSc hons, Alison M. Michie, PhD BSc
Journal: Blood
Blood (2015) 126 (23): 488.
https://doi.org/10.1182/blood.V126.23.488.488
Published: 2015
Journal Articles

The ATP-Competitive mTOR Inhibitor AZD8055 Reduces Cell Proliferation and Tumour Load in Chronic Lymphocytic Leukaemia

Emilio Cosimo, Bsc, PhD, Anuradha Tarafdar, PhD, Ailsa Holroyd, MD, Karen Dunn, BSc hons, Mark Catherwood, PhD, Alison M. Michie, PhD BSc
Journal: Blood
Blood (2015) 126 (23): 5287.
https://doi.org/10.1182/blood.V126.23.5287.5287
Published: 2015
Journal Articles

HIF-1α Is Not Essential For The Establishment Of MLL-Leukaemic Stem Cells

Deniz Gezer, Amelie V Guitart, Milica Vukovic, Chithra Subramani, Karen Dunn, Patrick Pollard, Peter J Ratcliffe, Tessa L. Holyoake, PhD, Kamil Kranc
Journal: Blood
Blood (2013) 122 (21): 3767.
https://doi.org/10.1182/blood.V122.21.3767.3767
Published: 2013
Journal Articles

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance

Brief Report
Amelie V. Guitart, Chithra Subramani, Alejandro Armesilla-Diaz, Gillian Smith, Catarina Sepulveda, Deniz Gezer, Milica Vukovic, Karen Dunn, Patrick Pollard, Tessa L. Holyoake, Tariq Enver, Peter J. Ratcliffe, Kamil R. Kranc
Journal: Blood
Blood (2013) 122 (10): 1741–1745.
https://doi.org/10.1182/blood-2013-02-484923
Published: 2013
Includes: Supplemental data